Hypothesis: Interleukin-5 production impairment can be a key point in the pathogenesis of the MHC-linked selective IgA deficiency

Autoimmunity

Volumn 27, Issue 3, 1998, Pages 185-188

  Lio, Domenico ^a   D'Anna, Claudia ^a   Leone, Francesco ^b   Currò, Maria Francesca ^b   Candore, Giuseppina ^a   Caruso, Calogero ^a  

^a Institute of General Pathology   (Italy)

^b Palliative Medicine Teaching   (Italy)

Author keywords

DR3; HLA B8; IgA deficiency; IL 5

Indexed keywords

CHLORIDE; GAMMA INTERFERON; HLA B8 ANTIGEN; HLA DR3 ANTIGEN; IMMUNOGLOBULIN A; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 5; LEUKOCYTE ANTIGEN;

ANIMAL TISSUE; ANTIGEN SPECIFICITY; CONTROLLED STUDY; IMMUNOGLOBULIN A DEFICIENCY; IMMUNOGLOBULIN PRODUCTION; LYMPH NODE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PATHOGENESIS; SHORT SURVEY;

EID: 0031971238     PISSN: 08916934     EISSN: None     Source Type: Journal    
DOI: 10.3109/08916939809003866     Document Type: Short Survey

References (32)

1. Hammarstrom, L., Carlsson, B., Smith, C. I. E., Wallin, J. and Wieslander, L. (1985). Detection of IgA heavy chain constant region genes in IgA deficient donors: Evidences against gene deletion. Clin. Exp. Immunol., 60, 661-664.
2. Vorechovsky, I., Zetterquist, H., Paganelli, R., Koskinen, S., Webster, A. D. B., Bjorkander. J., et al. (1995). Family and linkage study of selective IgA deficiency and common variable immunodeficiency. Clin. Immunol. Immunopathol., 77, 185-192.
3. Islam, K. B., Baskin, B., Nilsson, L., Hammarstrom, L., Sideras, P. and Smith, C. I. E. (1994). Molecular analysis of IgA deficiency evidence for impaired switching of IgA. J. Immunol., 152, 1442-1452.
4. Azuma, C., Tanabe, T., Konishi, M., Kinashi, T., Nowa, T., Matsuda, F., et al. (1986). Cloning of c-DNA for human T-cell replacing factor (interleukin-5) and comparison with the murine homologue. Nucl. Acid. Res., 14, 9149-9158.
5. Yokota, T., Koffman, R. L., Hagiwara, H., Rennick, D. M., Takebe, Y., Yokota, K., et al. (1987). Isolation and characterization of lymphokine cDNA clones encoding mouse and human IgA-enhancing factor and eosinophil colony stimulating factor activities: relationship to IL-5. PNAS USA, 84, 7388-7392.
6. Bertolini, J. N., Sanderson, C. J. and Benson, E. M. (1993). Human interleukin-5 induces Staphilococcal A Cowan I strain activated human B cells to secrete IgM. Eur. J. Immunol., 23, 398-402.
7. Smith, C. I. E., Moller, G., Severinson, E. and Hammarstrom, L. (1990). Frequencies of interleukin-5 mRNA-producing cells in healthy individuals and in immunoglobulin deficient patients measured by in situ hybridization. Clin. Exp. Immunol., 81, 417-423.
8. Stavnezer, J. (1995). Regulation of antibody production and class switching by TGFb. J. Immunol., 155, 1647-1651.
9. Armitage, R. J., Macduff, B. M., Spriggs, M. K. and Fanslow, W. C. (1993). Human B cell proliferation and Ig secretion induced by recombinant CD40 ligand are modulated by soluble cytokines. J. Immunol., 150, 3671-3680.
10. Coffman, R., Lebman, D. A. and Rothman, P. (1993). Mechanism and Regulation of immunoglobulin Isotype switching. Adv. Immunol., 54, 229-270.
11. Huston, M. M., More, J. P., Mettes, H. J., Tavana, G. and Huston, D. P. (1996). Human B cells express IL-5 receptor messenger ribonucleic acid and respond to IL-5 with enhanced IgM production after mitogenic stimulation with Moraxella catarrhalis. J. Immunol., 156, 1392-1401.
12. Lio, D., Bellavia, D., Cigna, D., Feo, S., Barone, T., Maring, J. A., Scherz, R. and Brai, M. (1994). Multiple genetic influences in IgA deficiency (IgA-D) inheritance. Proc. fifth European Meeting on complement in human disease. Clin Exp. Immunol., 97, 32.
13. Friman, V., Hanson, L. A., Bridon, J.-M., Tarkowski, A., Banchereau, J. and Briere, F. (1996). IL- 10-driven immunoglobulin production by B lymphocytes from IgA-deticient individuals correlates to infection proneness. Clin. Exp. Immunol., 104, 432-438.
14. Olerup, O., Smith, C. I. E., Bjorkander, J. and Hammarstrom, L. (1992). Shared HLA class II associated genetic susceptibility and resistance, related to the HLA-DQB1 gene, in IgA deficiency and common variable immunodeficiency. PNAS USA, 89, 10653-10657.
15. Wilton, A. N., Cobain, T. J. and Dawkins, R. (1985). Family studies of IgA deficiency. Immunogenetics, 21, 333-342.
16. Klemola, T., Savilahti, E., Koskimies, S. and Pelkonen, P. (1988). Tissue Antigens, 32, 218-223.
17. Olerup, O., Smith, C. I. E. and Hammarstrom, L. (1990). Different aminoacids at position 57 of the HLA-DQ2b chain associated with susceptibility and resistance to IgA deficiency. Nature, 347, 289-290.
18. French, M. A. K. and Dawkins, R. L. (1990). Central MHC genes IgA deficiency and autoimmune disease. Immunol. Today, 11, 271-274.
19. Dieli, F., Sireci, G., Lio, D., Bonanno, C. T. and Salerno, A. (1993). Major hystocompatibility complex regulation of interleukin-5 production in mouse. Eur. J. Immunol., 23, 2897-2902.
20. Caruso, C., Candore, G., Modica, M. A., Sireci, G., Dieli, F. and Salerno, A. (1996). Major Histocompability Complex regulation of cytokine production. J. Interferon Cytokine Res., 16, 983-988.
21. Candore, G., Colonna Romano, G., D'Anna, C., Di Lorenzo, G., Gervasi, F., Lio, D., Modica, M. A., Potestio, M. and Caruso, C. (1997). Biological Basis of the HLA-B8, DR3 Associated Progression of Acquired Immune Deficiency Virus Syndrome. Pathobiology, [in press].
22. Dieli, F., Asherson, G. L., Sireci, G., Lio, D., Bonanno, C. T. and Salerno, A. (1995). IL-5 enhances in vitro and in vivo antigen specific IgA production in MHC genetically determined low IL-5 responder mice. Cell. Immunol., 163, 309-313.
23. Modica, M. A., Freddi, S. and Caruso, C. (1989). Bllod IgA, IgM and IgE levels are influenced by sex and HLA phenotype. Exp. Clin. Immunogenet., 6, 251-257.
24. Lio, D., D'Anna, C., Gervasi, F., Cigna, D., Modica, M. A., Candore, G. and Caruso, C. (1995). In vitro impairment of interleukin-5 production in HLA-B8, DR3-positive subjects: implication for Immunoglobulin-A synthesis disfunction. Human Immunol., 44, 170-174.
25. Hammarstrom, L., Axelsson, U., Bjorkander, J., Hanson, A., Moller, E. and Smith, C. I. E.(1984). HLA antigens in selective IgA deficiency: distribution in healthy donors and patients with recurrent resiratory tract infections. Tissue Antigen, 24, 35-42.
26. Candore, G., Cigna, D., Gervasi, F., Colucci, A. T., Modica, M. A. and Caruso, C. (1994). In vitro cytokine production by HLA-B8, DR3 positive subjects. Autoimmunity, 18, 121-127.
27. Candore, G., Colombo, A., Colonna Romano, G., D'Anna, C., Di Lorenzo, G., Gervasi, F., Iona, P., Lio, D., Lucania, G., Modica, M. A., Potestio, M. and Caruso, C. (1996). In vitro dissociated production of IL-10 and IL-12 by mononuclear cells (MNC) from HLA-B8, DR3-positive individuals. In: Pathogenesis and Immunotherapy of Autoimmune Disease - Second Symposium, Milan October 25-27. Abstract book 1996, 185.
28. Candore, G., Cigna, D., Todaro, M., DeMaria, R., Stassi, G., Giordano, C. and Caruso, C. (1995). T cell activation in HLA-B8, DR3-positive individuals: early antigen expression defect in vitro. Hum. Immunol., 42, 289.
29. Testi, R., d'Ambrosio, D., De Maria, R. and Santoni, A. (1994). The CD69 receptor: a multipurpose cell surface trigger for hematopoietic cells. Immunol Today, 15, 479-483.
30. German, T. and Rude, E. (1995). Interleukin 12. Int. Arch. Allergy Immunol., 108, 103-112.
31. Morikawa, K., Oseko, F., Morikawa, S., Imai, K. and Sawada, M. (1993). Recombinant human IL-5 augments immunoglobulin generation by Human B lymphocytes in the presence of IL-2. Cell. Immunol., 149, 390-401.
32. Marsh, D. G., Neely, J. D., Breazeale, D. R., Ghosh, B., Freidhof, R. L., Ehrlich-Kautzky Schou, C., Krishnaswamay, G. and Beaty, T. H. (1994). Likage analysis of IL-4 and other chromosome 5q31.1 markers and total serum IgE concentrations. Science, 264, 152-154.