Alternative splicing and differential expression of the islet autoantigen IGRP between pancreas and thymus contributes to immunogenicity of pancreatic islets but not diabetogenicity in humans

Diabetologia

Volumn 56, Issue 12, 2013, Pages 2651-2658

  De Jong, V Martijn ^a   Abreu, Joana R F ^a   Verrijn Stuart, Annemarie A ^b   Van Der Slik, Arno R ^a   Verhaeghen, Katrijn ^c   Engelse, Marten A ^a   Blom, Bianca ^d   Staal, Frank J T ^a   Gorus, Frans K ^c   Roep, Bart O ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c FREE UNIVERSITY OF BRUSSELS   (Belgium)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Alternative splicing; Autoantibodies; CD8 T cell; HLA multimers; IGRP; Immunopathogenesis; Islet autoantigen; Thymic selection; Tolerance

Indexed keywords

GLUCOSE 6 PHOSPHATASE; HLA A2 ANTIGEN; QUANTUM DOT;

ALTERNATIVE RNA SPLICING; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; DIABETOGENESIS; DISEASE PREDISPOSITION; FRAMESHIFT MUTATION; G6PC2 GENE; GEL ELECTROPHORESIS; GENE; GENE AMPLIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGENICITY; IMMUNOLOGICAL TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; LIMIT OF DETECTION; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PANCREAS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE;

ALTERNATIVE SPLICING; ANTIBODY FORMATION; AUTOANTIGENS; BASE SEQUENCE; DIABETES MELLITUS, TYPE 1; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC PREDISPOSITION TO DISEASE; GLUCOSE-6-PHOSPHATASE; HUMANS; ISLETS OF LANGERHANS; MALE; PANCREAS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES; THYMUS GLAND; TRANSCRIPTION, GENETIC;

EID: 84888013690     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-3034-6     Document Type: Article

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