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Volumn 26, Issue 12, 2013, Pages 1742-1750

Diffusion tensor imaging detects treatment effects of FTY720 in experimental autoimmune encephalomyelitis mice

Author keywords

Axial diffusivity; Axonal injury; Demyelination; Diffusion tensor imaging; Experimental autoimmune encephalomyelitis; FTY720; Multiple sclerosis; Radial diffusivity

Indexed keywords

AXIAL DIFFUSIVITY; AXONAL INJURY; DEMYELINATION; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FTY720; MULTIPLE SCLEROSIS; RADIAL DIFFUSIVITY;

EID: 84888025913     PISSN: 09523480     EISSN: 10991492     Source Type: Journal    
DOI: 10.1002/nbm.3012     Document Type: Article
Times cited : (20)

References (56)
  • 1
    • 0029979038 scopus 로고    scopus 로고
    • Epidemiology of multiple sclerosis
    • Weinshenker BG. Epidemiology of multiple sclerosis. Neurol. Clin. 1996; 14(2): 291-308.
    • (1996) Neurol. Clin. , vol.14 , Issue.2 , pp. 291-308
    • Weinshenker, B.G.1
  • 3
    • 0034026912 scopus 로고    scopus 로고
    • Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation
    • Bitsch A, Schuchardt J, Bunkowski S, Kuhlmann T, Bruck W. Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation. Brain, 2000; 123(Pt 6): 1174-1183.
    • (2000) Brain , vol.123 , Issue.PART 6 , pp. 1174-1183
    • Bitsch, A.1    Schuchardt, J.2    Bunkowski, S.3    Kuhlmann, T.4    Bruck, W.5
  • 4
    • 48249139449 scopus 로고    scopus 로고
    • Multiple sclerosis: an immune or neurodegenerative disorder?
    • Trapp BD, Nave KA. Multiple sclerosis: an immune or neurodegenerative disorder? Annu. Rev. Neurosci. 2008; 31: 247-269.
    • (2008) Annu. Rev. Neurosci. , vol.31 , pp. 247-269
    • Trapp, B.D.1    Nave, K.A.2
  • 5
    • 36148952124 scopus 로고    scopus 로고
    • Toward the development of rational therapies in multiple sclerosis: what is on the horizon?
    • Hemmer B, Hartung HP. Toward the development of rational therapies in multiple sclerosis: what is on the horizon? Ann. Neurol. 2007; 62(4): 314-326.
    • (2007) Ann. Neurol. , vol.62 , Issue.4 , pp. 314-326
    • Hemmer, B.1    Hartung, H.P.2
  • 13
    • 35348970884 scopus 로고    scopus 로고
    • Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis
    • Foster CA, Howard LM, Schweitzer A, Persohn E, Hiestand PC, Balatoni B, Reuschel R, Beerli C, Schwartz M, Billich A. Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis. J. Pharmacol. Exp. Ther. 2007; 323(2): 469-475.
    • (2007) J. Pharmacol. Exp. Ther. , vol.323 , Issue.2 , pp. 469-475
    • Foster, C.A.1    Howard, L.M.2    Schweitzer, A.3    Persohn, E.4    Hiestand, P.C.5    Balatoni, B.6    Reuschel, R.7    Beerli, C.8    Schwartz, M.9    Billich, A.10
  • 14
    • 61649121740 scopus 로고    scopus 로고
    • FTY720 rescue therapy in the dark agouti rat model of experimental autoimmune encephalomyelitis: expression of central nervous system genes and reversal of blood-brain-barrier damage
    • Foster CA, Mechtcheriakova D, Storch MK, Balatoni B, Howard LM, Bornancin F, Wlachos A, Sobanov J, Kinnunen A, Baumruker T. FTY720 rescue therapy in the dark agouti rat model of experimental autoimmune encephalomyelitis: expression of central nervous system genes and reversal of blood-brain-barrier damage. Brain Pathol. 2009; 19(2): 254-266.
    • (2009) Brain Pathol. , vol.19 , Issue.2 , pp. 254-266
    • Foster, C.A.1    Mechtcheriakova, D.2    Storch, M.K.3    Balatoni, B.4    Howard, L.M.5    Bornancin, F.6    Wlachos, A.7    Sobanov, J.8    Kinnunen, A.9    Baumruker, T.10
  • 15
    • 53049085954 scopus 로고    scopus 로고
    • Central nervous system-directed effects of FTY720 (fingolimod)
    • Miron VE, Schubart A, Antel JP. Central nervous system-directed effects of FTY720 (fingolimod). J. Neurol. Sci. 2008; 274(1-2): 13-17.
    • (2008) J. Neurol. Sci. , vol.274 , Issue.1-2 , pp. 13-17
    • Miron, V.E.1    Schubart, A.2    Antel, J.P.3
  • 16
    • 77951073508 scopus 로고    scopus 로고
    • Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis
    • Chun J, Hartung HP. Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis. Clin. Neuropharmacol. 2010; 33(2): 91-101.
    • (2010) Clin. Neuropharmacol. , vol.33 , Issue.2 , pp. 91-101
    • Chun, J.1    Hartung, H.P.2
  • 17
    • 77954864204 scopus 로고    scopus 로고
    • Fingolimod is a potential novel therapy for multiple sclerosis
    • Aktas O, Kury P, Kieseier B, Hartung HP. Fingolimod is a potential novel therapy for multiple sclerosis. Nat. Rev. Neurol. 2010; 6(7): 373-382.
    • (2010) Nat. Rev. Neurol. , vol.6 , Issue.7 , pp. 373-382
    • Aktas, O.1    Kury, P.2    Kieseier, B.3    Hartung, H.P.4
  • 18
    • 84857859497 scopus 로고    scopus 로고
    • FTY720 on the way from the base camp to the summit of the mountain: relevance for remyelination
    • Kipp M, Amor S. FTY720 on the way from the base camp to the summit of the mountain: relevance for remyelination. Mult. Scler. 2012; 18(3): 258-263.
    • (2012) Mult. Scler. , vol.18 , Issue.3 , pp. 258-263
    • Kipp, M.1    Amor, S.2
  • 20
    • 84856219980 scopus 로고    scopus 로고
    • S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures
    • Sheridan GK, Dev KK. S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures. Glia, 2012; 60(3): 382-392.
    • (2012) Glia , vol.60 , Issue.3 , pp. 382-392
    • Sheridan, G.K.1    Dev, K.K.2
  • 21
    • 79959846854 scopus 로고    scopus 로고
    • Fingolimod modulates microglial activation to augment markers of remyelination
    • Jackson SJ, Giovannoni G, Baker D. Fingolimod modulates microglial activation to augment markers of remyelination. J. Neuroinflammation, 2011; 8: 76.
    • (2011) J. Neuroinflammation , vol.8 , pp. 76
    • Jackson, S.J.1    Giovannoni, G.2    Baker, D.3
  • 23
    • 79960258821 scopus 로고    scopus 로고
    • Immunosuppression with FTY720 is insufficient to prevent secondary progressive neurodegeneration in experimental autoimmune encephalomyelitis
    • Al-Izki S, Pryce G, Jackson SJ, Giovannoni G, Baker D. Immunosuppression with FTY720 is insufficient to prevent secondary progressive neurodegeneration in experimental autoimmune encephalomyelitis. Mult. Scler. 2011; 17(8): 939-948.
    • (2011) Mult. Scler. , vol.17 , Issue.8 , pp. 939-948
    • Al-Izki, S.1    Pryce, G.2    Jackson, S.J.3    Giovannoni, G.4    Baker, D.5
  • 24
    • 0036430645 scopus 로고    scopus 로고
    • Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water
    • Song SK, Sun SW, Ramsbottom MJ, Chang C, Russell J, Cross AH. Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. Neuroimage, 2002; 17(3): 1429-1436.
    • (2002) Neuroimage , vol.17 , Issue.3 , pp. 1429-1436
    • Song, S.K.1    Sun, S.W.2    Ramsbottom, M.J.3    Chang, C.4    Russell, J.5    Cross, A.H.6
  • 25
    • 0344983758 scopus 로고    scopus 로고
    • Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia
    • Song SK, Sun SW, Ju WK, Lin SJ, Cross AH, Neufeld AH. Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia. Neuroimage, 2003; 20(3): 1714-1722.
    • (2003) Neuroimage , vol.20 , Issue.3 , pp. 1714-1722
    • Song, S.K.1    Sun, S.W.2    Ju, W.K.3    Lin, S.J.4    Cross, A.H.5    Neufeld, A.H.6
  • 26
    • 63849246613 scopus 로고    scopus 로고
    • Axial diffusivity is the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord: a quantitative pixelwise analysis
    • Budde MD, Xie M, Cross AH, Song SK. Axial diffusivity is the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord: a quantitative pixelwise analysis. J. Neurosci. 2009; 29(9): 2805-2813.
    • (2009) J. Neurosci. , vol.29 , Issue.9 , pp. 2805-2813
    • Budde, M.D.1    Xie, M.2    Cross, A.H.3    Song, S.K.4
  • 27
    • 79955455801 scopus 로고    scopus 로고
    • Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis
    • Cohen JA, Chun J. Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis. Ann. Neurol. 2011; 69(5): 759-777.
    • (2011) Ann. Neurol. , vol.69 , Issue.5 , pp. 759-777
    • Cohen, J.A.1    Chun, J.2
  • 31
    • 3042750654 scopus 로고    scopus 로고
    • Predictability of FTY720 efficacy in experimental autoimmune encephalomyelitis by in vivo macrophage tracking: clinical implications for ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging
    • Rausch M, Hiestand P, Foster CA, Baumann DR, Cannet C, Rudin M. Predictability of FTY720 efficacy in experimental autoimmune encephalomyelitis by in vivo macrophage tracking: clinical implications for ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging. J. Magn. Reson. Imaging, 2004; 20(1): 16-24.
    • (2004) J. Magn. Reson. Imaging , vol.20 , Issue.1 , pp. 16-24
    • Rausch, M.1    Hiestand, P.2    Foster, C.A.3    Baumann, D.R.4    Cannet, C.5    Rudin, M.6
  • 33
    • 48349129527 scopus 로고    scopus 로고
    • Axonal injury detected by in vivo diffusion tensor imaging correlates with neurological disability in a mouse model of multiple sclerosis
    • Budde MD, Kim JH, Liang HF, Russell JH, Cross AH, Song SK. Axonal injury detected by in vivo diffusion tensor imaging correlates with neurological disability in a mouse model of multiple sclerosis. NMR Biomed. 2008; 21(6): 589-597.
    • (2008) NMR Biomed. , vol.21 , Issue.6 , pp. 589-597
    • Budde, M.D.1    Kim, J.H.2    Liang, H.F.3    Russell, J.H.4    Cross, A.H.5    Song, S.K.6
  • 34
    • 0017799082 scopus 로고
    • The cervical cord in multiple sclerosis
    • Oppenheimer DR. The cervical cord in multiple sclerosis. Neuropathol. Appl. Neurobiol. 1978; 4(2): 151-162.
    • (1978) Neuropathol. Appl. Neurobiol. , vol.4 , Issue.2 , pp. 151-162
    • Oppenheimer, D.R.1
  • 35
    • 8944248824 scopus 로고    scopus 로고
    • Spinal cord atrophy and disability in multiple sclerosis. A new reproducible and sensitive MRI method with potential to monitor disease progression
    • Losseff NA, Webb SL, O'Riordan JI, Page R, Wang L, Barker GJ, Tofts PS, McDonald WI, Miller DH, Thompson AJ. Spinal cord atrophy and disability in multiple sclerosis. A new reproducible and sensitive MRI method with potential to monitor disease progression. Brain, 1996; 119(Pt 3): 701-708.
    • (1996) Brain , vol.119 , Issue.PART 3 , pp. 701-708
    • Losseff, N.A.1    Webb, S.L.2    O'Riordan, J.I.3    Page, R.4    Wang, L.5    Barker, G.J.6    Tofts, P.S.7    McDonald, W.I.8    Miller, D.H.9    Thompson, A.J.10
  • 36
    • 0041989798 scopus 로고    scopus 로고
    • Spinal cord atrophy and disability in multiple sclerosis over four years: application of a reproducible automated technique in monitoring disease progression in a cohort of the interferon beta-1a (Rebif) treatment trial
    • Lin X, Tench CR, Turner B, Blumhardt LD, Constantinescu CS. Spinal cord atrophy and disability in multiple sclerosis over four years: application of a reproducible automated technique in monitoring disease progression in a cohort of the interferon beta-1a (Rebif) treatment trial. J. Neurol. Neurosurg. Psychiatry, 2003; 74(8): 1090-1094.
    • (2003) J. Neurol. Neurosurg. Psychiatry , vol.74 , Issue.8 , pp. 1090-1094
    • Lin, X.1    Tench, C.R.2    Turner, B.3    Blumhardt, L.D.4    Constantinescu, C.S.5
  • 37
    • 57149141944 scopus 로고    scopus 로고
    • Assessing optic nerve pathology with diffusion MRI: from mouse to human
    • Xu J, Sun SW, Naismith RT, Snyder AZ, Cross AH, Song SK. Assessing optic nerve pathology with diffusion MRI: from mouse to human. NMR Biomed. 2008; 21(9): 928-940.
    • (2008) NMR Biomed. , vol.21 , Issue.9 , pp. 928-940
    • Xu, J.1    Sun, S.W.2    Naismith, R.T.3    Snyder, A.Z.4    Cross, A.H.5    Song, S.K.6
  • 41
    • 33747405927 scopus 로고    scopus 로고
    • Diffusion tensor imaging in multiple sclerosis: assessment of regional differences in the axial plane within normal-appearing cervical spinal cord
    • Hesseltine SM, Law M, Babb J, Rad M, Lopez S, Ge Y, Johnson G, Grossman RI. Diffusion tensor imaging in multiple sclerosis: assessment of regional differences in the axial plane within normal-appearing cervical spinal cord. Am. J. Neuroradiol. 2006; 27(6): 1189-1193.
    • (2006) Am. J. Neuroradiol. , vol.27 , Issue.6 , pp. 1189-1193
    • Hesseltine, S.M.1    Law, M.2    Babb, J.3    Rad, M.4    Lopez, S.5    Ge, Y.6    Johnson, G.7    Grossman, R.I.8
  • 42
    • 34848853605 scopus 로고    scopus 로고
    • Diffusion tensor MR imaging of the cervical spinal cord in patients with multiple sclerosis
    • Ohgiya Y, Oka M, Hiwatashi A, Liu X, Kakimoto N, Westesson PL, Ekholm SE. Diffusion tensor MR imaging of the cervical spinal cord in patients with multiple sclerosis. Eur. Radiol. 2007; 17(10): 2499-2504.
    • (2007) Eur. Radiol. , vol.17 , Issue.10 , pp. 2499-2504
    • Ohgiya, Y.1    Oka, M.2    Hiwatashi, A.3    Liu, X.4    Kakimoto, N.5    Westesson, P.L.6    Ekholm, S.E.7
  • 44
    • 67650077131 scopus 로고    scopus 로고
    • A diffusion tensor imaging group study of the spinal cord in multiple sclerosis patients with and without T2 spinal cord lesions
    • van Hecke W, Nagels G, Emonds G, Leemans A, Sijbers J, van Goethem J, Parizel PM. A diffusion tensor imaging group study of the spinal cord in multiple sclerosis patients with and without T2 spinal cord lesions. J. Magn. Reson. Imaging, 2009; 30(1): 25-34.
    • (2009) J. Magn. Reson. Imaging , vol.30 , Issue.1 , pp. 25-34
    • van Hecke, W.1    Nagels, G.2    Emonds, G.3    Leemans, A.4    Sijbers, J.5    van Goethem, J.6    Parizel, P.M.7
  • 46
    • 70849086174 scopus 로고    scopus 로고
    • FTY720 (fingolimod) in multiple sclerosis: therapeutic effects in the immune and the central nervous system
    • Brinkmann V. FTY720 (fingolimod) in multiple sclerosis: therapeutic effects in the immune and the central nervous system. Br. J. Pharmacol. 2009; 158(5): 1173-1182.
    • (2009) Br. J. Pharmacol. , vol.158 , Issue.5 , pp. 1173-1182
    • Brinkmann, V.1
  • 47
    • 0036773971 scopus 로고    scopus 로고
    • FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity
    • Brinkmann V, Lynch KR. FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity. Curr. Opin. Immunol. 2002; 14(5): 569-575.
    • (2002) Curr. Opin. Immunol. , vol.14 , Issue.5 , pp. 569-575
    • Brinkmann, V.1    Lynch, K.R.2
  • 48
  • 49
    • 35548984947 scopus 로고    scopus 로고
    • The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors
    • Coelho RP, Payne SG, Bittman R, Spiegel S, Sato-Bigbee C. The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors. J. Pharmacol. Exp. Ther. 2007; 323(2): 626-635.
    • (2007) J. Pharmacol. Exp. Ther. , vol.323 , Issue.2 , pp. 626-635
    • Coelho, R.P.1    Payne, S.G.2    Bittman, R.3    Spiegel, S.4    Sato-Bigbee, C.5
  • 51
    • 0037401639 scopus 로고    scopus 로고
    • The roles of ceramide and complex sphingolipids in neuronal cell function
    • Buccoliero R, Futerman AH. The roles of ceramide and complex sphingolipids in neuronal cell function. Pharmacol. Res. 2003; 47(5): 409-419.
    • (2003) Pharmacol. Res. , vol.47 , Issue.5 , pp. 409-419
    • Buccoliero, R.1    Futerman, A.H.2
  • 52
    • 0036720034 scopus 로고    scopus 로고
    • Why does remyelination fail in multiple sclerosis?
    • Franklin RJ. Why does remyelination fail in multiple sclerosis? Nat. Rev. Neurosci. 2002; 3(9): 705-714.
    • (2002) Nat. Rev. Neurosci. , vol.3 , Issue.9 , pp. 705-714
    • Franklin, R.J.1
  • 53
  • 54
    • 34247554847 scopus 로고    scopus 로고
    • Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration
    • Novgorodov AS, El-Alwani M, Bielawski J, Obeid LM, Gudz TI. Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration. Faseb J. 2007; 21(7): 1503-1514.
    • (2007) Faseb J. , vol.21 , Issue.7 , pp. 1503-1514
    • Novgorodov, A.S.1    El-Alwani, M.2    Bielawski, J.3    Obeid, L.M.4    Gudz, T.I.5
  • 55
    • 53149089045 scopus 로고    scopus 로고
    • Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod
    • Miron VE, Hall JA, Kennedy TE, Soliven B, Antel JP. Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod. Am. J. Pathol. 2008; 173(4): 1143-1152.
    • (2008) Am. J. Pathol. , vol.173 , Issue.4 , pp. 1143-1152
    • Miron, V.E.1    Hall, J.A.2    Kennedy, T.E.3    Soliven, B.4    Antel, J.P.5
  • 56
    • 39049125218 scopus 로고    scopus 로고
    • FTY720 modulates human oligodendrocyte progenitor process extension and survival
    • Miron VE, Jung CG, Kim HJ, Kennedy TE, Soliven B, Antel JP. FTY720 modulates human oligodendrocyte progenitor process extension and survival. Ann. Neurol. 2008; 63(1): 61-71.
    • (2008) Ann. Neurol. , vol.63 , Issue.1 , pp. 61-71
    • Miron, V.E.1    Jung, C.G.2    Kim, H.J.3    Kennedy, T.E.4    Soliven, B.5    Antel, J.P.6


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