Endothelial functions: Translating theory into clinical application

Clinical Hemorheology and Microcirculation

Volumn 45, Issue 2-4, 2010, Pages 109-115

  Muxel, Selina ^a   Fasola, Federica ^a   Radmacher, Marie Christine ^a   Jabs, Alexander ^a   Münzel, Thomas ^a   Gori, Tommaso ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

coronary artery disease; Endothelium; flow mediated dilation; low flow mediated constriction

Indexed keywords

BLOOD FLOW; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; DIAGNOSTIC IMAGING; EARLY DIAGNOSIS; ENDOTHELIAL DYSFUNCTION; HOMEOSTASIS; HUMAN; PROGNOSIS; REVIEW; VASCULAR ENDOTHELIUM; VASOCONSTRICTION; VASODILATATION;

CARDIOVASCULAR DISEASES; ENDOTHELIUM, VASCULAR; HOMEOSTASIS; HUMANS; METHODS;

EID: 77957280740     PISSN: 13860291     EISSN: None     Source Type: Journal    
DOI: 10.3233/CH-2010-1288     Document Type: Review

References (55)

1. T.J. Anderson, A. Uehata, M.D. Gerhard, I.T. Meredith, S. Knab, D. Delagrange, E.H. Lieberman, P. Ganz, M.A. Creager and A.C. Yeung, Close relation of endothelial function in the human coronary and peripheral circulations, J Am Coll Cardiol 26 (1995), 1235-1241.
2. A.M. Artoli, A. Sequeira, A.S. Silva-Herdade and C. Saldanha, Localized hydrodynamics of clustering leukocytes, Clin Hemorheol Microcirc 39 (2008), 375-380. (Pubitemid 352040020)
3. P. Bogaty, D. Hackett, G. Davies and A. Maseri, Vasoreactivity of the culprit lesion in unstable angina, Circulation 90 (1994), 5-11. (Pubitemid 24203655)
4. P.O. Bonetti, L.O. Lerman and A. Lerman, Endothelial dysfunction: A marker of atherosclerotic risk, Arterioscler Thromb Vasc Biol 23 (2003), 168-175. (Pubitemid 36231924)
5. D.S. Celermajer, K.E. Sorensen, V.M. Gooch, D.J. Spiegelhalter, O.I. Miller, I.D. Sullivan, J.K. Lloyd and J.E. Deanfield, Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis, Lancet 340 (1992), 1111-1115.
6. A.T. Cheung, M.M. Tomic, P.C. Chen, E. Miguelino, C.S. Li and S. Devaraj, Correlation of microvascular abnormalities and endothelial dysfunction in Type-1 Diabetes Mellitus (T1DM): A real-time intravital microscopy study, Clin Hemorheol Microcirc 42 (2009), 285-295.
7. D.A. Cox, J.A. Vita, C.B. Treasure, R.D. Fish, R.W. Alexander, P. Ganz and A.P. Selwyn, Atherosclerosis impairs flowmediated dilation of coronary arteries in humans, Circulation 80 (1989), 458-465. (Pubitemid 19231379)
8. J. Deanfield, A. Donald, C. Ferri, C. Giannattasio, J. Halcox, S. Halligan, A. Lerman, G. Mancia, J.J. Oliver, A.C. Pessina, D. Rizzoni, G.P. Rossi, A. Salvetti, E.L. Schiffrin, S. Taddei and D.J. Webb, Endothelial function and dysfunction. Part I: Methodological issues for assessment in the different vascular beds: A statement by theWorking Group on Endothelin and Endothelial Factors of the European Society of Hypertension, J Hypertens 23 (2005), 7-17. (Pubitemid 40128972)
9. R. Fathi, B. Haluska, N. Isbel, L. Short and T.H. Marwick, The relative importance of vascular structure and function in predicting cardiovascular events, J Am Coll Cardiol 43 (2004), 616-623. (Pubitemid 38229534)
10. S. Fichtlscherer, G. Rosenberger, D.H.Walter, S. Breuer, S. Dimmeler and A.M. Zeiher, Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease, Circulation 102 (2000), 1000-1006. (Pubitemid 30657516)
11. M. Fineschi, T. Gori, C. Pierli and A. Bravi, Non-Q-wave myocardial infarction associated with three-vessel thrombosis, J Cardiovasc Med (Hagerstown) 8 (2007), 457-458. (Pubitemid 46763377)
12. S. Forconi and T. Gori, The evolution of the meaning of blood hyperviscosity in cardiovascular physiopathology: Should we reinterpret Poiseuille? Clin Hemorheol Microcirc 42 (2009), 1-6.
13. M. Frick, A. Suessenbacher, H.F. Alber,W. Dichtl, H. Ulmer, O. Pachinger and F.Weidinger, Prognostic value of brachial artery endothelial function and wall thickness, J Am Coll Cardiol 46 (2005), 1006-1010. (Pubitemid 41316507)
14. N. Gokce, J.F. Keaney Jr., L.M. Hunter, M.T. Watkins, Z.S. Nedeljkovic, J.O. Menzoian and J.A. Vita, Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease, J Am Coll Cardiol 41 (2003), 1769-1775. (Pubitemid 36584251)
15. T. Gori, G. Di Stolfo, S. Sicuro, S. Dragoni, M. Lisi, J.D. Parker and S. Forconi, Correlation analysis between different parameters of conduit artery and microvascular vasodilation, Clin Hemorheol Microcirc 35 (2006), 509-515. (Pubitemid 44812464)
16. T. Gori, S. Dragoni, M. Lisi, G. Di Stolfo, S. Sonnati, M. Fineschi and J.D. Parker, Conduit artery constriction mediated by low flow a novel noninvasive method for the assessment of vascular function, J Am Coll Cardiol 51 (2008), 1953-1958. (Pubitemid 351636451)
17. S. Grotti and T. Gori, Endothelium, ischemia and the good side of oxygen free radicals, Clin Hemorheol Microcirc 39 (2008), 197-203. (Pubitemid 352039997)
18. T. Gori, S. Grotti, S. Dragoni, M. Lisi, S. Sonnati, M. Fineschi, G. Di Stolfo and J.D. Parker, Vascular function assessment: Flow-mediated constriction complements the information of flow-mediated dilation, Heart 96(2) (2010), 141-147.
19. J.P. Halcox,W.H. Schenke, G. Zalos, R. Mincemoyer,A. Prasad, M.A.Waclawiw, K.R. Nour and A.A. Quyyumi, Prognostic value of coronary vascular endothelial dysfunction, Circulation 106 (2002), 653-658. (Pubitemid 34851922)
20. M. Hashimoto, K.Kozaki, M. Eto, M. Akishita, J. Ako, K. Iijima, S. Kim, K. Toba, M.Yoshizumi andY. Ouchi, Association of coronary risk factors and endothelium-dependent flow-mediated dilatation of the brachial artery, Hypertens Res 23 (2000), 233-238. (Pubitemid 30326252)
21. T. Heitzer, T. Schlinzig, K. Krohn, T. Meinertz and T. Munzel, Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease, Circulation 104 (2001), 2673-2678. (Pubitemid 33108132)
22. Z. Jambrik, L. Venneri, A. Varga, F. Rigo, A. Borges and E. Picano, Peripheral vascular endothelial function testing for the diagnosis of coronary artery disease, Am Heart J 148 (2004), 684-689. (Pubitemid 39349389)
23. B. Kaku, S. Mizuno, K. Ohsato, T. Murakami, I. Moriuchi, Y. Arai, Y. Nio, H. Hirase, M. Nagata, Y. Takahashi and M. Ohnaka, The correlation between coronary stenosis index and flow-mediated dilation of the brachial artery, Jpn Circ J 62 (1998), 425-430. (Pubitemid 28257460)
24. J.T.Kuvin, A.R. Patel, K.A. Sliney, N.G. Pandian,W.M. Rand, J.E. Udelson and R.H. Karas, Peripheral vascular endothelial function testing as a noninvasive indicator of coronary artery disease, J Am Coll Cardiol 38 (2001), 1843-1849.
25. S. Lavi, J.H. Bae, C.S. Rihal, A. Prasad, G.W. Barsness, R.J. Lennon, D.R. Holmes Jr. and A. Lerman, Segmental coronary endothelial dysfunction in patients with minimal atherosclerosis is associated with necrotic core plaques, Heart 95(18) (2009), 1525-1530.
26. B.K. Lee, A. Durairaj, A. Mehra, R.B. Wenby, H.J. Meiselman and T. Alexy, Hemorheological abnormalities in stable angina and acute coronary syndromes, Clin Hemorheol Microcirc 39 (2008), 43-51. (Pubitemid 352039980)
27. M.C. Leone, T. Gori and M. Fineschi, The coronary slow flow phenomenon: A new cardiac "Y" syndrome? Clin Hemorheol Microcirc 39 (2008), 185-190. (Pubitemid 352039994)
28. A. Lerman and A.M. Zeiher, Endothelial function: Cardiac events, Circulation 111 (2005), 363-368. (Pubitemid 40165345)
29. K. Matschke and F. Jung, Regulation of the myocardial microcirculation, Clin Hemorheol Microcirc 39 (2008) 265-279. (Pubitemid 352040008)
30. Y. Matsushima, B. Takase, A. Uehata, H. Kawano, K. Yano, F. Ohsuzu, M. Ishihara and A. Kurita, Comparative predictive and diagnostic value of flow-mediated vasodilation in the brachial artery and intima media thickness of the carotid artery for assessment of coronary artery disease severity, Int J Cardiol 117 (2007), 165-172. (Pubitemid 46452757)
31. M. Naghavi, P. Libby, E. Falk, S.W. Casscells, S. Litovsky, J. Rumberger, J.J. Badimon, C. Stefanadis, P. Moreno, G. Pasterkamp, Z. Fayad, P.H. Stone, S. Waxman, P. Raggi, M. Madjid, A. Zarrabi, A. Burke, C. Yuan, P.J. Fitzgerald, D.S. Siscovick, C.L. de Korte, M. Aikawa, K.E. Juhani Airaksinen, G. Assmann, C.R. Becker, J.H. Chesebro, A. Farb, Z.S. Galis, C. Jackson, I.K. Jang,W. Koenig, R.A. Lodder, K. March, J. Demirovic, M. Navab, S.G. Priori, M.D. Rekhter, R. Bahr, S.M. Grundy, R. Mehran, A. Colombo, E. Boerwinkle, C. Ballantyne, W. Insull Jr., R.S. Schwartz, R. Vogel, P.W. Serruys, G.K. Hansson, D.P. Faxon, S. Kaul, H. Drexler, P. Greenland, J.E. Muller,R.Virmani, P.M. Ridker, D.P. Zipes, P.K. Shah and J.T. Willerson, From vulnerable plaque to vulnerable patient: A call for new definitions and risk assessment strategies: Part I, Circulation 108 (2003), 1664-1672. (Pubitemid 37243650)
32. G.B. Nash, T. Watts, C. Thornton and M. Barigou, Red cell aggregation as a factor influencing margination and adhesion of leukocytes and platelets, Clin Hemorheol Microcirc 39 (2008), 303-310. (Pubitemid 352040024)
33. T. Neunteufl, R. Katzenschlager, A. Hassan, U. Klaar, S. Schwarzacher, D. Glogar, P. Bauer and F. Weidinger, Systemic endothelial dysfunction is related to the extent and severity of coronary artery disease, Atherosclerosis 129 (1997), 111-118. (Pubitemid 27104258)
34. G.I. Papaioannou, C. Kasapis, R.L. Seip, N.J. Grey, D. Katten, F.J.Wackers, S.E. Inzucchi, S. Engel, A. Taylor, L.H.Young, D.A. Chyun, J.A. Davey, A.E. Iskandrian, R.E. Ratner, E.C. Robinson, S. Carolan and G.V. Heller, Value of peripheral vascular endothelial function in the detection of relative myocardial ischemia in asymptomatic type 2 diabetic patients who underwent myocardial perfusion imaging, J Nucl Cardiol 13 (2006), 362-368. (Pubitemid 43792987)
35. P. Perrone-Filardi, A. Cuocolo, G. Brevetti, A. Silvestro, G. Storto, S. Dellegrottaglie, L. Corrado, M. Cafiero, R. Camerino, M. Polimeno, A. Zarrilli, G. Caiazzo, A. Maglione, A. Petretta and M. Chiariello, Relation of brachial artery flow-mediated vasodilation to significant coronary artery disease in patients with peripheral arterial disease, Am J Cardiol 96 (2005), 1337-1341. (Pubitemid 41505421)
36. F. Perticone, R. Ceravolo, A. Pujia, G. Ventura, S. Iacopino, A. Scozzafava, A. Ferraro, M. Chello, P. Mastroroberto, P. Verdecchia and G. Schillaci, Prognostic significance of endothelial dysfunction in hypertensive patients, Circulation 104 (2001), 191-196. (Pubitemid 32655837)
37. A. Prasad, J. Zhu, J.P. Halcox, M.A. Waclawiw, S.E. Epstein and A.A. Quyyumi, Predisposition to atherosclerosis by infections: Role of endothelial dysfunction, Circulation 106 (2002), 184-190. (Pubitemid 34761297)
38. W.J. Proudfit, A.V. Bruschke, J.P. MacMillan, G.W. Williams and F.M. Sones Jr., Fifteen year survival study of patients with obstructive coronary artery disease, Circulation 68 (1983), 986-997. (Pubitemid 14238475)
39. M. Rossi, A. Carpi, C. Di Maria, F. Galetta and G. Santoro, Spectral analysis of laser Doppler skin blood flow oscillations in human essential arterial hypertension, Microvasc Res 72 (2006), 34-41. (Pubitemid 44118389)
40. M. Rossi, C. Di Maria, P. Erba, F. Galetta, A. Carpi and G. Santoro, Study of skin vasomotion during phollicular and luteal phase in young healthy women, Clin Hemorheol Microcirc 42 (2009), 107-115.
41. J.W. Rush and R.J. Ford, Nitric oxide, oxidative stress and vascular endothelium in health and hypertension, Clin Hemorheol Microcirc 37 (2007), 185-192. (Pubitemid 47015824)
42. V. Schachinger, M.B. Britten and A.M. Zeiher, Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease, Circulation 101 (2000), 1899-1906. (Pubitemid 30225269)
43. S. Schroeder, M.D. Enderle, R. Ossen, C. Meisner, A. Baumbach, M. Pfohl, C. Herdeg, M. Oberhoff, H.U. Haering and K.R. Karsch, Noninvasive determination of endothelium-mediated vasodilation as a screening test for coronary artery disease: Pilot study to assess the predictive value in comparison with angina pectoris, exercise electrocardiography, and myocardial perfusion imaging, Am Heart J 138 (1999), 731-739. (Pubitemid 29471049)
44. A.P. Selwyn, S. Kinlay, M. Creager, P. Libby and P. Ganz, Cell dysfunction in atherosclerosis and the ischemic manifestations of coronary artery disease, Am J Cardiol 79 (1997), 17-23. (Pubitemid 27157075)
45. K.E. Sorensen, D.S. Celermajer, D. Georgakopoulos, G. Hatcher, D.J. Betteridge and J.E. Deanfield, Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein(a) level, J Clin Invest 93 (1994), 50-55. (Pubitemid 24030819)
46. H.O. Steinberg, H. Chaker, R. Leaming, A. Johnson, G. Brechtel and A.D. Baron, Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance, J Clin Invest 97 (1996), 2601-2610. (Pubitemid 26187348)
47. B. Takase, A. Hamabe, K. Satomura, T. Akima, A. Uehata, T. Matsui, F. Ohsuzu, M. Ishihara and A. Kurita, Comparable prognostic value of vasodilator response to acetylcholine in brachial and coronary arteries for predicting long-term cardiovascular events in suspected coronary artery disease, Circ J 70 (2006), 49-56. (Pubitemid 43021234)
48. H. Teragawa, M. Kato, J. Kurokawa, T. Yamagata, H. Matsuura and K. Chayama, Usefulness of flow-mediated dilation of the brachial artery and/or the intima-media thickness of the carotid artery in predicting coronary narrowing in patients suspected of having coronary artery disease, Am J Cardiol 88 (2001), 1147-1151. (Pubitemid 33043848)
49. H. Teragawa, K. Ueda, K. Matsuda, M. Kimura, Y. Higashi, T. Oshima, M. Yoshizumi and K. Chayama, Relationship between endothelial function in the coronary and brachial arteries, Clin Cardiol 28 (2005), 460-466. (Pubitemid 41434272)
50. L. Venneri, E. Poggianti, Z. Jambrik, A. Varga, A. Palinkas and E. Picano, The elusive prognostic value of systemic endothelial function in patients with chest pain syndrome, Int J Cardiol 119 (2007), 109-111. (Pubitemid 46818479)
51. S. Verma and T.J. Anderson, Fundamentals of endothelial function for the clinical cardiologist, Circulation 105 (2002), 546-549. (Pubitemid 34123425)
52. D.R. Witte, J. Westerink, E.J. de Koning, G.Y. van der, D.E. Grobbee and M.L. Bots, Is the association between flowmediated dilation and cardiovascular risk limited to low-risk populations? J Am Coll Cardiol 45 (2005), 1987-1993. (Pubitemid 40814119)
53. J. Yeboah, J.R. Crouse, F.C. Hsu, G.L. Burke and D.M. Herrington, Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: The Cardiovascular Health Study, Circulation 115 (2007), 2390-2397. (Pubitemid 46717961)
54. G.B. Yvonne-Tee, A.H. Rasool, A.S. Halim, A.R.Wong and A.R. Rahman, Method optimization on the use of postocclusive hyperemia model to assess microvascular function, Clin Hemorheol Microcirc 38 (2008), 119-133.
55. X. Zhang, S.P. Zhao, X.P. Li, M. Gao and Q.C. Zhou, Endothelium-dependent and -independent functions are impaired in patients with coronary heart disease, Atherosclerosis 149 (2000), 19-24. (Pubitemid 30125967)