Long-acting insulins alter milk composition and metabolism of lactating dairy cows

Journal of Dairy Science

Volumn 96, Issue 12, 2013, Pages 7565-7577

  Winkelman, L A ^a   Overton, T R ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

Dairy cow; Insulin; Milk protein

Indexed keywords

BOS; MAMMALIA;

FATTY ACID; GLARGINE; GLUCOSE BLOOD LEVEL; HUMAN INSULIN; INSULIN; ISOPHANE INSULIN; ISOPHANE INSULIN, HUMAN; LONG ACTING INSULIN;

ANIMAL; BOVINE; CHEMISTRY; CONTROLLED STUDY; DRUG EFFECTS; FEMALE; GLUCOSE BLOOD LEVEL; METABOLISM; MILK; RANDOMIZED CONTROLLED TRIAL; STANDARDS; SUBCUTANEOUS DRUG ADMINISTRATION; UREA NITROGEN BLOOD LEVEL; VETERINARY; WESTERN BLOTTING;

ANIMALS; BLOOD GLUCOSE; BLOOD UREA NITROGEN; BLOTTING, WESTERN; CATTLE; FATTY ACIDS, NONESTERIFIED; FEMALE; INJECTIONS, SUBCUTANEOUS; INSULIN; INSULIN, ISOPHANE; INSULIN, LONG-ACTING; INSULIN, REGULAR, HUMAN; MILK;

EID: 84888049442     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.2012-6498     Document Type: Article

References (52)

1. Amaral-Phillips D.M., McGilliard A.D., Lindberg G.L., Veenhuizen J.J., Young J.W. Effects of decreased availability of glucose for dairy cows. J. Dairy Sci 1993, 76:752-761.
2. International AOAC Official Methods of Analysis 2000, AOAC International, Arlington, VA. 17th.
3. Barbano D.M., Clark J.L., Dunham C.E. Comparison of the Babcock and ether extraction methods for determination of fat content in milk: Collaborative study. J. Assoc. Off. Anal. Chem 1988, 71:898-914.
4. Barbano D.M., Clark J.L., Dunham C.E., Fleming J.R. Kjeldahl method for determination of total nitrogen content of milk: Collaborative study. J. Assoc. Off. Anal. Chem 1990, 73:849-854.
5. Barbano D.M., Lynch J.M., Fleming J.R. Direct and indirect determination of true protein content of milk by Kjeldahl analysis: Collaborative study. J. Assoc. Off. Anal. Chem 1991, 74:281-288.
6. Bauman D.E., Peel C.J., Steinhour W.D., Reynolds P.J., Tyrrell H.F., Brown A.C., Haaland G.L. Effect of bovine somatotropin on metabolism of lactating dairy cows: Influence on rates of irreversible loss and oxidation of glucose and nonesterified fatty acids. J. Nutr 1988, 118:1031-1040.
7. Bequette B.J., Kyle C.E., Crompton L.A., Buchan V., Hanigan M.D. Insulin regulates milk production and mammary gland and hind-leg amino acid fluxes and blood flow in lactating goats. J. Dairy Sci 2001, 84:241-255.
8. Bionaz M., Loor J.J. Gene networks driving bovine milk fat synthesis during the lactation cycle. BMC Genomics 2008, 9:366. http://dx.doi.org/10.1186/1471-2164-9-366.
9. Bolster D.R., Jefferson L.S., Kimball S.R. Regulation of protein synthesis associated with skeletal muscle hypertrophy by insulin-, amino acid- and exercise-induced signalling. Proc. Nutr. Soc 2004, 63:351-356.
10. Bradford B.J., Allen M.S. Phlorizin induces lipolysis and alters meal patterns in both early- and late-lactation dairy cows. J. Dairy Sci 2007, 90:1810-1815.
11. Brockman R.P. Roles of glucagon and insulin in the regulation of metabolism in ruminants. Can. Vet. J 1978, 19:55-62.
12. Brockman R.P., Laarveld B. Hormonal regulation of metabolism in ruminants; a review. Livest. Prod. Sci 1986, 14:313-334.
13. Burgos S.A., Cant J.P. IGF-1 stimulates protein synthesis by enhanced signaling through mTORC1 in bovine mammary epithelial cells. Domest. Anim. Endocrinol 2010, 38:211-221.
14. Burgos S.A., Dai M., Cant J.P. Nutrient availability and lactogenic hormones regulate mammary protein synthesis through the mammalian target of rapamycin signaling pathway. J. Dairy Sci 2010, 93:153-161.
15. Campbell L.E., Wang X., Proud C.G. Nutrients differentially regulate multiple translation factors and their control by insulin. Biochem. J 1999, 344:433-441.
16. Corl B.A., Butler S.T., Butler W.R., Bauman D.E. Short communication: Regulation of milk fat yield and fatty acid composition by insulin. J. Dairy Sci 2006, 89:4172-4175.
17. Dairy, R. M. S. 2010. DHI-210 Monthly Report. 12/10. Dairy Records Management Systems, Raleigh, NC.
18. Dubois M., Gilles K.A., Hamilton J.K., Rebers P.A., Smith F. Colorimetric method for determination of sugars and related substances. Anal. Chem 1956, 28:350-356.
19. Goering, H. K., and P. J. Van Soest. 1970. Forage fiber analysis. USDA-ARS Handbook No. 379. US Governmental Printing Office, Washington, DC.
20. Griinari J.M., McGuire M.A., Dwyer D.A., Bauman D.E., Barbano D.M., House W.A. The role of insulin in the regulation of milk protein synthesis in dairy cows. J. Dairy Sci 1997, 80:2361-2371.
21. Griinari J.M., McGuire M.A., Dwyer D.A., Bauman D.E., Palmquist D.L. Role of insulin in the regulation of milk fat synthesis in dairy cows. J. Dairy Sci 1997, 80:1076-1084.
22. Gustafsson A.H., Palmquist D.L. Diurnal variation of rumen ammonia, serum urea, and milk urea in dairy cows at high and low yields. J. Dairy Sci 1993, 76:475-484.
23. Hall M.B. Determination of starch, including maltooligosaccharides, in animal feeds: Comparison of methods and a method recommended for AOAC collaborative study. J. AOAC Int 2009, 92:42-49.
24. Hayashi A.A., Nones K., Roy N.C., McNabb W.C., Mackenzie D.S., Pacheco D., McCoard S. Initiation and elongation steps of mRNA translation are involved in the increase in milk protein yield caused by growth hormone administration during lactation. J. Dairy Sci 2009, 92:1889-1899.
25. Jackson M.B., Lammi-Keefe C.J., Jensen R.G., Couch S.C., Ferris A.M. Total lipid and fatty acid composition of milk from women with and without insulin-dependent diabetes mellitus. Am. J. Clin. Nutr 1994, 60:353-361.
26. Krishnamoorthy U., Muscato T.V., Sniffen C.J., Van Soest P.J. Nitrogen fractions in selected feedstuffs. J. Dairy Sci 1982, 65:217-225.
27. Kronfeld D.S., Mayer G.P., Robertson J.M., Raggi F. Depression of milk secretion during insulin administration. J. Dairy Sci 1963, 46:559-563.
28. Laarveld B., Christensen D.A., Brockman R.P. The effect of insulin on net metabolism of glucose and amino acids by the bovine mammary gland. Endocrinology 1981, 108:2217-2221.
29. Léonard M., Block E. Effects on nutrient and hormonal profile of long-term infusions of glucose or insulin plus glucose in cows treated with recombinant bovine somatotropin before peak milk yield. J. Dairy Sci 1997, 80:127-143.
30. Lynch J.M., Barbano D.M., Fleming J.R. Indirect and direct determination of the casein content of milk by Kjeldahl nitrogen analysis: Collaborative study. J. AOAC Int 1998, 81:763-774.
31. Mackle T.R., Dwyer D.A., Ingvartsen K.L., Chouinard P.Y., Lynch J.M., Barbano D.M., Bauman D.E. Effects of insulin and amino acids on milk protein concentration and yield from dairy cows. J. Dairy Sci 1999, 82:1512-1524.
32. Mahoney S.J., Dempsey J.M., Blenis J. Chapter 2: Cell signaling in protein synthesis: Ribosome biogenesis and translation initiation and elongation. Prog. Mol. Biol. Transl. Sci 2009, 90:53-107.
33. McGuire M.A., Griinari J.M., Dwyer D.A., Bauman D.E. Role of insulin in the regulation of mammary synthesis of fat and protein. J. Dairy Sci 1995, 78:816-824.
34. Metcalf J.A., Mansbridge R.J., Blake J.S., Oldham J.D., Newbold J.R. The efficiency of conversion of metabolisable protein into milk true protein over a range of metabolisable protein intakes. Animal 2008, 2:1193-1202.
35. Metcalf J.A., Sutton J.D., Cockburn J.E., Napper D.J., Beever D.E. The influence of insulin and amino acid supply on amino acid uptake by the lactating bovine mammary gland. J. Dairy Sci 1991, 74:3412-3420.
36. Nelson B.K., Barbano D.M. Reduced-fat Cheddar cheese manufactured using a novel fat removal process. J. Dairy Sci 2004, 87:841-853.
37. Proud C.G. Regulation of protein synthesis by insulin. Biochem. Soc. Trans 2006, 34:213-216.
38. Proud C.G. Signalling to translation: How signal transduction pathways control the protein synthetic machinery. Biochem. J 2007, 403:217-234.
39. Rius A.G., Appuhamy J.A.D.R., Cyriac J., Kirovski D., Becvar O., Escobar J., McGilliard M.L., Bequette B.J., Akers R.M., Hanigan M.D. Regulation of protein synthesis in mammary glands of lactating dairy cows by starch and amino acids. J. Dairy Sci 2010, 93:3114-3127.
40. Rook J.A.F., Storry J.E., Wheelock J.V. Plasma glucose and acetate and milk secretion in the ruminant. J. Dairy Sci 1965, 48:745-747.
41. SAS Institute. 2001. SAS User's Guide: Statistics. Version 8 ed. SAS Inst. Inc., Cary, NC.
42. Schmidt G.H. Effect of insulin on yield and composition of milk of dairy cows. J. Dairy Sci 1966, 49:381-385.
43. Shukla A., Grisouard J., Ehemann V., Hermani A., Enzmann H., Mayer D. Analysis of signaling pathways related to cell proliferation stimulated by insulin analogs in human mammary epithelial cell lines. Endocr. Relat. Cancer 2009, 16:429-441.
44. Thivierge M.C., Petitclerc D., Bernier J.F., Couture Y., Lapierre H. Variations in mammary metabolism during the natural filling of the udder with milk over a 12-h period between two milkings. J. Dairy Sci 2002, 85:1839-1854.
45. Thivierge M.C., Petitclerc D., Bernier J.F., Couture Y., Lapierre H. Variations in mammary protein metabolism during the natural filling of the udder with milk over a 12-h period between two milkings: Leucine kinetics. J. Dairy Sci 2002, 85:2974-2985.
46. Toerien C.A., Trout D.R., Cant J.P. Nutritional stimulation of milk protein yield of cows is associated with changes in phosphorylation of mammary eukaryotic initiation factor 2 and ribosomal S6 kinase 1. J. Nutr 2010, 140:285-292.
47. Tylutki T.P., Fox D.G., Durbal V.M., Tedeschi L.O., Russell J.B., Van Amburgh M.E., Overton T.R., Chase L.E., Pell A.N. Cornell Net Carbohydrate and Protein System: A model for precision feeding of dairy cattle. Anim. Feed Sci. Technol 2008, 143:174-202.
48. Van Soest P.J., Robertson J.B., Lewis B.A. Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. J. Dairy Sci 1991, 74:3583-3597.
49. Winkelman L.A., Overton T.R. The effects of increasing doses of 2 preparations of long-acting insulin on short-term plasma profiles of glucose and insulin in lactating dairy cows. J. Dairy Sci 2012, 95:6974-6982.
50. Witters L.A., Watts T.D., Daniels D.L., Evans J.L. Insulin stimulates the dephosphorylation and activation of acetyl-CoA carboxylase. Proc. Natl. Acad. Sci. USA 1988, 85:5473-5477.
51. Wright T.C., Cant J.P., Brenna J.T., McBride B.W. Acetyl CoA carboxylase shares control of fatty acid synthesis with fatty acid synthase in bovine mammary homogenate. J. Dairy Sci 2006, 89:2552-2558.
52. Zhao F.Q., Keating A.F. Expression and regulation of glucose transporters in the bovine mammary gland. J. Dairy Sci 2007, 90(E-Suppl.):E76-E86.