Pharmacological evaluation of hyperin for antihyperglycemic activity and effect on lipid profile in diabetic rats

Indian Journal of Experimental Biology

Volumn 51, Issue 1, 2013, Pages 65-72

  Verma, Neeraj ^a   Amresh, G ^a   Sahu, P K ^b   Mishra, Neelam ^b   Rao, Ch V ^c   Singh, Anil Pratap ^c  

^a Goel Institute of Pharmacy and Sciences   (India)

^b SIKSHA O ANUSANDHAN DEEMED TO BE UNIVERSITY   (India)

^c CSIR NATIONAL BOTANICAL RESEARCH INSTITUTE   (India)

Author keywords

Anti hyperglycemic activity; Hyperin; Insulin; Rhododendron arboreum

Indexed keywords

ANTIDIABETIC AGENT; DRUG DERIVATIVE; GLIBENCLAMIDE; GLYCOGEN; HEXOKINASE; HYPERIN; INSULIN; LIPID; QUERCETIN;

ANIMAL; ARTICLE; CHEMICAL MODEL; CHEMISTRY; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE TOLERANCE TEST; LIVER; MALE; METABOLISM; RAT; RHODODENDRON; WISTAR RAT;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE TOLERANCE TEST; GLYBURIDE; GLYCOGEN; HEXOKINASE; HYPOGLYCEMIC AGENTS; INSULIN; LIPIDS; LIVER; MALE; MODELS, CHEMICAL; QUERCETIN; RATS; RATS, WISTAR; RHODODENDRON;

RATTUS; RHODODENDRON ARBOREUM;

EID: 84871754065     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Zhiyong L, Xinyi T, Chongwei Z, Yanhua L & Dongzhi W, Protective effects of hyperoside (quercetin-3-o-galactoside) to PC12 cells against cytotoxicity induced by hydrogen peroxide and tert-butyl hydroperoxide, Biomed Pharmacother, 59 (2005) 481.
2. Lee S, Park H S, Notsu Y, Ban H S, Kim Y P, Ishihara K, Hirasawa N, Jung S H, Lee Y S, Lim S S, Park E H, Shin K H, Seyama T, Hong J & Ohuchi K, Effects of hyperin, isoquercitrin and quercetin on lipopolysaccharide-induced nitrite production in rat peritoneal macrophages, Phytother Res, 22 (2008) 1552.
3. Shahat A A, Pieters L, Apers S, Nazeif N M, Abdel-Azim N S, Berghe D V & Vlietinck A J, Chemical and biological investigations on Zizyphus spina-christi L, Phytother Res, 15 (2001) 593.
4. Shi Y, Shi R B & Liu B, Studies on antiviral flavonoids in Yinqiaosan Powder, Chin J Chin Mat Med, 26 (2001) 320.
5. Chen Z W, Ma C G & Fang M, Mechanism of analgesic action of hyperin, Acta Pharm Sin, 24 (1989) 226.
6. Ma C G, Xiang Z M & Xu S Y, Mechanism of analgesic action of hyperin on centrum, Chin Pharmacol Bull, 7 (1991) 345.
7. Zhang J S, Chen Z W, Wang Y, Song B W, Dong L Y& Cen D Y, Mechanism of analgesic action of hyperin on spinal cord, Anhui Med, 19 (1998) 3.
8. Lee S J, Son K H, Chang H W, Do J C, Jung K Y& Kang S S, Anti-inflammatory activity of naturally occurring flavone and flavonol glycosides, Arch Pharm Res, 16 (1992) 25.
9. Zhang Z, Chang Q, Zhu M, Huang Y, Ho W K & Chen Z, Characterization of antioxidants present in hawthorn fruits, J Nutr Biochem, 12 (2001) 144.
10. Li Q L, Yu G X, Chen Z & Ma C G, Inhibitory mechanism of hyperin of the apoptosis in myocardial ischemia/reperfusion in rats, Acta Pharm Sin, 37 (2002) 849.
11. Wang W Q, Ma C G & Xu S Y, Protective effect of hyperin against myocardial ischemia and reperfusion injury, Acta Pharmacol Sin, 17 (1996) 341.
12. Xiong Q, Fan W, Tezuka Y, Adnyana I K, Stampoulis P, Hattori M, Namba T & Kadota S, Hepatoprotective effect of Apocynum venetum and its active constituents, Planta Medica, 66 (2000) 127.
13. Carlo G D, Mascolo N, Izzo A A & Capasso F, Flavonoids: old and new aspects of a class of natural therapeutic drugs, Life Sci, 65(1999) 337.
14. Ito M, Shimura H, Watanaba N, Tamai M, Hanada K, Takahashi A,Tanaka Y, Arai K, Zhang P L & Chang R, Hepatoprotective compounds from Canarium album and Euphorbia nematocypha, Chem Pharm Bull, 38 (1990) 2201.
15. Zhao W Z, Chen Z W, Song B W, Wang Y L, Wang Q, Fang M, et al. The protective effect of hyperin on gastric mucosal injury in mice and its mechanism, Acta Anhui Med Univ, 3 (1999) 178.
16. Song B W, Chen Z W& Ma C G, The cell protective effect of hyperin on gastric mucosal injury in rats, Chin Pharmacol Bull, 11 (1995) 46.
17. Verma N, Singh A P, Gupta A, Sahu P K & Rao Ch V, Anti-inflammatory and anti-nociceptive activity of Rhododendron arboreum, J Pharm Res, 3 (2010) 1376.
18. Bhandary M R & Jun Kawabata, Antidiabetic activity of Laligurans (Rhododendron arboreum Sm.) flower, J Food Sci Technol, 4 (2008) 61.
19. Verma N, Singh A P, Gupta A, Sahu P K & Rao Ch V, Protective effect of ethyl acetate fraction of Rhododendron arboreum flowers against carbon tetrachloride-induced hepatotoxicity in experimental models, Indian J Pharmacol, 43 (2011) 291.
20. Verma N, Singh A P, Gupta A, Sahu P K & Rao Ch V. Antidiarrheal potential of standardized extract of Rhododendron arboreum Smith flowers in experimental animals, Indian J Pharmacol, 43 (2011) 689.
21. Verma N, Singh A P, Gupta A, Sahu P K & Rao Ch V, Antihyperglycemic and antihyperlipidemic activity of ethyl acetate fraction of Rhododendron arboreum Smith flowers in streptozotocin induced diabetic rats and its role in regulating carbohydrate metabolism, Asian Pac J Trop Biomed, 2 (2012) 1.
22. Ghosh M N, Fundamentals of Experiment Pharmacology, 2nd ed, (Scientific Book Agency, Calcutta) 1984, 192.
23. Turner R, Acute toxicity: The determination of LD50. In Screening Methods in Pharmacology, (Academic Press, New York) 1965, 300.
24. Erejuwa O O, Sulaiman S A, Mohd Wahab S A, Kuttulebbai Sirajudeen N S, Md Salzihan, Md Salleh & Sunil G, Antioxidant protective effect of glibenclamide and metformin in combination with honey in pancreas of streptozotocin-induced diabetic rats, Int J Mol Sci, 11 (2010) 2056.
25. Trinder P, Determinations of blood glucose using 4-aminophenazone as oxygen acceptor, J Clin Path, 22 (1969b) 246.
26. Eross J, Kreutzmann D, Jimenez M, Keen R, Rogers S, Colwell C, Vines R & Sinik M, Colorimetric measurement of glycosylated protein in whole blood cells plasma and dried blood, Ann Clin Biochem, 21 (1984) 519.
27. Rao P V, Madhavi K & Naidu M D, Hypolipidemic properties of Rhinacanthus nasutus in streptozotocininduced diabetic rats, J Pharmaco Toxicol, 6 (2011) 589.
28. Friedewald W T, Levy R I & Fradrickson D S, Estimation of concentration of low density lipoprotein cholesterol in plasma without the use of preparative ultracentrifuge, Clin Chem, 18 (1972) 499.
29. Sadasivam S & Manickam A, Methods in Biochemistry, (New Age International Pvt. Ltd, New Delhi)7 1996, 11.
30. Guruvayoorappam C & Sudha G, Phytopharmacological evaluation of Byesukar for hypoglycaemic activity and its effect on lipid profile and hepatic enzymes of glucose metabolism in diabetic rats, Ann hepatol, 7 (2008) 358.
31. Leloir L F & Goldenberg S H, Glycogen synthetase from rat liver, In Methods of Enzymology, (Academic Press, New York) 1965,145.
32. Cornblath M, Randle P J, Parmeggiani A & Morgan H E, Regulation of glycogenolysis in muscle: Effects of glucagon and anoxia on lactate production, glycogen content and phosphorylase activity in perfused isolated rat heart, J Biol Chem, 238 (1963) 1592.
33. Qi X Y, Chen W J, Zhang L Q & Xie B J, Mogrosides extract from Siraitia grosvenori scavenges free radicals invitro and lowers oxidative stress, serum glucose and lipid levels in alloxan-induced diabetic mice, Nutr Res, 28 (2008) 278.
34. Sharma S B, Nasir A, Prabhu K M, Murthy P S & Dev G. Hypogyycemic and hypolipidemic effect of flavonoid rich extract from Eugenia jambolana seed on streptozotocininduced diabetic rats, Food Chem Toxicol, 46 (2003) 2376.
35. Stalmans W, Cadefau J, Wera S & Bollen M, New insight into the regulation of liver glycogen metabolism by glucose, Biochem Soc Trans, 25 (1997) 19.
36. Akatsuka A, Singh T J & Huang K P, Comparision of liver glycogen synthase from normal and streptozotocin-induced diabetic rats, Arch Biochem Biophys, 220 (1983) 426.
37. Roesler W J & Khanderwal R L, Quantitation of glycogen synthase and phosphorylase protein mouse liver: Correlation between enzymatic protein and enzymatic acivity, Arch Biochem Biophys, 244 (1986) 397.
38. Laakso M, Malkki M & Deeb S S, Aminoacid substituents in hexokinase II among patients with NIDDM, Diabetes 44 (1995) 330.
39. Baquer N Z, Gupta D & Raju J, Regulation of metabolic pathways in liver and kidney during experimental diabetes: effects of antidiabetic compounds, Indian J Clin Biochem, 13 (1998) 63.