Atypical ductular proliferation and its inhibition by transforming growth factor β1 in the 3,5-diethoxycarbonyl-1,4-dihydrocollidine mouse model for chronic alcoholic liver disease

Laboratory Investigation

Volumn 79, Issue 2, 1999, Pages 103-109

  Preisegger, Karl Heinz ^a,b   Factor, Valentina M ^a   Fuchsbichler, Andrea ^b   Stumptner, Conny ^b   Denk, Helmut ^b   Thorgeirsson, Snorri S ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO 2,4,6 TRIMETHYL 3,5 PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER; TRANSFORMING GROWTH FACTOR BETA1;

ALCOHOL LIVER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CHRONIC DISEASE; CONTROLLED STUDY; LIVER CELL; LIVER NECROSIS; LIVER REGENERATION; MOUSE; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL;

ANIMALS; BILE DUCTS, INTRAHEPATIC; CELL DIVISION; CHRONIC DISEASE; COMMON BILE DUCT; DICARBETHOXYDIHYDROCOLLIDINE; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; HEPATECTOMY; LIGATION; LIVER; LIVER DISEASES; LIVER DISEASES, ALCOHOLIC; LIVER REGENERATION; MICE; MICE, TRANSGENIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033025803     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Alison MR (1986). Regulation of liver growth. Physiol Rev 66:499-541.
2. Bisgaard HC and Thorgeirsson SS (1991). Evidence for a common cell of origin for primitive epithelial cells isolated from rat liver and pancreas. J Cell Physiol 147:333-343.
3. Denk H, Gschnait F, and Wolff K (1975). Hepatocellular hyalin (Mallory bodies) in long term griseofulvin-treated mice: A new experimental model for the study of hyalin formation. Lab Invest 31:773-777.
4. Desmet VJ (1985). Intrahepatic bile ducts under the lens. J Hepatol 1:545-559.
5. Desmet VJ (1986). Current problems in diagnosis of biliary disease and cholestasis. Semin Liver Dis 6:233-245.
6. Desmet VJ (1987): Modulation of biliary epithelium. In: Reutter W, Popper H, Arias IM, Heinrich PC, Keppler D, and Landmann L, editors: Modulation of liver cell expression. Lancaster, England: M.T.P. Press Limited, Kluwer Academic Publishers Group, 195-214.
7. Desmet V, Roskams T, and Van Eyken P (1995). Ductular reaction in the liver. Path Res Pract 191:513-524.
8. Engelhardt NV, Factor VM, Yasova AK, Poltoranina VS, Baranov VN, and Lazareva MN (1990). Common antigen of mouse oval and biliary epithelial cells: Expression on newly formed hepatocytes. Differentiation 45:29-37.
9. Engelhardt NV, Factor VM, Medvinsky AL, Baranov VN, Lazareva MN, and Poltoranina VS (1993). Common antigen of oval and biliary epithelial cells (A6) is a differentiation marker of epithelial and erythroid cell lineages in early development of the mouse. Differentiation 55:19-26.
10. Evarts RP, Nagy P, Marsden E, and Thorgeirsson SS (1987). A precursor-product relationship exists between oval cells and hepatocytes in rat liver. Carcinogenesis 8:1737-1740.
11. Factor VM, Radaeva SA, and Thorgeirsson SS (1994). Origin and fate of oval cells in Dipin-induced hepatocarcinogenesis in the mouse. Am J Pathol 145:409-422.
12. Farber E (1990). Clonal adaption during carcinogenesis. Biochem Pharmacol 39:1837-1846.
13. Fausto N, Lemire JM, and Shiojiri N (1992): Oval cells in liver carcinogenesis: cell lineages in hepatic development and the identification of facultative stem cells in normal liver. In: Sirica AF, editor: The role of cell types in hepatocarcinogenesis. Boca Raton, FL: CRC Press, 89-109.
14. Gall JA and Bhathal PS (1990a). A quantitative analysis of the liver following ligation of the common bile duct. Liver 10:116-125.
15. Gall JA and Bhathal PS (1990b). Origin and involution of hyperplastic bile ductules following total biliary obstruction. Liver 10:106-115.
16. Gerber MA and Thung SN (1992). Cell lineages in human liver development, regeneration, and transformation. In: Sirica AE, editor: The role of cell types in hepatocarcinogenesis. Boca Raton, FL: CRC Press, 209-226.
17. Gerber MA, Thung SN, Sehn S, Stromeyer MFW, and Ishak KG (1983). Phenotypic characterization of hepatic proliferation: antigenic expression by proliferating epithelial cells in fetal liver, massive hepatic necrosis and nodular transformation of the liver. Am J Pathol 110:70-76.
18. Goldfarb S, Singer EJ, and Popper H (1962). Experimental cholangitis due to alpha-naphthylisothiocyanate (ANIT). Am J Pathol 40:685-698.
19. Grisham JW (1980). Cell types in long-term propagable culture of rat liver. Ann N Y Acad Sci 349:28-37.
20. Grisham JW and Thorgeirsson SS (1997): Liver stem cells. In: Potten CP editor: Stem cells. Philadelphia: Academic Press Ltd., 233-282.
21. Haque S, Haruna Y, Saito K, Nalensik MA, Atillasoy E, Thung SN, and Gerber MA (1996). Identification of bipotential progenitor cells in human liver regeneration. Lab Invest 75:699-705.
22. Higgins GM and Anderson RM (1931). Experimental pathology of the liver. 1. Restoration of the liver of the white rat following partial surgical removal. Arch Pathol 12:186-202.
23. Hixson DC, Faris RA, and Thompson NL (1990). An antigenic portrait of the liver during carcinogenesis. Pathobiology 58: 65-77.
24. Lemire JM, Shiojiri N, and Fausto N (1991). Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine. Am J Pathol 139:535-552.
25. Milani S, Herbst H, Schuppan D, Stein H, and Surrenti C (1991). Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease. Am J Pathol 139:12221-12229.
26. Nakamura T, Tomita Y, Hirai R, Yamaoka K, Kaji K, and Ichihara A (1985). Inhibitory effect of transforming growth factor-beta in DNA-synthesis of adult rat hepatocytes in primary culture. Biochem Biophys Res Commun 133:1040-1050.
27. Nakanauma Y and Ohta G (1986). Immunohistochemical study on bile ductular proliferation in various hepatobiliary diseases. Liver 6:205-211.
28. Popper H, Kent G, and Stein R (1957). Ductular cell reaction in the liver in hepatic injury. J Mt Sinai Hosp 24:551-556.
29. Rhim JA, Sandgren EP, Degen JL, Palmiter RD, and Brinster RL (1994). Replacement of diseased mouse liver by hepatic cell transplantation. Science 263:1149-1152.
30. Roskams T, De Vos R, van den Oord JJ, and Desmet V (1991). Cells with neuroendocrine features in regenerating human liver. APMIS Suppl 23:32-39.
31. Rubin EM, Martin AA, Thung SN, and Gerber MA (1995). Morphometric and immunohistochemical characterization of human liver regeneration. Am J Pathol 147:397-404.
32. Sanderson N, Factor V, Nagy P, Kopp J, Kondaiah P, Wakefield L, Roberts AB, Sporn MB, and Thorgeirsson SS (1995). Hepatic expression of mature transforming growth factor beta-1 in transgenic mice results in multiple tissue lesions. Proc Natl Acad Sci U S A 92:2572-2576.
33. Scarpelli DG (1985). Multipotent development capacity of cells in the adult animal. Lab Invest 52:331-333.
34. Sell S (1990). Is there a liver stem cell? Cancer Res 50:3811-3815.
35. Sigal SH, Brill S, and Reid LM (1992). The liver as a stem cell and lineage system. Am J Physiol 263:139-148.
36. Thorgeirsson SS and Evarts RP (1992). Growth and differentiation of stem cells in adult rat liver. In: Sirica AF, editor: The role of cell types in hepatocarcinogenesis. Boca Raton, FL: CRC Press, 110-120.
37. Thung SN (1990). The development of proliferating ductular structures in liver disease. Arch Pathol Lab Med 114:407-411.
38. Uchida T and Peters RL (1983). The nature and origin of proliferated bile ductules in alcoholic liver disease. Am J Clin Pathol 79:326-333.
39. Uryvaeva IV and Factor VM (1988). Total replacement of parenchymal liver cells induced by Dipin and partial hepatectomy. Bull Exp Biol Med 105:96-98.
40. Vandersteenhoven AM, Burchette J, and Michalopoulos G (1990). Characterization of ductular hepatocytes in end-stage cirrhosis. Arch Pathol Lab Med 114:403-406.
41. Van Eyken P and Desmet VJ (1992). Development of intrahepatic bile ducts, ductular metaplasia of hepatocytes, and cytokeratin patterns in various types of human hepatic neoplasms. In: Sirica AE, editor: The role of cell types in hepatocarcinogenesis. Boca Raton, FL: CRC Press, 227-263.
42. Van Eyken P, Sciot R, and Desmet VJ (1989). A cytokeratin immunohistochemical study of cholestatic liver disease: evidence that hepatocytes can express bile duct-type cytokeratins. Histopathology 15:125-135.
43. Wright NA and Alison MR (1984). The biology of epithelial cell populations, vol 2. Oxford: Clarendon Press, 873-980.
44. Yasui O, Miura N, Terada K, Kawarada Y, Koyama K, and Sugiyama T (1997). Isolation of oval cells from Long-Evans Cinnamon rats and their transformation into hepatocytes in vivo in the rat liver. Hepatology 25:329-334.
45. Yokoo H, Harwood TR, Racker D, and Arak S (1982). Experimental production of Mallory bodies by diet containing 3:5-diethoxycarbonyl-1,4-dihydrocollidine. Gastroenterology 83:109-113.