Local action of the proinflammatory cytokines IL-1β and IL-6 on intracranial meningeal nociceptors

Cephalalgia

Volumn 32, Issue 1, 2012, Pages 66-72

  Zhang, Xichun ^a   Burstein, Rami ^a   Levy, Dan ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Center for Life Science   (United States)

Author keywords

headache; IL 1 ; IL 6; inflammation; Meningeal nociceptor; sensitization

Indexed keywords

RECOMBINANT INTERLEUKIN 1BETA; RECOMBINANT INTERLEUKIN 6;

ANIMAL EXPERIMENT; ARTICLE; IN VIVO STUDY; INNERVATION; MALE; MECHANICAL STIMULATION; MENINX; NOCICEPTION; NOCICEPTIVE RECEPTOR; NONHUMAN; PAIN THRESHOLD; RAT; RECEPTOR SENSITIVITY; TRIGEMINUS GANGLION;

ANESTHESIA; ANIMALS; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; MECHANORECEPTORS; MENINGES; MIGRAINE DISORDERS; NOCICEPTORS; RATS; RATS, SPRAGUE-DAWLEY; TRIGEMINAL GANGLION;

EID: 84863077943     PISSN: 03331024     EISSN: 14682982     Source Type: Journal    
DOI: 10.1177/0333102411430848     Document Type: Article

References (25)

1. Strassman AM, Raymond SA. On the origin of headaches. Endeavour. 1997 ; 21: 97-100 (Pubitemid 27439431)
2. Messlinger K. Migraine: where and how does the pain originate?. Exp Brain Res. 2009 ; 196: 179-193
3. Olesen J, Burstein R, Ashina M, et al. Origin of pain in migraine: evidence for peripheral sensitisation. Lancet Neurol. 2009 ; 8: 679-690
4. Levy D. Migraine pain and nociceptor activation-where do we stand?. Headache. 2010 ; 50: 909-916
5. Levy D. Migraine pain, meningeal inflammation, and mast cells. Curr Pain Headache Rep. 2009 ; 13: 237-240
6. Sarchielli P, Alberti A, Baldi A, et al. Proinflammatory cytokines, adhesion molecules, and lymphocyte integrin expression in the internal jugular blood of migraine patients without aura assessed ictally. Headache. 2006 ; 46: 200-207
7. Zhang XC, Kainz V, Burstein R, et al. Tumor necrosis factor- α induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions. Pain. 2011 ; 152: 140-149
8. Obreja O, Rathee PK, Lips KS, et al. IL-1 beta potentiates heat-activated currents in rat sensory neurons: involvement of IL-1RI, tyrosine kinase, and protein kinase C. FASEB J. 2002 ; 16: 1497-1503 (Pubitemid 35154632)
9. Binshtok AM, Wang H, Zimmermann K, et al. Nociceptors are interleukin-1beta sensors. J Neurosci. 2008 ; 28: 14062-14073
10. Oprée A, Kress M. Involvement of the proinflammatory cytokines tumor necrosis factor-alpha, IL-1 beta, and IL-6 but not IL-8 in the development of heat hyperalgesia: effects on heat-evoked calcitonin gene-related peptide release from rat skin. J Neurosci. 2000 ; 20: 6289-6293 (Pubitemid 30658424)
11. Obreja O, Schmelz M, Poole S, et al. Interleukin-6 in combination with its soluble IL-6 receptor sensitises rat skin nociceptors to heat, in vivo. Pain. 2002 ; 96: 57-62 (Pubitemid 34270628)
12. Obreja O, Biasio W, Andratsch M, et al. Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons. Brain. 2005 ; 128: 1634-1641 (Pubitemid 41373682)
13. Andratsch M, Mair N, Constantin CE, et al. A key role for gp130 expressed on peripheral sensory nerves in pathological pain. J Neurosci. 2009 ; 29: 13473-13483
14. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 1983 ; 16: 109-110 (Pubitemid 13058546)
15. Zhang X, Strassman AM, Burstein R, et al. Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators. J Pharmacol Exp Ther. 2007 ; 322: 806-812 (Pubitemid 47105821)
16. Levy D, Zhang XC, Jakubowski M, et al. Sensitization of meningeal nociceptors: inhibition by naproxen. Eur J Neurosci. 2008 ; 27: 917-922 (Pubitemid 351365179)
17. Levy D, Strassman AM. Mechanical response properties of A and C primary afferent neurons innervating the rat intracranial dura. J Neurophysiol. 2002 ; 88: 3021-3031 (Pubitemid 35448688)
18. Ferreira SH, Lorenzetti BB, Bristow AF, et al. Interleukin-1 beta as a potent hyperalgesic agent antagonized by a tripeptide analogue. Nature. 1988 ; 334: 698-700
19. Perini F, D'Andrea G, Galloni E, et al. Plasma cytokine levels in migraineurs and controls. Headache. 2005 ; 45: 926-931 (Pubitemid 41045371)
20. Ingram SL, Williams JT. Modulation of the hyperpolarization-activated current (Ih) by cyclic nucleotides in guinea-pig primary afferent neurons. J Physiol. 1996 ; 492 (Pt 1). 97-106
21. Burstein R. Deconstructing migraine headache into peripheral and central sensitization. Pain. 2001 ; 89: 107-110 (Pubitemid 32146388)
22. Dina OA, Green PG, Levine JD. Role of interleukin-6 in chronic muscle hyperalgesic priming. Neuroscience. 2008 ; 152: 521-525
23. Melemedjian OK, Asiedu MN, Tillu DV, et al. IL-6- and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex. J Neurosci. 2010 ; 30: 15113-15123
24. Quarta S, Vogl C, Constantin CE, et al. Genetic evidence for an essential role of neuronally expressed IL-6 signal transducer gp130 in the induction and maintenance of experimentally induced mechanical hypersensitivity in vivo and in vitro. Mol Pain. 2011 ; 7: 73-73
25. Nishimoto N, Miyasaka N, Yamamoto K, et al. Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study. Ann Rheum Dis. 2009 ; 68: 1580-1584