A diffusion tensor MRI study of cervical cord damage in benign and secondary progressive multiple sclerosis patients

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 81, Issue 1, 2010, Pages 26-30

  Benedetti, B ^a   Rocca, M A ^a   Rovaris, M ^a,b   Caputo, D ^b   Zaffaroni, M ^c   Capra, R ^d   Bertolotto, A ^e   Martinelli, V ^a   Comi, G ^a   Filippi, M ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

^c Ospedale di Gallarate   (Italy)

^d Multiple Sclerosis Centre   (Italy)

^e SAN LUIGI GONZAGA HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ANISOTROPY; ARTICLE; BRAIN MAPPING; CERVICAL SPINAL CORD INJURY; CONTROLLED STUDY; DIFFUSION TENSOR IMAGING; DISABILITY; DISEASE SEVERITY; EXPANDED DISABILITY STATUS SCALE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL;

ADULT; BRAIN; DIFFUSION TENSOR IMAGING; DISABILITY EVALUATION; FEMALE; HUMANS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE; SPINAL CORD;

EID: 73449090438     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp.2009.173120     Document Type: Article

References (34)

1. Lin X, Blumhardt L, Costantimescu C. The relationship of brain and cervical cord volume to disability in clinical subtypes of multiple sclerosis: a three-dimensional MRI study. Acta Neurol Scand 2003;108:401-6.
2. Brass SD, Narayanan S, Antel JP, et al. Axonal damage in multiple sclerosis patients with high versus low expanded disability status scale score. Can J Neurol Sci 2004;3:225-8.
3. Bieniek M, Altmann DR, Davies GR, et al. Cord atrophy separates early primary progressive and relapsing remitting multiple sclerosis. J Neurol Neurosurg Psychiatry 2006;77:1036-9.
4. Lycklama à Nijeholt GJ, Thompson A, Filippi M, et al. Spinal-cord MRI in multiple sclerosis. Lancet Neurol 2003;2:555-62.
5. Ramsaransing G, De Keyser J. Benign course in multiple sclerosis. A review. Acta Neurol Scand 2006;113:359-69.
6. Hawkins SA, McDonnel GV. Benign multiple sclerosis? Clinical course, long term follow up, and assessment of prognostic factors. J Neurol Neurosurg Psychiatry 1999;67:148-52.
7. Pittock SJ, McClelland RL, Mayr WT, et al. Clinical implications of benign multiple sclerosis: a 20-year population-based follow-up study. Ann Neurol 2004;56:303-6.
8. Lublin FD, Reingold SC. The National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Defining the clinical course of multiple sclerosis: results of an international survey. Neurology 1996;46:907-11.
9. Barkhof F. The clinico-radiological paradox in multiple sclerosis revisited. Curr Opin Neurol 2002;15:239-45.
10. Agosta F, Benedetti B, Rocca MA, et al. Quantification of cervical cord pathology in primary progressive MS using diffusion tensor MRI. Neurology 2005;64:631-5.
11. Agosta F, Absinta M, Sormani MP, et al. In vivo assessment of cervical cord damage in MS patients: a longitudinal diffusion tensor MRI study. Brain 2007;130:2211-19.
12. Benedetti B, Valsasina P, Judica E, et al. Grading cervical cord damage in neuromyelitis optica and MS by diffusion tensor MRI. Neurology 2006;67:161-3.
13. Benedetti B, Rovaris M, Judica E, et al. Assessing "occult" cervical cord damage in patients with neuropsychiatric systemic lupus erythematosus using diffusion tensor MRI. J Neurol Neurosurg Psychiatry 2007;78:893-5.
14. Valsasina P, Rocca MA, Agosta F, et al. Mean diffusivity and fractional anisotropy histogram analysis of the cervical cord in MS patients. Neuroimage 2005;26:822-8.
15. Pierpaoli C, Jezzard P, Basser PJ, et al. Diffusion tensor MR imaging of the human brain. Radiology 1996;201:637-48.
16. Droogan AG, Clark CA, Werring DJ, et al. Comparison of multiple sclerosis clinical subgroups using navigated spin echo diffusion-weighted imaging. Magn Reson Imaging 1999;17:653-61.
17. Horsfield MA, Lai M, Webb SL, et al. Apparent diffusion coefficients in benign and secondary progressive multiple sclerosis by nuclear magnetic resonance. Magn Reson Med 1996;36:393-400.
18. Rovaris M, Riccitelli G, Judica E, et al. Cognitive impairment and structural brain damage in benign multiple sclerosis. Neurology 2008;71:1521-6.
19. Ceccarelli A, Rocca MA, Pagani E, et al. The topographical distribution of tissue injury in benign MS: a 3T multiparametric MRI study. Neuroimage 2008;39:1499-509.
20. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983;33:1444- 52.
21. Jones DK, Horsfield MA, Simmons A. Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging. Magn Reson Med 1999;42:515-25.
22. Losseff NA, Webb SL, O'Riordan JI, et al. Spinal cord atrophy and disability in multiple sclerosis. A new reproducible and sensitive MRI method with potential to monitor disease progression. Brain 1996;119:701-8.
23. Costelloe L, Thompson A, Walsh C, et al. Long term clinical relevance of criteria for designating multiple sclerosis as benign after ten years of disease. J Neurol Neurosurg Psychiatry 2008;79:1245-58.
24. De Stefano N, Battaglini M, Stromillo ML, et al. Brain damage as detected by magnetization transfer imaging is less pronounced in benign than in early relapsing multiple sclerosis. Brain 2006;129:2008-16.
25. Falini A, Calabrese G, Filippi M, et al. Benign versus secondary-progressive multiple sclerosis: the potential role of proton MR spectroscopy in defining the nature of disability. AJNR Am J Neuroradiol 1998;19:223-9.
26. Filippi M, Campi A, Martinelli V, et al. Brain and spinal cord MR in benign multiple sclerosis: a follow-up study. J Neurol Sci 1996;143:143-9.
27. Lycklama à Nijeholt GJ, van Walderveen MA, Castelijns JA, et al. Brain and spinal cord abnormalities in multiple sclerosis. Correlation between MRI parameters, clinical subtypes and symptoms. Brain 1998;121:687-97.
28. Bergers E, Bot JC, De Groot CJ, et al. Axonal damage in the spinal cord of MS patients occurs largely independent of T2 MRI lesions. Neurology 2002;59:1766-71.
29. DeLuca GC, Williams K, Evangelou N, et al. The contribution of demyelination to axonal loss in multiple sclerosis. Brain 2006;129:1507-16.
30. Ganter P, Prince C, Esiri MM. Spinal cord axonal loss in multiple sclerosis: a postmortem study. Neuropathol Appl Neurobiol 1999;25:459-67.
31. Lycklama à Nijeholt GJ, Bergers E, Kamphorst W, et al. Post-mortem highresolution MRI of the spinal cord in multiple sclerosis: a correlative study with conventional MRI, histopathology and clinical phenotype. Brain 2001;124:154-66.
32. Bot JC, Blezer EL, Kamphorst W, et al. The spinal cord in multiple sclerosis: relationship of high-spatial-resolution quantitative MR imaging findings to histopathologic results. Radiology 2004;233:531-40.
33. Filippi M, Campi A, Colombo B, et al. A spinal cord MRI study of benign and secondary progressive multiple sclerosis. J Neurol 1996;243:502-5.
34. Rovaris M, Bozzali M, Santuccio G, et al. Relative contributions of brain and cervical cord pathology to multiple sclerosis disability: a study with magnetisation transfer ratio histogram analysis. J Neurol Neurosurg Psychiatry 2000;69:723-7.