Transgenic overproduction of omega-3 polyunsaturated fatty acids provides neuroprotection and enhances endogenous neurogenesis after stroke

Current Molecular Medicine

Volumn 13, Issue 9, 2013, Pages 1465-1473

  Hu, X ^a,b,e   Zhang, F ^a,b,e   Leak, R K ^c   Zhang, W ^b   Iwai, M ^e   Stetler, R A ^a,b,e   Dai, Y ^d   Zhao, A ^d   Gao, Y ^b   Chen, J ^a,b,e  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b FUDAN UNIVERSITY   (China)

^c DUQUESNE UNIVERSITY   (United States)

^d NANJING MEDICAL UNIVERSITY   (China)

^e UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Neurogenesis; Neuroprotection; Oligodendrogenesis; Omega 3 polyunsaturated fatty acids; Stroke

Indexed keywords

BROXURIDINE; OMEGA 3 FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN INFARCTION SIZE; CELL PROLIFERATION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; EXTRACTION; FAT 1 GENE; GAS CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NEUROBLAST; NEUROPROTECTION; NONHUMAN; OLIGODENDROGLIA; TRANSGENE; TRANSIENT ISCHEMIC ATTACK;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL DIFFERENTIATION; CELL PROLIFERATION; FATTY ACID DESATURASES; FATTY ACIDS, OMEGA-3; MICE; MICE, TRANSGENIC; NEURAL STEM CELLS; NEUROGENESIS; NEUROPROTECTIVE AGENTS; STROKE; TRANSGENES;

EID: 84887873495     PISSN: 15665240     EISSN: 18755666     Source Type: Journal    
DOI: 10.2174/15665240113139990075     Document Type: Article

References (27)

1. Zhang ZG, Chopp M. Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic. Lancet Neurol 2009; 8(5): 491-500.
2. Arvidsson A, Collin T, Kirik D, Kokaia Z, Lindvall O. Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat Med 2002; 8(9): 963-70.
3. Parent JM, Vexler ZS, Gong C, Derugin N, Ferriero DM. Rat forebrain neurogenesis and striatal neuron replacement after focal stroke. Ann Neurol 2002; 52(6): 802-13.
4. Coti Bertrand P, O'Kusky JR, Innis SM. Maternal dietary (n-3) fatty acid deficiency alters neurogenesis in the embryonic rat brain. J Nutr 2006; 136(6): 1570-5.
5. Katakura M, Hashimoto M, Shahdat HM, et al. Docosahexaenoic acid promotes neuronal differentiation by regulating basic helix-loop-helix transcription factors and cell cycle in neural stem cells. Neuroscience 2009; 160(3): 651-60.
6. Cao D, Xue R, Xu J, Liu Z. Effects of docosahexaenoic acid on the survival and neurite outgrowth of rat cortical neurons in primary cultures. J Nutr Biochem 2005; 16(9): 538-46.
7. Beltz BS, Tlusty MF, Benton JL, Sandeman DC. Omega-3 fatty acids upregulate adult neurogenesis. Neurosci Lett 2007; 415(2): 154-8.
8. Gamoh S, Hashimoto M, Hossain S, Masumura S. Chronic administration of docosahexaenoic acid improves the performance of radial arm maze task in aged rats. Clin Exp Pharmacol Physiol 2001; 28(4): 266-70.
9. Gamoh S, Hashimoto M, Sugioka K, et al. Chronic administration of docosahexaenoic acid improves reference memory-related learning ability in young rats. Neuroscience 1999; 93(1): 237-41.
10. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959; 37(8): 911-7.
11. Wei D, Li J, Shen M, et al. Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death. Diabetes 2010; 59(2): 471-8.
12. Sawada M, Alkayed NJ, Goto S, et al. Estrogen receptor antagonist ICI182, 780 exacerbates ischemic injury in female mouse. J Cereb Blood Flow Metab 2000; 20(1): 112-8.
13. Stetler RA, Cao G, Gao Y, et al. Hsp27 protects against ischemic brain injury via attenuation of a novel stressresponse cascade upstream of mitochondrial cell death signaling. J Neurosci 2008; 28(49): 13038-55.
14. Iwai M, Sato K, Omori N, et al. Three steps of neural stem cells development in gerbil dentate gyrus after transient ischemia. J Cereb Blood Flow Metab 2002; 22(4): 411-9.
15. Marcheselli VL, Hong S, Lukiw WJ, et al. Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. J Biol Chem 2003; 278(44): 43807-17.
16. Bas O, Songur A, Sahin O, et al. The protective effect of fish n-3 fatty acids on cerebral ischemia in rat hippocampus. Neurochem Int 2007; 50(3): 548-54.
17. Belayev L, Khoutorova L, Atkins KD, Bazan NG. Robust docosahexaenoic acid-mediated neuroprotection in a rat model of transient, focal cerebral ischemia. Stroke 2009; 40(9): 3121-6.
18. Pantoni L, Garcia JH, Gutierrez JA. Cerebral white matter is highly vulnerable to ischemia. Stroke 1996; 27(9): 1641-6; discussion 7.
19. Iso H, Rexrode KM, Stampfer MJ, et al. Intake of fish and omega-3 fatty acids and risk of stroke in women. JAMA 2001; 285(3): 304-12.
20. He K, Rimm EB, Merchant A, et al. Fish consumption and risk of stroke in men. JAMA 2002; 288(24): 3130-6.
21. Mozaffarian D, Longstreth WT Jr, Lemaitre RN, et al. Fish consumption and stroke risk in elderly individuals: the cardiovascular health study. Arch Intern Med 2005; 165(2): 200-6.
22. Sun Y, Jin K, Xie L, et al. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J Clin Invest 2003; 111(12): 1843-51.
23. Zhu W, Fan Y, Frenzel T, et al. Insulin growth factor-1 gene transfer enhances neurovascular remodeling and improves long-term stroke outcome in mice. Stroke 2008; 39(4): 1254-61.
24. Tang Y, Yasuhara T, Hara K, et al. Transplantation of bone marrow-derived stem cells: a promising therapy for stroke. Cell Transplant 2007; 16(2): 159-69.
25. Jin K, Mao X, Xie L, et al. Delayed transplantation of human neural precursor cells improves outcome from focal cerebral ischemia in aged rats. Aging Cell 2010; 9(6): 1076-83.
26. Lee HJ, Lim IJ, Lee MC, Kim SU. Human neural stem cells genetically modified to overexpress brain-derived neurotrophic factor promote functional recovery and neuroprotection in a mouse stroke model. J Neurosci Res 2010; 88(15): 3282-94.
27. Franklin RJ, Kotter MR. The biology of CNS remyelination: the key to therapeutic advances. J Neurol 2008; 255 Suppl 1: 19-25.