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Volumn 29, Issue 8, 2010, Pages 715-720

Antiangiogenic therapy: A novel approach to overcome tumor hypoxia

Author keywords

Antiangiogenesis; Cell hypoxia; Radiotherapy

Indexed keywords

ANGINEX; ANGIOPOIETIN 1; BEVACIZUMAB; CEDIRANIB; CETUXIMAB; CISPLATIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; FLUOROURACIL; FUMAGILLOL CHLOROACETYLCARBAMATE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMATINIB; MONOCLONAL ANTIBODY DC101; N ACETYLCOLCHINOL PHOSPHATE; NAVELBINE; ORANTINIB; OXYGEN; RECOMBINANT ENDOSTATIN; ROUNDABOUT RECEPTOR; SEMAPHORIN 3A; SEMAXANIB; SUNITINIB; THALIDOMIDE; TIVOZANIB; TRASTUZUMAB; VANDETANIB; VASCULOTROPIN; VASCULOTROPIN ANTIBODY;

EID: 79955812472     PISSN: 1000467X     EISSN: 1944446X     Source Type: Journal    
DOI: 10.5732/cjc.010.10010     Document Type: Review
Times cited : (16)

References (39)
  • 1
    • 0038176480 scopus 로고    scopus 로고
    • Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: Exploring mechanisms of interaction [J]
    • Wachsberger P, Burd R, Dicker AP. Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: exploring mechanisms of interaction [J]. Clin Cancer Res, 2003, 9(6): 1957-1971.
    • (2003) Clin Cancer Res , vol.9 , Issue.6 , pp. 1957-1971
    • Wachsberger, P.1    Burd, R.2    Dicker, A.P.3
  • 2
    • 34547121206 scopus 로고    scopus 로고
    • Hypoxia in cancer: Significance and impact on clinical outcome [J]
    • Vaupel P, Mayer A. Hypoxia in cancer: significance and impact on clinical outcome [J]. Cancer Metastasis Rev, 2007, 26(2): 225-239.
    • (2007) Cancer Metastasis Rev , vol.26 , Issue.2 , pp. 225-239
    • Vaupel, P.1    Mayer, A.2
  • 3
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases [J]
    • Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases [J]. Nature, 2000, 407(6801): 249-257.
    • (2000) Nature , vol.407 , Issue.6801 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 5
    • 30944446883 scopus 로고    scopus 로고
    • Lessons from phase III clinical trials on anti-VEGF therapy for cancer [J]
    • Jain RK, Duda DG, Clark JW, et al. Lessons from phase III clinical trials on anti-VEGF therapy for cancer [J]. Nat Clin Pract Oncol, 2006, 3(1): 24-40.
    • (2006) Nat Clin Pract Oncol , vol.3 , Issue.1 , pp. 24-40
    • Jain, R.K.1    Duda, D.G.2    Clark, J.W.3
  • 6
    • 57649135172 scopus 로고    scopus 로고
    • A role for VEGF as a negative regulator of pericyte function and vessel maturation [J]
    • Greenberg JI, Shields DJ, Barillas SG, et al. A role for VEGF as a negative regulator of pericyte function and vessel maturation [J]. Nature, 2008, 456(7223): 809-813.
    • (2008) Nature , vol.456 , Issue.7223 , pp. 809-813
    • Greenberg, J.I.1    Shields, D.J.2    Barillas, S.G.3
  • 7
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer [J]
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer [J]. N Engl J Med, 2004, 350(23): 2335-2342.
    • (2004) N Engl J Med , vol.350 , Issue.23 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 8
    • 67649921334 scopus 로고    scopus 로고
    • Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: A multidisciplinary phase II study [J]
    • Willett CG, Duda DG, di Tomaso E, et al. Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study [J]. J Clin Oncol, 2009, 27(18): 3020-3026.
    • (2009) J Clin Oncol , vol.27 , Issue.18 , pp. 3020-3026
    • Willett, C.G.1    Duda, D.G.2    di Tomaso, E.3
  • 9
    • 27644476564 scopus 로고    scopus 로고
    • Results of phase III trial of rhendostatin (YH-16) in advanced non-small cell lung cancer (NSCLC) patients [J]
    • Sun Y, Wang J, Liu Y, et al. Results of phase III trial of rhendostatin (YH-16) in advanced non-small cell lung cancer (NSCLC) patients [J]. J Clin Oncol, 2005, 23(16): 654S.
    • (2005) J Clin Oncol , vol.23 , Issue.16
    • Sun, Y.1    Wang, J.2    Liu, Y.3
  • 10
    • 33344472286 scopus 로고    scopus 로고
    • Antiangiogenesis in cancer therapy--endostatin and its mechanisms of action [J]
    • Folkman J. Antiangiogenesis in cancer therapy--endostatin and its mechanisms of action [J]. Exp Cell Res, 2006, 312(5): 594-607.
    • (2006) Exp Cell Res , vol.312 , Issue.5 , pp. 594-607
    • Folkman, J.1
  • 11
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy [J]
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy [J]. Science, 2005, 307(5706): 58-62.
    • (2005) Science , vol.307 , Issue.5706 , pp. 58-62
    • Jain, R.K.1
  • 12
    • 19944422751 scopus 로고    scopus 로고
    • Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metalloproteinases [J]
    • Winkler F, Kozin SV, Tong RT, et al. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases [J]. Cancer Cell, 2004, 6(6): 553-563.
    • (2004) Cancer Cell , vol.6 , Issue.6 , pp. 553-563
    • Winkler, F.1    Kozin, S.V.2    Tong, R.T.3
  • 13
    • 30944452436 scopus 로고    scopus 로고
    • Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: Continued experience of a phase I trial in rectal cancer patients [J]
    • Willett CG, Boucher Y, Duda DG, et al. Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients [J]. J Clin Oncol, 2005, 23(31): 8136-8139.
    • (2005) J Clin Oncol , vol.23 , Issue.31 , pp. 8136-8139
    • Willett, C.G.1    Boucher, Y.2    Duda, D.G.3
  • 14
    • 11144354392 scopus 로고    scopus 로고
    • Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer [J]
    • Willett CG, Boucher Y, di Tomaso E, et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer [J]. Nat Med, 2004, 10(2): 145-147.
    • (2004) Nat Med , vol.10 , Issue.2 , pp. 145-147
    • Willett, C.G.1    Boucher, Y.2    di Tomaso, E.3
  • 15
    • 34250660932 scopus 로고    scopus 로고
    • Scheduling of radiation with angiogenesis inhibitors anginex and Avastin improves therapeutic outcome via vessel normalization [J]
    • Dings RP, Loren M, Heun H, et al. Scheduling of radiation with angiogenesis inhibitors anginex and Avastin improves therapeutic outcome via vessel normalization [J]. Clin Cancer Res, 2007, 13 (11): 3395-3402.
    • (2007) Clin Cancer Res , vol.13 , Issue.11 , pp. 3395-3402
    • Dings, R.P.1    Loren, M.2    Heun, H.3
  • 16
    • 57149137027 scopus 로고    scopus 로고
    • Her2/neu signaling blockade improves tumor oxygenation in a multifactorial fashion in Her2/neu(+) tumors [J]
    • Hardee M, Eapen R, Rabbani Z, et al. Her2/neu signaling blockade improves tumor oxygenation in a multifactorial fashion in Her2/neu(+) tumors [J]. Cancer Chemother Pharmacol, 2009, 63(2): 219-228.
    • (2009) Cancer Chemother Pharmacol , vol.63 , Issue.2 , pp. 219-228
    • Hardee, M.1    Eapen, R.2    Rabbani, Z.3
  • 17
    • 68349137598 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy [J]
    • Cerniglia GJ, Pore N, Tsai JH, et al. Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy [J]. PLoS One, 2009, 4(8): e6539.
    • (2009) PLoS One , vol.4 , Issue.8
    • Cerniglia, G.J.1    Pore, N.2    Tsai, J.H.3
  • 18
    • 33750296338 scopus 로고    scopus 로고
    • Mechanism of reoxygenation after antiangiogenic therapy using SU5416 and its importance for guiding combined antitumor therapy [J]
    • Ansiaux R, Baudelet C, Jordan BF, et al. Mechanism of reoxygenation after antiangiogenic therapy using SU5416 and its importance for guiding combined antitumor therapy [J]. Cancer Res, 2006, 66(19): 9698-9704.
    • (2006) Cancer Res , vol.66 , Issue.19 , pp. 9698-9704
    • Ansiaux, R.1    Baudelet, C.2    Jordan, B.F.3
  • 19
    • 70449704420 scopus 로고    scopus 로고
    • Decrease in tumor cell oxygen consumption after treatment with vandetanib (ZACTIMA; ZD6474) and its effect on response to radiotherapy [J]
    • Ansiaux R, Dewever J, Gregoire V, et al. Decrease in tumor cell oxygen consumption after treatment with vandetanib (ZACTIMA; ZD6474) and its effect on response to radiotherapy [J]. Radiat Res, 2009, 172(5): 584-591.
    • (2009) Radiat Res , vol.172 , Issue.5 , pp. 584-591
    • Ansiaux, R.1    Dewever, J.2    Gregoire, V.3
  • 20
    • 19944426756 scopus 로고    scopus 로고
    • Thalidomide radiosensitizes tumors through early changes in the tumor microenvironment [J]
    • Ansiaux R, Baudelet C, Jordan BF, et al. Thalidomide radiosensitizes tumors through early changes in the tumor microenvironment [J]. Clin Cancer Res, 2005, 11(2 Pt 1): 743-750.
    • (2005) Clin Cancer Res , vol.11 , Issue.2 PART 1 , pp. 743-750
    • Ansiaux, R.1    Baudelet, C.2    Jordan, B.F.3
  • 21
    • 17844374383 scopus 로고    scopus 로고
    • Anginex synergizes with radiation therapy to inhibit tumor growth by radiosensitizing endothelial cells [J]
    • Dings RPM, Williams BW, Song CW, et al. Anginex synergizes with radiation therapy to inhibit tumor growth by radiosensitizing endothelial cells [J]. Int J Cancer, 2005, 115(2): 312-319.
    • (2005) Int J Cancer , vol.115 , Issue.2 , pp. 312-319
    • Dings, R.P.M.1    Williams, B.W.2    Song, C.W.3
  • 22
    • 0034306974 scopus 로고    scopus 로고
    • Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions [J]
    • Lee CG, Heijn M, di Tomaso E, et al. Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions [J]. Cancer Res, 2000, 60(19): 5565-5570.
    • (2000) Cancer Res , vol.60 , Issue.19 , pp. 5565-5570
    • Lee, C.G.1    Heijn, M.2    di Tomaso, E.3
  • 23
    • 12244296444 scopus 로고    scopus 로고
    • Effect of the tumor vascular-damaging agent, ZD6126, on the radioresponse of U87 glioblastoma [J]
    • Wachsberger PR, Burd R, Marero N, et al. Effect of the tumor vascular-damaging agent, ZD6126, on the radioresponse of U87 glioblastoma [J]. Clin Cancer Res, 2005, 11(2): 835-842.
    • (2005) Clin Cancer Res , vol.11 , Issue.2 , pp. 835-842
    • Wachsberger, P.R.1    Burd, R.2    Marero, N.3
  • 24
    • 0036569804 scopus 로고    scopus 로고
    • Enhancement of radiation therapy by the novel vascular targeting agent ZD6126 [J]
    • Siemann DW, Rojiani AM. Enhancement of radiation therapy by the novel vascular targeting agent ZD6126 [J]. Int J Radiat Oncol Biol Phys, 2002, 53(1): 164-171.
    • (2002) Int J Radiat Oncol Biol Phys , vol.53 , Issue.1 , pp. 164-171
    • Siemann, D.W.1    Rojiani, A.M.2
  • 25
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy [J]
    • Jain RK. Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy [J]. Nat Med, 2001, 7(9): 987-989.
    • (2001) Nat Med , vol.7 , Issue.9 , pp. 987-989
    • Jain, R.K.1
  • 26
    • 2542628099 scopus 로고    scopus 로고
    • Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors [J]
    • Tong RT, Boucher Y, Kozin SV, et al. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors [J]. Cancer Res, 2004, 64(11): 3731-3736.
    • (2004) Cancer Res , vol.64 , Issue.11 , pp. 3731-3736
    • Tong, R.T.1    Boucher, Y.2    Kozin, S.V.3
  • 27
    • 40949141801 scopus 로고    scopus 로고
    • Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide [J]
    • Zhou QY, Guo P, Gallo JM. Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide [J]. Clin Cancer Res, 2008, 14(5): 1540-1549.
    • (2008) Clin Cancer Res , vol.14 , Issue.5 , pp. 1540-1549
    • Zhou, Q.Y.1    Guo, P.2    Gallo, J.M.3
  • 28
    • 72949117051 scopus 로고    scopus 로고
    • TSU68, an antiangiogenic receptor tyrosine kinase inhibitor, induces tumor vascular normalization in a human cancer xenograft nude mouse model [J]
    • Ohta M, Kawabata T, Yamamoto M, et al. TSU68, an antiangiogenic receptor tyrosine kinase inhibitor, induces tumor vascular normalization in a human cancer xenograft nude mouse model [J]. Surg Today, 2009, 39(12): 1046-1053.
    • (2009) Surg Today , vol.39 , Issue.12 , pp. 1046-1053
    • Ohta, M.1    Kawabata, T.2    Yamamoto, M.3
  • 29
    • 38949178751 scopus 로고    scopus 로고
    • Anti-tumor activity and tumor vessel normalization by the vascular endothelial growth factor receptor tyrosine kinase inhibitor KRN951 in a rat peritoneal disseminated tumor model [J]
    • Taguchi E, Nakamura K, Miura T, et al. Anti-tumor activity and tumor vessel normalization by the vascular endothelial growth factor receptor tyrosine kinase inhibitor KRN951 in a rat peritoneal disseminated tumor model [J]. Cancer Sci, 2008, 99(3): 623-630.
    • (2008) Cancer Sci , vol.99 , Issue.3 , pp. 623-630
    • Taguchi, E.1    Nakamura, K.2    Miura, T.3
  • 30
    • 33846149645 scopus 로고    scopus 로고
    • AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients [J]
    • Batchelor TT, Sorensen AG, di Tomaso E, et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients [J]. Cancer Cell, 2007, 11(1): 83-95.
    • (2007) Cancer Cell , vol.11 , Issue.1 , pp. 83-95
    • Batchelor, T.T.1    Sorensen, A.G.2    di Tomaso, E.3
  • 31
    • 43749112760 scopus 로고    scopus 로고
    • Vascular normalization in Rgs5-deficient tumours promotes immune destruction [J]
    • Hamzah J, Jugold M, Kiessling F, et al. Vascular normalization in Rgs5-deficient tumours promotes immune destruction [J]. Nature, 2008, 453(7193): 410-414.
    • (2008) Nature , vol.453 , Issue.7193 , pp. 410-414
    • Hamzah, J.1    Jugold, M.2    Kiessling, F.3
  • 32
    • 59649117924 scopus 로고    scopus 로고
    • Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization [J]
    • Mazzone M, Dettori D, de Leite OR, et al. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization [J]. Cell, 2009, 136(5): 839-851.
    • (2009) Cell , vol.136 , Issue.5 , pp. 839-851
    • Mazzone, M.1    Dettori, D.2    de Leite, O.R.3
  • 33
    • 40449100456 scopus 로고    scopus 로고
    • Perivascular nitric oxide gradients normalize tumor vasculature [J]
    • Kashiwagi S, Tsukada K, Xu L, et al. Perivascular nitric oxide gradients normalize tumor vasculature [J]. Nat Med, 2008, 14(3): 255-257.
    • (2008) Nat Med , vol.14 , Issue.3 , pp. 255-257
    • Kashiwagi, S.1    Tsukada, K.2    Xu, L.3
  • 34
    • 43249125565 scopus 로고    scopus 로고
    • Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability [J]
    • Jones CA, London NR, Chen HY, et al. Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability [J]. Nat Med, 2008, 14(5): 585.
    • (2008) Nat Med , vol.14 , Issue.5 , pp. 585
    • Jones, C.A.1    London, N.R.2    Chen, H.Y.3
  • 35
    • 70350456094 scopus 로고    scopus 로고
    • Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculature [J]
    • Hedlund EM, Hosaka K, Zhong Z, et al. Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculature [J]. Proc Natl Acad Sci U S A, 2009, 106 (41): 17505-17510.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.41 , pp. 17505-17510
    • Hedlund, E.M.1    Hosaka, K.2    Zhong, Z.3
  • 36
    • 77449146694 scopus 로고    scopus 로고
    • Targeting a unique EGFR epitope with monoclonal antibody 806 activates NF-kappaB and initiates tumor vascular normalization [J]
    • Gan HK, Lappas M, Cao DX, et al. Targeting a unique EGFR epitope with monoclonal antibody 806 activates NF-kappaB and initiates tumor vascular normalization [J]. J Cell Mol Med, 2009.
    • (2009) J Cell Mol Med
    • Gan, H.K.1    Lappas, M.2    Cao, D.X.3
  • 37
    • 70449428715 scopus 로고    scopus 로고
    • Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models [J]
    • Maione F, Molla F, Meda C, et al. Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models [J]. J Clin Invest, 2009, 119(11): 3356-3372.
    • (2009) J Clin Invest , vol.119 , Issue.11 , pp. 3356-3372
    • Maione, F.1    Molla, F.2    Meda, C.3
  • 38
    • 73649112748 scopus 로고    scopus 로고
    • Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels [J]
    • Falcon BL, Hashizume H, Koumoutsakos P, et al. Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels [J]. Am J Pathol, 2009, 175(5): 2159-2170.
    • (2009) Am J Pathol , vol.175 , Issue.5 , pp. 2159-2170
    • Falcon, B.L.1    Hashizume, H.2    Koumoutsakos, P.3
  • 39
    • 65249183165 scopus 로고    scopus 로고
    • PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment [J]
    • di Tomaso E, London N, Fuja D, et al. PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment [J]. PLoS One, 2009, 4(4): e5123.
    • (2009) PLoS One , vol.4 , Issue.4
    • di Tomaso, E.1    London, N.2    Fuja, D.3


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