Effect of topiramate on interleukin 6 expression in the hippocampus of amygdala-kindled epileptic rats

Experimental and Therapeutic Medicine

Volumn 7, Issue 1, 2013, Pages 223-227

  Ye, Fei ^d   Chen, Xu Qin ^b   Bao, Guan Shui ^a   Hua, Yin ^c   Wang, Zhe Dong ^b   Bao, Yi Chuan ^e  

^a School of Medicine   (China)

^b CHILDREN S HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^c WUXI PEOPLE S HOSPITAL AFFILIATED TO NANJING MEDICAL UNIVERSITY   (China)

^d JINHUA MUNICIPAL CENTRAL HOSPITAL   (China)

^e XI AN JIAOTONG LIVERPOOL UNIVERSITY   (China)

Author keywords

Basolateral amygdale; Epilepsy; Interleukin 6; Kindling; Rat; Topiramate

Indexed keywords

INTERLEUKIN 6; MESSENGER RNA; TOPIRAMATE;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASOLATERAL AMYGDALA; CONTROLLED STUDY; ELECTROENCEPHALOGRAPHY; ELECTROSTIMULATION; EPILEPSY; KINDLING; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEIZURE; UPREGULATION;

EID: 84887905582     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2013.1396     Document Type: Article

References (42)

1. Jankowsky JL and Patterson PH: The role of cytokines and growth factors in seizures and their sequelae. Prog Neurobiol 63: 125-149, 2001.
2. Jankowsky JL and Patterson TA: Differential regulation of cytokine expression following pilocarpine-induced seizure. Exp Neurol 159: 333-346, 1999.
3. Maroso M, Balosso S, Ravizza T, et al: Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. Nat Med 16: 413-419, 2010.
4. Wang Y and Fuller GM: Phosphorylation and internalization of gp130 occur after IL-6 activation of Jak2 kinase in hepatocytes. Mol Biol Cell 5: 819-828, 1994.
5. Heinrich PC, Behrmann I, Müller-Newen G, Schaper F and Graeve L: Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J 334: 297-314, 1998.
6. Funk JA, Gohlke J, Kraft AD, McPherson CA, Collins JB and Jean HG: Voluntary exercise protects hippocampal neurons from trimethyltin injury: possible role of interleukin-6 to modulate tumor necrosis factor receptor-mediated neurotoxicity. Brain Behav Immun 25: 1063-1077, 2011.
7. Liu Z, Qiu YH, Li B, Ma SH and Peng YP: Neuroprotection of interleukin-6 against NMDA-induced apoptosis and its signal-transduction mechanisms. Neurotox Res 19: 484-495, 2011.
8. Thier M, März P, Otten U, Weis J and Rose-John S: Interleukin-6 (IL-6) and its soluble receptor support survival of sensory neurons. J Neurosci Res 55: 411-422, 1999.
9. Sterneck E, Kaplan DR and Johnson PF: Interleukin-6 induces expression of peripherin and cooperates with Trk receptor signaling to promote neuronal differentiation in PC12 cells. J Neurochem 67: 1365-1374, 1996.
10. Akaneya Y, Takahashi M and Hatanaka H: Interleukin-1 beta enhances survival and interleukin-6 protects against MPP+ neurotoxicity in cultures of fetal rat dopaminergic neurons. Exp Neurol 136: 44-52, 1995.
11. Toulmond S, Vige X, Fage D and Benavides J: Local infusion of interleukin-6 attenuates the neurotoxic effects of NMDA on rat striatal cholinergic neurons. Neurosci Lett 144: 49-52, 1992.
12. Mrz P, Heese K, Dimitriades-Schmutz B, Rose-John S and Otten U: Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expression. Glia 26: 191-200, 1999.
13. Tancredi V, D'Antuono M, Cafè C, etal: The inhibitory effects of interleukin-6 on synaptic plasticity in the rat hippocampus are associated with an inhibition of mitogen-activated protein kinase ERK. J Neurochem 75: 634-643, 2000.
14. Qiu Z, Parsons KL and Gruol DL: Interleukin-6 selectively enhances the intracellular calcium response to NMDA in developing CNS neurons. J Neurosci 15: 6688-6699, 1995.
15. Quarta S, Vogl C, Constantin CE, Üçeyler N, Sommer C and Kress M: Genetic evidence for an essential role of neuronally expressed IL-6 signal transducer gp130 in the induction and maintenance of experimentally induced mechanical hypersensitivity invivo and invitro. Mol Pain 7: 73, 2011.
16. Lee RH, Mills EA, Schwartz N, etal: Neurodevelopmental effects of chronic exposure to elevated levels of pro-inflammatory cytokines in a developing visual system. Neural Dev 5: 2, 2010.
17. Burton MD, Sparkman NL and Johnson RW: Inhibition of interleukin-6 trans-signaling in the brain facilitates recovery from lipopolysaccharide-induced sickness behavior. J Neuroinflammation 8: 54, 2011.
18. Munster BC, Aronica E, Zwinderman AH, Eikelenboom P, Cunningham C and Rooij SE: Neuroinflammation in delirium: a postmortem case-control study. Rejuvenation Res 14: 615-622, 2011.
19. Jankord R, Zhang R, Flak JN, Solomon MB, Albertz J and HermanJP: Stress activation of IL-6 neurons in the hypothalamus. Am J Physiol Regul Integr Comp Physiol 299: R343-R351, 2010.
20. Wei H, Zou H, Sheikh AM, etal: IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation. J Neuroinflammation 8: 52, 2011.
21. Zhang X, Burstein R and Levy D: Local action of the proinflammatory cytokines IL-1β and IL-6 on intracranial meningeal nociceptors. Cephalalgia 32: 66-72, 2012.
22. D'Arcangelo G, Tancredi V, Onofri F, D'Antuono M, Giovedì S and Benfenati F: Interleukin-6 inhibits neurotransmitter release and the spread of excitation in the rat cerebral cortex. Eur J Neurosci 12: 1241-52, 2000.
23. Terada S, Tsujimoto T, Takei Y, etal: Inhibitory synaptic transmission in mice lacking synapsin I. Neurosci Res 28 (Suppl1): S57, 1997.
24. Steffensen SC, Campbell IL and Henriksen SJ: Site-specific hippocampal pathophysiology due to cerebral overexpression of interleukin-6 in transgenic mice. Brain Res 652: 149-153, 1994.
25. Kirkman NJ, Libbey JE, Wilcox KS, White HS and FujinamiRS: Innate but not adaptive immune responses contribute to behavioral seizures following viral infection. Epilepsia 51: 454-464, 2010.
26. Libbey JE, Kennett NJ, Wilcox KS, White HS and Fujinami RS: Interleukin-6, produced by resident cells of the central nervous system and infiltrating cells, contributes to the development of seizures following viral infection. J Virol 85: 6913-6922, 2011.
27. Libbey JE, Kennett NJ, Wilcox KS, White HS and Fujinami RS: Once initiated, viral encephalitis-induced seizures are consistent no matter the treatment or lack of interleukin-6. J Neurovirol 17: 496-499, 2011.
28. Fukuda M, Morimoto T, Suzuki Y, Shinonaga C and Ishida Y: Interleukin-6 attenuates hyperthermia-induced seizures in developing rats. Brain Dev 29: 644-648, 2007.
29. Lehtimäki KA, Peltola J, Koskikallio E, Keränen T and Honkaniemi J: Expression of cytokines and cytokine receptors in the rat brain after kainic acid-induced seizures. Brain Res Mol Brain Res 110: 253-260, 2003.
30. Kalueff AV, Lehtimaki KA, Ylinen A, Honkaniemi J and PeltolaJ: Intranasal administration of human IL-6 increases the severity of chemically induced seizures in rats. Neurosci Lett365: 106-110, 2004.
31. Peltola J, Hurme M, Miettinen A and Keränen T: Elevated levels of interleukin-6 may occur in cerebrospinal fluid from patients with recent epileptic seizures. Epilepsy Res 31: 129-133, 1998.
32. Lehtimäki KA, Keränen T, Palmio J, etal: Increased plasma levels of cytokines after seizures in localization-related epilepsy. Acta Neurol Scand 116: 226-230, 2007.
33. Fukumoto Y, Okumura A, Hayakawa F, etal: Serum levels of cytokines and EEG findings in children with influenza associated with mild neurological complications. Brain Dev 29: 425-430, 2007.
34. Ben-Menachem E, Sander JW, Stefan H, Schwalen S and Schauble B: Topiramate monotherapy in the treatment of newly or recently diagnosed epilepsy. Clin Ther 30: 1180-1195, 2008.
35. Edmonds HL Jr, Jiang YD, Zhang PY and Shank R: Topiramate as a neuroprotectant in a rat model of global ischemia-induced neurodegeneration. Life Sci 69: 2265-2277, 2001.
36. Castillo CG, Mendoza S, Freed WJ and Giordano M: Intranigral transplants of immortalized GABAergic cells decrease the expression of kainic acid-induced seizures in the rat. Behav Brain Res 171: 109-115, 2006.
37. Gadient RA and Otten UH: Interleukin-6 (IL-6)-a molecule with both beneficial and destuctive potentials. Prog Neurobiol52: 379-390, 1997.
38. Pitkänen A, Savander V and LeDoux JE: Organization of intra-amygdaloid circuitries in the rat: an emerging framework for understanding functions of the amygdala. Trends Neurosci20: 517-523, 1997.
39. Jankowsky JL, Derrick BE and Patterson PH: Cytokine responses to LTP induction in the rat hippocampus: a comparison of invitro and invivo techniques. Learn Mem 7: 400-412, 2000.
40. Ali C, Nicole O, Docagne F, etal: Ischemia-induced interleukin-6 as a potential endogenous neuroprotective cytokine against NMDA receptor-mediated excitotoxicity in the brain. JCereb Blood Flow Metab 20: 956-966, 2000.
41. Calkavur S, Akisu M, Olukman O, etal: Genetic factors that influence short-term neurodevelopmental outcome in term hypoxic-ischaemic encephalopathic neonates. J Int Med Res 39: 1744-1756, 2011.
42. Pitkänen A: Efficacy of current antiepileptics to prevent neurodegeneration in epilepsy models. Epilepsy Res 50: 141-160, 2002.