An Anti-Phospholipase A2 Receptor Quantitative Immunoassay and Epitope Analysis in Membranous Nephropathy Reveals Different Antigenic Domains of the Receptor

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Behnert, Astrid ^a   Fritzler, Marvin J ^b   Teng, Beina ^a   Zhang, Meifeng ^b   Bollig, Frank ^a   Haller, Hermann ^a   Skoberne, Andrej ^a   Mahler, Michael ^c   Schiffer, Mario ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF CALGARY   (Canada)

^c INOVA DIAGNOSTICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; PHOSPHOLIPASE A2 RECEPTOR; SYNTHETIC PEPTIDE; AUTOANTIGEN; PEPTIDE FRAGMENT;

ADDRESSABLE LASER BEAD IMMUNOASSAY; ARTICLE; CONTROLLED STUDY; EPITOPE MAPPING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IDIOPATHIC MEMBRANOUS GLOMERULONEPHRITIS; IMMUNOASSAY; IMMUNOREACTIVITY; MEMBRANOUS GLOMERULONEPHRITIS; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION; PROTEIN DOMAIN; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; AMINO ACID SEQUENCE; CHEMISTRY; GLOMERULONEPHRITIS, MEMBRANOUS; HEK293 CELL LINE; IMMUNOLOGY; LASER; MOLECULAR GENETICS; PROCEDURES; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; AUTOANTIBODIES; AUTOANTIGENS; EPITOPE MAPPING; GLOMERULONEPHRITIS, MEMBRANOUS; HEK293 CELLS; HUMANS; IMMUNOASSAY; LASERS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, PHOSPHOLIPASE A2;

EID: 84876896093     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0061669     Document Type: Article

References (34)

1. Hanko JB, Mullan RN, O'Rourke DM, McNamee PT, Maxwell AP, et al. (2009) The changing pattern of adult primary glomerular disease. Nephrology Dialysis Transplantation 24: 3050-3054.
2. McGrogan A, Franssen CFM, De Vries CS, (2011) The incidence of primary glomerulonephritis worldwide: A systematic review of the literature. Nephrology Dialysis Transplantation 26: 414-430.
3. Kuroki A, Shibata T, Honda H, Totsuka D, Kobayashi K, et al. (2002) Glomerular and serum IgG subclasses in diffuse proliferative lupus nephritis, membranous lupus nephritis, and idiopathic membranous nephropathy. Intern Med 41: 936-942.
4. Heymann W, Hackel DB, Harwood S, Wilson SG, Hunter JL, (1959) Production of nephrotic syndrome in rats by freund's adjuvants and rat kidney suspensions. Proc Soc Exp Biol Med 100: 660-664.
5. Beck LH, Jr, Salant DJ, (2010) Membranous nephropathy: Recent travels and new roads ahead. Kidney Int 77: 765-770.
6. Bindon CI, Hale G, Bruggemann M, Waldmann H, (1988) Human monoclonal IgG isotypes differ in complement activating function at the level of C4 as well as C1q. J Exp Med 168: 127-142.
7. Daha NA, Banda NK, Roos A, Beurskens FJ, Bakker JM, et al. (2011) Complement activation by (auto-) antibodies. Mol Immunol 48: 1656-1665.
8. Debiec H, Guigonis V, Mougenot B, Decobert F, Haymann JP, et al. (2002) Antenatal membranous glomerulonephritis due to anti-neutral endopeptidase antibodies. N Engl J Med 346: 2053-2060.
9. Glassock RJ, (2010) The pathogenesis of idiopathic membranous nephropathy: A 50-year odyssey. American Journal of Kidney Diseases 56: 157-167.
10. Beck LH, Jr, Bonegio RG, Lambeau G, Beck DM, Powell DW, et al. (2009) M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med 361: 11-21.
11. Hanasaki K, (2004) Mammalian phospholipase A2: Phospholipase A2 receptor. Biol Pharm Bull 27: 1165-1167.
12. Hofstra JM, Wetzels JF, (2012) Anti-PLA 2R antibodies in membranous nephropathy: Ready for routine clinical practice? Neth J Med 70: 109-113.
13. Qin W, Beck LH, Jr, Zeng C, Chen Z, Li S, et al. (2011) Anti-phospholipase A2 receptor antibody in membranous nephropathy. J Am Soc Nephrol 22: 1137-1143.
14. Svobodova B, Honsova E, Ronco P, Tesar V, Debiec H (2012) Kidney biopsy is a sensitive tool for retrospective diagnosis of PLA2R-related membranous nephropathy. Nephrol Dial Transplant.
15. Bruschi M, Carnevali ML, Murtas C, Candiano G, Petretto A, et al. (2011) Direct characterization of target podocyte antigens and auto-antibodies in human membranous glomerulonephritis: Alfa-enolase and borderline antigens. J Proteomics 74: 2008-2017.
16. Prunotto M, Carnevali ML, Candiano G, Murtas C, Bruschi M, et al. (2010) Autoimmunity in membranous nephropathy targets aldose reductase and SOD2. J Am Soc Nephrol 21: 507-519.
17. Hofstra JM, Beck Jr LH, Beck DM, Wetzels JF, Salant DJ, (2011) Anti-phospholipase a 2 receptor antibodies correlatewith clinical status in idiopathic membranous nephropathy. Clinical Journal of the American Society of Nephrology 6: 1286-1291.
18. Stahl R, Hoxha E, Fechner K, (2010) PLA2R autoantibodies and recurrent membranous nephropathy after transplantation. N Engl J Med 363: 496-498.
19. Debiec H, Martin L, Jouanneau C, Dautin G, Mesnard L, et al. (2011) Autoantibodies specific for the phospholipase A 2 receptor in recurrent and de novo membranous nephropathy. American Journal of Transplantation 11: 2144-2152.
20. Debiec H, Ronco P, (2011) Nephrotic syndrome: A new specific test for idiopathic membranous nephropathy. Nature Reviews Nephrology 7: 496-498.
21. Hoxha E, Harendza S, Zahner G, Panzer U, Steinmetz O, et al. (2011) An immunofluorescence test for phospholipase-A2-receptor antibodies and its clinical usefulness in patients with membranous glomerulonephritis. Nephrology Dialysis Transplantation 26: 2526-2532.
22. Kanigicherla D, Gummadova J, McKenzie EA, Roberts SA, Harris S, et al. (2013) Anti-PLA2R antibodies measured by ELISA predict long-term outcome in a prevalent population of patients with idiopathic membranous nephropathy. Kidney Int.
23. Kessenbrock K, Raijmakers R, Fritzler MJ, Mahler M, (2007) Synthetic peptides: The future of patient management in systemic rheumatic diseases? Curr Med Chem 14: 2831-2838.
24. Frank R, (2002) The SPOT-synthesis technique. synthetic peptide arrays on membrane supports-principles and applications. J Immunol Methods 267: 13-26.
25. Stinton LM, Swain M, Myers RP, Shaheen AA, Fritzler MJ, (2011) Autoantibodies to GW bodies and other autoantigens in primary biliary cirrhosis. Clin Exp Immunol 163: 147-156.
26. Mahler M, Bluthner M, Pollard KM, (2003) Advances in B-cell epitope analysis of autoantigens in connective tissue diseases. Clin Immunol 107: 65-79.
27. Mahler M, Fritzler MJ, Bluthner M, (2005) Identification of a SmD3 epitope with a single symmetrical dimethylation of an arginine residue as a specific target of a subpopulation of anti-sm antibodies. Arthritis Res Ther 7: R19-29.
28. Mahler M, Mierau R, Bluthner M, (2000) Fine-specificity of the anti-CENP-A B-cell autoimmune response. J Mol Med (Berl) 78: 460-467.
29. Mahler M, Mierau R, Schlumberger W, Bluthner M, (2001) A population of autoantibodies against a centromere-associated protein A major epitope motif cross-reacts with related cryptic epitopes on other nuclear autoantigens and on the epstein-barr nuclear antigen 1. J Mol Med (Berl) 79: 722-731.
30. Jia XY, Qu Z, Cui Z, Yang R, Zhao J, et al. (2012) Circulating anti-glomerular basement membrane autoantibodies against alpha3(IV)NC1 undetectable by commercially available enzyme-linked immunosorbent assays. Nephrology (Carlton) 17: 160-166.
31. de Laat B, van Berkel M, Urbanus RT, Siregar B, de Groot PG, et al. (2011) Immune responses against domain I of beta(2)-glycoprotein I are driven by conformational changes: Domain I of beta(2)-glycoprotein I harbors a cryptic immunogenic epitope. Arthritis Rheum 63: 3960-3968.
32. Mattioli M, Reichlin M, (1973) Physical association of two nuclear antigens and mutual occurrence of their antibodies: The relationship of the SM and RNAprotein (MO) systems in SLE sera. J Immunol 110: 1318-1324.
33. Northway JD, Tan EM (1972) Differentiation of antinuclear antibodies giving speckled staining patterns in immunofluorescence.: 140-154.
34. Vanderlugt CL, Miller SD, (2002) Epitope spreading in immune-mediated diseases: Implications for immunotherapy. Nat Rev Immunol 2: 85-95.