Effects of radiation on the expression of adhesion molecules and cytokines in a static model of human dermal microvascular endothelial cells

Clinical Hemorheology and Microcirculation

Volumn 54, Issue 4, 2013, Pages 371-379

  Haubner, F ^a   Ohmann, E ^a   Pohl, F ^a   Prantl, L ^a   Strutz, J ^a   Gassner, H G ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

adhesion molecules; cytokines; Endothelial cells; endothelial dysfunction; growth factors; radiation therapy

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; CELL COUNT; CELL DENSITY; CELL PROLIFERATION; CELL SIZE; CELL VIABILITY; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; MICROCIRCULATION; MICROVASCULAR ENDOTHELIAL CELL; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; RADIATION; RADIATION DOSE;

ADHESION MOLECULES; CYTOKINES; ENDOTHELIAL CELLS; ENDOTHELIAL DYSFUNCTION; GROWTH FACTORS; RADIATION THERAPY;

CELL ADHESION MOLECULES; CELLS, CULTURED; CYTOKINES; ENDOTHELIAL CELLS; HUMANS; MICROCIRCULATION; SKIN;

EID: 84887858610     PISSN: 13860291     EISSN: 18758622     Source Type: Journal    
DOI: 10.3233/CH-2012-1626     Document Type: Article

References (28)

1. P.O. Bonetti, L.O. Lerman and A. Lerman, Endothelial dysfunction: A marker of atherosclerotic risk, Arterioscler Thromb Vasc Biol 23 (2003), 168-175. (Pubitemid 36231924)
2. C.H. Chou, S.U. Chen and J.C. Cheng, Radiation-induced interleukin-6 expression through MAPK/p38/NF-kappaB signaling pathway and the resultant antiapoptotic effect on endothelial cells through Mcl-1 expression with sIL6-Ralpha, Int J Radiat Oncol Biol Phys 75 (2009), 1553-1561.
3. E.L. Dormand, P.E. Banwell and T.E. Goodacre, Radiotherapy and wound healing, Int Wound J 2 (2005), 112-127.
4. Ethical guidelines for publication in Clinical Hemorheology and Microcirculation. Clin Hemorheol Microcirc 44 (2010), 1-2.
5. J. Fareh, R. Martel, P. Kermani and G. Leclerc, Cellular effects of beta-particle delivery on vascular smooth muscle cells and endothelial cells: A dose-response study, Circulation 99 (1999), 1477-1484. (Pubitemid 29140915)
6. M.H. Gaugler, C. Squiban, A. van der Meeren, J.M. Bertho, M. Vandamme and M.A. Mouthon, Late and persistent upregulation of intercellular adhesion molecule-1 (ICAM-1) expression by ionizing radiation in human endothelial cells in vitro, Int J Radiat Biol 72 (1997), 201-209. (Pubitemid 27339415)
7. M.H. Gaugler, V. Vereycken-Holler, C. Squiban, M. Vandamme, M.C. Vozenin-Brotons and M. Benderitter, Pravastatin limits endothelial activation after irradiation and decreases the resulting inflammatory and thrombotic responses, Radiat Res 163 (2005), 479-487. (Pubitemid 41490643)
8. R.G. Gerrity, The role of the monocyte in atherogenesis: II. Migration of foam cells from atherosclerotic lesions, Am J Pathol 103 (1981), 191-200. (Pubitemid 11112974)
9. R.E. Gerszten, E.A. Garcia-Zepeda and Y.C. Lim, et al., MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions, Nature 398 (1999), 718-723.
10. E.F. Grabowski, C.A. Carter,O. Tsukurov, et al., Comparison of human umbilical vein and adult saphenous vein endothelial cells: Implications for newborn hemostasis and for laboratory models of endothelial cell function, J Pediatr Hematol Oncol 22 (2000), 266-268. (Pubitemid 32268315)
11. E. Henning, H. Dittmann, J.Wiskirchen, et al., Dose dependent effects of the combined beta-gamma-emitter 188Rhenium on the growth of human vessel wall cells, Rofo 176 (2004), 404-408. (Pubitemid 38391375)
12. D.B. Hom, G. Adams, M. Koreis and R. Maisel, Choosing the optimal wound dressing for irradiated soft tissue wounds, Otolaryngol Head Neck Surg 121 (1999), 591-598. (Pubitemid 29519928)
13. T.K. K.D. Hunt and K.K. Thakral, Cellular control of repair. In Hunt TK, Heppenstall RB, Pines E, Rovee D, ediors. Soft and hard tissue repair: Biological and clinical aspects, Praeger, New York, 184, 3-19.
14. S. Khaled, K.B. Gupta and D.F. Kucik, Ionizing radiation increases adhesiveness of human aortic endothelial cells via a chemokine-dependent mechanism, Radiat Res 177 (2012), 594-601.
15. P.M. Lambert, M. Patel, E. Gutman and H.A. Campana, Dermal grafts to bony defects in irradiated and nonirradiated tissues, Arch Otolaryngol 110 (1984), 657-659. (Pubitemid 14008110)
16. S. Lee and C. Thiele, Factors associated with free flap complications after head and neck reconstruction and the molecular basis of fibrotic tissue rearrangement in preirradiated soft tissue, J Oral Maxillofac Surg 68 (2010), 2169-2178.
17. S. Muxel, F. Fasola, M.C. Radmacher, A. Jabs, T. Munzel and T. Gori, Endothelial functions: Translating theory into clinical application, Clin Hemorheol Microcirc 45 (2010), 109-115.
18. J. Panes, D.C. Anderson, M. Miyasaka and D.N. Granger, Role of leukocyte-endothelial cell adhesion in radiation-induced microvascular dysfunction in rats, Gastroenterology 108 (1995), 1761-1769.
19. F. Peng and M. Chen, Antiangiogenic therapy: A novel approach to overcome tumor hypoxia, Chin J Cancer 29 (2010), 715-720.
20. F. Pohl, S. Hassel, A. Nohe, et al., Radiation-induced suppression of the Bmp2 signal transduction pathway in the pluripotent mesenchymal cell line C2C12: An in vitro model for prevention of heterotopic ossification by radiotherapy, Radiat Res 159 (2003), 345-350. (Pubitemid 36314949)
21. J.D. Pollard, S. Quan, T. Kang and R.J. Koch, Effects of copper tripeptide on the growth and expression of growth factors by normal and irradiated fibroblasts, Arch Facial Plast Surg 7 (2005), 27-31. (Pubitemid 43973838)
22. S. Quarmby, P. Kumar and S. Kumar, Radiation-induced normal tissue injury: Role of adhesion molecules in leukocyteendothelial cell interactions, Int J Cancer 82 (1999), 385-395. (Pubitemid 29302980)
23. F. Riedel, K. Philipp, H. Sadick, U. Goessler,K. Hormann and T.Verse, Immunohistochemical analysis of radiation-induced non-healing dermal wounds of the head and neck, In Vivo 19 (2005), 343-350. (Pubitemid 40467618)
24. K. Tamama, H. Kawasaki, S.S. Kerpedjieva, J. Guan, R.K. Ganju and C.K. Sen, Differential roles of hypoxia inducible factor subunits in multipotential stromal cells under hypoxic condition, J Cell Biochem 112 (2011), 804-817.
25. P.H. Tan, C. Chan, S.A. Xue, et al., Phenotypic and functional differences between human saphenous vein (HSVEC) and umbilical vein (HUVEC) endothelial cells, Atherosclerosis 173 (2004), 171-183. (Pubitemid 38469784)
26. A. van der Meeren, C. Squiban, P. Gourmelon, H. Lafont and M.H. Gaugler, Differential regulation by IL-4 and IL-10 of radiation-induced IL-6 and IL-8 production and ICAM-1 expression by human endothelial cells, Cytokine 11 (1999), 831-838. (Pubitemid 29537531)
27. J.Wondergem, L.E.Wedekind, C.I. Bart, A. Chin, A. van der Laarse and H. Beekhuizen, Irradiation of mechanically-injured human arterial endothelial cells leads to increased gene expression and secretion of inflammatory and growth promoting cytokines, Atherosclerosis 175 (2004), 59-67. (Pubitemid 38746910)
28. J. Yarnold and M.C. Brotons, Pathogenetic mechanisms in radiation fibrosis, Radiother Oncol 97 (2010), 149-161.