Hyperoside downregulates the receptor for advanced glycation end products (RAGE) and promotes proliferation in ECV304 cells via the c-Jun N-terminal Kinases (JNK) pathway following stimulation by advanced glycation end-products In Vitro

International Journal of Molecular Sciences

Volumn 14, Issue 11, 2013, Pages 22697-22707

  Zhang, Zhengyu ^a,b   Sethiel, Mosha Silas ^b   Shen, Weizhi ^a   Liao, Sentai ^a   Zou, Yuxiao ^a  

^a INSTITUTE OF ANIMAL SCIENCE   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

AGE; ECV304; Hyperoside; JNK; RAGE

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; HYPERIN; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVATION; ENZYME INHIBITION; GENE; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN EXPRESSION; RAGE GENE; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

APOPTOSIS; CELL PROLIFERATION; CELL SURVIVAL; DRUGS, CHINESE HERBAL; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; QUERCETIN; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION;

EID: 84887858618     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms141122697     Document Type: Article

References (29)

1. Li, H. B.; Yi, X.; Gao, J. M.; Ying, X. X.; Guan, H. Q.; Li, J. C. The mechanism of hyperoside protection of ecv-304 cells against tert-butyl hydroperoxide-induced injury. Pharmacology 2008, 82, 105-113.
2. Verma, N.; Amresh, G.; Sahu, P. K.; Mishra, N.; Rao Ch, V.; Singh, A. P. Pharmacological evaluation of hyperin for antihyperglycemic activity and effect on lipid profile in diabetic rats. Indian J. Exp. Biol. 2013, 51, 65-72.
3. Yamamoto, Y.; Yamamoto, H. Rage-mediated inflammation, type 2 diabetes, and diabetic vascular complication. Front. Endocrinol. (Lausanne) 2013, 4, 105.
4. Tanaka, N.; Yonekura, H.; Yamagishi, S.; Fujimori, H.; Yamamoto, Y.; Yamamoto, H. The receptor for advanced glycation end products is induced by the glycation products themselves and tumor necrosis factor-alpha through nuclear factor-kappa b, and by 17beta-estradiol through sp-1 in human vascular endothelial cells. J. Biol. Chem. 2000, 275, 25781-25790.
5. Lin, W. D.; Lu, S. L.; Qing, C.; Yao, M.; Chen, X. F.; Xiang, J.; Qiao, L.; Liu, Y. K.; Dong, J. Y.; Shi, G. Y.; et al. Proliferation-inhibiting effect of advanced glycation end products modified human serum albumin to vascular endothelial cell ecv304. Zhonghua Yi Xue Za Zhi 2003, 83, 572-576.
6. Chen, X. F.; Lin, W. D.; Lu, S. L.; Xie, T.; Ge, K.; Shi, Y. Q.; Zou, J. J.; Liu, Z. M.; Liao, W. Q. Mechanistic study of endogenous skin lesions in diabetic rats. Exp. Dermatol. 2010, 19, 1088-1095.
7. Neeper, M.; Schmidt, A. M.; Brett, J.; Yan, S. D.; Wang, F.; Pan, Y. C.; Elliston, K.; Stern, D.; Shaw, A. Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J. Biol. Chem. 1992, 267, 14998-15004.
8. Brett, J.; Schmidt, A. M.; Yan, S. D.; Zou, Y. S.; Weidman, E.; Pinsky, D.; Nowygrod, R.; Neeper, M.; Przysiecki, C.; Shaw, A.; et al. Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues. Am. J. Pathol. 1993, 143, 1699-1712.
9. Schmidt, A. M.; Hori, O.; Brett, J.; Yan, S. D.; Wautier, J. L.; Stern, D. Cellular receptors for advanced glycation end products. Implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions. Arterioscler. Thromb. 1994, 14, 1521-1528.
10. Schmidt, A. M.; Yan, S. D.; Wautier, J. L.; Stern, D. Activation of receptor for advanced glycation end products: A mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis. Circ. Res. 1999, 84, 489-497.
11. Yan, S. D.; Schmidt, A. M.; Anderson, G. M.; Zhang, J.; Brett, J.; Zou, Y. S.; Pinsky, D.; Stern, D. Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. J. Biol. Chem. 1994, 269, 9889-9897.
12. Lander, H. M.; Tauras, J. M.; Ogiste, J. S.; Hori, O.; Moss, R. A.; Schmidt, A. M. Activation of the receptor for advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress. J. Biol. Chem. 1997, 272, 17810-17814.
13. Shi, L.; Yu, X.; Yang, H.; Wu, X. Advanced glycation end products induce human corneal epithelial cells apoptosis through generation of reactive oxygen species and activation of jnk and p38 mapk pathways. PLoS One 2013, 8, e66781.
14. Yamagishi, S.; Matsui, T.; Nakamura, K.; Takeuchi, M.; Inoue, H. Telmisartan inhibits advanced glycation end products (ages)-elicited endothelial cell injury by suppressing age receptor (rage) expression via peroxisome proliferator-activated receptor-gammaactivation. Protein Pept. Lett. 2008, 15, 850-853.
15. Liu, Y.; Liang, C.; Liu, X.; Liao, B.; Pan, X.; Ren, Y.; Fan, M.; Li, M.; He, Z.; Wu, J.; et al. Ages increased migration and inflammatory responses of adventitial fibroblasts via rage, mapk and nf-kappab pathways. Atherosclerosis 2010, 208, 34-42.
16. de Bittencourt Pasquali, M. A.; Gelain, D. P.; Zeidan-Chulia, F.; Pires, A. S.; Gasparotto, J.; Terra, S. R.; Moreira, J. C. Vitamin a (retinol) downregulates the receptor for advanced glycation endproducts (rage) by oxidant-dependent activation of p38 mapk and nf-kb in human lung cancer a549 cells. Cell. Signal. 2013, 25, 939-954.
17. Pillai, S. S.; Sugathan, J. K.; Indira, M. Selenium downregulates rage and nfkappab expression in diabetic rats. Biol. Trace Elem. Res. 2012, 149, 71-77.
18. Wei, W.; Chen, M.; Zhu, Y.; Wang, J.; Zhu, P.; Li, Y.; Li, J. Down-regulation of vascular hmgb1 and rage expression by n-3 polyunsaturated fatty acids is accompanied by amelioration of chronic vasculopathy of small bowel allografts. J. Nutr. Biochem. 2012, 23, 1333-1340.
19. Cuccurullo, C.; Iezzi, A.; Fazia, M. L.; De Cesare, D.; Di Francesco, A.; Muraro, R.; Bei, R.; Ucchino, S.; Spigonardo, F.; Chiarelli, F.; et al. Suppression of rage as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes. Arterioscler. Thromb. Vasc. Biol. 2006, 26, 2716-2723.
20. Marx, N.; Walcher, D.; Ivanova, N.; Rautzenberg, K.; Jung, A.; Friedl, R.; Hombach, V.; de Caterina, R.; Basta, G.; Wautier, M. P.; et al. Thiazolidinediones reduce endothelial expression of receptors for advanced glycation end products. Diabetes 2004, 53, 2662-2668.
21. Wang, K.; Zhou, Z.; Zhang, M.; Fan, L.; Forudi, F.; Zhou, X.; Qu, W.; Lincoff, A. M.; Schmidt, A. M.; Topol, E. J.; et al. Peroxisome proliferator-activated receptor gamma down-regulates receptor for advanced glycation end products and inhibits smooth muscle cell proliferation in a diabetic and nondiabetic rat carotid artery injury model. J. Pharmacol. Exp. Ther. 2006, 317, 37-43.
22. Yan, F. L.; Zheng, Y.; Zhao, F. D. Effects of ginkgo biloba extract egb761 on expression of rage and lrp-1 in cerebral microvascular endothelial cells under chronic hypoxia and hypoglycemia. Acta Neuropathol. 2008, 116, 529-535.
23. Dou, L.; Lu, Y.; Shen, T.; Huang, X.; Man, Y.; Wang, S.; Li, J. Panax notogingseng saponins suppress rage/mapk signaling and nf-kappab activation in apolipoprotein-e-deficient atherosclerosis-prone mice. Cell. Physiol. Biochem. 2012, 29, 875-882.
24. Liu, R. L.; Xiong, Q. J.; Shu, Q.; Wu, W. N.; Cheng, J.; Fu, H.; Wang, F.; Chen, J. G.; Hu, Z. L. Hyperoside protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via nitric oxide signal pathway. Brain Res. 2012, 1469, 164-173.
25. Kim, J. Y.; Park, H. K.; Yoon, J. S.; Kim, S. J.; Kim, E. S.; Ahn, K. S.; Kim, D. S.; Yoon, S. S.; Kim, B. K.; Lee, Y. Y. Advanced glycation end product (age)-induced proliferation of hel cells via receptor for age-related signal pathways. Int. J. Oncol. 2008, 33, 493-501.
26. Galler, A.; Muller, G.; Schinzel, R.; Kratzsch, J.; Kiess, W.; Munch, G. Impact of metabolic control and serum lipids on the concentration of advanced glycation end products in the serum of children and adolescents with type 1 diabetes, as determined by fluorescence spectroscopy and nepsilon-(carboxymethyl)lysine elisa. Diabetes Care 2003, 26, 2609-2615.
27. Li, Y.; Liu, S.; Zhang, Z.; Xu, Q.; Xie, F.; Wang, J.; Ping, S.; Li, C.; Wang, Z.; Zhang, M.; et al. Rage mediates accelerated diabetic vein graft atherosclerosis induced by combined mechanical stress and ages via synergistic erk activation. PLoS One 2012, 7, e35016.
28. Zhang, Z.; Zhang, M.; Li, Y.; Liu, S.; Ping, S.; Wang, J.; Ning, F.; Xie, F.; Li, C. Simvastatin inhibits the additive activation of erk1/2 and proliferation of rat vascular smooth muscle cells induced by combined mechanical stress and oxldl through lox-1 pathway. Cell. Signal. 2013, 25, 332-340.
29. Yamada, Y.; Ishibashi, K.; Bhutto, I. A.; Tian, J.; Lutty, G. A.; Handa, J. T. The expression of advanced glycation endproduct receptors in rpe cells associated with basal deposits in human maculas. Exp. Eye Res. 2006, 82, 840-848.