Primary cutaneous carcinosarcoma: Insights into its clonal origin and mutational pattern expression analysis through next-generation sequencing

Human Pathology

Volumn 44, Issue 12, 2013, Pages 2853-2860

  Paniz Mondolfi, Alberto E ^a,b   Jour, George ^c   Johnson, Matthew ^d   Reidy, Jason ^e   Cason, Ronald C ^f   Barkoh, Bedia A ^f   Benaim, Gustavo ^g   Singh, Rajesh ^f   Luthra, Rajyalakshmi ^f  

^a TEXAS CHILDREN S HOSPITAL   (United States)

^b UNIVERSIDAD DE LOS ANDES   (Venezuela)

^c Department of Pathology and Laboratory Medicine ^*  (United States)

^d TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e BETH ISRAEL MEDICAL CENTER   (United States)

^f UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^g Instituto Internacional de Estudios Avanzados IDEA   (Venezuela)

Author keywords

Biphenotypic tumors; Cancer stem cells; Carcinosarcoma; Cutaneous; Mutation; Next generation sequencing; TP53; Tumorigenesis

Indexed keywords

PROTEIN P53;

ARTICLE; CANCER GENETICS; CARCINOSARCOMA; CELL DIFFERENTIATION; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM TUMOR; EXON; GENE MUTATION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; LASER CAPTURE MICRODISSECTION; MUTATIONAL ANALYSIS; POINT MUTATION; PRIMARY CUTANEOUS CARCINOSARCOMA; PRIMARY TUMOR; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SKIN CARCINOMA; STEM CELL; ULTRASTRUCTURE;

BIPHENOTYPIC TUMORS; CANCER STEM CELLS; CARCINOSARCOMA; CUTANEOUS; MUTATION; NEXT-GENERATION SEQUENCING; TP53; TUMORIGENESIS;

CARCINOSARCOMA; DNA MUTATIONAL ANALYSIS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MUTATION; SKIN NEOPLASMS;

EID: 84888017097     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2013.07.014     Document Type: Article

References (26)

1. S.M. Bigby, A. Charlton, and M.V. Miller Biphasic sarcomatoid basal cell carcinoma (carcinosarcoma): four cases with immunohistochemistry and review of the literature J Cutan Pathol 32 2005 141 147
2. E. Upjohn, A. Braue, and A. Ryan Primary cutaneous carcinosarcoma: dermoscopic and immunohistochemical features Australas J Dermatol 51 2010 26 28
3. T. El Harroudi, S. Ech-charif, and M. Amrani Primary carcinosarcoma of the skin J Hand Microsurg 2 2010 79 81
4. T. Chiyoda, H. Tsuda, and H. Tanaka Expression profiles of carcinosarcoma of the uterine corpus-are these similar to carcinoma or sarcoma? Genes Chromosomes Cancer 51 2012 229 239
5. M.R. Wick, J. Fitzgibbon, and P.E. Swanson Cutaneous sarcomas and sarcomatoid neoplasms of the skin Semin Diagn Pathol 10 1993 148 158
6. J. Syme-Grant, N.J. Syme-Grant, and L. Motta Are primary cutaneous carcinosarcomas underdiagnosed? Five cases and a review of the literature J Plast Reconstr Aesthet Surg 59 2006 1402 1408
7. T. Reya, and H. Clevers Wnt signalling in stem cells and cancer Nature 434 2005 843 850
8. A.E. Paniz Mondolfi, D. Slova, and W. Fan Mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder: a possible stem cell tumor Pathol Int 61 2011 608 614
9. L. Gambardella, and Y. Barrandon The multifaceted adult epidermal stem cell Curr Opin Cell Biol 15 2003 771 777
10. G. Jour, A. Paniz Mondolfi, and J. Reidy Squamo-melanocytic tumor: a case report and further insights into its possible histogenesis Am J Dermatopathol 2013 In press
11. R.R. Singh, K.P. Patel, and M. Routbort Clinical validation of a next generation sequencing screen for mutational hotspots in 46 cancer-related genes J Mol Diagn 15 2013 607 622
12. M. Routbort, K.P. Patel, and R.R. Singh OncoSeek - A versatile annotation and reporting system for next generation sequencing-based clinical mutation analysis of cancer specimens J Mol Diagn 14 2012 747
13. E.K. Dawson Carcino-sarcoma of the skin J R Coll Surg Edinb 17 1972 243 246
14. K.Y. Suh, M. Lacouture, and P. Gerami p63 in primary cutaneous carcinosarcoma Am J Dermatopathol 29 2007 374 377
15. N. Patel, P. McKee, and N. Smith Primary metaplastic carcinoma (carcinosarcoma) of the skin. A clinicopathologic study of four cases and review of the literature Am J Dermatopathol 19 1997 363 372
16. B. Baum, J. Settleman, and M.P. Quinlan Transitions between epithelial and mesenchymal states in development and disease Semin Cell Dev Biol 19 2008 294 308
17. M. Al-Hajj, M.W. Becker, and M. Wicha Therapeutic implications of cancer stem cells Curr Opin Genet Dev 14 2004 43 47
18. J.H. Taube, J.I. Herschkowitz, and K. Komurov Core epithelial-to- mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes Proc Natl Acad Sci USA 107 2010 15449 15454
19. J. Yang, S.A. Mani, and J.L. Donaher Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis Cell 117 2004 927 939
20. A.J. Levine p53, the cellular gatekeeper for growth and division Cell 88 1997 323 331
21. M.A. Nelson, J.G. Einspahr, and D.S. Alberts Analysis of the p53 gene in human precancerous actinic keratosis lesions and squamous cell cancers Cancer Lett 85 1994 23 29
22. R. Marks, G. Rennis, and T. Selwood The relationship of basal cell carcinomas and squamous cell carcinomas to solar keratoses Arch Dermatol 124 1988 1039 1042
23. S.M. Yoon, D. Gerasimidou, and R. Kuwahara Epithelial cell adhesion molecule (EpCAM) marks hepatocytes newly derived from stem/progenitor cells in humans Hepatology 53 2011 964 973
24. C.J. De Boer, J.H. van Krieken, and C.M. Janssen-van Rhijn Expression of Ep-CAM in normal, regenerating, metaplastic, and neoplastic liver J Pathol 188 1999 201 206
25. E. Schmelzer, E. Wauthier, and L.M. Reid The phenotypes of pluripotent human hepatic progenitors Stem Cells 24 2006 1852 1858
26. T. Yamashita, J. Ji, and A. Budhu EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features Gastroenterology 136 2009 1012 1024