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Volumn 68, Issue 7, 2008, Pages 2329-2339

Loss of E-cadherin promotes ovarian cancer metastasis via α5-integrin, which is a therapeutic target

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA5 INTEGRIN; BETA CATENIN; BIOLOGICAL MARKER; EPIDERMAL GROWTH FACTOR RECEPTOR; FOCAL ADHESION KINASE; IMMUNOGLOBULIN G; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN ANTIBODY; UVOMORULIN;

EID: 42049107076     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-5167     Document Type: Article
Times cited : (317)

References (41)
  • 1
    • 0035008525 scopus 로고    scopus 로고
    • Ovarian surface epithelium: Biology, endocrinology and pathology
    • Auersperg N, Wong AST, Choi K, et al. Ovarian surface epithelium: biology, endocrinology and pathology. Endocr Rev 2001;22:255-88.
    • (2001) Endocr Rev , vol.22 , pp. 255-288
    • Auersperg, N.1    Wong, A.S.T.2    Choi, K.3
  • 2
    • 19744368302 scopus 로고    scopus 로고
    • Cancer of the ovary
    • Cannistra SA. Cancer of the ovary. N Engl J Med 2004; 351:2519-29.
    • (2004) N Engl J Med , vol.351 , pp. 2519-2529
    • Cannistra, S.A.1
  • 3
    • 24644480749 scopus 로고    scopus 로고
    • Molecular requirements for epithelial-mesenchymal transition during tumor progression
    • Huber MA, Kraut N, Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol 2006;17:548-58.
    • (2006) Curr Opin Cell Biol , vol.17 , pp. 548-558
    • Huber, M.A.1    Kraut, N.2    Beug, H.3
  • 4
    • 1042267263 scopus 로고    scopus 로고
    • Cell adhesion and signalling by cadherins and IG-cams in cancer
    • Cavallaro U, Christofori G. Cell adhesion and signalling by cadherins and IG-cams in cancer. Nat Rev 2004;4:118-32.
    • (2004) Nat Rev , vol.4 , pp. 118-132
    • Cavallaro, U.1    Christofori, G.2
  • 5
    • 0028021979 scopus 로고
    • Differential expression of the cell-cell adhesion molecule E-cadherin in ascites and solid human ovarian tumor cells
    • Veatch AL, Carson LF, Ramakrishnan S. Differential expression of the cell-cell adhesion molecule E-cadherin in ascites and solid human ovarian tumor cells. Int J Cancer 1994;58:393-9.
    • (1994) Int J Cancer , vol.58 , pp. 393-399
    • Veatch, A.L.1    Carson, L.F.2    Ramakrishnan, S.3
  • 6
    • 0030761757 scopus 로고    scopus 로고
    • Expression of cadherins in benign, borderline, and malignant ovarian epithelial tumors: A clinicopathologic study of 60 cases
    • Darai E, Scoazec JY, Walker-Combrouze F, et al. Expression of cadherins in benign, borderline, and malignant ovarian epithelial tumors: a clinicopathologic study of 60 cases. Hum Pathol 1997;28:922-8.
    • (1997) Hum Pathol , vol.28 , pp. 922-928
    • Darai, E.1    Scoazec, J.Y.2    Walker-Combrouze, F.3
  • 7
    • 33947219432 scopus 로고    scopus 로고
    • Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent E-cadherin ectodomain shedding in ovarian carcinoma cells
    • Symowicz J, Adley BP, Gleason KJ, et al. Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent E-cadherin ectodomain shedding in ovarian carcinoma cells. Cancer Res 2007;67:2030-9.
    • (2007) Cancer Res , vol.67 , pp. 2030-2039
    • Symowicz, J.1    Adley, B.P.2    Gleason, K.J.3
  • 8
    • 0027176482 scopus 로고
    • Binding of ovarian cancer cells to peritoneal mesothelium in vitro is partly mediated by CD44H
    • Cannistra SA, Kansas GS, Niloff J, et al. Binding of ovarian cancer cells to peritoneal mesothelium in vitro is partly mediated by CD44H. Cancer Res 1993;53:3830-8.
    • (1993) Cancer Res , vol.53 , pp. 3830-3838
    • Cannistra, S.A.1    Kansas, G.S.2    Niloff, J.3
  • 9
    • 18944402351 scopus 로고    scopus 로고
    • Ascites induces modulation of a6b1 integrin and urokinase plasminogen activator receptor expression and associated functions in ovarian carcinoma
    • Ahmed N, Riley C, Oliva K, et al. Ascites induces modulation of a6b1 integrin and urokinase plasminogen activator receptor expression and associated functions in ovarian carcinoma. Br J Cancer 2005;92:1475-85.
    • (2005) Br J Cancer , vol.92 , pp. 1475-1485
    • Ahmed, N.1    Riley, C.2    Oliva, K.3
  • 10
    • 0028354768 scopus 로고
    • An experimental model for ovarian tumor invasion of cultured mesothelial cell monolayer
    • Sawada M, Shii J, Akedo H, et al. An experimental model for ovarian tumor invasion of cultured mesothelial cell monolayer. Lab Invest 1994;70:333-8.
    • (1994) Lab Invest , vol.70 , pp. 333-338
    • Sawada, M.1    Shii, J.2    Akedo, H.3
  • 11
    • 33947415318 scopus 로고    scopus 로고
    • αE β7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis
    • Le Floc'h A, Jalil A, Vergnon I, et al. αE β7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis. J Exp Med 2007;204:559-70.
    • (2007) J Exp Med , vol.204 , pp. 559-570
    • Le Floc'h, A.1    Jalil, A.2    Vergnon, I.3
  • 12
    • 33847746580 scopus 로고    scopus 로고
    • C-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion
    • Sawada K, Radjabi AR, Shinomiya N, et al. C-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion. Cancer Res 2007;67:1670-80.
    • (2007) Cancer Res , vol.67 , pp. 1670-1680
    • Sawada, K.1    Radjabi, A.R.2    Shinomiya, N.3
  • 13
    • 34547463506 scopus 로고    scopus 로고
    • Let-7 expression defines two differentiation stages of cancer
    • Shell S, Park S, Radjabi AR, et al. Let-7 expression defines two differentiation stages of cancer. Proc Natl Acad Sci U S A 2007;104:11400-5.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 11400-11405
    • Shell, S.1    Park, S.2    Radjabi, A.R.3
  • 14
    • 0034007093 scopus 로고    scopus 로고
    • Phorbol ester-induced U-937 differentiation: Effects on integrin a5 gene transcription
    • Boles BK, Ritzenthaler J, Birkenmeier T, et al. Phorbol ester-induced U-937 differentiation: effects on integrin a5 gene transcription. Am J Physiol Cell Mol Physiol 2000;278:703-12.
    • (2000) Am J Physiol Cell Mol Physiol , vol.278 , pp. 703-712
    • Boles, B.K.1    Ritzenthaler, J.2    Birkenmeier, T.3
  • 15
    • 34548274060 scopus 로고    scopus 로고
    • Development of an organotypic peritoneal three-dimensional culture to study peritoneal attachment of ovarian cancer cells
    • Kenny HA, Krausz T, Yamada SD, et al. Development of an organotypic peritoneal three-dimensional culture to study peritoneal attachment of ovarian cancer cells. Int J Cancer 2007;121:1463-72.
    • (2007) Int J Cancer , vol.121 , pp. 1463-1472
    • Kenny, H.A.1    Krausz, T.2    Yamada, S.D.3
  • 16
    • 0034909346 scopus 로고    scopus 로고
    • Expression of latent matrix metalloproteinase 9 (MMP-9) predicts survival in advanced ovarian cancer
    • Lengyel E, Schmalfeldt B, Konik E, et al. Expression of latent matrix metalloproteinase 9 (MMP-9) predicts survival in advanced ovarian cancer. Gynecol Oncol 2001;82:291-8.
    • (2001) Gynecol Oncol , vol.82 , pp. 291-298
    • Lengyel, E.1    Schmalfeldt, B.2    Konik, E.3
  • 17
    • 0030996974 scopus 로고    scopus 로고
    • Elevated urokinase-type plasminogen activator receptor expression in a colon cancer cell line is due to a constitutively activated extracellular-signal regulated kinase 1 dependent signaling cascade
    • Lengyel E, Wang H, Gum R, et al. Elevated urokinase-type plasminogen activator receptor expression in a colon cancer cell line is due to a constitutively activated extracellular-signal regulated kinase 1 dependent signaling cascade. Oncogene 1997;14:2563-74.
    • (1997) Oncogene , vol.14 , pp. 2563-2574
    • Lengyel, E.1    Wang, H.2    Gum, R.3
  • 18
    • 19944399371 scopus 로고    scopus 로고
    • C-Met overexpression in node-positive breast cancer identifies patients with poor clinical outcome independent of Her2/Neu
    • Lengyel E, Prechtel D, Resau JH, et al. C-Met overexpression in node-positive breast cancer identifies patients with poor clinical outcome independent of Her2/Neu. Int J Cancer 2005;113:678-82.
    • (2005) Int J Cancer , vol.113 , pp. 678-682
    • Lengyel, E.1    Prechtel, D.2    Resau, J.H.3
  • 19
    • 4143051355 scopus 로고    scopus 로고
    • Prognostic significance of E-cadherin protein expression in pathological stage I-III endometrial cancer
    • Mell LK, Meyer JJ, Tretiakova MS, et al. Prognostic significance of E-cadherin protein expression in pathological stage I-III endometrial cancer. Clin Cancer Res 2004;10:5546-53.
    • (2004) Clin Cancer Res , vol.10 , pp. 5546-5553
    • Mell, L.K.1    Meyer, J.J.2    Tretiakova, M.S.3
  • 20
    • 21244496102 scopus 로고    scopus 로고
    • Uniform overexpression and rapid accessibility of a5b1 integrin on blood vessels in tumors
    • Wingerter P, Kazman I, Norberg S, et al. Uniform overexpression and rapid accessibility of a5b1 integrin on blood vessels in tumors. Am J Pathol 2005;167:193-211.
    • (2005) Am J Pathol , vol.167 , pp. 193-211
    • Wingerter, P.1    Kazman, I.2    Norberg, S.3
  • 21
    • 0026770377 scopus 로고
    • Integrins: Versatility, modulation, and signaling in cell adhesion
    • Hynes R. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 1992;69:11-25.
    • (1992) Cell , vol.69 , pp. 11-25
    • Hynes, R.1
  • 22
    • 0027158079 scopus 로고
    • Bacterial internalization mediated by b1chain integrins is determined by ligand affinity and receptor density
    • Nhieu G, Isberg R. Bacterial internalization mediated by b1chain integrins is determined by ligand affinity and receptor density. EMBO J 1993;12:1887-95.
    • (1993) EMBO J , vol.12 , pp. 1887-1895
    • Nhieu, G.1    Isberg, R.2
  • 23
    • 0028170977 scopus 로고
    • h-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor
    • Hoschuetzky H, Aberle H, Kemler R. h-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. J Cell Biol 1994;127:1375-80.
    • (1994) J Cell Biol , vol.127 , pp. 1375-1380
    • Hoschuetzky, H.1    Aberle, H.2    Kemler, R.3
  • 24
    • 0033621689 scopus 로고    scopus 로고
    • Significance of integrin-a5 gene expression as a prognostic factor in node-negative non small cell lung cancer
    • Adachi A, Taki T, Higashiyama M, et al. Significance of integrin-a5 gene expression as a prognostic factor in node-negative non small cell lung cancer. Clin Cancer Res 2000;6:96-101.
    • (2000) Clin Cancer Res , vol.6 , pp. 96-101
    • Adachi, A.1    Taki, T.2    Higashiyama, M.3
  • 25
    • 33750065136 scopus 로고    scopus 로고
    • Clinical evaluation of E-cadherin expression and its regulation mechanism in epithelial ovarian cancer
    • Yuecheng Y, Hongmei L, Xiaoyan X. Clinical evaluation of E-cadherin expression and its regulation mechanism in epithelial ovarian cancer. Clin Exp Metastasis 2006;23:65-74.
    • (2006) Clin Exp Metastasis , vol.23 , pp. 65-74
    • Yuecheng, Y.1    Hongmei, L.2    Xiaoyan, X.3
  • 26
    • 23044466227 scopus 로고    scopus 로고
    • Promoter hypermethylation profile of ovarian epithelial neoplasms
    • Makarla PB, Saboorian MH, Ashfaq R, et al. Promoter hypermethylation profile of ovarian epithelial neoplasms. Clin Cancer Res 2005;11:5365-9.
    • (2005) Clin Cancer Res , vol.11 , pp. 5365-5369
    • Makarla, P.B.1    Saboorian, M.H.2    Ashfaq, R.3
  • 27
    • 0030694894 scopus 로고    scopus 로고
    • Fibronectin secretion from human peritoneal tissue induces Mr 92,000 type IV collagenase expression and invasion in ovarian cancer cell lines
    • Shibata K, Kikkawa F, Nawa A, et al. Fibronectin secretion from human peritoneal tissue induces Mr 92,000 type IV collagenase expression and invasion in ovarian cancer cell lines. Cancer Res 1997;57:5416-20.
    • (1997) Cancer Res , vol.57 , pp. 5416-5420
    • Shibata, K.1    Kikkawa, F.2    Nawa, A.3
  • 28
    • 0032588084 scopus 로고    scopus 로고
    • b1-integrins partly mediate binding of ovarian cancer cells to peritoneal mesothelium in vitro
    • Strobel T, Cannistra SA. b1-integrins partly mediate binding of ovarian cancer cells to peritoneal mesothelium in vitro. Gynecol Oncol 1999;73:362-7.
    • (1999) Gynecol Oncol , vol.73 , pp. 362-367
    • Strobel, T.1    Cannistra, S.A.2
  • 29
    • 0035184068 scopus 로고    scopus 로고
    • b1-integrins regulate the formation and adhesion of ovarian carcinoma multicellular spheroids
    • Casey RC, Burleson KM, Skubitz KM, et al. b1-integrins regulate the formation and adhesion of ovarian carcinoma multicellular spheroids. Am J Pathol 2001;159:2071-80.
    • (2001) Am J Pathol , vol.159 , pp. 2071-2080
    • Casey, R.C.1    Burleson, K.M.2    Skubitz, K.M.3
  • 30
    • 16444368158 scopus 로고    scopus 로고
    • Tumor cell invasiveness correlates with changes in integrin expression and localization
    • Maschler S, Wirl G, Spring H, et al. Tumor cell invasiveness correlates with changes in integrin expression and localization. Oncogene 2005;24:2032-41.
    • (2005) Oncogene , vol.24 , pp. 2032-2041
    • Maschler, S.1    Wirl, G.2    Spring, H.3
  • 31
    • 0037064134 scopus 로고    scopus 로고
    • Proteinase suppression by E-cadherin-mediated cell-cell attachment in premalignant oral keratinocytes
    • Munshi HG, Ghosh S, Mukhopadhyay S, et al. Proteinase suppression by E-cadherin-mediated cell-cell attachment in premalignant oral keratinocytes. J Biol Chem 2002;277:38159-67.
    • (2002) J Biol Chem , vol.277 , pp. 38159-38167
    • Munshi, H.G.1    Ghosh, S.2    Mukhopadhyay, S.3
  • 32
    • 0022195920 scopus 로고
    • Interactions of human ovarian tumor cells with human mesothelial cells grown on extracellular matrix
    • Niedbala MJ, Crickard K, Bernacki R. Interactions of human ovarian tumor cells with human mesothelial cells grown on extracellular matrix. Exp Cell Res 1985;160:499-513.
    • (1985) Exp Cell Res , vol.160 , pp. 499-513
    • Niedbala, M.J.1    Crickard, K.2    Bernacki, R.3
  • 33
    • 2342564453 scopus 로고    scopus 로고
    • Tumor-induced apoptosis in human mesothelial cells: A mechanism of peritoneal invasion by Fas Ligand/Fas interaction
    • Heath R, Jayne D, O'Leary R, et al. Tumor-induced apoptosis in human mesothelial cells: a mechanism of peritoneal invasion by Fas Ligand/Fas interaction. Br J Cancer 2004;90:1437-42.
    • (2004) Br J Cancer , vol.90 , pp. 1437-1442
    • Heath, R.1    Jayne, D.2    O'Leary, R.3
  • 34
    • 0037477627 scopus 로고    scopus 로고
    • Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin
    • Wong AST, Gumbiner BM. Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin. J Cell Biol 2003;161:1191-203.
    • (2003) J Cell Biol , vol.161 , pp. 1191-1203
    • Wong, A.S.T.1    Gumbiner, B.M.2
  • 35
    • 2442552774 scopus 로고    scopus 로고
    • E-cadherin-mediated adhesion inhibits ligand-dependent activation of diverse receptor tyrosine kinases
    • Qian X, Karpova T, Sheppard AM, et al. E-cadherin-mediated adhesion inhibits ligand-dependent activation of diverse receptor tyrosine kinases. EMBO J 2004;23:1739-48.
    • (2004) EMBO J , vol.23 , pp. 1739-1748
    • Qian, X.1    Karpova, T.2    Sheppard, A.M.3
  • 36
    • 0033843942 scopus 로고    scopus 로고
    • Regulation of angiogenesis in vivo by ligation of integrin a5b1 with the central cell-binding domain of fibronectin
    • Kim S, Bell K, Mousa SA, et al. Regulation of angiogenesis in vivo by ligation of integrin a5b1 with the central cell-binding domain of fibronectin. Am J Pathol 2000;156:1345-62.
    • (2000) Am J Pathol , vol.156 , pp. 1345-1362
    • Kim, S.1    Bell, K.2    Mousa, S.A.3
  • 37
    • 16844373504 scopus 로고    scopus 로고
    • Rapid access of antibodies to a5b1 integrin overexpressed on the luminal surface of tumor blood vessels
    • Magnussen A, Kasman I, Norberg S, et al. Rapid access of antibodies to a5b1 integrin overexpressed on the luminal surface of tumor blood vessels. Cancer Res 2005;65:2712-21.
    • (2005) Cancer Res , vol.65 , pp. 2712-2721
    • Magnussen, A.1    Kasman, I.2    Norberg, S.3
  • 38
    • 33749349945 scopus 로고    scopus 로고
    • Preclinical evaluation of an anti-a5b1 integrin antibody as a novel anti-angiogenic agent
    • Ramakrishnan V, Bhaskar V, Law DA, et al. Preclinical evaluation of an anti-a5b1 integrin antibody as a novel anti-angiogenic agent. J Exp Ther Oncol 2007;5:273-86.
    • (2007) J Exp Ther Oncol , vol.5 , pp. 273-286
    • Ramakrishnan, V.1    Bhaskar, V.2    Law, D.A.3
  • 39
    • 33745728177 scopus 로고    scopus 로고
    • The small a5b1 integrin antagonist, SJ749, reduces proliferation and clonogencity of human astrocytoma cells
    • Maglott A, Bartik P, Cosgun S, et al. The small a5b1 integrin antagonist, SJ749, reduces proliferation and clonogencity of human astrocytoma cells. Cancer Res 2006;66:6002-8.
    • (2006) Cancer Res , vol.66 , pp. 6002-6008
    • Maglott, A.1    Bartik, P.2    Cosgun, S.3
  • 40
    • 0037457423 scopus 로고    scopus 로고
    • Inhibition of integrin a5b1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice
    • Stoeltzing O, Liu W, Reinmuth N, et al. Inhibition of integrin a5b1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice. Int J Cancer 2003;104:496-503.
    • (2003) Int J Cancer , vol.104 , pp. 496-503
    • Stoeltzing, O.1    Liu, W.2    Reinmuth, N.3
  • 41
    • 0034650758 scopus 로고    scopus 로고
    • Anti-invasive, antitumorigenic, and antimetastatic activities of the PHSCN sequence in prostate carcinoma
    • Livant DL, Brabec RK, Pienta KJ, et al. Anti-invasive, antitumorigenic, and antimetastatic activities of the PHSCN sequence in prostate carcinoma. Cancer Res 2000;60:309-20.
    • (2000) Cancer Res , vol.60 , pp. 309-320
    • Livant, D.L.1    Brabec, R.K.2    Pienta, K.J.3


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