Light fractionation significantly improves the response of superficial basal cell carcinoma to aminolaevulinic acid photodynamic therapy: Five-year follow-up of a randomized, prospective trial

Acta Dermato-Venereologica

Volumn 92, Issue 6, 2012, Pages 641-647

  De Vijlder, Hannah C ^a   Sterenborg, Henricus J C M ^a   Martino Neumann, H A ^a   Robinson, Dominic J ^a   De Haas, Ellen R M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

ALA PDT; Basal cell carcinoma; Dosimetry; Light fractionation; PpIX

Indexed keywords

AMINOLEVULINIC ACID;

ADULT; AGED; ARTICLE; BASAL CELL CARCINOMA; BROADBAND LIGHT; DIODE LASER; DRUG RESPONSE; ELECTRICAL EQUIPMENT; FOLLOW UP; HUMAN; ILLUMINATION; LIGHT EMITTING DIODE; LIGHT FRACTIONATION; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL (TOPIC); TREATMENT OUTCOME;

ADMINISTRATION, CUTANEOUS; ADULT; AGED; AGED, 80 AND OVER; AMINOLEVULINIC ACID; CARCINOMA, BASAL CELL; FEMALE; FOLLOW-UP STUDIES; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; NETHERLANDS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PROSPECTIVE STUDIES; SKIN NEOPLASMS; TIME FACTORS; TREATMENT OUTCOME;

EID: 84867827651     PISSN: 00015555     EISSN: 16512057     Source Type: Journal    
DOI: 10.2340/00015555-1448     Document Type: Article

References (46)

1. Brown SB, Brown EA, Walker I. The present and future role of photodynamic therapy in cancer treatment. Lancet Oncol 2004; 5: 497-508.
2. Fan BG, Andrén-Sandberg A. Photodynamic therapy for pancreatic cancer. Pancreas 2007; 34: 385-389.
3. Davidson SR, Weersink RA, Haider MA, Gertner MR, Bogaards A, Giewercer D, et al. Treatment planning and dose analysis for interstitial photodynamic therapy of prostate cancer. Phys Med Biol 2009; 54: 2293-2313.
4. Wildeman MA, Nyst HJ, Karakullukcu B, Tan BI. Photodynamic therapy in the therapy for recurrent/persistent nasopharyngeal cancer. Head Neck Oncol 2009; 1: 40.
5. Weishaupt R, Gomer CJ, Dougherty TJ. Identification of singlet oxygen as the cytotoxic agent in photo-activation of a murine tumor. J. Natl Cancer Inst 1993; 85: 443-456.
6. Busch TM. Local physiological changes during photodynamic therapy. Lasers Surg Med 2006; 38: 494-499.
7. Castano AP, Mroz P, Hamblin MR. Photodynamic therapy and anti-tumour immunity. Nat Rev Cancer 2006; 6: 535-545.
8. Woodhams JH, Macrobert AJ, Bown SG. The role of oxygen monitoring during photodynamic therapy and its potential for treatment dosimetry. Photochem Photobiol Sci 2007; 6: 1246-1256.
9. Kennedy JC, Pottier RH, Pross DC. Photodynamic therapy with endogenous protoporhyrin IX: basic principles and present clinical experience. J Photochem. Photobiol B 1990; 6:143-148.
10. Kennedy JC, Pottier RH, Endogenous protoporphyrin IX, a clinically useful photosensitiser for photodynamic therapy J Photochem Photobiol B, 1992; 14: 275-292.
11. Morton CA, McKenna KE, Rhodes LE. Guidelines for topical photodynamic therapy: update; British Association of Dermatologists Therapy Guidelines and Audit Subcommittee and the British Photodermatology Group. Br J Dermatol 2008; 159: 1245-1266.
12. Biel MA. Photodynamic therapy of head and neck cancers. Methods Mol Biol 2010; 635: 281-293.
13. Wang JB, Liu LX. Use of photodynamic therapy in malignant lesions of stomach, bile duct, pancreas, colon and rectum. Hepatogastroenterology 2007; 54: 718-724.
14. Lehmann P. Methyl aminolaevulinate-photodynamic therapy: a review of clinical trials in the treatment of actinic keratoses and nonmelanoma skin cancer. Br J Dermatol 2007; 156: 793-801.
15. Pariser DM, Lowe NJ, Stewart DM, Jarratt MT, Lucky AW, Pariser RJ, et al. Photodynamic therapy with topical methyl aminolevulinate for actinic keratosis: results of a prospective randomized multicenter trial. J Am Acad Dermatol 2003; 48: 227-232.
16. Robinson DJ, de Bruijn HS, van der Veen N, Stringer MR, Brown SB, Star WM. Fluorescence photobleaching of ALA induced protoporphyrin IX during photodynamic therapy of normal hairless mouse skin: the effect of light dose and irradiance and the resulting biological effect. Photochem Photobiol 1998; 67: 140-149.
17. Peng, Q, Soler A-M, Warloe T, Nesland JM, Giercksky K-E. Selective distribution of porphyrins in skin thick basal cell carcinoma after topical application of methyl 5-aminolevulinate. J. Photochem Photobiol B: Biol 2001; 62: 140-145.
18. Henderson BW, Dougherty TJ. How does photodynamic therapy work? Photochem Photobiol 1992; 55: 145-157.
19. Merclin N, Bramer T, Edsman K. Iontophoretic delivery of 5-aminolevulinic acid and its methyl ester using a carbopol gel as vehicle. J Control Release 2004; 98: 57-65.
20. Gerritsen MJ, Smits T, Kleinpenning MM, van de Kerkhof PC, van Erp PE. Pretreatment to enhance protoporphyrin IX accumulation in photodynamic therapy. Dermatology 2009; 218: 193-202.
21. Campbell SM, Morton CA, Alyahya R, Horton S, Pye A, Curnow A. Clinical investigation of the novel iron-chelating agent, CP94, to enhance topical photodynamic therapy of nodular basal cell carcinoma. Br J Dermatol 2008; 159: 387-393.
22. Fotinos N, Campo MA, Popowycz F, Gurny R, Lange N. 5-Aminolevulinic acid derivatives in photomedicine: characteristics, application and perspectives. Photochem Photobiol 2006; 82: 994-1015.
23. Braathen LR, Szeimies RM, Basset-Seguin N, Bissonnette R, Foley P, Pariser D, et al. Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: an international consensus. International Society for Photodynamic Therapy in Dermatology, 2005. J Am Acad Dermatol 2007; 56: 125-143.
24. Souza CS, Felicio LB, Ferreira J, Kurachi C, Bentley MV, Tedesco AC, et al. Long-term follow-up of topical 5-aminolaevulinic acid photodynamic therapy diode laser single session for non-melanoma skin cancer. Photodiagnosis Photodyn Ther 2009; 3/4: 207-213.
25. Star WM, van't Veen AJ, Robinson DJ, Munte K, de Haas ERM, Sterenborg HJCM. Topical 5-aminolevulinic acid mediated photodynamic therapy of superficial basal cell carcinoma using 2 light-fractions with a 2-hour interval: longterm follow-up. Acta Derm Venereol 2006; 86: 412-417.
26. Robinson DJ, de Bruijn HS, Star WM, Sterenborg HJCM. Dose and timing of the first light fraction in two-fold illumination schemes for topical ALA-mediated photodynamic therapy of hairless mouse skin. Photochem Photobiol 2003; 77: 319-323.
27. de Bruijn HS, van der Ploeg-van den Heuvel A, Sterenborg HJ, Robinson DJ. Fractionated illumination after topical application of 5-aminolevulinic acid on normal skin of hairless mice: the influence of the dark interval. J Photochem Photobiol B 2006; 85: 184-190.
28. de Haas ERM, Kruijt B, Sterenborg HJCM, Neumann HAM, Robinson DJ. Fractionated illumination significantly improves the response of superficial basal cell carcinoma to aminolevulinic acid photodynamic therapy. J Invest Dermatol 2006; 126: 2679-2686.
29. van der Veen N, van Leengoed HL, Star WM. In vivo fluorescence kinetics and photodynamic therapy using 5-aminolaevulinic acid-induced porphyrin: increased damage after multiple irradiations. Br J Cancer 1994; 70: 867-872.
30. van der Veen N, Hebeda KM, de Bruijn HS, Star WM. Photodynamic effectiveness and vasoconstriction in hairless mouse skin after topical 5-aminolevulinic acid and singleor two-fold illumination. Photochem Photobiol 1999; 70: 921-929.
31. Middelburg TA, Van Zaane F, De Bruijn HS, Van Der Ploeg-van den Heuvel A, Sterenborg HJ, Neumann HA, et al. Fractionated illumination at low fluence rate photodynamic therapy in mice. Photochem Photobiol 2010; 86: 1140-1146.
32. Smits T, Moor AC. New aspects in photodynamic therapy of actinic keratoses. J Photochem Photobiol B 2009; 96: 159-169.
33. Basset-Seguin N, Ibbotson SH, Emtestam L, Tarstedt M, Morton C, Maroti M, et al. Topical methyl aminolaevulinate photodynamic therapy versus cryotherapy for superficial basal cell carcinoma: a 5 year randomized trial. Eur J Dermatol 2008; 18: 547-553.
34. Thissen MR, Neumann MH, Schouten LJ. A systematic review of treatment modalities for primary basal cell carcinomas. Arch Dermatol 1999; 135: 1177-1183.
35. Mougel F, Debarbieux S, Ronger-Savlé S, Dalle S, Thomas L. Methylaminolaevulinate photodynamic therapy in patients with multiple basal cell carcinomas in the setting of Gorlin-Goltz syndrome or after radiotherapy. Dermatology 2009; 219: 138-142.
36. Bøgelund FS, Philipsen PA, Gniadecki R. Factors affecting the recurrence rate of basal cell carcinoma. Acta Derm Venereol 2007; 87: 330-334.
37. Telfer NR, Colver GB, Bowers PW. Guidelines for the management of basal cell carcinoma. British Association of Dermatologists. Br J Dermatol 1999; 141: 415-423.
38. Soergel P, Hillemanns P. Photodynamic therapy for intraepithelial neoplasia of the lower genital tract. Photodiagnosis Photodyn Ther 2010; 7: 10-14.
39. Kelty CJ, Ackroyd R, Brown NJ, Brown SB, Reed MW Comparison of high- vs low-dose 5-aminolevulinic acid for photodynamic therapy of Barrett's esophagus. Surg Endosc 2004; 18: 452-458.
40. Clark C, Bryden A, Dawe R, Moseley H, Ferguson J, Ibbotson S. Topical 5-aminolaevulinic acid photodynamic therapy for cutaneous lesions: outcome and comparison of light sources. Photodermatol Photoimmunol Photomed 2003; 9: 134-141.
41. Gudgin Dickson EF, Pottier RH. On the role of protoporphyrin IX photoproducts in photodynamic therapy. J Photochem Photobiol B 1995; 29: 91-93.
42. de Bruijn, HS, Casas A, Di Venosa G, Gandara L, Sterenborg HJCM, Battle A, et al. Light fractionated ALA-PDT enhances therapeutic efficacy in-vitro; the influence of PpIX concentration and illumination parameters. Photochem. Photobiol Sci 2012 (in press).
43. de Bruijn HS, Light fractionated ALA-PDT. PhD thesis. Rotterdam: Erasmus University Rotterdam; 2008.
44. de Bruijn HS, Casas A, Di Venosa G, Rodriguez L, Sterenborg HJCM, Battle A, et al. Fractionated ALA-PDT in PAM212 cells. Photodiagnosis Photodyn Ther 2011; 2: 203-204.
45. de Bruijn HS, de Haas ERM, Hebeda KM, van der Ploegvan den Heuvel A, Sterenborg HJCM, Neumann HAM, et al. Light fractionation does not enhance the efficacy of methyl 5-aminolevulinate mediated photodynamic therapy in normal mouse skin. Photochem Photobiol Sci 2007; 6: 1325-1331.
46. Sotiriou E, Apalla Z. Chovarda E, Goussi C, Trigoni A. Single vs. fractionated photodynamic therapy for face and scalp actinic keratoses: a randomized, intraindividual comparison trial with 12-month follow-up. J Eur Acad Dermatol 2012; 26: 36-40.