메뉴 건너뛰기




Volumn 34, Issue 4, 2013, Pages 867-880

Novel medical therapies for pulmonary arterial hypertension

Author keywords

Endothelial progenitor cells; Endothelin receptor antagonists; Guanylate cyclase stimulators; Prostacyclin receptor agonists; Rho kinase inhibitors; Tyrosine kinase inhibitors

Indexed keywords

ATORVASTATIN; BERAPROST; BISOPROLOL; BOSENTAN; CARDICOR; DASATINIB; ENDOTHELIN 1; ENDOTHELIN RECEPTOR ANTAGONIST; FLUOXETINE; IMATINIB; MACITENTAN; NILOTINIB; NITRIC OXIDE; PHOSPHODIESTERASE V INHIBITOR; PLACEBO; PROSTACYCLIN; PROSTANOID; RIOCIGUAT; SELEXIPAG; SENATEK; SEROTONIN; SILDENAFIL; SIMVASTATIN; SORAFENIB; TADALAFIL; TERGURIDE; TEZOSENTAN; TREPROSTINIL; UNCLASSIFIED DRUG; UNINDEXED DRUG; VARDENAFIL; VASOACTIVE INTESTINAL POLYPEPTIDE; WARFARIN;

EID: 84888186611     PISSN: 02725231     EISSN: 15578216     Source Type: Journal    
DOI: 10.1016/j.ccm.2013.08.002     Document Type: Review
Times cited : (9)

References (113)
  • 1
    • 80052081315 scopus 로고    scopus 로고
    • Treatment of pulmonary arterial hypertension with targeted therapies
    • O'Callaghan D., Savale L., Montani D., et al. Treatment of pulmonary arterial hypertension with targeted therapies. Nat Rev Cardiol 2011, 8:526-538.
    • (2011) Nat Rev Cardiol , vol.8 , pp. 526-538
    • O'Callaghan, D.1    Savale, L.2    Montani, D.3
  • 2
    • 77954758530 scopus 로고    scopus 로고
    • Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era
    • Humbert M., Sitbon O., Chaouat A., et al. Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era. Circulation 2010, 122(2):156-163.
    • (2010) Circulation , vol.122 , Issue.2 , pp. 156-163
    • Humbert, M.1    Sitbon, O.2    Chaouat, A.3
  • 3
    • 0025837793 scopus 로고
    • Survival in patients with primary pulmonary hypertension. Results from a national prospective registry
    • D'Alonzo G., Barst R., Ayres S., et al. Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann Intern Med 1991, 115(5):343-349.
    • (1991) Ann Intern Med , vol.115 , Issue.5 , pp. 343-349
    • D'Alonzo, G.1    Barst, R.2    Ayres, S.3
  • 4
    • 0027324745 scopus 로고
    • Expression of endothelin-1 in the lungs of patients with pulmonary hypertension
    • Giaid A., Yanagisawa M., Langleben D., et al. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. NEngl J Med 1993, 328(24):1732-1739.
    • (1993) NEngl J Med , vol.328 , Issue.24 , pp. 1732-1739
    • Giaid, A.1    Yanagisawa, M.2    Langleben, D.3
  • 5
    • 34547558919 scopus 로고    scopus 로고
    • Results of European post-marketing surveillance of bosentan in pulmonary hypertension
    • Humbert M., Segal E., Kiely D., et al. Results of European post-marketing surveillance of bosentan in pulmonary hypertension. Eur Respir J 2007, 30(2):338-344.
    • (2007) Eur Respir J , vol.30 , Issue.2 , pp. 338-344
    • Humbert, M.1    Segal, E.2    Kiely, D.3
  • 7
    • 84888166435 scopus 로고    scopus 로고
    • Macitentan for the treatment of idiopathic pulmonary fibrosis: the randomised controlled MUSIC trial
    • [Epub ahead of print]
    • Raghu G., Million-Rousseau R., Morganti A., et al. Macitentan for the treatment of idiopathic pulmonary fibrosis: the randomised controlled MUSIC trial. Eur Respir J 2013, [Epub ahead of print]. 10.1183/09031936.00104612.
    • (2013) Eur Respir J
    • Raghu, G.1    Million-Rousseau, R.2    Morganti, A.3
  • 8
    • 57349133022 scopus 로고    scopus 로고
    • Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist
    • Iglarz M., Binkert C., Morrison K., et al. Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist. JPharmacol Exp Ther 2008, 327(3):736-745.
    • (2008) JPharmacol Exp Ther , vol.327 , Issue.3 , pp. 736-745
    • Iglarz, M.1    Binkert, C.2    Morrison, K.3
  • 9
    • 70349807555 scopus 로고    scopus 로고
    • Comparison of the dissolution and pharmacokinetic profiles of two galenical formulations of the endothelin receptor antagonist macitentan
    • Kummer O., Haschke M., Hammann F., et al. Comparison of the dissolution and pharmacokinetic profiles of two galenical formulations of the endothelin receptor antagonist macitentan. Eur J Pharm Sci 2009, 38(4):384-388.
    • (2009) Eur J Pharm Sci , vol.38 , Issue.4 , pp. 384-388
    • Kummer, O.1    Haschke, M.2    Hammann, F.3
  • 10
    • 80054771944 scopus 로고    scopus 로고
    • Macitentan: entry-into-humans study with a new endothelin receptor antagonist
    • Sidharta P., van Giersbergen P., Halabi A., et al. Macitentan: entry-into-humans study with a new endothelin receptor antagonist. Eur J Clin Pharmacol 2011, 67(10):977-984.
    • (2011) Eur J Clin Pharmacol , vol.67 , Issue.10 , pp. 977-984
    • Sidharta, P.1    van Giersbergen, P.2    Halabi, A.3
  • 11
    • 77956242973 scopus 로고    scopus 로고
    • Macitentan, a tissue-targeting endothelin receptor antagonist for the potential oral treatment of pulmonary arterial hypertension and idiopathic pulmonary fibrosis
    • Raja S. Macitentan, a tissue-targeting endothelin receptor antagonist for the potential oral treatment of pulmonary arterial hypertension and idiopathic pulmonary fibrosis. Curr Opin Investig Drugs 2010, 11(9):1066-1073.
    • (2010) Curr Opin Investig Drugs , vol.11 , Issue.9 , pp. 1066-1073
    • Raja, S.1
  • 12
    • 84883108940 scopus 로고    scopus 로고
    • Macitentan and morbidity and mortality in pulmonary arterial hypertension
    • Pulido T., Adzerikho I., Channick R., et al. Macitentan and morbidity and mortality in pulmonary arterial hypertension. N Engl J Med 2013, 369(9):809-818.
    • (2013) N Engl J Med , vol.369 , Issue.9 , pp. 809-818
    • Pulido, T.1    Adzerikho, I.2    Channick, R.3
  • 13
    • 0026628265 scopus 로고
    • An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension
    • Christman B., McPherson C., Newman J., et al. An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. NEngl J Med 1992, 327(2):70-75.
    • (1992) NEngl J Med , vol.327 , Issue.2 , pp. 70-75
    • Christman, B.1    McPherson, C.2    Newman, J.3
  • 14
    • 0028597038 scopus 로고
    • Survival in primary pulmonary hypertension with long-term continuous intravenous prostacyclin
    • Barst R., Rubin L., McGoon M., et al. Survival in primary pulmonary hypertension with long-term continuous intravenous prostacyclin. Ann Intern Med 1994, 121(6):409-415.
    • (1994) Ann Intern Med , vol.121 , Issue.6 , pp. 409-415
    • Barst, R.1    Rubin, L.2    McGoon, M.3
  • 15
    • 84888191798 scopus 로고    scopus 로고
    • US NIH ClinicalTrials.gov. Study of a new thermo stable formulation of epoprostenol sodium to treatpulmonary arterial hypertension (PAH). Available at: Last updated October 18, 2012. Last Accessed September 29
    • US NIH ClinicalTrials.gov. Study of a new thermo stable formulation of epoprostenol sodium to treatpulmonary arterial hypertension (PAH). Available at: Last updated October 18, 2012. Last Accessed September 29, 2013. http://www.clinicaltrials.gov/ct2/show/NCT01462565?term=veletri%26rank=12011.
    • (2013)
  • 16
    • 84873198900 scopus 로고    scopus 로고
    • EPITOME-2, An open-label study evaluating a new formulation of epoprostenol sodium in pulmonary arterial hypertension patients switched from Flolan
    • Sitbon O., Delcroix M., Bergot E., et al. EPITOME-2, An open-label study evaluating a new formulation of epoprostenol sodium in pulmonary arterial hypertension patients switched from Flolan. Am J Resp Crit Care Med 2012, 10.1164/ajrccm-conference.2012.185.1_MeetingAbstracts.A2500.
    • (2012) Am J Resp Crit Care Med
    • Sitbon, O.1    Delcroix, M.2    Bergot, E.3
  • 17
    • 84885954778 scopus 로고    scopus 로고
    • Treatment of patients with pulmonary arterial hypertension at the time of death or deterioration to functional classIV: Insights from the REVEAL registry
    • pii: S1053-2498(13)01392-2. [Epub ahead of print]
    • Farber H., Miller D., Meltzer L., et al. Treatment of patients with pulmonary arterial hypertension at the time of death or deterioration to functional classIV: Insights from the REVEAL registry. J Heart Lung Transplant 2013, pii: S1053-2498(13)01392-2. [Epub ahead of print].
    • (2013) J Heart Lung Transplant
    • Farber, H.1    Miller, D.2    Meltzer, L.3
  • 18
    • 84866515810 scopus 로고    scopus 로고
    • Oral treprostinil for the treatment of pulmonary arterial hypertension in patients on background endothelin receptor antagonist and/or phosphodiesterase type 5 inhibitor therapy (the FREEDOM-C study): a randomized controlled trial
    • Tapson V., Torres F., Kermeen F., et al. Oral treprostinil for the treatment of pulmonary arterial hypertension in patients on background endothelin receptor antagonist and/or phosphodiesterase type 5 inhibitor therapy (the FREEDOM-C study): a randomized controlled trial. Chest 2012, 142(6):1383-1390.
    • (2012) Chest , vol.142 , Issue.6 , pp. 1383-1390
    • Tapson, V.1    Torres, F.2    Kermeen, F.3
  • 19
    • 84888176106 scopus 로고    scopus 로고
    • US NIH ClinicalTrials.gov. A 16-week, international, multicenter, double-blind, randomized, placebo-controlled study of the efficacy and safety of oral UT-15C sustained release tablets in subjects with pulmonary arterial hypertension (FREEDOM-C2). Available at: Last updated December 7, 2012. Last Accessed September 29,
    • US NIH ClinicalTrials.gov. A 16-week, international, multicenter, double-blind, randomized, placebo-controlled study of the efficacy and safety of oral UT-15C sustained release tablets in subjects with pulmonary arterial hypertension (FREEDOM-C2). Available at: Last updated December 7, 2012. Last Accessed September 29, 2013. http://www.clinicaltrials.gov/ct2/show/NCT00887978?term=FREEDOM-C2%26rank=12011.
    • (2013)
  • 20
    • 84888165395 scopus 로고    scopus 로고
    • United Therapeutics. UT-15C treprostinil diethanolamine sustained release tablets (oral treprostinil). Available at: Last Accessed September 29
    • United Therapeutics. UT-15C treprostinil diethanolamine sustained release tablets (oral treprostinil). Available at: Last Accessed September 29, 2013. http://www.unither.com/oral-treprostinil-for-pah.
    • (2013)
  • 21
    • 84888194026 scopus 로고    scopus 로고
    • US NIH ClinicalTrials.gov. FREEDOM - M: oral treprostinil as monotherapy for the treatment of pulmonary arterial hypertension (PAH). Available at:. Last updated February 12, 2013. Last Accessed September 29
    • US NIH ClinicalTrials.gov. FREEDOM - M: oral treprostinil as monotherapy for the treatment of pulmonary arterial hypertension (PAH). Available at:. Last updated February 12, 2013. Last Accessed September 29, 2013. http://www.clinicaltrials.gov/ct2/show/NCT00325403?term=FREEDOM-M%26rank=12012.
    • (2013)
  • 22
    • 84888170363 scopus 로고    scopus 로고
    • US NIH ClinicalTrials.gov. Trial of the early combination of oral treprostinil with a PDE-5 inhibitor or ERA in subjects with pulmonary arterial hypertension (FREEDOM-Ev) [Internet]. Available at: Last updated September 20, 2013. Last Accessed September 29
    • US NIH ClinicalTrials.gov. Trial of the early combination of oral treprostinil with a PDE-5 inhibitor or ERA in subjects with pulmonary arterial hypertension (FREEDOM-Ev) [Internet]. Available at: Last updated September 20, 2013. Last Accessed September 29, 2013. http://www.clinicaltrials.gov/ct2/show/NCT01560624?term=FREEDOM-Ev%26;rank=1.
    • (2013)
  • 23
    • 0038037766 scopus 로고    scopus 로고
    • Beraprost therapy for pulmonary arterial hypertension
    • Barst R., McGoon M., McLaughlin V., et al. Beraprost therapy for pulmonary arterial hypertension. JAm Coll Cardiol 2003, 41(12):2119-2125.
    • (2003) JAm Coll Cardiol , vol.41 , Issue.12 , pp. 2119-2125
    • Barst, R.1    McGoon, M.2    McLaughlin, V.3
  • 24
    • 84888169616 scopus 로고    scopus 로고
    • US NIH Clinicaltrials.gov. A multinational, multicenter study to assess the efficacy and safety of BPS-314d-MR in subjects with pulmonary arterial hypertension currently receiving treatment with anendothelin receptor antagonist and or a phosphodiesterase-5 inhibitor. Available at: Last updated September 26, 2013. Last Accessed September 29
    • US NIH Clinicaltrials.gov. A multinational, multicenter study to assess the efficacy and safety of BPS-314d-MR in subjects with pulmonary arterial hypertension currently receiving treatment with anendothelin receptor antagonist and or a phosphodiesterase-5 inhibitor. Available at: Last updated September 26, 2013. Last Accessed September 29, 2013. http://clinicaltrialsfeeds.org/clinical-trials/show/NCT01458236.
    • (2013)
  • 25
    • 58349110755 scopus 로고    scopus 로고
    • Metered dose inhaler delivery of treprostinil for the treatment of pulmonary hypertension
    • Voswinckel R., Reichenberger F., Gall H., et al. Metered dose inhaler delivery of treprostinil for the treatment of pulmonary hypertension. Pulm Pharmacol Ther 2009, 22(1):50-56.
    • (2009) Pulm Pharmacol Ther , vol.22 , Issue.1 , pp. 50-56
    • Voswinckel, R.1    Reichenberger, F.2    Gall, H.3
  • 26
    • 42949166212 scopus 로고    scopus 로고
    • Prostacyclin therapies for the treatment of pulmonary arterial hypertension
    • Gomberg-Maitland M., Olschewski H. Prostacyclin therapies for the treatment of pulmonary arterial hypertension. Eur Respir J 2008, 31(4):891-901.
    • (2008) Eur Respir J , vol.31 , Issue.4 , pp. 891-901
    • Gomberg-Maitland, M.1    Olschewski, H.2
  • 27
    • 34548101404 scopus 로고    scopus 로고
    • 2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug
    • Kuwano K., Hashino A., Asaki T., et al. 2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug. JPharmacol Exp Ther 2007, 322(3):1181-1188.
    • (2007) JPharmacol Exp Ther , vol.322 , Issue.3 , pp. 1181-1188
    • Kuwano, K.1    Hashino, A.2    Asaki, T.3
  • 28
    • 84863528040 scopus 로고    scopus 로고
    • Selexipag, an oral, selective IP receptor agonist for the treatment of pulmonary arterial hypertension
    • Simonneau G., Torbicki A., Hoeper M., et al. Selexipag, an oral, selective IP receptor agonist for the treatment of pulmonary arterial hypertension. Eur Respir J 2012, 40(4):874-880.
    • (2012) Eur Respir J , vol.40 , Issue.4 , pp. 874-880
    • Simonneau, G.1    Torbicki, A.2    Hoeper, M.3
  • 29
    • 82555195583 scopus 로고    scopus 로고
    • Looking to the future: a new decade of pulmonary arterial hypertension therapy
    • McLaughlin V. Looking to the future: a new decade of pulmonary arterial hypertension therapy. Eur Respir Rev 2011, 20(122):262-269.
    • (2011) Eur Respir Rev , vol.20 , Issue.122 , pp. 262-269
    • McLaughlin, V.1
  • 30
    • 84888171953 scopus 로고    scopus 로고
    • US NIH ClinicalTrials.gov. ACT-293987 in pulmonary arterial hypertension. Available at: Last updated September 3, 2013. Last Accessed September 29
    • US NIH ClinicalTrials.gov. ACT-293987 in pulmonary arterial hypertension. Available at: Last updated September 3, 2013. Last Accessed September 29, 2013. http://www.clinicaltrials.gov/ct2/show/NCT01106014?term=GRIPHON%26rank=1.
    • (2013)
  • 31
    • 84860285994 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 inhibitors for pulmonary arterial hypertension
    • Archer S., Michelakis E. Phosphodiesterase type 5 inhibitors for pulmonary arterial hypertension. NEngl J Med 2009, 361(19):1864-1871.
    • (2009) NEngl J Med , vol.361 , Issue.19 , pp. 1864-1871
    • Archer, S.1    Michelakis, E.2
  • 32
    • 0141459297 scopus 로고    scopus 로고
    • Acute hemodynamic effects and home therapy using a novel pulsed nasal nitric oxide delivery system in children and young adults with pulmonary hypertension
    • Ivy D., Parker D., Doran A., et al. Acute hemodynamic effects and home therapy using a novel pulsed nasal nitric oxide delivery system in children and young adults with pulmonary hypertension. Am J Cardiol 2003, 92(7):886-890.
    • (2003) Am J Cardiol , vol.92 , Issue.7 , pp. 886-890
    • Ivy, D.1    Parker, D.2    Doran, A.3
  • 33
    • 0029896789 scopus 로고    scopus 로고
    • Pulsed delivery of inhaled nitric oxide to patients with primary pulmonary hypertension: an ambulatory delivery system and initial clinical tests
    • Channick R., Newhart J., Johnson F., et al. Pulsed delivery of inhaled nitric oxide to patients with primary pulmonary hypertension: an ambulatory delivery system and initial clinical tests. Chest 1996, 109(6):1545-1549.
    • (1996) Chest , vol.109 , Issue.6 , pp. 1545-1549
    • Channick, R.1    Newhart, J.2    Johnson, F.3
  • 34
    • 26444534291 scopus 로고    scopus 로고
    • Sildenafil citrate therapy for pulmonary arterial hypertension
    • Galie N., Ghofrani H., Torbicki A., et al. Sildenafil citrate therapy for pulmonary arterial hypertension. NEngl J Med 2005, 353(20):2148-2157.
    • (2005) NEngl J Med , vol.353 , Issue.20 , pp. 2148-2157
    • Galie, N.1    Ghofrani, H.2    Torbicki, A.3
  • 35
    • 67649523052 scopus 로고    scopus 로고
    • Tadalafil therapy for pulmonary arterial hypertension
    • Galie N., Brundage B., Ghofrani H., et al. Tadalafil therapy for pulmonary arterial hypertension. Circulation 2009, 119(22):2894-2903.
    • (2009) Circulation , vol.119 , Issue.22 , pp. 2894-2903
    • Galie, N.1    Brundage, B.2    Ghofrani, H.3
  • 36
    • 4243194585 scopus 로고    scopus 로고
    • Vardenafil: structural basis for higher potency over sildenafil in inhibiting cGMP-specific phosphodiesterase-5 (PDE5)
    • Corbin J., Beasley A., Blount M., et al. Vardenafil: structural basis for higher potency over sildenafil in inhibiting cGMP-specific phosphodiesterase-5 (PDE5). Neurochem Int 2004, 45(6):859-863.
    • (2004) Neurochem Int , vol.45 , Issue.6 , pp. 859-863
    • Corbin, J.1    Beasley, A.2    Blount, M.3
  • 37
    • 69449088801 scopus 로고    scopus 로고
    • Vardenafil treatment for patients with pulmonary arterial hypertension: a multicentre, open-label study
    • Jing Z., Jiang X., Wu B., et al. Vardenafil treatment for patients with pulmonary arterial hypertension: a multicentre, open-label study. Heart 2009, 95(18):1531-1536.
    • (2009) Heart , vol.95 , Issue.18 , pp. 1531-1536
    • Jing, Z.1    Jiang, X.2    Wu, B.3
  • 38
    • 80051559475 scopus 로고    scopus 로고
    • Vardenafil in pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled study
    • Jing Z., Yu Z., Shen J., et al. Vardenafil in pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled study. Am J Respir Crit Care Med 2011, 183(12):1723-1729.
    • (2011) Am J Respir Crit Care Med , vol.183 , Issue.12 , pp. 1723-1729
    • Jing, Z.1    Yu, Z.2    Shen, J.3
  • 39
    • 33748312096 scopus 로고    scopus 로고
    • NO-independentstimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential
    • Evgenov O., Pacher P., Schmidt P., et al. NO-independentstimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat Rev Drug Discov 2006, 5(9):755-768.
    • (2006) Nat Rev Drug Discov , vol.5 , Issue.9 , pp. 755-768
    • Evgenov, O.1    Pacher, P.2    Schmidt, P.3
  • 40
    • 63849256355 scopus 로고    scopus 로고
    • First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension
    • Grimminger F., Weimann G., Frey R., et al. First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension. Eur Respir J 2009, 33(4):785-792.
    • (2009) Eur Respir J , vol.33 , Issue.4 , pp. 785-792
    • Grimminger, F.1    Weimann, G.2    Frey, R.3
  • 41
    • 84865065450 scopus 로고    scopus 로고
    • The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats
    • Lang M., Kojonazarov B., Tian X., et al. The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats. PLoS One 2012, 7(8):e43433.
    • (2012) PLoS One , vol.7 , Issue.8
    • Lang, M.1    Kojonazarov, B.2    Tian, X.3
  • 42
    • 77956664858 scopus 로고    scopus 로고
    • Riociguat for chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension: a phase II study
    • Ghofrani H., Hoeper M., Halank M., et al. Riociguat for chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension: a phase II study. Eur Respir J 2010, 36(4):792-799.
    • (2010) Eur Respir J , vol.36 , Issue.4 , pp. 792-799
    • Ghofrani, H.1    Hoeper, M.2    Halank, M.3
  • 43
    • 84888797522 scopus 로고    scopus 로고
    • Riociguat for the treatment of pulmonary arterial hypertension (PAH): a phase III long-term extension study (PATENT-2)
    • Available at:
    • Rubin L., Galie N., Grimminger F., et al. Riociguat for the treatment of pulmonary arterial hypertension (PAH): a phase III long-term extension study (PATENT-2). Am J Respir Crit Care Med 2013, Available at:. http://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2013.187.1_MeetingAbstracts.A3531.
    • (2013) Am J Respir Crit Care Med
    • Rubin, L.1    Galie, N.2    Grimminger, F.3
  • 44
    • 84880721470 scopus 로고    scopus 로고
    • Riociguat for the treatment of pulmonary arterial hypertension
    • Ghofrani H., Galie N., Grimminger F., et al. Riociguat for the treatment of pulmonary arterial hypertension. NEngl J Med 2013, 369:330-340.
    • (2013) NEngl J Med , vol.369 , pp. 330-340
    • Ghofrani, H.1    Galie, N.2    Grimminger, F.3
  • 45
    • 84880732460 scopus 로고    scopus 로고
    • Riociguat for the treatment of chronic thromboembolic pulmonary hypertension
    • Ghofrani H., D'Armini A., Grimminger F., et al. Riociguat for the treatment of chronic thromboembolic pulmonary hypertension. NEngl J Med 2013, 369:319-329.
    • (2013) NEngl J Med , vol.369 , pp. 319-329
    • Ghofrani, H.1    D'Armini, A.2    Grimminger, F.3
  • 46
    • 33746584053 scopus 로고    scopus 로고
    • Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond
    • Ghofrani H., Osterloh I., Grimminger F. Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat Rev Drug Discov 2006, 5(8):689-702.
    • (2006) Nat Rev Drug Discov , vol.5 , Issue.8 , pp. 689-702
    • Ghofrani, H.1    Osterloh, I.2    Grimminger, F.3
  • 47
    • 84888156853 scopus 로고    scopus 로고
    • US NIH ClinicalTrials.gov. Evaluation of the pharmacodynamic effect of the combination of sildenafil and riociguat on blood pressure and other safety parameters (PATENT PLUS). Available at: Last updated May 21, 2013. Last Accessed September 29
    • US NIH ClinicalTrials.gov. Evaluation of the pharmacodynamic effect of the combination of sildenafil and riociguat on blood pressure and other safety parameters (PATENT PLUS). Available at: Last updated May 21, 2013. Last Accessed September 29, 2013. http://clinicaltrials.gov/ct2/show/NCT01179334.
    • (2013)
  • 48
    • 84859628413 scopus 로고    scopus 로고
    • Bisoprolol delays progression towards right heart failure in experimental pulmonary hypertension
    • de Man F., Handoko M., van Ballegoij J., et al. Bisoprolol delays progression towards right heart failure in experimental pulmonary hypertension. Circ Heart Fail 2012, 5(1):97-105.
    • (2012) Circ Heart Fail , vol.5 , Issue.1 , pp. 97-105
    • de Man, F.1    Handoko, M.2    van Ballegoij, J.3
  • 49
    • 84860475234 scopus 로고    scopus 로고
    • Usefulness of beta-blocker therapy and outcomes in patients with pulmonary arterial hypertension
    • So P., Davies R., Chandy G., et al. Usefulness of beta-blocker therapy and outcomes in patients with pulmonary arterial hypertension. Am J Cardiol 2012, 109(10):1504-1509.
    • (2012) Am J Cardiol , vol.109 , Issue.10 , pp. 1504-1509
    • So, P.1    Davies, R.2    Chandy, G.3
  • 50
    • 46349109892 scopus 로고    scopus 로고
    • Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension
    • Perros F., Montani D., Dorfmuller P., et al. Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med 2008, 178(1):81-88.
    • (2008) Am J Respir Crit Care Med , vol.178 , Issue.1 , pp. 81-88
    • Perros, F.1    Montani, D.2    Dorfmuller, P.3
  • 51
    • 26444540768 scopus 로고    scopus 로고
    • Reversal of experimental pulmonary hypertension by PDGF inhibition
    • Schermuly R., Dony E., Ghofrani H., et al. Reversal of experimental pulmonary hypertension by PDGF inhibition. JClin Invest 2005, 115(10):2811-2821.
    • (2005) JClin Invest , vol.115 , Issue.10 , pp. 2811-2821
    • Schermuly, R.1    Dony, E.2    Ghofrani, H.3
  • 52
    • 77956709644 scopus 로고    scopus 로고
    • Imatinib in pulmonary arterial hypertension patients with inadequate response to established therapy
    • Ghofrani H., Morrell N., Hoeper M., et al. Imatinib in pulmonary arterial hypertension patients with inadequate response to established therapy. Am J Respir Crit Care Med 2010, 182(9):1171-1177.
    • (2010) Am J Respir Crit Care Med , vol.182 , Issue.9 , pp. 1171-1177
    • Ghofrani, H.1    Morrell, N.2    Hoeper, M.3
  • 53
    • 84874948946 scopus 로고    scopus 로고
    • Imatinib mesylate as add-on therapy for pulmonary arterial hypertension: results of the randomized IMPRES study
    • Hoeper M., Barst R., Bourge R., et al. Imatinib mesylate as add-on therapy for pulmonary arterial hypertension: results of the randomized IMPRES study. Circulation 2013, 127(10):1128-1138.
    • (2013) Circulation , vol.127 , Issue.10 , pp. 1128-1138
    • Hoeper, M.1    Barst, R.2    Bourge, R.3
  • 54
    • 36849056267 scopus 로고    scopus 로고
    • An anticancer C-Kit kinase inhibitor is reengineered to make it more active and less cardiotoxic
    • Fernández A., Sanguino A., Peng Z., et al. An anticancer C-Kit kinase inhibitor is reengineered to make it more active and less cardiotoxic. JClin Invest 2007, 117(12):4044-4054.
    • (2007) JClin Invest , vol.117 , Issue.12 , pp. 4044-4054
    • Fernández, A.1    Sanguino, A.2    Peng, Z.3
  • 55
    • 84862125953 scopus 로고    scopus 로고
    • Clinical cardiac safety profile of nilotinib
    • Kim T., le Coutre P., Schwarz M., et al. Clinical cardiac safety profile of nilotinib. Haematologica 2012, 97(6):883-889.
    • (2012) Haematologica , vol.97 , Issue.6 , pp. 883-889
    • Kim, T.1    le Coutre, P.2    Schwarz, M.3
  • 56
    • 84888171038 scopus 로고    scopus 로고
    • US NIH ClinicalTrials.gov. Efficacy, safety, tolerability and pharmacokinetics (PK) of nilotinib (AMN107) in pulmonary arterial hypertension. Available at: Last updated March 25, 2013. Last Accessed September 29
    • US NIH ClinicalTrials.gov. Efficacy, safety, tolerability and pharmacokinetics (PK) of nilotinib (AMN107) in pulmonary arterial hypertension. Available at: Last updated March 25, 2013. Last Accessed September 29, 2013. http://clinicaltrials.gov/ct2/show/NCT01179737?term=Nilotinib+pulmonary%26rank=12010.
    • (2013)
  • 57
    • 40749109217 scopus 로고    scopus 로고
    • Genomic assessment of a multikinase inhibitor, sorafenib, in a rodent model of pulmonary hypertension
    • Moreno-Vinasco L., Gomberg-Maitland M., Maitland M., et al. Genomic assessment of a multikinase inhibitor, sorafenib, in a rodent model of pulmonary hypertension. Physiol Genomics 2008, 33(2):278-291.
    • (2008) Physiol Genomics , vol.33 , Issue.2 , pp. 278-291
    • Moreno-Vinasco, L.1    Gomberg-Maitland, M.2    Maitland, M.3
  • 58
    • 77149179051 scopus 로고    scopus 로고
    • Adosing/cross-development study of the multikinase inhibitor sorafenib in patients with pulmonary arterial hypertension
    • Gomberg-Maitland M., Maitland M., Barst R., et al. Adosing/cross-development study of the multikinase inhibitor sorafenib in patients with pulmonary arterial hypertension. Clin Pharmacol Ther 2010, 87(3):303-310.
    • (2010) Clin Pharmacol Ther , vol.87 , Issue.3 , pp. 303-310
    • Gomberg-Maitland, M.1    Maitland, M.2    Barst, R.3
  • 60
    • 84860346274 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension in patients treated by Dasatinib
    • Montani D., Bergot E., Gunther S., et al. Pulmonary arterial hypertension in patients treated by Dasatinib. Circulation 2012, 125(17):2128-2137.
    • (2012) Circulation , vol.125 , Issue.17 , pp. 2128-2137
    • Montani, D.1    Bergot, E.2    Gunther, S.3
  • 61
    • 0029033224 scopus 로고
    • Increased plasma serotonin in primary pulmonary hypertension
    • Herve P., Launay J., Scrobohaci M., et al. Increased plasma serotonin in primary pulmonary hypertension. Am J Med 1995, 99(3):249-254.
    • (1995) Am J Med , vol.99 , Issue.3 , pp. 249-254
    • Herve, P.1    Launay, J.2    Scrobohaci, M.3
  • 62
    • 0036799278 scopus 로고    scopus 로고
    • Function of theserotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension
    • Launay J., Herve P., Peoc'h K., et al. Function of theserotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension. Nat Med 2002, 8(10):1129-1135.
    • (2002) Nat Med , vol.8 , Issue.10 , pp. 1129-1135
    • Launay, J.1    Herve, P.2    Peoc'h, K.3
  • 63
    • 53849130971 scopus 로고    scopus 로고
    • Pulmonary hypertension: therapeutic targets within the serotonin system
    • Dempsie Y., MacLean M. Pulmonary hypertension: therapeutic targets within the serotonin system. BrJ Pharmacol 2008, 155(4):455-462.
    • (2008) BrJ Pharmacol , vol.155 , Issue.4 , pp. 455-462
    • Dempsie, Y.1    MacLean, M.2
  • 64
    • 33846017361 scopus 로고    scopus 로고
    • Drugs and valvular heart disease
    • Roth B.L. Drugs and valvular heart disease. NEngl J Med 2007, 356(1):6-9.
    • (2007) NEngl J Med , vol.356 , Issue.1 , pp. 6-9
    • Roth, B.L.1
  • 65
    • 0034776773 scopus 로고    scopus 로고
    • Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension
    • Eddahibi S., Humbert M., Fadel E., et al. Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension. JClin Invest 2001, 108(8):1141-1150.
    • (2001) JClin Invest , vol.108 , Issue.8 , pp. 1141-1150
    • Eddahibi, S.1    Humbert, M.2    Fadel, E.3
  • 66
    • 0142085751 scopus 로고    scopus 로고
    • Polymorphism of the serotonin transporter gene and pulmonary hypertension in chronic obstructive pulmonary disease
    • Eddahibi S., Chaouat A., Morrell N., et al. Polymorphism of the serotonin transporter gene and pulmonary hypertension in chronic obstructive pulmonary disease. Circulation 2003, 108(15):1839-1844.
    • (2003) Circulation , vol.108 , Issue.15 , pp. 1839-1844
    • Eddahibi, S.1    Chaouat, A.2    Morrell, N.3
  • 67
    • 68549112957 scopus 로고    scopus 로고
    • Fluoxetine protects against monocrotaline-induced pulmonary arterial hypertension: potential roles of induction of apoptosis and upregulation of Kv1.5 channels in rats
    • Zhai F., Zhang X., Wang H. Fluoxetine protects against monocrotaline-induced pulmonary arterial hypertension: potential roles of induction of apoptosis and upregulation of Kv1.5 channels in rats. Clin Exp Pharmacol Physiol 2009, 36(8):850-856.
    • (2009) Clin Exp Pharmacol Physiol , vol.36 , Issue.8 , pp. 850-856
    • Zhai, F.1    Zhang, X.2    Wang, H.3
  • 68
    • 70049112738 scopus 로고    scopus 로고
    • Selective serotonin reuptake inhibitors and the incidence and outcome of pulmonary hypertension
    • Shah S., Gomberg-Maitland M., Thenappan T. Selective serotonin reuptake inhibitors and the incidence and outcome of pulmonary hypertension. Chest 2009, 136(3):694-700.
    • (2009) Chest , vol.136 , Issue.3 , pp. 694-700
    • Shah, S.1    Gomberg-Maitland, M.2    Thenappan, T.3
  • 69
    • 79955663912 scopus 로고    scopus 로고
    • Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats
    • Dumitrascu R., Kulcke C., Konigshoff M., et al. Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats. Eur Respir J 2011, 37(5):1104-1118.
    • (2011) Eur Respir J , vol.37 , Issue.5 , pp. 1104-1118
    • Dumitrascu, R.1    Kulcke, C.2    Konigshoff, M.3
  • 70
    • 84870738242 scopus 로고    scopus 로고
    • Proof-of-concept study to investigate the efficacy, haemodynamics and tolerability of teguride vs placebo in subjects with pulmonary arterial hypertension: results of a double-blind randomised, prospective IIa study
    • Ghofrani H., Al-Hitit H., Vonk-Noordegraaf H., et al. Proof-of-concept study to investigate the efficacy, haemodynamics and tolerability of teguride vs placebo in subjects with pulmonary arterial hypertension: results of a double-blind randomised, prospective IIa study. Am J Respir Crit Care Med 2012, 185:A2496.
    • (2012) Am J Respir Crit Care Med , vol.185
    • Ghofrani, H.1    Al-Hitit, H.2    Vonk-Noordegraaf, H.3
  • 71
    • 41149115441 scopus 로고    scopus 로고
    • Enhancement of pulmonary vascular remodelling and inflammatory genes with VIP gene deletion
    • Hamidi S., Prabhakar S., Said S. Enhancement of pulmonary vascular remodelling and inflammatory genes with VIP gene deletion. Eur Respir J 2008, 31(1):135-139.
    • (2008) Eur Respir J , vol.31 , Issue.1 , pp. 135-139
    • Hamidi, S.1    Prabhakar, S.2    Said, S.3
  • 72
    • 33947721196 scopus 로고    scopus 로고
    • Moderate pulmonary arterial hypertension in male mice lacking the vasoactive intestinal peptide gene
    • Said S., Hamidi S., Dickman K., et al. Moderate pulmonary arterial hypertension in male mice lacking the vasoactive intestinal peptide gene. Circulation 2007, 115(10):1260-1268.
    • (2007) Circulation , vol.115 , Issue.10 , pp. 1260-1268
    • Said, S.1    Hamidi, S.2    Dickman, K.3
  • 73
    • 80555144097 scopus 로고    scopus 로고
    • VIP and endothelin receptor antagonist: an effective combination against experimental pulmonary arterial hypertension
    • Hamidi S., Lin R., Szema A., et al. VIP and endothelin receptor antagonist: an effective combination against experimental pulmonary arterial hypertension. Respir Res 2011, 12:141.
    • (2011) Respir Res , vol.12 , pp. 141
    • Hamidi, S.1    Lin, R.2    Szema, A.3
  • 74
    • 0038369941 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide as a new drug for treatment of primary pulmonary hypertension
    • Petkov V., Mosgoeller W., Ziesche R., et al. Vasoactive intestinal peptide as a new drug for treatment of primary pulmonary hypertension. JClin Invest 2003, 111(9):1339-1346.
    • (2003) JClin Invest , vol.111 , Issue.9 , pp. 1339-1346
    • Petkov, V.1    Mosgoeller, W.2    Ziesche, R.3
  • 75
    • 84907492809 scopus 로고    scopus 로고
    • Effects of inhaled aviptadil (vasoactive intestinal peptide) in patients with pulmonary arterial hypertension (PAH): results from a phase II study.
    • Galie N, Badesch D, Fleming T, et al. Effects of inhaled aviptadil (vasoactive intestinal peptide) in patients with pulmonary arterial hypertension (PAH): results from a phase II study. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_MeetingAbstracts.A2516.
    • Galie, N.1    Badesch, D.2    Fleming, T.3
  • 76
    • 19044366349 scopus 로고    scopus 로고
    • Simvastatin treatment of pulmonary hypertension: an observational case series
    • Kao P.N. Simvastatin treatment of pulmonary hypertension: an observational case series. Chest 2005, 127(4):1446-1452.
    • (2005) Chest , vol.127 , Issue.4 , pp. 1446-1452
    • Kao, P.N.1
  • 77
    • 0033618378 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1)
    • Laufs U., Marra D., Node K. 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1). JBiol Chem 1999, 274(31):21926-21931.
    • (1999) JBiol Chem , vol.274 , Issue.31 , pp. 21926-21931
    • Laufs, U.1    Marra, D.2    Node, K.3
  • 78
    • 70349649065 scopus 로고    scopus 로고
    • Simvastatin and sildenafil combine to attenuate pulmonary hypertension
    • Zhao L., Sebkhi A., Ali O., et al. Simvastatin and sildenafil combine to attenuate pulmonary hypertension. Eur Respir J 2009, 34(4):948-957.
    • (2009) Eur Respir J , vol.34 , Issue.4 , pp. 948-957
    • Zhao, L.1    Sebkhi, A.2    Ali, O.3
  • 79
    • 77953273837 scopus 로고    scopus 로고
    • Simvastatin as a treatment for pulmonary hypertension trial (SiPHT)
    • Wilkins M.R., Ali O., Bradlow W., et al. Simvastatin as a treatment for pulmonary hypertension trial (SiPHT). Am J Respir Crit Care Med 2010, 181(10):1106-1113.
    • (2010) Am J Respir Crit Care Med , vol.181 , Issue.10 , pp. 1106-1113
    • Wilkins, M.R.1    Ali, O.2    Bradlow, W.3
  • 80
    • 79960020590 scopus 로고    scopus 로고
    • Randomized clinical trial of aspirin and simvastatin for pulmonary arterial hypertension: ASA-STAT
    • Kawut S.M., Bagiella E., Lederer D.J., et al. Randomized clinical trial of aspirin and simvastatin for pulmonary arterial hypertension: ASA-STAT. Circulation 2011, 123(25):2985-2993.
    • (2011) Circulation , vol.123 , Issue.25 , pp. 2985-2993
    • Kawut, S.M.1    Bagiella, E.2    Lederer, D.J.3
  • 81
    • 84863500159 scopus 로고    scopus 로고
    • Atorvastatin in pulmonary arterial hypertension (APATH) study
    • Zeng W., Xiong C., Zhao L., et al. Atorvastatin in pulmonary arterial hypertension (APATH) study. Eur Respir J 2012, 40(1):67-74.
    • (2012) Eur Respir J , vol.40 , Issue.1 , pp. 67-74
    • Zeng, W.1    Xiong, C.2    Zhao, L.3
  • 82
    • 0031892616 scopus 로고    scopus 로고
    • Long-term effects of cicletanine on secondary pulmonary hypertension
    • Saadjian A., Philip-Joet F., Paganelli F. Long-term effects of cicletanine on secondary pulmonary hypertension. JCardiovasc Pharmacol 1998, 31(3):364-371.
    • (1998) JCardiovasc Pharmacol , vol.31 , Issue.3 , pp. 364-371
    • Saadjian, A.1    Philip-Joet, F.2    Paganelli, F.3
  • 83
    • 84888144865 scopus 로고    scopus 로고
    • US NIH ClinicalTrials.gov. Study of cicletanine for pulmonary arterial hypertension (PAH). Available at: Last updated August 22, 2012. Last Accessed September 29
    • US NIH ClinicalTrials.gov. Study of cicletanine for pulmonary arterial hypertension (PAH). Available at: Last updated August 22, 2012. Last Accessed September 29, 2013. http://www.clinicaltrials.gov/show/NCT/00832507.
    • (2013)
  • 84
    • 67449105737 scopus 로고    scopus 로고
    • RhoA and Rho kinase activation in human pulmonary hypertension: role of 5-HT signaling
    • Guilluy C., Eddahibi S., Agard C., et al. RhoA and Rho kinase activation in human pulmonary hypertension: role of 5-HT signaling. Am J Respir Crit Care Med 2009, 179(12):1151-1158.
    • (2009) Am J Respir Crit Care Med , vol.179 , Issue.12 , pp. 1151-1158
    • Guilluy, C.1    Eddahibi, S.2    Agard, C.3
  • 85
    • 53849089211 scopus 로고    scopus 로고
    • Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension
    • Oka M., Fagan K., Jones P. Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension. Br J Pharmacol 2008, 155(4):444-454.
    • (2008) Br J Pharmacol , vol.155 , Issue.4 , pp. 444-454
    • Oka, M.1    Fagan, K.2    Jones, P.3
  • 86
    • 10744222390 scopus 로고    scopus 로고
    • Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats
    • Abe K., Shimokawa H., Morikawa K., et al. Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Circ Res 2004, 94(3):385-393.
    • (2004) Circ Res , vol.94 , Issue.3 , pp. 385-393
    • Abe, K.1    Shimokawa, H.2    Morikawa, K.3
  • 87
    • 14244260105 scopus 로고    scopus 로고
    • Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension
    • Fukumoto Y., Matoba T., Ito A., et al. Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension. Heart 2005, 91(3):391-392.
    • (2005) Heart , vol.91 , Issue.3 , pp. 391-392
    • Fukumoto, Y.1    Matoba, T.2    Ito, A.3
  • 89
    • 77957828780 scopus 로고    scopus 로고
    • Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension
    • Dahal B., Kosanovic D., Pamarthi P., et al. Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension. Eur Respir J 2010, 36(4):808-818.
    • (2010) Eur Respir J , vol.36 , Issue.4 , pp. 808-818
    • Dahal, B.1    Kosanovic, D.2    Pamarthi, P.3
  • 90
    • 6344257102 scopus 로고    scopus 로고
    • Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis
    • McMurtry M., Bonnet S., Wu X., et al. Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis. Circ Res 2004, 95(8):830-840.
    • (2004) Circ Res , vol.95 , Issue.8 , pp. 830-840
    • McMurtry, M.1    Bonnet, S.2    Wu, X.3
  • 91
    • 77952492039 scopus 로고    scopus 로고
    • New therapies for pulmonary arterial hypertension: an update on current bench to bedside translation
    • Dewachter L., Dewachter C., Naeije R. New therapies for pulmonary arterial hypertension: an update on current bench to bedside translation. Expert Opin Investig Drugs 2010, 19(4):469-488.
    • (2010) Expert Opin Investig Drugs , vol.19 , Issue.4 , pp. 469-488
    • Dewachter, L.1    Dewachter, C.2    Naeije, R.3
  • 92
    • 84888186905 scopus 로고    scopus 로고
    • US NIH ClinicalTrials.gov. Dichloroacetate (DCA) for the treatment of pulmonary arterial hypertension. Available at: 2010. Last updated November 3, 2011. Last Accessed September 29
    • US NIH ClinicalTrials.gov. Dichloroacetate (DCA) for the treatment of pulmonary arterial hypertension. Available at: 2010. Last updated November 3, 2011. Last Accessed September 29, 2013. http://clinicaltrials.gov/ct2/show/NCT01083524?term=Dichloroacetate%26rank=1.
    • (2013)
  • 93
    • 79954416675 scopus 로고    scopus 로고
    • ACE2, a promising therapeutic target for pulmonary hypertension
    • Shenoy V., Qi Y., Katovich M., et al. ACE2, a promising therapeutic target for pulmonary hypertension. Curr Opin Pharmacol 2011, 11(2):150-155.
    • (2011) Curr Opin Pharmacol , vol.11 , Issue.2 , pp. 150-155
    • Shenoy, V.1    Qi, Y.2    Katovich, M.3
  • 94
    • 79851513938 scopus 로고    scopus 로고
    • Autoantibodies to angiotensin-converting enzyme 2 in patients with connective tissue diseases
    • Takahashi Y., Haga S., Ishizaka Y., et al. Autoantibodies to angiotensin-converting enzyme 2 in patients with connective tissue diseases. Arthritis Res Ther 2010, 12(3):R85.
    • (2010) Arthritis Res Ther , vol.12 , Issue.3
    • Takahashi, Y.1    Haga, S.2    Ishizaka, Y.3
  • 95
    • 84875686064 scopus 로고    scopus 로고
    • The changes of serum angiotensin-converting enzyme 2 in patients with pulmonary arterial hypertension due to congenital heart disease
    • Dai H., Guo Y., Guang X., et al. The changes of serum angiotensin-converting enzyme 2 in patients with pulmonary arterial hypertension due to congenital heart disease. Cardiology 2013, 124(4):208-212.
    • (2013) Cardiology , vol.124 , Issue.4 , pp. 208-212
    • Dai, H.1    Guo, Y.2    Guang, X.3
  • 96
    • 68549122789 scopus 로고    scopus 로고
    • Prevention of pulmonary hypertension by angiotensin-converting enzyme 2 gene transfer
    • Yamazato Y., Ferreira A., Hong K., et al. Prevention of pulmonary hypertension by angiotensin-converting enzyme 2 gene transfer. Hypertension 2009, 54(2):365-371.
    • (2009) Hypertension , vol.54 , Issue.2 , pp. 365-371
    • Yamazato, Y.1    Ferreira, A.2    Hong, K.3
  • 97
    • 84863279449 scopus 로고    scopus 로고
    • Cytoskeletal defects in BMPR2-associated pulmonary arterial hypertension
    • Johnson J., Perrien A., Schuster M., et al. Cytoskeletal defects in BMPR2-associated pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol 2012, 302(5):L474-L484.
    • (2012) Am J Physiol Lung Cell Mol Physiol , vol.302 , Issue.5
    • Johnson, J.1    Perrien, A.2    Schuster, M.3
  • 98
    • 66249133083 scopus 로고    scopus 로고
    • Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension
    • Ferreira A., Shenoy V., Yamazato Y., et al. Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension. Am J Respir Crit Care Med 2009, 179(11):1048-1054.
    • (2009) Am J Respir Crit Care Med , vol.179 , Issue.11 , pp. 1048-1054
    • Ferreira, A.1    Shenoy, V.2    Yamazato, Y.3
  • 99
    • 49749133902 scopus 로고    scopus 로고
    • Rituximab treatment of pulmonary arterial hypertension associated with systemic lupus erythematosus: a case report
    • Hennigan S., Channick R., Silverman G. Rituximab treatment of pulmonary arterial hypertension associated with systemic lupus erythematosus: a case report. Lupus 2008, 17(8):754-756.
    • (2008) Lupus , vol.17 , Issue.8 , pp. 754-756
    • Hennigan, S.1    Channick, R.2    Silverman, G.3
  • 100
    • 84888153339 scopus 로고    scopus 로고
    • US NIH ClinicalTrials.gov. Rituximab for treatment of systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH). Available at: 2013. Last updated August 17, 2013. Last Accessed September 29
    • US NIH ClinicalTrials.gov. Rituximab for treatment of systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH). Available at: 2013. Last updated August 17, 2013. Last Accessed September 29, 2013. http://clinicaltrials.gov/ct2/show/NCT01086540.
    • (2013)
  • 101
    • 53349173222 scopus 로고    scopus 로고
    • Failure of bone morphogenetic protein receptor trafficking in pulmonary arterial hypertension: potential for rescue
    • Sobolewski A., Rudarakanchana N., Upton P., et al. Failure of bone morphogenetic protein receptor trafficking in pulmonary arterial hypertension: potential for rescue. Hum Mol Genet 2008, 17(20):3180-3190.
    • (2008) Hum Mol Genet , vol.17 , Issue.20 , pp. 3180-3190
    • Sobolewski, A.1    Rudarakanchana, N.2    Upton, P.3
  • 102
    • 84883480295 scopus 로고    scopus 로고
    • Correction of nonsense BMPR2 and SMAD9 mutations by ataluren in pulmonary arterial hypertension
    • Drake K., Dunmore B., McNelly L., et al. Correction of nonsense BMPR2 and SMAD9 mutations by ataluren in pulmonary arterial hypertension. Am J Respir Cell Mol Biol 2013, 49(3):403-409.
    • (2013) Am J Respir Cell Mol Biol , vol.49 , Issue.3 , pp. 403-409
    • Drake, K.1    Dunmore, B.2    McNelly, L.3
  • 103
    • 84884185388 scopus 로고    scopus 로고
    • Critical role for the advanced glycation end-products receptor in pulmonary arterial hypertension etiology
    • Meloche J., Courchesne A., Barrier M., et al. Critical role for the advanced glycation end-products receptor in pulmonary arterial hypertension etiology. JAm Heart Assoc 2013, 2(1):e005157.
    • (2013) JAm Heart Assoc , vol.2 , Issue.1
    • Meloche, J.1    Courchesne, A.2    Barrier, M.3
  • 104
    • 84879285500 scopus 로고    scopus 로고
    • Rapamycin reverses pulmonary-artery smooth-muscle-cell proliferation in pulmonary hypertension
    • Houssaini A., Abid S., Mouraret N., et al. Rapamycin reverses pulmonary-artery smooth-muscle-cell proliferation in pulmonary hypertension. Am J Respir Cell Mol Biol 2013, 48(5):568-577.
    • (2013) Am J Respir Cell Mol Biol , vol.48 , Issue.5 , pp. 568-577
    • Houssaini, A.1    Abid, S.2    Mouraret, N.3
  • 105
    • 84864290214 scopus 로고    scopus 로고
    • Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid
    • Zhao L., Chen C., Hajji N., et al. Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. Circulation 2012, 126(4):455-467.
    • (2012) Circulation , vol.126 , Issue.4 , pp. 455-467
    • Zhao, L.1    Chen, C.2    Hajji, N.3
  • 106
    • 79956200230 scopus 로고    scopus 로고
    • Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats
    • Bogaard H., Mizuno S., Hussaini A., et al. Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats. Am J Respir Crit Care Med 2011, 183(10):1402-1410.
    • (2011) Am J Respir Crit Care Med , vol.183 , Issue.10 , pp. 1402-1410
    • Bogaard, H.1    Mizuno, S.2    Hussaini, A.3
  • 107
    • 79251493500 scopus 로고    scopus 로고
    • Safety of sapropterin dihydrochloride (6r-bh4) in patients with pulmonary hypertension
    • Robbins I., Hemnes A., Gibbs J., et al. Safety of sapropterin dihydrochloride (6r-bh4) in patients with pulmonary hypertension. Exp Lung Res 2011, 37(1):26-34.
    • (2011) Exp Lung Res , vol.37 , Issue.1 , pp. 26-34
    • Robbins, I.1    Hemnes, A.2    Gibbs, J.3
  • 109
    • 84857499429 scopus 로고    scopus 로고
    • Serotonin 5-HT2B receptors are required for bone-marrow contribution to pulmonary arterial hypertension
    • Launay J., Herve P., Callebert J., et al. Serotonin 5-HT2B receptors are required for bone-marrow contribution to pulmonary arterial hypertension. Blood 2011, 119(7):1772-1780.
    • (2011) Blood , vol.119 , Issue.7 , pp. 1772-1780
    • Launay, J.1    Herve, P.2    Callebert, J.3
  • 110
    • 79958008167 scopus 로고    scopus 로고
    • Targeting of c-kit+ haematopoietic progenitor cells prevents hypoxic pulmonary hypertension
    • Gambaryan N., Perros F., Montani D., et al. Targeting of c-kit+ haematopoietic progenitor cells prevents hypoxic pulmonary hypertension. Eur Respir J 2011, 37(6):1392-1399.
    • (2011) Eur Respir J , vol.37 , Issue.6 , pp. 1392-1399
    • Gambaryan, N.1    Perros, F.2    Montani, D.3
  • 111
    • 14844360656 scopus 로고    scopus 로고
    • Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: efficacy of combined cell and eNOS gene therapy in established disease
    • Zhao Y., Courtman D., Deng Y., et al. Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: efficacy of combined cell and eNOS gene therapy in established disease. Circ Res 2005, 96(4):442-450.
    • (2005) Circ Res , vol.96 , Issue.4 , pp. 442-450
    • Zhao, Y.1    Courtman, D.2    Deng, Y.3
  • 112
    • 34047108549 scopus 로고    scopus 로고
    • Transplantation of autologous endothelial progenitor cells may be beneficial in patients with idiopathic pulmonary arterial hypertension: a pilot randomized controlled trial
    • Wang X., Zhang F., Shang Y., et al. Transplantation of autologous endothelial progenitor cells may be beneficial in patients with idiopathic pulmonary arterial hypertension: a pilot randomized controlled trial. JAm Coll Cardiol 2007, 49(14):1566-1571.
    • (2007) JAm Coll Cardiol , vol.49 , Issue.14 , pp. 1566-1571
    • Wang, X.1    Zhang, F.2    Shang, Y.3
  • 113
    • 84888170175 scopus 로고    scopus 로고
    • US NIH ClinicalTrials.gov. Pulmonary hypertension: assessment of cell therapy (PHACeT). Available at: Last updated March 7, 2013. Last Accessed September 29
    • US NIH ClinicalTrials.gov. Pulmonary hypertension: assessment of cell therapy (PHACeT). Available at: Last updated March 7, 2013. Last Accessed September 29, 2013. http://clinicaltrials.gov/ct2/show/NCT00469027?term=PHACeT%26rank=12010.
    • (2013)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.