Differential diagnosis of membranous nephropathy with autoantibodies to phospholipase A2 receptor 1

Autoimmunity Reviews

Volumn 13, Issue 2, 2014, Pages 108-113

  Schlumberger, Wolfgang ^a   Hornig, Nora ^a   Lange, Sascha ^a   Probst, Christian ^a   Komorowski, Lars ^a   Fechner, Kai ^a   Dähnrich, Cornelia ^a   Stöcker, Winfried ^a  

^a Institute for Experimental Immunology   (Germany)

Author keywords

Autoantibodies; ELISA; Indirect immunofluorescence; Membranous nephropathy; Nephrotic syndrome; Phospholipase A2 receptor 1

Indexed keywords

AUTOANTIBODY; MEMBRANE METALLOENDOPEPTIDASE; PHOSPHOLIPASE A2 RECEPTOR;

ANTIBODY DETECTION; CLINICAL FEATURE; DIFFERENTIAL DIAGNOSIS; DISEASE ACTIVITY; DISEASE CLASSIFICATION; DISULFIDE BOND; GLOMERULUS; HEYMANN NEPHRITIS; HUMAN; MEDICAL HISTORY; MEDICAL RESEARCH; MEMBRANOUS GLOMERULONEPHRITIS; PATHOGENESIS; PROTEIN ANALYSIS; PROTEIN FUNCTION; REVIEW; SEROLOGY;

AUTOANTIBODIES; ELISA; INDIRECT IMMUNOFLUORESCENCE; MEMBRANOUS NEPHROPATHY; NEPHROTIC SYNDROME; PHOSPHOLIPASE A2 RECEPTOR 1;

ANIMALS; AUTOANTIBODIES; BIOLOGICAL MARKERS; DIAGNOSIS, DIFFERENTIAL; DISEASE MODELS, ANIMAL; GLOMERULONEPHRITIS, MEMBRANOUS; HUMANS; RATS; RECEPTORS, PHOSPHOLIPASE A2;

EID: 84888005267     PISSN: 15689972     EISSN: 18730183     Source Type: Journal    
DOI: 10.1016/j.autrev.2013.09.005     Document Type: Review

References (62)

1. Ronco P., Debiec H. Pathogenesis of membranous nephropathy: recent advances and future challenges. Nat Rev Nephrol 2012, 8:203-213.
2. Beck L.H., Salant D.J. Membranous nephropathy: recent travels and new roads ahead. Kidney Int 2010, 77:765-770.
3. Scheidat S., Stahl R.A. Membranous glomerulonephritis. Internist 2003, 44:1120-1130.
4. Steinman T.I., Nissenson A.R., Glassock R.J., Dickmeyer J., Mattern W.D., Parker T.F., et al. L-carnitine use in dialysis patients: is national coverage for supplementation justified? What were CMS regulators thinking-or were they?. Nephrol News Issues 2003, 17:28-36.
5. McQuarrie E.P., Mackinnon B., Stewart G.A., Geddes C.C. Membranous nephropathy remains the commonest primary cause of nephrotic syndrome in a northern European Caucasian population. Nephrol Dial Transplant 2010, 25:1009-1010.
6. Glassock R.J. Pathogenesis of membranous nephropathy: a new paradigm in evolution. Contrib Nephrol 2013, 181:131-142.
7. Kidney Disease: Improving Global Outcomes (KDIGO) Glomerulonephritis work group KDIGO clinical practise guideline for glomerulonephritis. Kidney Int Suppl 2012, 2:186-197.
8. Bell E. Renal diseases 1946, 141-253.
9. Jones D.B. Nephrotic glomerulonephritis. Am J Pathol 1957, 33:313-329.
10. Mellors R.C., Ortega L.G., Holman H.R. Role of gamma globulins in pathogenesis of renal lesions in systemic lupus erythematosus and chronic membranous glomerulonephritis, with an observation on the lupus erythematosus cell reaction. J Exp Med 1957, 106:191-202.
11. Heymann W., Hackel D.B., Harwood S., Wilson S.G., Hunter J.L. Production of nephrotic syndrome in rats by Freund's adjuvants and rat kidney suspensions. Proc Soc Exp Biol Med 1959, 100:660-664.
12. Couser W.G., Steinmuller D.R., Stilmant M.M., Salant D.J., Lowenstein L.M. Experimental glomerulonephritis in the isolated perfused rat kidney. J Clin Invest 1978, 62:1275-1287.
13. Van Damme B.J., Fleuren G.J., Bakker W.W., Vernier R.L., Hoedemaeker P.J. Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. V. Fixed glomerular antigens in the pathogenesis of heterologous immune complex glomerulonephritis. Lab Invest 1978, 38:502-510.
14. Couser W.G., Salant D.J. In situ immune complex formation and glomerular injury. Kidney Int 1980, 17:1-13.
15. Kerjaschki D., Farquhar M.G. Immunocytochemical localization of the Heymann nephritis antigen (GP330) in glomerular epithelial cells of normal Lewis rats. J Exp Med 1983, 157:667-686.
16. Kerjaschki D., Miettinen A., Farquhar M.G. Initial events in the formation of immune deposits in passive Heymann nephritis. gp330-anti-gp330 immune complexes form in epithelial coated pits and rapidly become attached to the glomerular basement membrane. J Exp Med 1987, 166:109-128.
17. Chatelet F., Brianti E., Ronco P., Roland J., Verroust P. Ultrastructural localization by monoclonal antibodies of brush border antigens expressed by glomeruli I. Renal distribution. Am J Pathol 1986, 122:500-511.
18. Debiec H., Guigonis V., Mougenot B., Decobert F., Haymann J.P., Bensman A., et al. Antenatal membranous glomerulonephritis due to anti-neutral endopeptidase antibodies. N Engl J Med 2002, 346:2053-2060.
19. Debiec H., Nauta J., Coulet F., van der B.M., Guigonis V., Schurmans T., et al. Role of truncating mutations in MME gene in fetomaternal alloimmunisation and antenatal glomerulopathies. Lancet 2004, 364:1252-1259.
20. Kerjaschki D. Pathomechanisms and molecular basis of membranous glomerulopathy. Lancet 2004, 364:1194-1196.
21. Beck L.H., Bonegio R.G., Lambeau G., Beck D.M., Powell D.W., Cummins T.D., et al. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med 2009, 361:11-21.
22. Lambeau G., Lazdunski M. Receptors for a growing family of secreted phospholipases A2. Trends Pharmacol Sci 1999, 20:162-170.
23. East L., Isacke C.M. The mannose receptor family. Biochim Biophys Acta 2002, 1572:364-386.
24. Zvaritch E., Lambeau G., Lazdunski M. Endocytic properties of the M-type 180-kDa receptor for secretory phospholipases A2. J Biol Chem 1996, 271:250-257.
25. Llorca O. Extended and bent conformations of the mannose receptor family. Cell Mol Life Sci 2008, 65:1302-1310.
26. Prunotto M., Carnevali M.L., Candiano G., Murtas C., Bruschi M., Corradini E., et al. Autoimmunity in membranous nephropathy targets aldose reductase and SOD2. J Am Soc Nephrol 2010, 21:507-519.
27. Herrmann S.M., Sethi S., Fervenza F.C. Membranous nephropathy: the start of a paradigm shift. Curr Opin Nephrol Hypertens 2012, 21:203-210.
28. Murtas C., Ravani P., Ghiggeri G.M. New insights into membranous glomerulonephritis: from bench to bedside. Nephrol Dial Transplant 2011, 26:2428-2430.
29. Murtas C., Bruschi M., Candiano G., Moroni G., Magistroni R., Magnano A., et al. Coexistence of different circulating anti-podocyte antibodies in membranous nephropathy. Clin J Am Soc Nephrol 2012, 7:1394-1400.
30. Bruschi M., Carnevali M.L., Murtas C., Candiano G., Petretto A., Prunotto M., et al. Direct characterization of target podocyte antigens and auto-antibodies in human membranous glomerulonephritis: alfa-enolase and borderline antigens. J Proteomics 2011, 74:2008-2017.
31. Terrier B., Degand N., Guilpain P., Servettaz A., Guillevin L., Mouthon L. Alpha-enolase: a target of antibodies in infectious and autoimmune diseases. Autoimmun Rev 2007, 6:176-182.
32. Cavazzini F., Magistroni R., Furci L., Lupo V., Ligabue G., Granito M., et al. Identification and characterization of a new autoimmune protein in membranous nephropathy by immunoscreening of a renal cDNA library. PLoS One 2012, 7.
33. Meyer-Schwesinger C., Dehde S., Klug P., Becker J.U., Mathey S., Arefi K., et al. Nephrotic syndrome and subepithelial deposits in a mouse model of immune-mediated anti-podocyte glomerulonephritis. J Immunol 2011, 187:3218-3229.
34. Meyer T.N., Schwesinger C., Wahlefeld J., Dehde S., Kerjaschki D., Becker J.U., et al. A new mouse model of immune-mediated podocyte injury. Kidney Int 2007, 72:841-852.
35. Beck L.H., Fervenza F.C., Beck D.M., Bonegio R.G., Malik F.A., Erickson S.B., et al. Rituximab-induced depletion of anti-PLA2R autoantibodies predicts response in membranous nephropathy. J Am Soc Nephrol 2011, 22:1543-1550.
36. Hofstra J.M., Beck L.H., Beck D.M., Wetzels J.F., Salant D.J. Anti-phospholipase A(2) receptor antibodies correlate with clinical status in idiopathic membranous nephropathy. Clin J Am Soc Nephrol 2011, 6:1286-1291.
37. Ronco P., Debiec H. Antigen identification in membranous nephropathy moves toward targeted monitoring and new therapy. J Am Soc Nephrol 2010, 21:564-569.
38. Aalberse R.C., Schuurman J. IgG4 breaking the rules. Immunology 2002, 105:9-19.
39. van der Zee J.S., van S.P., Aalberse R.C. Inhibition of complement activation by IgG4 antibodies. Clin Exp Immunol 1986, 64:415-422.
40. Hinglais N., Kazatchkine M.D., Bhakdi S., Appay M.D., Mandet C., Grossetete J., et al. Immunohistochemical study of the C5b-9 complex of complement in human kidneys. Kidney Int 1986, 30:399-410.
41. Brenchley P.E., Coupes B., Short C.D., O'Donoghue D.J., Ballardie F.W., Mallick N.P. Urinary C3dg and C5b-9 indicate active immune disease in human membranous nephropathy. Kidney Int 1992, 41:933-937.
42. Beck L.H. Monoclonal anti-PLA2R and recurrent membranous nephropathy: another piece of the puzzle. J Am Soc Nephrol 2012, 23:1911-1913.
43. Lhotta K., Schlogl A., Kronenberg F., Joannidis M., Konig P. Glomerular deposition of the complement C4 isotypes C4A and C4B in glomeruonephritis. Nephrol Dial Transplant 1996, 11:1024-1028.
44. Hoxha E., Harendza S., Zahner G., Panzer U., Steinmetz O., Fechner K., et al. An immunofluorescence test for phospholipase-A(2)-receptor antibodies and its clinical usefulness in patients with membranous glomerulonephritis. Nephrol Dial Transplant 2011, 26:2526-2532.
45. Stöcker W. Rational histochemical analysis by means of a new microanalytical method. Acta Histochem Suppl 1985, 31:269-281.
46. Hofstra J.M., Debiec H., Short C.D., Pelle T., Kleta R., Mathieson P.W., et al. Antiphospholipase A2 receptor antibody titer and subclass in idiopathic membranous nephropathy. J Am Soc Nephrol 2012, 23:1735-1743.
47. Dähnrich C., Komorowski L., Probst C., Seitz-Polski B., Esnault V., Wetzels J.F., et al. Development of a standardized ELISA for the determination of autoantibodies against human M-type phospholipase A2 receptor in primary membranous nephropathy. Clin Chim Acta 2013, 421:213-218.
48. Gunnarsson I., Schlumberger W., Ronnelid J. Antibodies to M-type phospholipase A2 receptor (PLA2R) and membranous lupus nephritis. Am J Kidney Dis 2012, 59:585-586.
49. Qin W., Beck L.H., Zeng C., Chen Z., Li S., Zuo K., et al. Anti-phospholipase A2 receptor antibody in membranous nephropathy. J Am Soc Nephrol 2011, 22:1137-1143.
50. Hoxha E., Kneissler U., Stege G., Zahner G., Thiele I., Panzer U., et al. Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy. Kidney Int 2012, 82:797-804.
51. Kanigicherla D., Gummadova J., McKenzie E.A., Roberts S.A., Harris S., Nikam M., et al. Anti-PLA2R antibodies measured by ELISA predict long-term outcome in a prevalent population of patients with idiopathic membranous nephropathy. Kidney Int 2013, 83:940-948.
52. Stahl R., Hoxha E., Fechner K. PLA2R autoantibodies and recurrent membranous nephropathy after transplantation. N Engl J Med 2010, 363:496-498.
53. Hofstra J.M., Fervenza F.C., Wetzels J.F. Treatment of idiopathic membranous nephropathy. Nat Rev Nephrol 2013, 9:443-458.
54. El-Zoghby Z.M., Grande J.P., Fraile M.G., Norby S.M., Fervenza F.C., Cosio F.G. Recurrent idiopathic membranous nephropathy: early diagnosis by protocol biopsies and treatment with anti-CD20 monoclonal antibodies. Am J Transplant 2009, 9:2800-2807.
55. Debiec H., Martin L., Jouanneau C., Dautin G., Mesnard L., Rondeau E., et al. Autoantibodies specific for the phospholipase A2 receptor in recurrent and de novo membranous nephropathy. Am J Transplant 2011, 11:2144-2152.
56. Larsen C.P., Walker P.D. Phospholipase A2 receptor (PLA2R) staining is useful in the determination of de novo versus recurrent membranous glomerulopathy. Transplantation 2013, 95:1259-1262.
57. Hofstra J.M., Wetzels J.F. Anti-PLA(2)R antibodies in membranous nephropathy: ready for routine clinical practice?. Neth J Med 2012, 70:109-113.
58. Debiec H., Ronco P. PLA2R autoantibodies and PLA2R glomerular deposits in membranous nephropathy. N Engl J Med 2011, 364:689-690.
59. Behnert A., Fritzler M.J., Teng B., Zhang M., Bollig F., Haller H., et al. An anti-phospholipase A2 receptor quantitative immunoassay and epitope analysis in membranous nephropathy reveals different antigenic domains of the receptor. PLoS One 2013, 8.
60. Cossey L.N., Walker P.D., Larsen C.P. Phospholipase A2 receptor staining in pediatric idiopathic membranous glomerulopathy. Pediatr Nephrol 2013, 10.1007/s00467-013-2574-9.
61. Larsen C.P., Messias N.C., Silva F.G., Messias E., Walker P.D. Determination of primary versus secondary membranous glomerulopathy utilizing phospholipase A2 receptor staining in renal biopsies. Mod Pathol 2013, 26:709-715.
62. Svobodova B., Honsova E., Ronco P., Tesar V., Debiec H. Kidney biopsy is a sensitive tool for retrospective diagnosis of PLA2R-related membranous nephropathy. Nephrol Dial Transplant 2013, 28:1839-1844.