Noninvasive metabolomic profiling of embryo culture media using Raman and near-infrared spectroscopy correlates with reproductive potential of embryos in women undergoing in vitro fertilization

Fertility and Sterility

Volumn 88, Issue 5, 2007, Pages 1350-1357

  Seli, Emre ^a   Sakkas, Denny ^a   Scott, Richard ^b   Kwok, Shing C ^c   Rosendahl, Scott M ^c   Burns, David H ^c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Reproductive Medicine Associates   (United States)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

culture media; embryo viability; IVF; Metabolomics; near infrared; Raman; reproductive potential; spectroscopy

Indexed keywords

ADULT; ANALYTIC METHOD; ARTICLE; CLINICAL ARTICLE; CULTURE MEDIUM; EMBRYO; EMBRYO CULTURE; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; GENETIC ALGORITHM; HUMAN; INFERTILITY THERAPY; INSTRUMENTATION; METABOLOMICS; NEAR INFRARED SPECTROSCOPY; PREDICTION; PREGNANCY; PRIORITY JOURNAL; RAMAN SPECTROMETRY; REPRODUCTION; SPECTROPHOTOMETER;

CULTURE MEDIA; EMBRYO CULTURE TECHNIQUES; EMBRYO TRANSFER; EMBRYONIC DEVELOPMENT; FEMALE; FERTILIZATION IN VITRO; HUMANS; OOCYTE RETRIEVAL; PROSPECTIVE STUDIES; SPECTROSCOPY, NEAR-INFRARED; SPECTRUM ANALYSIS, RAMAN;

EID: 35648974233     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2007.07.1390     Document Type: Article

References (46)

1. Mosher W.D., and Pratt W.F. Fecundity and infertility in the United Sates: incidence and trends. Fertil Steril 56 (1991) 192-193
2. Society for Assisted Reproductive Technology. Assisted reproductive technology success rates. National summary and fertility clinic reports (2004), Centers for Disease Control and Prevention, Atlanta, GA
3. Martin J.A., Hamilton B.E., Ventura S.J., Menacker F., and Park M.M. Births: final data for 2000. Natl Vital Stat Rep 50 (2002) 1-101
4. Luke B., and Martin J. The rise in multiple births in the United States: who, what, when, where, and why. Clin Obstet Gynecol 47 (2004) 118-133
5. Keith L.G., Oleszczuk J.J., and Keith D.M. Multiple gestation: reflections on epidemiology, causes, and consequences. Int J Fertil Womens Med 45 (2000) 206-214
6. U.S. Department of Health and Human Services, Public Health Service. U.S. vital statistics, 1998 and from U.S. Public Health Service. Healthy People 2000: National Health Promotion and Disease Prevention Objectives, DHHS Pub No. (PHS) 90-50212.
7. Steptoe P.C., and Edwards R.G. Birth after the reimplantation of a human embryo. Lancet 2 (1978) 366
8. Trounson A., Leeton J., Wood C., Webb J., and Wood J. Pregnancies in humans by fertilization in vitro and embryo transfer in the controlled ovulatory cycle. Science 216 (1981) 681-682
9. Edwards R., Fishel S., and Cohen J. Factors influencing the success of in vitro fertilization for alleviating human infertility. J In Vitro Fert Embryo Transf (1984) 3-23
10. Cummins J., Breen T., Harrison K., Shaw J., Wilson L., and Hennessey J. A formula for scoring human embryo growth rates in in vitro fertilization: its value in predicting pregnancy and in comparison with visual estimates of embryo quality. J In Vitro Fert Embryo Transf (1986) 284-295
11. Hill G., Freeman M., Bastias M., Rogers B.J., Herbert III C.M., Osteen K.G., et al. The influence of oocyte maturity and embryo quality on pregnancy rate in a program for in vitro fertilization-embryo transfer. Fertil Steril (1989) 801-806
12. Steer C., Mills C., Tan S., Campbell S., and Edwards R.G. The cumulative embryo score: a predictive embryo scoring technique to select the optimal number of embryos to transfer in an in-vitro fertilization and embryo transfer programme. Human Reprod 7 (1992) 117-119
13. Veeck L. An atlas of human gametes and conceptuses: an illustrated reference for assisted reproductive technology (1999), Parthenon, New York
14. Sakkas D., Percival G., D'Arcy Y., Sharif K., and Afnan M. Assessment of early cleaving in vitro fertilized human embryos at the 2-cell stage before transfer improves embryo selection. Fertil Steril 76 (2001) 1150-1156
15. Toner J.P. Progress we can be proud of: U.S. trends in assisted reproduction over the first 20 years. Fertil Steril 78 (2002) 943-950
16. Sakkas D., and Gardner D.K. Noninvasive methods to assess embryo quality. Curr Opin Obstet Gynecol 17 (2005) 283-288
17. Conaghan J., Hardy K., Handyside A.H., Winston R.M., and Leese H.J. Selection criteria for human embryo transfer: a comparison of pyruvate uptake and morphology. J Assist Reprod Genet 10 (1993) 21-30
18. Gardner D.K., Lane M., Stevens J., and Schoolcraft W.B. Noninvasive assessment of human embryo nutrient consumption as a measure of developmental potential. Fertil Steril 76 (2001) 1175-1180
19. Brison D.R., Houghton F.D., Falconer D., Roberts S.A., Hawkhead J., Humpherson P.G., et al. Identification of viable embryos in IVF by non-invasive measurement of amino acid turnover. Hum Reprod 19 (2004) 2319-2324
20. Oliver S.G., Winson M.K., Kell D.B., and Baganz F. Systematic functional analysis of the yeast genome. Trends Biotechnol 16 (1998) 373-378
21. Ellis D.I., and Goodacre R. Metabolic fingerprinting in disease diagnosis: biomedical applications of infrared and Raman spectroscopy. Analyst 131 (2006) 875-885
22. Lasch P., Boese M., Pacifico A., and Diem M. FT-IR spectroscopic investigations of single cells on the subcellular level. Vib Spectrosc 28 (2002) 147-157
23. Lasch P., Chiriboga L., Yee H., and Diem M. Infrared spectroscopy of human cells and tissue: detection of disease. Technol Cancer Res Treat 1 (2002) 1-7
24. Wong P.T.T., Wong R.K., Caputo T.A., Godwin T.A., and Rigas B. Infrared spectroscopy of exfoliated human cervical cells: evidence of extensive structural changes during carcinogenesis. Proc Natl Acad Sci USA (1991) 8810988-8810992
25. Fung M.F.K., Senterman M., Eid P., Faught W., Mikhael N.Z., and Wong P.T.T. Comparison of Fourier-transform infrared spectroscopic screening of exfoliated cervical cells with standard Papanicolaou screening. Gynecol Oncol 66 (1997) 10-15
26. Wood B.R., Quinn M.A., Tait B., Ashdown M., Hislop T., Romeo M., et al. FTIR microspectroscopic study of cell types and potential confounding variables in screening for cervical malignancies. Biospectroscopy 4 (1998) 75-91
27. Thomas N., Goodacre R., Timmins E.M., Gaudoin M., and Fleming R. Fourier transform infrared spectroscopy of follicular fluid from large and small antral follicles. Hum Reprod 15 (2000) 1667-1671
28. Barãot O., Balarin M., Gamulin O., JeÏek D., Romac P., and Brnjas-Kraljeviç J. Investigation of spermatozoa and seminal plasma by Fourier transform infrared spectroscopy. Appl Spectrosc 61 (2007) 309-313
29. Lua K.T., and Ng S.-C. Computer imaging of mouse embryos. In: Goh J.C.H., and Balasubramaniam P. (Eds). Biomechanical engineering: an interdisciplinary research (1987), Faculty of Medicine, National University of Singapore, Singapore 282-290
30. Ahmadi A., and Ng S.-C. Developmental capacity of damaged spermatozoa. Hum Reprod 14 (1999) 2279-2285
31. Muasher S.J., Abdallah R.T., and Hubayter Z.R. Optimal stimulation protocols for in vitro fertilization. Fertil Steril 86 (2006) 267-273
32. Gributs C.F.E.W., and Burns D.H. Parsimonious calibration models for near-infrared spectroscopy using wavelets and scaling functions. Chemometr Intell Lab Syst 83 (2006) 44-53
33. Hosmer D.W., and Lemeshow S. Applied logistic regression. 2nd ed. (2000), Wiley, New York
34. Sakkas D., D'Arcy Y., Percival G., Sinclair L., Afnan M., and Sharif K. Use of the egg-share model to investigate the paternal influence on fertilization and embryo development after in vitro fertilization and intracytoplasmic sperm injection. Fertil Steril 82 (2004) 74-79
35. Scott RT, Seli E, Miller K, Kwok CS, Scott K, Burns DH. Non-invasive metabolomic profiling of human embryo culture media using Raman spectroscopy predicts embryonic reproductive potential. Fertil Steril. In press.
36. Lane M., and Gardner D.K. Embryo culture medium: which is the best?. Best Pract Res Clin Obstet Gynaecol 21 (2007) 83-100
37. Burns D.A., and Ciurczak E.K. Handbook of near-infrared analysis (2001), Marcel Dekker, New York
38. Siesler H.W., Ozaki Y., Kawata S., and Heise H.M. Near-infrared spectroscopy (2002), Wiley-VCH, Weinheim
39. Gributs C.E.W., and Burns D.H. In vivo near-infrared spectometry. In: Chalmers J.M., and Griffiths P.R. (Eds). Handbook of vibrational spectroscopy vol. 5 (2002), Wiley, Chichester, UK 3362-3375
40. Williams P. In: Chalmers J.M., and Griffiths P.R. (Eds). Handbook of vibrational spectroscopy (2002), Wiley, Chichester, UK 3693-3719
41. Alam M.K. In: Chalmers J.M., and Griffiths P.R. (Eds). Handbook of vibrational spectroscopy (2002), Wiley, Chichester, UK 3266-3279
42. Afseth N.K., Segtnan V.H., Marquardt B.J., and Wold J.P. Raman and near-infrared spectroscopy for quantification of fat composition in a complex food model system. Appl Spectrosc 59 (2005) 1324-1332
43. Chan J.W., Motton D., Rutledge J.C., Keim N.L., and Huser T. Raman spectroscopic analysis of biochemical changes in individual triglyceride-rich lipoproteins in the pre- and postprandial state. Anal Chem 77 (2005) 5870-5876
44. Goetz M.J.J., Cote G.L., Erckens R., March W., and Motamedi M. Application of a multivariate technique to Raman spectra for quantification of body chemicals. IEEE Trans Biomed Eng 42 (1995) 728-731
45. Pelletier C.C., Lambert J.L., and Borchert M. Determination of glucose in human aqueous humor using Raman spectroscopy and designed-solution calibration. Appl Spectrosc 59 (2005) 1024-1031
46. Agarwal A., Gupta S., and Sharma R.K. Role of oxidative stress in female reproduction. Reprod Biol Endocrinol 3 (2005) 28