The effect of light fractionation with a 2-h dark interval on the efficacy of topical hexyl-aminolevulinate photodynamic therapy in normal mouse skin

Photodiagnosis and Photodynamic Therapy

Volumn 10, Issue 4, 2013, Pages 703-709

  Middelburg, T A ^a   de Bruijn, H S ^a   van der Ploeg van den Heuvel, A ^a   Neumann, H A M ^a   Robinson, D J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

ALA; HAL; Light fractionation; Mouse skin; PDT

Indexed keywords

AMINOLEVULINIC ACID HEXYL ESTER; PROTOPORPHYRIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEACHING; DARKNESS; DRUG EFFICACY; ENDOTHELIUM CELL; FLUORESCENCE; FRACTIONATION; ILLUMINATION; LIGHT FRACTIONATION; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; SCORING SYSTEM; SKIN DEFECT; TREATMENT RESPONSE; VASCULARIZATION;

ALA; AMINOLEVULINIC ACID; AREA UNDER THE CURVE; AUC; HAL; HEXYL-AMINOLEVULINATE; LIGHT FRACTIONATION; MAL; METHYL-AMINOLEVULINATE; MOUSE SKIN; PDT; PHOTODYNAMIC THERAPY; PPIX; PROTOPORPHYRIN IX; SD; STANDARD DEVIATION;

ADMINISTRATION, TOPICAL; AMINOLEVULINIC ACID; ANIMALS; DOSE FRACTIONATION; LIGHT; MICE; MICE, NUDE; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; REFERENCE VALUES; SKIN; TREATMENT OUTCOME;

EID: 84888043472     PISSN: 15721000     EISSN: 18731597     Source Type: Journal    
DOI: 10.1016/j.pdpdt.2013.09.002     Document Type: Article

References (33)

1. Kennedy J.C., Pottier R.H., Pross D.C. Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience. J Photochem Photobiol B 1990, 6(1-2):143-148.
2. de Haas E.R., Kruijt B., Sterenborg H.J., Martino Neumann H.A., Robinson D.J. Fractionated illumination significantly improves the response of superficial basal cell carcinoma to aminolevulinic acid photodynamic therapy. J Invest Dermatol 2006, 126(12):2679-2686.
3. de Vijlder H.C., Sterenborg H.J., Neumann H.A., Robinson D.J., de Haas E.R. Light fractionation significantly improves the response of superficial basal cell carcinoma to aminolaevulinic acid photodynamic therapy: five-year follow-up of a randomized, prospective trial. Acta Derm Venereol 2012, 92(6):641-647. 10.2340/00015555-1448.
4. Robinson D.J., de Bruijn H.S., van der Veen N., Stringer M.R., Brown S.B., Star W.M. Fluorescence photobleaching of ALA-induced protoporphyrin IX during photodynamic therapy of normal hairless mouse skin: the effect of light dose and irradiance and the resulting biological effect. Photochem Photobiol 1998, 67(1):140-149.
5. Robinson D.J., de Bruijn H.S., de Wolf W.J., Sterenborg H.J., Star W.M. Topical 5-aminolevulinic acid-photodynamic therapy of hairless mouse skin using two-fold illumination schemes: PpIX fluorescence kinetics, photobleaching and biological effect. Photochem Photobiol 2000, 72(6):794-802.
6. Robinson D.J., de Bruijn H.S., Star W.M., Sterenborg H.J. Dose and timing of the first light fraction in two-fold illumination schemes for topical ALA-mediated photodynamic therapy of hairless mouse skin. Photochem Photobiol 2003, 77(3):319-323.
7. de Bruijn H.S., van der Ploeg-van den Heuvel A., Sterenborg H.J., Robinson D.J. Fractionated illumination after topical application of 5-aminolevulinic acid on normal skin of hairless mice: the influence of the dark interval. J Photochem Photobiol B 2006, 85(3):184-190.
8. de Bruijn H.S., de Haas E.R., Hebeda K.M., et al. Light fractionation does not enhance the efficacy of methyl 5-aminolevulinate mediated photodynamic therapy in normal mouse skin. Photochem Photobiol Sci 2007, 6(12):1325-1331.
9. de Bruijn H.S., Meijers C., van der Ploeg-van den Heuvel A., Sterenborg H.J., Robinson D.J. Microscopic localisation of protoporphyrin IX in normal mouse skin after topical application of 5-aminolevulinic acid or methyl 5-aminolevulinate. J Photochem Photobiol B 2008, 92(2):91-97. 10.1016/j.jphotobiol.2008.05.005.
10. Middelburg T.A., de Vijlder H.C., de Bruijn H.S., et al. Topical photodynamic therapy using different porphyrin precursors leads to differences in vascular photosensitization and vascular damage in normal mouse skin. J Photochem Photobiol 2013, submitted for publication.
11. de Vijlder H., de Bruijn H., van der Ploeg-van den Heuvel A., et al. Acute vascular responses during photodynamic therapy using topically administered porphyrin precursors. Photochem Photobiol Sci 2013, [in press].
12. Soergel P., Wang X., Stepp H., Hertel H., Hillemanns P. Photodynamic therapy of cervical intraepithelial neoplasia with hexaminolevulinate. Lasers Surg Med 2008, 40(9):611-615. 10.1002/lsm.20686.
13. Soergel P., Makowski L., Makowski E., Schippert C., Hertel H., Hillemanns P. Treatment of high grade cervical intraepithelial neoplasia by photodynamic therapy using hexylaminolevulinate may be costeffective compared to conisation procedures due to decreased pregnancy-related morbidity. Lasers Surg Med 2011, 43(7):713-720. 10.1002/lsm.21072.
14. Soergel P., Dahl G.F., Onsrud M., Hillemanns P. Photodynamic therapy of cervical intraepithelial neoplasia 1-3 and human papilloma virus (HMV) infection with methylaminolevulinate and hexaminolevulinate - a double-blind, dose-finding study. Lasers Surg Med 2012, 44(6):468-474. 10.1002/lsm.22041.
15. Juzeniene A., Nielsen K.P., Zhao L., et al. Changes in human skin after topical PDT with hexyl aminolevulinate. Photodiagnosis Photodyn Ther 2008, 5(3):176-181.
16. Bader M.J., Stepp H., Beyer W., et al. Photodynamic therapy of bladder cancer - a phase I study using hexaminolevulinate (HAL). Urol Oncol 2012, 20:20.
17. Dognitz N., Salomon D., Zellweger M., et al. Comparison of ALA- and ALA hexyl-ester-induced PpIX depth distribution in human skin carcinoma. J Photochem Photobiol B 2008, 93(3):140-148.
18. Rodriguez L., de Bruijn H.S., Di Venosa G., et al. Porphyrin synthesis from aminolevulinic acid esters in endothelial cells and its role in photodynamic therapy. J Photochem Photobiol B 2009, 96(3):249-254.
19. Middelburg T.A., De Bruijn H.A., Tettero L., et al. Topical hexylaminolevulinate and aminolevulinic acid photodynamic therapy: complete arteriole vasoconstriction occurs frequently and depends on protoporphyrin IX concentration in vessel wall. J Photochem Photobiol B. 2013, Epub July 11. 10.1016/j.jphotobiol.2013.06.014.
20. Langmack K., Mehta R., Twyman P., Norris P. Topical photodynamic therapy at low fluence rates - theory and practice. J Photochem Photobiol B 2001, 60(1):37-43.
21. Finlay J.C., Mitra S., Patterson M.S., Foster T.H. Photobleaching kinetics of photofrin in vivo and in multicell tumour spheroids indicate two simultaneous bleaching mechanisms. Phys Med Biol 2004, 49(21):4837-4860.
22. Middelburg T.A., Van Zaane F., De Bruijn H.S., et al. Fractionated illumination at low fluence rate photodynamic therapy in mice. Photochem Photobiol 2010, 86(5):1140-1146. 10.1111/j.1751-1097.2010.00760.x.
23. de Bruijn H.S., Casas A.G., Di Venosa G., et al. Light fractionated ALA-PDT enhances therapeutic efficacy in vitro; the influence of PpIX concentration and illumination parameters. Photochem Photobiol Sci 2013, 12(2):241-245. 10.1039/c2pp25287b.
24. Marti A., Jichlinski P., Lange N., et al. Comparison of aminolevulinic acid and hexylester aminolevulinate induced protoporphyrin IX distribution in human bladder cancer. J Urol 2003, 170(2 Pt 1):428-432.
25. Endlicher E., Rummele P., Hausmann F., et al. Protoporphyrin IX distribution following local application of 5-aminolevulinic acid and its esterified derivatives in the tissue layers of the normal rat colon. Br J Cancer 2001, 85(10):1572-1576.
26. Casas A., Perotti C., Fukuda H., Rogers L., Butler A.R., Batlle A. ALA and ALA hexyl ester-induced porphyrin synthesis in chemically induced skin tumours: the role of different vehicles on improving photosensitization. Br J Cancer 2001, 85(11):1794-1800.
27. Rud E., Gederaas O., Hogset A., Berg K. 5-Aminolevulinic acid, but not 5-aminolevulinic acid esters, is transported into adenocarcinoma cells by system BETA transporters. Photochem Photobiol 2000, 71(5):640-647.
28. Rodriguez L., Batlle A., Di Venosa G., et al. Mechanisms of 5-aminolevulinic acid ester uptake in mammalian cells. Br J Pharmacol 2006, 147(7):825-833.
29. Rodriguez L., Batlle A., Di Venosa G., et al. Study of the mechanisms of uptake of 5-aminolevulinic acid derivatives by PEPT1 and PEPT2 transporters as a tool to improve photodynamic therapy of tumours. Int J Biochem Cell Biol 2006, 38(9):1530-1539.
30. Schulten R., Novak B., Schmitz B., Lubbert H. Comparison of the uptake of 5-aminolevulinic acid and its methyl ester in keratinocytes and skin. Naunyn Schmiedebergs Arch Pharmacol 2012, 385(10):969-979. 10.1007/s00210-012-0777-4.
31. Ascencio M., Estevez J.P., Delemer M., Farine M.O., Collinet P., Mordon S. Comparison of continuous and fractionated illumination during hexaminolaevulinate-photodynamic therapy. Photodiagnosis Photodyn Ther 2008, 5(3):210-216.
32. Estevez J.P., Ascencio M., Colin P., Farine M.O., Collinet P., Mordon S. Continuous or fractionated photodynamic therapy? Comparison of three PDT schemes for ovarian peritoneal micrometastasis treatment in a rat model. Photodiagnosis Photodyn Ther 2010, 7(4):251-257. 10.1016/j.pdpdt.2010.07.007.
33. Mikolajewska P. Pain during topical photodynamic therapy [www document] 2011, [accessed 12.03.13]. http://www.duo.uio.no/handle/10852/11075%3Flocale-attribute=en.