Identification and Characterization of a New Autoimmune Protein in Membranous Nephropathy by Immunoscreening of a Renal cDNA Library

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Cavazzini, Fabrizio ^a   Magistroni, Riccardo ^a   Furci, Luciana ^b   Lupo, Valentina ^a   Ligabue, Giulia ^a   Granito, Maria ^a   Leonelli, Marco ^b   Albertazzi, Alberto ^a   Cappelli, Gianni ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; COMPLEMENTARY DNA; SYNAPTONEMAL COMPLEX PROTEIN 65; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BACTERIOPHAGE LAMBDA; CLINICAL ARTICLE; CONTROLLED STUDY; DNA LIBRARY; DNA SEQUENCE; FEMALE; FUNCTIONAL PROTEOMICS; GENETIC SCREENING; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; KIDNEY BIOPSY; KIDNEY DISEASE; MALE; MEMBRANOUS NEUROPATHY; MOLECULAR CLONING; NEUROPATHY; NUCLEOTIDE SEQUENCE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN TARGETING; RESTRICTION FRAGMENT; SEQUENCE ANALYSIS; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; AUTOANTIBODIES; AUTOANTIGENS; BIOPSY; BLOTTING, WESTERN; DNA, COMPLEMENTARY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE LIBRARY; GLOMERULONEPHRITIS, MEMBRANOUS; HUMANS; KIDNEY; MALE; MIDDLE AGED; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; SEQUENCE ANALYSIS, DNA; SYNAPTONEMAL COMPLEX;

EID: 84869004122     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0048845     Document Type: Article

References (27)

1. Ponticelli C, (2007) Membranous nephropathy. J Nephrol 20: 268-287.
2. Wasserstein AG, (1997) Membranous glomerulonephritis. J Am Soc Nephrol 8: 664-674.
3. Glassock RJ, (2003) Diagnosis and natural course of membranous nephropathy. Semin Nephrol 23: 324-332.
4. Imai H, Hamai K, Komatsuda A, Ohtani H, Miura AB, (1997) IgG subclasses in patients with membranoproliferative glomerulonephritis, membranous nephropathy, and lupus nephritis. Kidney Int 51: 270-276.
5. Noel LH, Aucouturier P, Monteiro RC, Preud'Homme JL, Lesavre P, (1988) Glomerular and serum immunoglobulin G subclasses in membranous nephropathy and anti-glomerular basement membrane nephritis. Clin Immunol Immunopathol 46: 186-194.
6. Kerjaschki D, Neale TJ, (1996) Molecular mechanisms of glomerular injury in rat experimental membranous nephropathy (Heymann nephritis). J Am Soc Nephrol 7: 2518-2526.
7. Prunotto M, Carnevali ML, Candiano G, Murtas C, Bruschi M, et al. (2010) Autoimmunity in membranous nephropathy targets aldose reductase and SOD2. J Am Soc Nephrol 21: 507-519.
8. Adler S, Baker PJ, Pritzl P, Couser WG, (1984) Detection of terminal complement components in experimental immune glomerular injury. Kidney Int 26: 830-837.
9. Heymann W, Hackel DB, Harwood S, Wilson SG, Hunter JL, (1959) Production of nephrotic syndrome in rats by Freund's adjuvants and rat kidney suspensions. Proc Soc Exp Biol Med 100: 660-664.
10. Kerjaschki D, Farquhar MG, (1983) Immunocytochemical localization of the Heymann nephritis antigen (GP330) in glomerular epithelial cells of normal Lewis rats. J Exp Med 157: 667-686.
11. Kerjaschki D, Farquhar MG, (1982) The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border. Proc Natl Acad Sci U S A 79: 5557-5561.
12. Bruschi M, Candiano G, Murtas C, Prunotto M, Santucci L, et al. (2009) Patients with primary membranous nephropathy lack auto-antibodies against LDL receptor, the homologue of megalin in human glomeruli. NDT Plus: sfp002.
13. Debiec H, Guigonis V, Mougenot B, Haymann JP, Bensman A, et al. (2003) Antenatal membranous glomerulonephritis with vascular injury induced by anti-neutral endopeptidase antibodies: toward new concepts in the pathogenesis of glomerular diseases. J Am Soc Nephrol 14Suppl 1: S27-32.
14. Debiec H, Nauta J, Coulet F, van der Burg M, Guigonis V, et al. (2004) Role of truncating mutations in MME gene in fetomaternal alloimmunisation and antenatal glomerulopathies. Lancet 364: 1252-1259.
15. Beck LH Jr, Bonegio RG, Lambeau G, Beck DM, Powell DW, et al. (2009) M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med 361: 11-21.
16. Bruschi M, Carnevali ML, Murtas C, Candiano G, Petretto A, et al. (2011) Direct characterization of target podocyte antigens and auto-antibodies in human membranous glomerulonephritis: Alfa-enolase and borderline antigens. J Proteomics 74: 2008-2017.
17. Ronco P, Debiec H (2009) First Identification of an Antigen in Autoimmune Idiopathic Membranous Nephropathy: Toward Targeted Therapy? Am J Kidney Dis.
18. Levey AS, Coresh J, Greene T, Stevens LA, Zhang YL, et al. (2006) Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med 145: 247-254.
19. Delunardo F, Conti F, Margutti P, Alessandri C, Priori R, et al. (2006) Identification and characterization of the carboxy-terminal region of Sip-1, a novel autoantigen in Behcet's disease. Arthritis Res Ther 8: R71.
20. Saleem MA, O'Hare MJ, Reiser J, Coward RJ, Inward CD, et al. (2002) A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression. J Am Soc Nephrol 13: 630-638.
21. Cameron JS, (1982) Membranous nephropathy: the treatment dilemma. Am J Kidney Dis 1: 371-375.
22. Cameron JS, (1992) Membranous nephropathy-still a treatment dilemma. N Engl J Med 327: 638-639.
23. Glassock RJ, (2004) The treatment of idiopathic membranous nephropathy: a dilemma or a conundrum? Am J Kidney Dis 44: 562-566.
24. Debiec H, Guigonis V, Mougenot B, Decobert F, Haymann JP, et al. (2002) Antenatal membranous glomerulonephritis due to anti-neutral endopeptidase antibodies. N Engl J Med 346: 2053-2060.
25. Willats WG, (2002) Phage display: practicalities and prospects. Plant Mol Biol 50: 837-854.
26. Ochs RL, Stein TW Jr, Chan EK, Ruutu M, Tan EM, (1996) cDNA cloning and characterization of a novel nucleolar protein. Mol Biol Cell 7: 1015-1024.
27. Fossa A, Siebert R, Aasheim HC, Maelandsmo GM, Berner A, et al. (2000) Identification of nucleolar protein No55 as a tumour-associated autoantigen in patients with prostate cancer. Br J Cancer 83: 743-749.