Determination of primary versus secondary membranous glomerulopathy utilizing phospholipase A2 receptor staining in renal biopsies

Modern Pathology

Volumn 26, Issue 5, 2013, Pages 709-715

  Larsen, Christopher P ^a,b   Messias, Nidia C ^a   Silva, Fred G ^a,b   Messias, Erick ^b   Walker, Patrick D ^a,b  

^a Nephropathology Associates   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

glomerulonephritis; membranous; proteinuria

Indexed keywords

IMMUNOGLOBULIN G4; NEUTROPHIL CYTOPLASMIC ANTIBODY; PHOSPHOLIPASE A2 RECEPTOR;

ADULT; AGED; ARTICLE; AUTOIMMUNE DISEASE; FEMALE; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IDIOPATHIC DISEASE; IMMUNOFLUORESCENCE TEST; KIDNEY BIOPSY; KIDNEY TUMOR; MAJOR CLINICAL STUDY; MALE; MEMBRANOUS GLOMERULONEPHRITIS; MIXED CONNECTIVE TISSUE DISEASE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SARCOIDOSIS; SENSITIVITY AND SPECIFICITY; SJOEGREN SYNDROME; STAINING; SYPHILIS; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 84877085738     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2012.207     Document Type: Article

References (27)

1. Ronco P, Debiec H. Molecular pathomechanisms of membranous nephropathy: from Heymann nephritis to alloimmunization. J Am Soc Nephrol 2005;16: 1205-1213.
2. Beck LH, Bonegio RG, Lambeau G, et al. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med 2009;361:11-21.
3. Qin W, Beck LH Jr, Zeng C, et al. Anti-phospholipase A2 receptor antibody in membranous nephropathy. J Am Soc Nephrol 2011;22:1137-1143.
4. Debiec H, Ronco P. PLA2R autoantibodies and PLA2R glomerular deposits in membranous nephropathy. N Engl J Med 2011;364:689-690.
5. Hoxha E, Kneissler U, Stege G, et al. Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy. Kidney Int 2012;82:797-804.
6. Walker PD, Cavallo T, Bonsib SM. Practice guidelines for the renal biopsy. Mod Pathol 2004;17:1555-1563.
7. Walker PD. The renal biopsy. Arch Pathol Lab Med 2009;133:181-188.
8. Ehrenreich T, Churg J. Pathology of membranous nephropathy. Pathol Annu 1968;2:145-186.
9. Jennette JC, Iskandar SS, Dalldorf FG. Pathologic differentiation between lupus and nonlupus membranous glomerulopathy. Kidney Int 1983;24:377-385.
10. Segal PE, Choi MJ. Recent advances and prognosis in idiopathic membranous nephropathy. Adv Chronic Kidney Dis 2012;19:114-119.
11. Nair R, Bell JM, Walker PD. Renal biopsy in patients aged 80 years and older. Am J Kidney Dis 2004;44: 618-626.
12. McQuarrie EP, Stirling CM, Geddes CC. Idiopathic membranous nephropathy and nephrotic syndrome: outcome in the era of evidence-based therapy. Nephrol Dial Transplant 2012;27:235-242.
13. Debiec H, Martin L, Jouanneau C, et al. Autoantibodies specific for the phospholipase A2 receptor in recurrent and De Novo membranous nephropathy. Am J Trans 2011;11:2144-2152.
14. Debiec H, Ronco P. Nephrotic syndrome: a new specific test for idiopathic membranous nephropathy. Nat Rev Nephrol 2011;7:496-498.
15. Glassock RJ. Attending rounds: an older patient with nephrotic syndrome. Clin J Am Soc Nephrol 2012;7:665-670.
16. Markowitz GS. Membranous glomerulopathy: emphasis on secondary forms and disease variants. Adv Anat Pathol 2001;8:119-125.
17. Glassock RJ. Secondary membranous glomerulonephritis. Nephrol Dial Transplant 1992;7:64-71.
18. Honig C, Mouradian JA, Montoliu J, et al. Mesangial electron-dense deposits in membranous nephropathy. Lab Invest 1980;42:427-432.
19. Obana M, Nakanishi K, Sako M, et al. Segmental membranous glomerulonephritis in children: comparison with global membranous glomerulonephritis. Clin J Am Soc Nephrol 2006;1:723-729.
20. Nasr SH, Satoskar A, Markowitz G, et al. Proliferative glomerulonephritis with monoclonal IgG deposits. J Am Soc Nephrol 2009;20:2055-2064.
21. Komatsuda A, Masai R, Ohtani H, et al. Monoclonal immunoglobulin deposition disease associated with membranous features. Nephrol Dial Transplant 2008;23:3888-3894.
22. Evans DJ, Macanovic M, Dunn MJ, et al. Membranous glomerulonephritis associated with follicular B-cell lymphoma and subepithelial deposition of IgG1-k paraprotein. Nephron Clin Pract 2003;93:112-118.
23. Doi T, Mayumi M, Kanatsu K, et al. Distribution of IgG subclasses in membranous nephropathy. Clin Exp Immunol 1984;58:57-62.
24. Ohtani H,Wakui H, Komatsuda A, et al. Distribution of glomerular IgG subclass deposits in malignancy-associated membranous nephropathy. Nephrol Dial Transplant 2004;19:574-579.
25. Haas M. IgG subclass deposits in glomeruli of lupus and nonlupus membranous nephropathies. Am J Kidney Dis 1994;23:358-364.
26. Kearney N, Podolak J, Matsumura L, et al. Patterns of IgG subclass deposits in membranous glomerulonephritis in renal allografts. Transplant Proc 2011;43:3743-3746.
27. Stanescu HC, Arcos-Burgos M, Medlar A, et al. Risk HLA-DQA1 and PLA2R1 alleles in idiopathic membranous nephropathy. N Engl J Med 2011;364:616-626.