Caspase 8 differentially controls hepatocytes and non-parenchymal liver cells during chronic cholestatic liver injury in mice

Journal of Hepatology

Volumn 59, Issue 6, 2013, Pages 1292-1298

  Chaudhary, Kunal ^a   Liedtke, Christian ^a   Wertenbruch, Svenja ^a   Trautwein, Christian ^a   Streetz, Konrad L ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Apoptosis resistance; Caspase 8; Hepatic immune cells; Progenitor cells; Secondary sclerosing cholangitis

Indexed keywords

1,4 DIHYDRO 2,4,6 TRIMETHYL 3,5 PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER; AMINOTRANSFERASE; BILIRUBIN; CASPASE 3; CASPASE 8; CHOLINE; ETHIONINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BILE DUCT LIGATION; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CHOLESTATIC HEPATITIS; CHRONIC LIVER DISEASE; CONTROLLED STUDY; ENZYME ACTIVITY; IMMUNOCOMPETENT CELL; LIVER CELL; LIVER FIBROSIS; LIVER PARENCHYMA; LIVER REGENERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUPPLEMENTATION;

3,5-DIETHOXYCARBONYL-1,4-DIHYDROCOLLIDINE; 4WEEKS; 4WK; 5-BROMO-2-DEOXYURIDINE; ALANINE-AMINOTRANSFERASE; ALT; APOPTOSIS RESISTANCE; BM; BMT; BONE MARROW; BONE MARROW TRANSPLANTATION; BRDU; CASP; CASP8 KNOCKOUT ALLELE; CASP8 KNOCKOUT MICE; CASP8(LOXP/LOXP); CASP8(ΔHEPA); CASP8(ΔMX); CASPASE; CASPASE-8; DDC; HEPATIC IMMUNE CELLS; I.P.; INTRAPERITONEALLY; LIVER PROGENITOR CELL; LPC; MX1; MYXOVIRUS RESISTANCE-1; NON-PARENCHYMAL CELLS; NPCS; PCR; PIPC; POLYMERASE CHAIN REACTION; POLYRIBOINOSINIC-POLYRIBOCYTIDYLIC; PROGENITOR CELLS; REAL-TIME; RT; SD; SECONDARY SCLEROSING CHOLANGITIS; STANDARD DEVIATION; TERMINAL DEOXYNUCLEOTIDYLTRANSFERASE-MEDIATED NICK END LABELLING; TUNEL; UBIQUITOUS DELETION OF CASP8; WEIGHT; WILD TYPE; WT;

ANIMALS; APOPTOSIS; CASPASE 8; CHOLANGITIS, SCLEROSING; CHOLESTASIS; CHRONIC DISEASE; CYTOPROTECTION; HEPATOCYTES; MICE; MICE, KNOCKOUT; PYRIDINES;

EID: 84888012916     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2013.07.026     Document Type: Article

References (29)

1. G.K. Michalopoulos, and M.C. DeFrances Liver regeneration Science 276 1997 60 66
2. F. Li, Q. Huang, J. Chen, Y. Peng, D.R. Roop, and J.S. Bedford Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration Sci Signal 3 2010 ra13
3. J. Desbarats, and M.K. Newell Fas engagement accelerates liver regeneration after partial hepatectomy Nat Med 6 2000 920 923
4. J. Yuan Transducing signals of life and death Curr Opin Cell Biol 9 1997 247 251
5. J.C. Reed Mechanisms of apoptosis Am J Pathol 157 2000 1415 1430
6. E.S. Alnemri, D.J. Livingston, D.W. Nicholson, G. Salvesen, N.A. Thornberry, and W.W. Wong Human ICE/CED-3 protease nomenclature Cell 87 1996 171
7. X. Wang, M. Foster, M. Al-Dhalimy, E. Lagasse, M. Finegold, and M. Grompe The origin and liver repopulating capacity of murine oval cells Proc Natl Acad Sci U S A 100 2003 11881 11888
8. K.H. Preisegger, V.M. Factor, A. Fuchsbichler, C. Stumptner, H. Denk, and S.S. Thorgeirsson Atypical ductular proliferation and its inhibition by transforming growth factor beta1 in the 3,5-diethoxycarbonyl-1,4- dihydrocollidine mouse model for chronic alcoholic liver disease Lab Invest 79 1999 103 109
9. M. Arai, O. Yokosuka, K. Fukai, F. Imazeki, T. Chiba, and H. Sumi Gene expression profiles in liver regeneration with oval cell induction Biochem Biophys Res Commun 317 2004 370 376
10. N. Fausto, and J.S. Campbell The role of hepatocytes and oval cells in liver regeneration and repopulation Mech Dev 120 2003 117 130
11. C. Liedtke, J.M. Bangen, J. Freimuth, N. Beraza, D. Lambertz, and F.J. Cubero Loss of caspase-8 protects mice against inflammation-related hepatocarcinogenesis but induces non-apoptotic liver injury Gastroenterology 141 2011 2176 2187
12. K. Shimano, M. Satake, A. Okaya, J. Kitanaka, N. Kitanaka, and M. Takemura Hepatic oval cells have the side population phenotype defined by expression of ATP-binding cassette transporter ABCG2/BCRP1 Am J Pathol 163 2003 3 9
13. C. Dorrell, L. Erker, K.M. Lanxon-Cookson, S.L. Abraham, T. Victoroff, and S. Ro Surface markers for the murine oval cell response Hepatology 48 2008 1282 1291
14. B.E. Petersen, B. Grossbard, H. Hatch, L. Pi, J. Deng, and E.W. Scott Mouse A6-positive hepatic oval cells also express several hematopoietic stem cell markers Hepatology 37 2003 632 640
15. + endothelial cells (SPECs) reside in the portal area of the liver and contribute to rapid recovery from acute liver disease Biochem Biophys Res Commun 365 2008 595 601
16. H. Strick-Marchand, G.X. Masse, M.C. Weiss, and J.P. Di Santo Lymphocytes support oval cell-dependent liver regeneration J Immunol 181 2008 2764 2771
17. K. Bettermann, M. Vucur, J. Haybaeck, C. Koppe, J. Janssen, and F. Heymann TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer Cancer Cell 17 2010 481 496
18. W. Plum, D.F. Tschaharganeh, D.C. Kroy, E. Corsten, S. Erschfeld, and U. Dierssen Lack of glycoprotein 130/signal transducer and activator of transcription 3-mediated signaling in hepatocytes enhances chronic liver injury and fibrosis progression in a model of sclerosing cholangitis Am J Pathol 176 2010 2236 2246
19. E. Seki, D.A. Brenner, and M. Karin A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches Gastroenterology 143 2012 307 320
20. J.M. Schattenberg, M.A. Worns, T. Zimmermann, Y.W. He, P.R. Galle, and M. Schuchmann The role of death effector domain-containing proteins in acute oxidative cell injury in hepatocytes Free Radic Biol Med 52 2012 1911 1917
21. T. Kaufmann, P.J. Jost, M. Pellegrini, H. Puthalakath, R. Gugasyan, and S. Gerondakis Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim Immunity 30 2009 56 66
22. P. Fickert, U. Stoger, A. Fuchsbichler, T. Moustafa, H.U. Marschall, and A.H. Weiglein A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis Am J Pathol 171 2007 525 536
23. E. Halilbasic, T. Claudel, and M. Trauner Bile acid transporters and regulatory nuclear receptors in the liver and beyond J Hepatol 58 2013 155 168
24. N.K. Van Hul, J. Abarca-Quinones, C. Sempoux, Y. Horsmans, and I.A. Leclercq Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE-induced murine model of chronic liver injury Hepatology 49 2009 1625 1635
25. A. Jakubowski, C. Ambrose, M. Parr, J.M. Lincecum, M.Z. Wang, and T.S. Zheng TWEAK induces liver progenitor cell proliferation J Clin Invest 115 2005 2330 2340
26. B. Knight, G.C. Yeoh, K.L. Husk, T. Ly, L.J. Abraham, and C. Yu Impaired preneoplastic changes and liver tumor formation in tumor necrosis factor receptor type 1 knockout mice J Exp Med 192 2000 1809 1818
27. R. Watanabe-Fukunaga, C.I. Brannan, N.G. Copeland, N.A. Jenkins, and S. Nagata Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis Nature 356 1992 314 317
28. P. Bobe, D. Bonardelle, M. Reynes, F. Godeau, J. Mahiou, and V. Joulin Fas-mediated liver damage in MRL hemopoietic chimeras undergoing lpr-mediated graft-vs.-host disease J Immunol 159 1997 4197 4204
29. A. Tamura, M. Katsumata, M.I. Greene, and K. Yui Inhibition of apoptosis and augmentation of lymphoproliferation in bcl-2 transgenic Fas/Fas ligand-defective mice Cell Immunol 168 1996 220 228