Downregulation of UBE2Q1 is associated with neuronal apoptosis in rat brain cortex following traumatic brain injury

Journal of Neuroscience Research

Volumn 92, Issue 1, 2014, Pages 1-12

  Wan, Chunhua ^a   Chen, Jian ^a   Hu, Baoying ^b   Zou, Huifei ^a   Li, Aihong ^a   Guo, Aihang ^a   Jiang, Junkang ^a  

^a NANTONG UNIVERSITY   (China)

^b NANTONG MEDICAL COLLEGE   (China)

Author keywords

Neuronal apoptosis; P53; Rat; Traumatic brain injury; UBE2Q1

Indexed keywords

CASPASE 3; HYDROGEN PEROXIDE; PROTEIN BAX; PROTEIN P21; PROTEIN P53; UBE2Q1 ENZYME; UBIQUITIN CONJUGATING ENZYME; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASSAY; ASTROCYTE; BRAIN CORTEX; CONTROLLED STUDY; GENE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MICROARRAY ANALYSIS; NERVE CELL; NEURONAL APOPTOSIS; NONHUMAN; PC12 CELL; PRIORITY JOURNAL; RAT; STAINING; TRAUMATIC BRAIN INJURY; WESTERN BLOTTING;

NEURONAL APOPTOSIS; P53; RAT; TRAUMATIC BRAIN INJURY; UBE2Q1;

ANIMALS; APOPTOSIS; ASTROCYTES; BRAIN INJURIES; CASPASE 3; CEREBRAL CORTEX; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOWN-REGULATION; NEURONS; PC12 CELLS; RATS; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-CONJUGATING ENZYMES;

EID: 84888036069     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.23305     Document Type: Article

References (40)

1. Ansari MA, Roberts KN, Scheff SW. 2008. Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury. Free Radic Biol Med 45:443-452.
2. Barik S. 2008. An intronic microRNA silences genes that are functionally antagonistic to its host gene. Nucleic Acids Res 36:5232-5241.
3. Bener A, Omar AO, Ahmad AE, Al-Mulla FH, Abdul Rahman YS. 2010. The pattern of traumatic brain injuries: a country undergoing rapid development. Brain Inj 24:74-80.
4. Chen J, Wu X, Shao B, Zhao W, Shi W, Zhang S, Ni L, Shen A. 2011. Increased expression of TNF receptor-associated factor 6 after rat traumatic brain injury. Cell Mol Neurobiol 31:269-275.
5. Clausen F, Lundqvist H, Ekmark S, Lewen A, Ebendal T, Hillered L. 2004. Oxygen free radical-dependent activation of extracellular signal-regulated kinase mediates apoptosis-like cell death after traumatic brain injury. J Neurotrauma 21:1168-1182.
6. Cregan SP, MacLaurin JG, Craig CG, Robertson GS, Nicholson DW, Park DS, Slack RS. 1999. Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons. J Neurosci 19:7860-7869.
7. Culmsee C, Mattson MP. 2005. p53 in neuronal apoptosis. Biochem Biophys Res Commun 331:761-777.
8. Di Giovanni S, Knights CD, Rao M, Yakovlev A, Beers J, Catania J, Avantaggiati ML, Faden AI. 2006. The tumor suppressor protein p53 is required for neurite outgrowth and axon regeneration. EMBO J 25:4084-4096.
9. Glickman MH, Ciechanover A. 2002. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev 82:373-428.
10. Hyder AA, Wunderlich CA, Puvanachandra P, Gururaj G, Kobusingye OC. 2007. The impact of traumatic brain injuries: a global perspective. Neurorehabilitation 22:341-353.
11. Kaya SS, Mahmood A, Li Y, Yavuz E, Goksel M, Chopp M. 1999. Apoptosis and expression of p53 response proteins and cyclin D1 after cortical impact in rat brain. Brain Res 818:23-33.
12. Kazim SF, Shamim MS, Tahir MZ, Enam SA, Waheed S. 2011. Management of penetrating brain injury. J Emerg Trauma Shock 4:395-402.
13. Klimaschewski L. 2003. Ubiquitin-dependent proteolysis in neurons. News Physiol Sci 18:29-33.
14. Konigsmark BW, Murphy EA. 1970. Neuronal populations in the human brain. Nature 228:1335-1336.
15. 2+ overload. J Neurosci Res 90:860-869.
16. Lewen A, Hillered L. 1998. Involvement of reactive oxygen species in membrane phospholipid breakdown and energy perturbation after traumatic brain injury in the rat. J Neurotrauma 15:521-530.
17. Lewen A, Sugawara T, Gasche Y, Fujimura M, Chan PH. 2001. Oxidative cellular damage and the reduction of APE/Ref-1 expression after experimental traumatic brain injury. Neurobiol Dis 8:380-390.
18. Liu Y, Wang Y, Cheng C, Chen Y, Shi S, Qin J, Xiao F, Zhou D, Lu M, Lu Q, Shen A. 2010. A relationship between p27(kip1) and Skp2 after adult brain injury: implications for glial proliferation. J Neurotrauma 27:361-371.
19. Liu Y, Chen Y, Lu X, Wang Y, Duan Y, Cheng C, Shen A. 2012. SCYL1BP1 modulates neurite outgrowth and regeneration by regulating the Mdm2/p53 pathway. Mol Biol Cell 23:4506-4514.
20. Logan A, Frautschy SA, Gonzalez AM, Baird A. 1992. A time course for the focal elevation of synthesis of basic fibroblast growth factor and one of its high-affinity receptors (flg) following a localized cortical brain injury. J Neurosci 12:3828-3837.
21. Luo Y, Umegaki H, Wang X, Abe R, Roth GS. 1998. Dopamine induces apoptosis through an oxidation-involved SAPK/JNK activation pathway. J Biol Chem 273:3756-3764.
22. Martin LJ, Kaiser A, Yu JW, Natale JE, Al-Abdulla NA. 2001. Injury-induced apoptosis of neurons in adult brain is mediated by p53-dependent and p53-independent pathways and requires Bax. J Comp Neurol 433:299-311.
23. Morganti-Kossmann MC, Rancan M, Stahel PF, Kossmann T. 2002. Inflammatory response in acute traumatic brain injury: a double-edged sword. Curr Opin Crit Care 8:101-105.
24. Nakamura T, Sakamoto K. 2008. Forkhead transcription factor FOXO subfamily is essential for reactive oxygen species-induced apoptosis. Mol Cell Endocrinol 281:47-55.
25. Napieralski JA, Raghupathi R, McIntosh TK. 1999. The tumor-suppressor gene, p53, is induced in injured brain regions following experimental traumatic brain injury. Brain Res Mol Brain Res 71:78-86.
26. Nonaka M, Chen XH, Pierce JE, Leoni MJ, McIntosh TK, Wolf JA, Smith DH. 1999. Prolonged activation of NF-kappaB following traumatic brain injury in rats. J Neurotrauma 16:1023-1034.
27. Otani N, Nawashiro H, Fukui S, Nomura N, Yano A, Miyazawa T, Shima K. 2002. Differential activation of mitogen-activated protein kinase pathways after traumatic brain injury in the rat hippocampus. J Cereb Blood Flow Metab 22:327-334.
28. Plesnila N, von Baumgarten L, Retiounskaia M, Engel D, Ardeshiri A, Zimmermann R, Hoffmann F, Landshamer S, Wagner E, Culmsee C. 2007. Delayed neuronal death after brain trauma involves p53-dependent inhibition of NF-kappaB transcriptional activity. Cell Death Differ 14:1529-1541.
29. Povlishock JT, Kontos HA. 1992. The role of oxygen radicals in the pathobiology of traumatic brain injury. Hum Cell 5:345-353.
30. Raghupathi R. 2004. Cell death mechanisms following traumatic brain injury. Brain Pathol 14:215-222.
31. Saha MN, Jiang H, Chang H. 2010. Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways. Cancer Biol Ther 10:567-578.
32. Saito A, Hayashi T, Okuno S, Nishi T, Chan PH. 2005. Modulation of p53 degradation via MDM2-mediated ubiquitylation and the ubiquitin-proteasome system during reperfusion after stroke: role of oxidative stress. J Cereb Blood Flow Metab 25:267-280.
33. Seghatoleslam A, Nikseresht M, Shafiee SM, Monabati A, Namavari MM, Talei A, Safaei A, Owji AA. 2012. Expression of the novel human gene, UBE2Q1, in breast tumors. Mol Biol Rep 39:5135-5141.
34. Slemmer JE, Shacka JJ, Sweeney MI, Weber JT. 2008. Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging. Curr Med Chem 15:404-414.
35. Sun X, Budas GR, Xu L, Barreto GE, Mochly-Rosen D, Giffard RG. 2013. Selective activation of protein kinase C in mitochondria is neuroprotective in vitro and reduces focal ischemic brain injury in mice. J Neurosci Res 91:799-807.
36. Tao T, Cheng C, Ji Y, Xu G, Zhang J, Zhang L, Shen A. 2012. Numbl inhibits glioma cell migration and invasion by suppressing TRAF5-mediated NF-kappaB activation. Mol Biol Cell 23:2635-2644.
37. Wan C, Jiang J, Mao H, Cao J, Wu X, Cui G. 2013. Involvement of upregulated p53-induced death domain protein (PIDD) in neuronal apoptosis after rat traumatic brain injury. J Mol Neurosci (in press).
38. Xiong Y, Mahmood A, Chopp M. 2009. Emerging treatments for traumatic brain injury. Expert Opin Emerg Drugs 14:67-84.
39. Yao X, Liu J, McCabe JT. 2007. Ubiquitin and ubiquitin-conjugated protein expression in the rat cerebral cortex and hippocampus following traumatic brain injury (TBI). Brain Res 1182:116-122.
40. Yao X, Liu J, McCabe JT. 2008. Alterations of cerebral cortex and hippocampal proteasome subunit expression and function in a traumatic brain injury rat model. J Neurochem 104:353-363.