Mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder: A possible stem cell tumor?

Pathology International

Volumn 61, Issue 10, 2011, Pages 608-614

  Mondolfi, Alberto E Paniz ^a,b,c   Slova, Denisa ^a,b   Fan, Wen ^a   Attiyeh, Fadi F ^a   Afthinos, John ^a   Reidy, Jason ^b   Pang, Yinghua ^a,b   Theise, Neil D ^b  

^a ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

^b BETH ISRAEL MEDICAL CENTER   (United States)

^c INSTITUTO DE BIOMEDICINA   (Venezuela)

Author keywords

Adenocarcinoma; Gallbladder; Neuroendocrine carcinoma; Stem cell tumor

Indexed keywords

CA 19-9 ANTIGEN; CARCINOEMBRYONIC ANTIGEN; CYTOKERATIN 19; EPITHELIAL CELL ADHESION MOLECULE; STEM CELL FACTOR; STEM CELL FACTOR RECEPTOR;

ADULT; ARTICLE; BILIARY TRACT SURGERY; CANCER STEM CELL; CANCER TISSUE; CASE REPORT; CELL ULTRASTRUCTURE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; ECHOGRAPHY; EPIGASTRIC PAIN; FEMALE; GALLBLADDER CARCINOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LAPAROSCOPY; LARGE CELL CARCINOMA; LIVER RESECTION; LIVER TUMOR; LYMPHADENOPATHY; MIXED ADENONEUROENDOCRINE CARCINOMA; PRIORITY JOURNAL; TUMOR VOLUME; UPPER ABDOMINAL PAIN;

ADENOCARCINOMA, PAPILLARY; CARCINOMA, NEUROENDOCRINE; CHOLECYSTECTOMY; CYTOPLASMIC GRANULES; FEMALE; GALLBLADDER; GALLBLADDER NEOPLASMS; HEPATECTOMY; HUMANS; LIVER NEOPLASMS; MICROSCOPY, ELECTRON, TRANSMISSION; MICROVILLI; MIDDLE AGED; NEOPLASMS, MULTIPLE PRIMARY; NEOPLASTIC STEM CELLS; POSITRON-EMISSION TOMOGRAPHY; TUMOR MARKERS, BIOLOGICAL;

EID: 80053329702     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2011.02709.x     Document Type: Article

References (49)

1. Albores-Saavedra J, Henson D. Tumours of the gallbladder and extrahepatic bile ducts. 2nd Series, fascicle 22. Washington, DC: Armed Forces Institute of Pathology, 1986.
2. Noske A, Pahl S. Combined adenosquamous and large-cell neuroendocrine carcinoma of the gallbladder. Virchows Arch 2006; 449: 135-6.
3. Yannakou N, Rizos S, Parissi-Mathiou P etal. Mixed (composite) glandular-endocrine cell carcinoma of the gallbladder. HPB 2001; 3: 7-9.
4. Oshiro H, Matsuo K, Mawatari H etal. Mucin-producing gallbladder adenocarcinoma with focal small cell and large cell neuroendocrine differentiation associated with pancreaticobiliary maljunction. Pathol Int 2008; 58: 780-6.
5. Pappoti M, Cassoni P, Sapino A etal. Large cell neuroendocrine carcinoma of the gallbladder. Am J Surg Pathol 2000; 24: 1424-8.
6. Friedman DJ, Wheeler WE. Cancer of the gallbladder. South Med J 1990; 83: 485-6.
7. Kelly TR, Chamberlain TR. Carcinoma of the gallbladder. Am J Surg 1982; 143: 737-41.
8. Sons HU, Borchard F, Joel BS. Carcinoma of the gallbladder: Autopsy findings in 287 cases and review of the literature. J Surg Oncol 1985; 28: 199-206.
9. Machado MC, Penteade S, Montagnini AL etal. Carcinoid tumor of the gallbladder. Rev Paul Med 1998; 116: 1741-3.
10. Klappenbach RS, Kurman RJ, Sinclair CF etal. Composite carcinoma-carcinoid tumours of the gastrointestinal tract. A morphologic, histochemical and immunohistochemical study. Am J Clin Pathol 1985; 84: 137-43.
11. Lewin K. Carcinoid tumours and mixed (composite) glandular- endocrine cell carcinomas. Am J Surg Pathol 1987; 11: 71-86.
12. Theise ND, Nakashima O, Park Y-N, Nakanuma Y. Combined hepatocellular-cholangiocarcinoma. In: Bosman F, Carneiro F, Hruban R, Theise ND, eds. WHO Classification of Tumours of the Digestive System, 4th edn. Geneva, Switzerland: WHO Press, 2010; 225-227.
13. Vadlamani I, Brunt E. Hepatocellular progenitor cell tumor of the gallbladder: A case report and review of the literature. Mod Pathol 2005; 18: 864-70.
14. Albores-Saavedra J, Scoazec JC, Wittekind C etal. Carcinoma of the gallbladder and extrahepatic bile ducts. In: Hamilton SR, Aaltonen LA, eds. Pathology and Genetics of Tumours of the Digestive System. Lyon: IARC Press, 2000; 206-14.
15. Muto Y, Okamoto K, Uichimura M. Composite tumour (ordinary adenocarcinoma, typical carcinoid and goblet cell adenocarcinoid) of the gallbladder: A variety of composite tumour. Am J Gastroenterol 1984; 79: 645-9.
16. Fish DE, Al-Izzi M, George PP etal. Combined endocrine cell carcinoma and adenocarcinoma of the gallbladder. Histopathology 1990; 17: 471-2.
17. Olinici CD, Waslu R. Composite endocrine cell, typical adenocarcinoma and signet-ring carcinoma of the gallbladder. Rom J Morphol Embryol 1991; 110: 604-10.
18. Ito J, Mizushima M, Soto H. Composite tumor exhibiting both carcinoid and undifferentiated carcinoma of the gallbladder. Tr Soc Pathol Jpn 1980; 69: 3699.
19. Sato K, Imai T, Shirota Y etal. Combined large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder. Pathol Res Pract 2010; 15 (206-6): 397-400.
20. Jun SR, Lee JM, Han JK etal. High-grade neuroendocrine carcinomas of the gallbladder and bile duct. J Comput Assist Tomogr 2006; 30: 604-9.
21. Nassar H, Albores-Saavedra J, Klimstra DS. High-grade neuroendocrine carcinoma of the ampulla of Vater: A clinicopathologic and immunohistochemical analysis of 14 cases. Am J Surg Pathol 2005; 29: 588-94.
22. Bosl GJ, Yagoda A, Camara-Lopes LH. Malignant carcinoid of the gallbladder; third reported case and review of the literature. J Surg Oncol 1980; 13: 215-22.
23. Tischler AS, Dichter MA, Biales B etal. Neuroendocrine neoplasms and their cells of origin. N Engl J Med 1977; 296: 919-65.
24. Roa I, De Aretxabala X, Araya JC etal. Preneoplastic lesions in gallbladder cancer. J Surg Oncol 2006; 93: 615-23.
25. Duarte I, Llanos O, Domke H etal. Metaplasia and precursor lesions of gallbladder carcinoma. Frequency, distribution and probability of detection in routine histologic samples. Cancer 1993; 72: 1878-84.
26. Yamagiwa H. Mucosal dysplasia of gallbladder: Isolated and adjacent lesions to carcinoma. Jpn J Cancer Res 1989; 80: 238-43.
27. Kushima R, Lohe B, Borchard F. Differentiation towards gastric foveolar, mucopeptic and intestinal goblet cells in gallbladder adenocarcinomas. Histopathology 1996; 29: 443-8.
28. Tatematsu M, Ichinose M, Miki K etal. Gastric phenotypic expression in human gallbladder cancers revealed by pepsinogen immunohistochemistry and mucin histochemistry. Virchows Arch A Pathol Anat Histopathol 1988; 413: 25-32.
29. Roa I, Aray JC, Villaseca M etal. Preneoplastic lesions in gallbladder cancer: An estimate of the period required for progression. Gastroenterology 1996; 111: 232-6.
30. Nakajo S, Yamamoto M, Tahara E. Morphometrical analysis of gallbladder adenoma and adenocarcinoma with reference to histogenesis and adenocarcinoma sequence. Virchows Arch A Pathol Anat Histopathol 1990; 417: 49-56.
31. Yanagisawa N, Mikami T, Saegusa M etal. More frequent beta-catenin exon 3 mutations in gallbladder adenomas than in carcinomas indicate different lineages. Cancer Res 2001; 61: 19-22.
32. Laitio M. Histogenesis of epithelial neoplasms of human gallbladder I. Dysplasia. Pathol Res Pract 1983; 178: 51-6.
33. Turner R, Lozoya O, Wang Y etal. Human hepatic stem cell and maturational liver lineage biology. Hepatology 2011; 53: 1035-45.
34. Cardinale V, Wang Y, Carpino G etal. Multipotent stem cells in the biliary tree. Ital J Anat Embryol 2010; 115: 85-90.
35. Theise ND, Saxena R, Portmann BC etal. The canals of Hering and hepatic stem cells in humans. Hepatology 1999; 30: 1425-33.
36. Yoon SM, Gerasimidou D, Kuwahara R etal. Epithelial cell adhesion molecule (EpCAM) marks hepatocytes newly derived from stem/progenitor cells in humans. Hepatology 2011; 53: 964-73.
37. de Boer CJ, van Krieken JH, Janssen-van Rhijn CM etal. Espression of Ep-CAM in normal, regenerating, metaplastic and neoplastic liver. J Pathol 1999; 188: 201-6.
38. Schmelzer E, Wauthier E, Reid LM. The phenotypes of pluripotent human hepatic progenitors. Stem Cells 2006; 24: 1852-8.
39. Yamashita T, Ji J, Budhu A etal. EpCAM-positive hepatocellular carcinoma cells are tumor initiating cells with stem/progenitor cell features. Gastroenterology 2009; 136: 1012-24.
40. Sell S, Dunsford HA. Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma. Am J Pathol 1989; 134: 1347-63.
41. Everts RP, Nkatsukasa H, Marsden ER etal. Cellular and molecular changes in the early stages of chemical hepatocarcinogenesis. Cancer Res 1990; 50: 3439-44.
42. Gindi T, Ghazarian DMD, Deitch D etal. An origin of presumptive preneoplastic foci and nodules from hepatocyte in chemical hepatocarcinogenesis. Cancer Lett 1994; 83: 75-80.
43. Dunsford HA, Karnasuta C, Hunt JM etal. Different cell lineages of chemically induced hepatocellular carcinoma in rats defined my monoclonal antibodies. Cancer Res 1989; 49: 4894-900.
44. Solt DB, Medline A, Farber E. Rapid emergence of carcinogen induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis. Am J Pathol 1977; 88: 595-609.
45. Shinozuka H, Lombardi B, Sell S etal. Early histological and functional alterations of ethionine liver carcinogenesis in rats fed a choline-deficient diet. Cancer Res 1978; 38: 1092-8.
46. Sell S, Leffert H, Shinozuka H etal. Rapid development of large numbers of alpha-fetoprotein containing 'oval' cells in the liver of rats fed N-2-flourenylacetamide in a choline-devoid diet. Jpn J Cancer Res 1981; 39: 2515-21.
47. Theise ND, Yao JL, Harada K etal. Hepatic 'stem cell' malignancies in adults: Four cases. Histopathology 2003; 43: 263-71.
48. Fujii T, Zen Y, Harada K etal. Participation of liver cancer stem/progenitor cells in tumorigenesis of scirrhous hepatocellular carcinoma-human and cell culture study. Hum Pathol 2008; 39: 1185-96.
49. Kim H, Park C, Han KH etal. Primary liver carcinoma of intermediate (hepatocyte-cholangiocyte) phenotype. J Hepatol 2004; 40: 298-304.