Fluorescence Photobleaching of ALA-induced Protoporphyrin IX during Photodynamic Therapy of Normal Hairless Mouse Skin: The Effect of Light Dose and Irradiance and the Resulting Biological Effect

Photochemistry and Photobiology

Volumn 67, Issue 1, 1998, Pages 140-149

  Robinson, Dominic J ^a   De Bruijn, Henriëtte S ^b   Van Der Veen, Nynke ^b   Stringer, Mark R ^a   Brown, Stanley B ^a   Star, Willem M ^b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOLEVULINIC ACID; PROTOPORPHYRIN;

ANIMAL; ARTICLE; FLUORESCENCE; HAIRLESS MOUSE; LIGHT; METABOLISM; MOUSE; PHOTOCHEMOTHERAPY; RADIATION EXPOSURE; RADIATION RESPONSE; SKIN;

AMINOLEVULINIC ACID; ANIMALS; DOSE-RESPONSE RELATIONSHIP, RADIATION; FLUORESCENCE; LIGHT; MICE; MICE, INBRED HRS; PHOTOCHEMOTHERAPY; PROTOPORPHYRINS; SKIN;

EID: 0031603032     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1751-1097.1998.tb05177.x     Document Type: Article

References (50)

1. Weishaupt, R., C. J. Gomer and T. J. Dougherty (1993) Identification of singlet oxygen as the cytotoxic agent in photo-activation of a murine tumor. J. Natl. Cancer Inst. 85, 443-456.
2. Gibson, S. L. and R. Hilf (1985) Interdependence of fluence, drug dose and oxygen on hematoporphyrin derivative induced photosensitisation of tumor mitochondria. Photochem. Photobiol. 42, 367-373.
3. Moan, J. and S. Sommer (1985) Oxygen dependence of the photosensitizing effect of hematoporphyrin derivative in NHIK 3025 cells. Cancer Res. 45, 1608-1610.
4. Parker, J. G. (1986) Optical detection of the photodynamic production of singlet oxygen in-vivo. Lasers Surg. Med. 6, 258-259.
5. Patterson, M. S., S. J. Madsen and B. C. Wilson (1990) Experimental tests of the feasibility of singlet oxygen luminescence monitoring in-vivo during photodynamic therapy. J. Photochem. Photobiol. B 29, 69-84.
6. Kennedy, J. C., R. H. Pottier and D. C. Pross (1990) Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical practice. J. Photochem. Photobiol B 6, 143-148.
7. Svanberg, K., T. Andersson, D. Killander, I. Wang, U. Stebram, S. Andersson-Engels, R. Berg, J. Johansson and S. Svanberg (1994) Photodynamic therapy of non-melanoma malignant tumours of the skin using topical δ-aminolaevulinic acid sensitization and laser irradiation. Br. J. Dermatol. 130, 743-751.
8. Cairnduff, F., M. R. Stringer, E. J. Hudson, D. V. Ash and S. B. Brown (1994) Superficial photodynamic therapy with topical 5-aminolaevulinic acid for superficial primary and secondary skin cancer. Br. J. Cancer 69, 605-608.
9. Fijan, S., H. Hönigsmann and B. Ortel (1995) Photodynamic therapy of epithelial skin tumours using delta-aminolaevulinic acid and desferrioxamine. Br. J. Dermatol. 133, 282-288.
10. Wyss, P., L. O. Svaassand, Y. Tadir, U. Haller, M. W. Berns, M. T. Wyss and B. J. Tromberg (1995) Photomedicine and the endometrium: experimental concepts. Hum. Reprod. 10, 221-226.
11. Boehncke, W. H., W. Sterry and R. Kauffmann (1994) Treatment of psoriasis by topical photodynamic therapy with polychromatic light. Lancet 343, 801.
12. Stringer, M. R., D. J. Robinson and P. Collins (1996) The establishment of treatment parameters for ALA-PDT of plaque psoriasis. Proc. Soc. Photo-Opt. Inst. Eng. 2924, 314-318.
13. Wolf, E. P., E. Rieger and H. Kerl (1993) Topical photodynamic therapy with endogenous porphyrins after application of 5-aminolevulinic acid. An alternative treatment modality for solar keratoses, superficial squamous cell carcinoma, and basal cell carcinomas? J. Am. Acad. Dermatol. 28, 17-21.
14. Orenstein, A., G. Kostenich, T. Haggai, E. Kogan and Z. Malik (1995) Temperature monitoring during photodynamic therapy of skin tumors with topical 5-aminolevulinic acid application. Cancer Lett. 93, 227-232.
15. Messmann, H., P. Mlkvy, G. Buonaccorsi, C. E. Davies, A. J. MacRobert and S. G. Bown (1995) Enhancement of photodynamic therapy with 5-aminolaevulinic acid-induced photosensitisation on normal rat colon by threshold and light fractionation studies. Br. J. Cancer 72, 589-594.
16. Hua, Z. X., S. E. Gibson, T. H. Foster and R. Hilf (1995) Effectiveness of delta-aminolevulinic acid-induced protoporphyrin as a photosensitizer for photodynamic therapy in-vivo. Cancer Res. 55, 1723-1731.
17. Van der Veen, N., H. L. L. M. van Leengoed and W. M. Star (1994) In-vivo fluorescence kinetics and photodynamic therapy using 5-aminolaevulinic acid-induced porphyrin: increased damage after multiple irradiations. Br. J. Cancer 70, 867-872.
18. Wolf, P., R. Fink-Puches, L. Cerroni and H. Kerl (1994) Photodynamic therapy for mycosis fungoides after topical photosensitization with 5-aminolevulinic acid. J. Am. Acad. Dermatol. 31, 678-680.
19. Moan, J., H. Berg, H. Anholt and K. Madslein (1994) Sulfonated aluminium phthalocyanines as sensitizers for photochemotherapy - effects of small light doses on localisation, dye fluorescence and photosensitivity in V79 cells. Int. J. Cancer 58, 865-870.
20. Mang, T. S., T. J. Dougherty, W. R. Potter, D. G. Boyle, S. Somer and J. Moan (1987) Photobleaching of porphyrins used in photodynamic therapy and implications for therapy. Photochem. Photobiol. 45, 501-506.
21. Potter, W. R., T. S. Mang and T. J. Dougherty (1987) The theory of photodynamic therapy dosimetry: consequences of photodestruction of sensitiser. Photochem. Photobiol. 46, 97-101.
22. Svaasand, L. O., P. Wyss, M.-T. Wyss, Y. Tadir, B. J. Tromberg and M. W. Berns (1996) Dosimetry model for photodynamic therapy with topically administered photosensitisers. Lasers Surg. Med. 18, 139-149.
23. Georgakoudi, I. and T. H. Foster (1996) Photobleaching of PpIX, NBSe and NBS during photodynamic therapy of multicellular tumour spheroids. Photochem. Photobiol. 63(s), 90s.
24. ® photobleaching and its consequences for photodynamic therapy. Photochem. Photobiol. 65, 135-144.
25. Robinson, D. J., M. R. Stringer and W. R. Crum (1995) A rate equation analysis of protoporphyrin IX photo-oxidation. Proc. Soc. Photo-Opt. Inst. Eng. 2625, 413-418.
26. Forrer, T. M., T. Glanzmann, D. Braichotte, G. Wagnières, H. van den Bergh, J. F. Savary and P. Monnier (1995) In-vivo measurement of fluorescence bleaching of meso-tetra hydroxyphenylchlorin (mTHPC) in the esophagus and the oral cavity. Proc. Soc. Photo-Opt. Inst. Eng. 2627, 33-39.
27. Van der Veen, N., H. S. de Bruijn, R. J. W. Berg and W. M. Star (1996) Kinetics and localisation of PpIX fluorescence after topical and systemic ALA application, observed in skin and skin tumours of UVB-treated mice. Br. J. Cancer 73, 925-930.
28. Robb, R. A. (1989) Interactive display and analysis of 3-D medical images. IEEE Trans. Med. Imag. 8, 217-226.
29. Van der Veen, N., H. S. de Bruijn and W. M. Star (1997) Photobleaching during and re-appearance after photodynamic therapy of topical ALA induced fluorescence in UVB-treated mouse skin. Int. J. Cancer. 72, 110-118.
30. Wang, L. H., S. L. Jacques and L. Q. Zheng (1995) MCML-Monte-Carlo modelling of light transport in multi-layered tissues. Comput. Methods Programs Biomed. 47, 131-146.
31. Jacques, S. L. (1991) The role of skin optics in diagnostic and therapeutic uses of lasers. In Lasers in Dermatology (Edited by R. Steiner, R. Kaufmann, M. Landthaler and O. Braun-Falco), pp. 1-21. Springer Verlag, Berlin and Heidelberg.
32. Moan, J. (1986) Effect of bleaching of porphyrin sensitisers during photodynamic therapy. Cancer Lett. 33, 43-53.
33. Moan, J. (1988) A change in the quantum yield of photoinactivation of cells observed during photodynamic treatment. Lasers Med. Sci. 3, 93-97
34. Moan, J., G. Streckyte, S. Bagdonas, O. Bech and K. Berg. (1997) Photobleaching of protoporphyrin IX in cells incubated with 5-aminolevulininc acid. Int. J. Cancer 70, 90-97.
35. Iinuma, S., S. S. Farshi, B. Oetel and T. Hasan (1994) A mechanistic study of cellular photodestruction with 5-aminolaevulinic acid-induced porphyrin. Br. J. Cancer 70, 21-28.
36. Moan, J., V. Iani, L. W. Ma and Q. Peng (1995) Photodegradation of sensitizers in mouse skin during PCT. Proc. Soc. Photo-Opt. Inst. Eng. 2625, 187-193.
37. Rhodes, L. E., M. M. Tsoukas, R. Anderson and N. Kollias (1997) Iontophoretic delivery of ALA provides a quantitative model for ALA pharmacokinetics and PpIX phototoxicity in human skin. J. Invest. Dermatol. 108, 87-91.
38. Dan, H., S. Shigeru and H. W. Lim (1993) Effect of UVA and blue light on porphyrin biosynthesis in epidermal cells. Photochem. Photobiol. 57, 825-829.
39. Konig, K., H. Schneckenburger, A. Ruck and R. Steiner (1993) In-vivo photoproduct formation during PDT with ALA-induced endogenous phorphyrins. J. Photochem. Photobiol. B 18, 287-290.
40. Ahram, M., W.-F. Cheong, K. Ward and D. Kessel (1994) Photoproduct formation during irradiation of tissues containing protoporphyrin. J. Photochem. Photobiol. B 26, 203-204.
41. Gudgin Dickson, E. F. and R. H. Pottier (1995) On the role of protoporphyrin IX photoproducts in photodynamic therapy. J. Photochem. Photobiol. B 29, 91-93.
42. König, K., H. Schneckenburger, A. Ruck and R. Steiner (1994) Studies on porphyrin photoproducts in solution, cells, and tumor tissue. Proc. Soc. Photo-Opt. Inst. Eng. 2133, 226-237.
43. Feins, R. H., R. Hilf, H. Ross and S. L. Gibson (1990) Photodynamic therapy for human malignant mesothelioma in the nude mouse. J. Surg. Res. 49, 311-314.
44. Gibson, S. L., T. H. Foster, R. H. Feins, R. F. Raubertas, M. A. Fallon and R. Hilf (1994) Effects of photodynamic therapy on xenografts of human mesothelioma and rat mammary carcinoma in nude mice. Br. J. Cancer 69, 473-481.
45. Cincotta, L., J. W. Foley, T. MacEachern, E. Lampros and A. H. Cincotta (1994) Novel photodynamic effects of benzophenothiazine on two different murine sarcomas. Cancer Res. 54, 1249-1258.
46. Chen, Q., M. Chopp, M. O. Dereski, B. C. Wilson, M. S. Patterson, A. Schreiber and F. W. Hetzel (1992) The effect of light fluence rate in photodynamic therapy of normal rat brain. Radiat. Res. 132, 120-123.
47. Farrell, T. J., B. C. Wilson, M. S. Patterson and R. Chow (1991) The dependence of photodynamic threshold dose on treatment parameters in normal rat liver in-vivo. Proc. Soc. Photo-Opt. Inst. Eng. 1426, 145-146.
48. Gomer, C. J., N. Rucker, N. J. Razum and A. L Murphree (1985) In-vitro and in-vivo light dose rate effects related to hematoporphyrin derivative photodynamic therapy. Cancer Res. 49, 1973-1977.
49. Foster, T. H. and L. Gao (1992) Dosimetry in photodynaic therapy: oxygen and the critical importance of capillary density. Radiat. Res. 130, 379-383.
50. Foster, T. H., R. S. Murant, R. G. Bryant, R. S. Knox, S. L. Gibson and. R. Hilf (1991) Oxygen consumption and diffusion effects in photodynamic therapy. Radiat. Res. 126, 296-303.