Differential immunomodulatory effects by Tripterygium wilfordii Hook f-derived refined extract PG27 and its purified component PG490 (triptolide) in human peripheral blood T cells: Potential therapeutics for arthritis and possible mechanisms explaining in part Chinese herbal theory " Junn-Chenn-Zuou-SS"

Journal of Translational Medicine

Volumn 11, Issue 1, 2013, Pages

  Ho, Ling Jun ^a,b   Chang, Wen Liang ^c   Chen, Ann ^c   Chao, Ping ^d   Lai, Jenn Haung ^e  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^d INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

^e CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

I kappaBalpha kinase beta; Nuclear factor kappaB; PG27; PG490 (Triptolide); T Cells; Tripterygium wilfordii Hook f

Indexed keywords

ANTIRHEUMATIC AGENT; HERBACEOUS AGENT; I KAPPA B ALPHA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOMODULATING AGENT; MITOGEN ACTIVATED PROTEIN KINASE; PG 27; TRANSCRIPTION FACTOR AP 1; TRIPTERYGIUM WILFORDII EXTRACT; TRIPTOLIDE; UNCLASSIFIED DRUG;

ARTHRITIS; ARTICLE; CELL ISOLATION; CELL PROTECTION; CHINESE MEDICINE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG PURIFICATION; ENZYME ACTIVITY; HERBAL MEDICINE; HUMAN; HUMAN CELL; IMMUNOMODULATION; PERIPHERAL LYMPHOCYTE; T LYMPHOCYTE; THEORY; TRIPTERYGIUM WILFORDII;

ADJUVANTS, IMMUNOLOGIC; ARTHRITIS; BASE SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DITERPENES; DNA PRIMERS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EPOXY COMPOUNDS; HUMANS; I-KAPPA B KINASE; PHENANTHRENES; PLANT EXTRACTS; PROTEOLYSIS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRIPTERYGIUM;

EID: 84887917591     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-11-294     Document Type: Article

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