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Volumn 27, Issue 12, 2013, Pages 1149-1159

The role of 5-HT1A receptors in the anti-aversive effects of cannabidiol on panic attack-like behaviors evoked in the presence of the wild snake Epicrates cenchria crassus (Reptilia, Boidae)

Author keywords

5 HT1A receptors; Cannabidiol; panic attacks; prey versus predator paradigm; serotonin

Indexed keywords

CANNABIDIOL; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A RECEPTOR; ANXIOLYTIC AGENT; N-(2-(4-(2-METHOXYPHENYL)-1-PIPERAZINYL)ETHYL)-N-(2-PYRIDINYL)CYCLOHEXANECARBOXAMIDE; PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; SEROTONIN ANTAGONIST;

EID: 84887829916     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881113493363     Document Type: Article
Times cited : (55)

References (56)
  • 1
    • 84873398890 scopus 로고    scopus 로고
    • Serotonergic neural links from the dorsal raphe nucleus modulate defensive behaviours organised by the dorsomedial hypothalamus and the elaboration of fear-induced antinociception via locus coeruleus pathways
    • Biagioni AF, de Freitas RL, da Silva LA, et al. Serotonergic neural links from the dorsal raphe nucleus modulate defensive behaviours organised by the dorsomedial hypothalamus and the elaboration of fear-induced antinociception via locus coeruleus pathways. Neuropharmacology. 2013 ; 67: 379-394
    • (2013) Neuropharmacology , vol.67 , pp. 379-394
    • Biagioni, A.F.1    De Freitas, R.L.2    Da Silva, L.A.3
  • 2
    • 84859622504 scopus 로고    scopus 로고
    • Panic-like defensive behavior but not fear-induced antinociception is differently organized by dorsomedial and posterior hypothalamic nuclei of Rattus norvegicus (Rodentia, Muridae)
    • Biagioni AF, Silva JA, Coimbra NC. Panic-like defensive behavior but not fear-induced antinociception is differently organized by dorsomedial and posterior hypothalamic nuclei of Rattus norvegicus (Rodentia, Muridae). Braz J Med Biol Res. 2012 ; 45: 328-336
    • (2012) Braz J Med Biol Res , vol.45 , pp. 328-336
    • Biagioni, A.F.1    Silva, J.A.2    Coimbra, N.C.3
  • 3
    • 0034751335 scopus 로고    scopus 로고
    • Molecular targets for cannabidiol and its synthetic analogues: Effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
    • Bisogno T, Hanus L, de Petrocellis L, et al. Molecular targets for cannabidiol and its synthetic analogues: Effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol. 2001 ; 134: 845-852
    • (2001) Br J Pharmacol , vol.134 , pp. 845-852
    • Bisogno, T.1    Hanus, L.2    De Petrocellis, L.3
  • 5
    • 0023800192 scopus 로고
    • Ethoexperimental approaches to the biology of emotion
    • Blanchard DC, Blanchard RJ. Ethoexperimental approaches to the biology of emotion. Annu Rev Psychol. 1988 ; 39: 43-68
    • (1988) Annu Rev Psychol , vol.39 , pp. 43-68
    • Blanchard, D.C.1    Blanchard, R.J.2
  • 6
    • 0034989828 scopus 로고    scopus 로고
    • Mouse defensive behaviors: Pharmacological and behavioral assays for anxiety and panic
    • Blanchard DC, Griebel G, Blanchard RJ. Mouse defensive behaviors: Pharmacological and behavioral assays for anxiety and panic. Neurosci Biobehav Rev. 2001 ; 25: 205-218
    • (2001) Neurosci Biobehav Rev , vol.25 , pp. 205-218
    • Blanchard, D.C.1    Griebel, G.2    Blanchard, R.J.3
  • 7
    • 0344196835 scopus 로고    scopus 로고
    • Conditioning and residual emotionality effects of predator stimuli: Some reflections on stress and emotion
    • Blanchard DC, Griebel G, Blanchard RJ. Conditioning and residual emotionality effects of predator stimuli: Some reflections on stress and emotion. Prog Neuropsychopharmacol Biol Psychiatry. 2003 ; 27: 1177-1185
    • (2003) Prog Neuropsychopharmacol Biol Psychiatry , vol.27 , pp. 1177-1185
    • Blanchard, D.C.1    Griebel, G.2    Blanchard, R.J.3
  • 8
    • 0030734332 scopus 로고    scopus 로고
    • Differentiation of anxiolytic and panicolytic drugs by effects on rat and mouse defense test batteries
    • Blanchard RJ, Griebel G, Henrie JA, et al. Differentiation of anxiolytic and panicolytic drugs by effects on rat and mouse defense test batteries. Neurosci Biobehav Rev. 1997 ; 21: 783-789
    • (1997) Neurosci Biobehav Rev , vol.21 , pp. 783-789
    • Blanchard, R.J.1    Griebel, G.2    Henrie, J.A.3
  • 9
    • 0031746421 scopus 로고    scopus 로고
    • Benzodiazepine and serotonergic modulation of antipredator and conspecific defense
    • Blanchard DC, Griegel G, Rodgers RJ, et al. Benzodiazepine and serotonergic modulation of antipredator and conspecific defense. Neurosci Biobehav Rev. 1998 ; 22: 597-612
    • (1998) Neurosci Biobehav Rev , vol.22 , pp. 597-612
    • Blanchard, D.C.1    Griegel, G.2    Rodgers, R.J.3
  • 10
    • 46649094780 scopus 로고    scopus 로고
    • Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats
    • Campos AC, Guimarães FS. Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats. Psychopharmacology. 2008 ; 199: 223-230
    • (2008) Psychopharmacology , vol.199 , pp. 223-230
    • Campos, A.C.1    Guimarães, F.S.2
  • 11
    • 0015656165 scopus 로고
    • Letter: Cannabidiol and Cannabis sativa extract protect mice and rats against convulsive agents
    • Carlini EA, Leite JR, Tannhauser M, et al. Letter: Cannabidiol and Cannabis sativa extract protect mice and rats against convulsive agents. J Pharm Pharmacol. 1973 ; 25: 664-665
    • (1973) J Pharm Pharmacol , vol.25 , pp. 664-665
    • Carlini, E.A.1    Leite, J.R.2    Tannhauser, M.3
  • 12
    • 33646734889 scopus 로고    scopus 로고
    • Inhibition of an equilibrative nucleoside transporter by cannabidiol: A mechanism of cannabinoid immunosuppression
    • Carrier EJ, Auchampach JA, Hillard CJ. Inhibition of an equilibrative nucleoside transporter by cannabidiol: A mechanism of cannabinoid immunosuppression. Proc Natl Acad Sci USA. 2006 ; 103: 7895-7900
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 7895-7900
    • Carrier, E.J.1    Auchampach, J.A.2    Hillard, C.J.3
  • 13
  • 15
    • 84862321576 scopus 로고    scopus 로고
    • Rostral ventromedial medulla modulates nociception and tonic immobility behavior through connections with the A7 catecholaminergic region
    • Da Silva LF, Coimbra NC, Menescal-de-Oliveira L. Rostral ventromedial medulla modulates nociception and tonic immobility behavior through connections with the A7 catecholaminergic region. Behav Brain Res. 2012 ; 233: 422-427
    • (2012) Behav Brain Res , vol.233 , pp. 422-427
    • Da Silva, L.F.1    Coimbra, N.C.2    Menescal-De-Oliveira, L.3
  • 16
    • 84873259613 scopus 로고    scopus 로고
    • Rostral ventromedial medulla connections in Cavia porcellus and their relation with tonic immobility defensive behavior: A biotinylated dextran amine neurotracing study
    • Da Silva LF, Coimbra NC, Menescal-de-Oliveira L. Rostral ventromedial medulla connections in Cavia porcellus and their relation with tonic immobility defensive behavior: A biotinylated dextran amine neurotracing study. Neurosci Lett. 2013a ; 535: 116-121
    • (2013) Neurosci Lett , vol.535 , pp. 116-121
    • Da Silva, L.F.1    Coimbra, N.C.2    Menescal-De-Oliveira, L.3
  • 17
    • 84871926375 scopus 로고    scopus 로고
    • Chemical neuroanatomical and psychopharmacological evidence that κ receptor-mediated endogenous opioid peptide neurotransmission in the dorsal and ventral mesencephalon modulates panic-like behaviour
    • Da Silva LA, de Freitas RL, Eichenberger GCD, et al. Chemical neuroanatomical and psychopharmacological evidence that κ receptor-mediated endogenous opioid peptide neurotransmission in the dorsal and ventral mesencephalon modulates panic-like behaviour. Eur J Pharmacol. 2013b ; 698: 235-245
    • (2013) Eur J Pharmacol , vol.698 , pp. 235-245
    • Da Silva, L.A.1    De Freitas, R.L.2    Gcd, E.3
  • 19
    • 85067757315 scopus 로고    scopus 로고
    • NMDA and AMPA/Kainate glutamatergic receptors in the prelimbic medial prefrontal cortex modulate the elaborated defensive behavior and innate fear-induced antinociception elicited by GABAA receptor blockade in the medial hypothalamus
    • De Freitas RL, Salgado-Rohner CJ, Biagioni AF, et al. NMDA and AMPA/Kainate glutamatergic receptors in the prelimbic medial prefrontal cortex modulate the elaborated defensive behavior and innate fear-induced antinociception elicited by GABAA receptor blockade in the medial hypothalamus. Cereb Cortex. 2013a ;:
    • (2013) Cereb Cortex
    • De Freitas, R.L.1    Salgado-Rohner, C.J.2    Biagioni, A.F.3
  • 20
    • 84883032895 scopus 로고    scopus 로고
    • Involvement of medial prefrontal cortex on panic-like elaborated defensive behavior and innate fear-induced antinociception elicited by GABAA receptor blockade in the medial hypothalamus: Role of the endocannabinoid CB1 receptor
    • De Freitas RL, Salgado-Rohner CJ, Hallak JEC, et al. Involvement of medial prefrontal cortex on panic-like elaborated defensive behavior and innate fear-induced antinociception elicited by GABAA receptor blockade in the medial hypothalamus: Role of the endocannabinoid CB1 receptor. Int J Neuropsychopharmacol. 2013b ; 16: 1781-1798
    • (2013) Int J Neuropsychopharmacol , vol.16 , pp. 1781-1798
    • De Freitas, R.L.1    Salgado-Rohner, C.J.2    Jec, H.3
  • 21
    • 79955632246 scopus 로고    scopus 로고
    • Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes
    • Di Marzo V, Piscitelli F, Mechoulam R. Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes. Handb Exp Pharmacol. 2011 ; 203: 75-104
    • (2011) Handb Exp Pharmacol , vol.203 , pp. 75-104
    • Di Marzo, V.1    Piscitelli, F.2    Mechoulam, R.3
  • 22
    • 0036144294 scopus 로고    scopus 로고
    • Neuroanatomical and psychopharmacological evidence for interaction between opioid and GABAergic neural pathways in the modulation of fear and defense elicited by electrical and chemical stimulation of the deep layers of the superior colliculus and dorsal periaqueductal gray matter
    • Eichenberger GCD, Ribeiro SJ, Osaki MY, et al. Neuroanatomical and psychopharmacological evidence for interaction between opioid and GABAergic neural pathways in the modulation of fear and defense elicited by electrical and chemical stimulation of the deep layers of the superior colliculus and dorsal periaqueductal gray matter. Neuropharmacology. 2002 ; 42: 48-59
    • (2002) Neuropharmacology , vol.42 , pp. 48-59
    • Gcd, E.1    Ribeiro, S.J.2    Osaki, M.Y.3
  • 23
    • 58149520644 scopus 로고    scopus 로고
    • Distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing
    • Fusar-Poli P, Crippa JA, Bhattacharyya S, et al. Distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing. Arch Gen Psychiatry. 2009 ; 66: 95-105
    • (2009) Arch Gen Psychiatry , vol.66 , pp. 95-105
    • Fusar-Poli, P.1    Crippa, J.A.2    Bhattacharyya, S.3
  • 24
    • 0034066256 scopus 로고    scopus 로고
    • Neuroanatomical hypothesis of panic disorder, revised
    • Gorman JM, Kent JM, Sullivan GM, et al. Neuroanatomical hypothesis of panic disorder, revised. Am J Psychiatry. 2000 ; 157: 493-505
    • (2000) Am J Psychiatry , vol.157 , pp. 493-505
    • Gorman, J.M.1    Kent, J.M.2    Sullivan, G.M.3
  • 25
    • 0000720482 scopus 로고
    • Burrows GD Roth M Noyes R, ed. Amsterdam: Elsevier Science Publishers;
    • Graeff FG Handbook of Anxiety: The Neurobiology of Anxiety. Burrows GD Roth M Noyes R, ed. Amsterdam: Elsevier Science Publishers ; 1990: 307-354.
    • (1990) Handbook of Anxiety: The Neurobiology of Anxiety , pp. 307-354
    • Graeff, F.G.1
  • 26
    • 0028415869 scopus 로고
    • Neuroanatomy and neurotransmitter regulation of defensive behaviors and related emotions in mammals
    • Graeff FG. Neuroanatomy and neurotransmitter regulation of defensive behaviors and related emotions in mammals. Braz J Med Biol Res. 1994 ; 27: 811-829
    • (1994) Braz J Med Biol Res , vol.27 , pp. 811-829
    • Graeff, F.G.1
  • 28
    • 0029999103 scopus 로고    scopus 로고
    • Predator-elicited flight responses in Swiss-Webster mice: An experimental model of panic attacks
    • Griebel G, Blanchard DC, Blanchard RJ. Predator-elicited flight responses in Swiss-Webster mice: An experimental model of panic attacks. Prog Neuro-Psychopharmacol Biol Psychiatry. 1996 ; 20: 185-205
    • (1996) Prog Neuro-Psychopharmacol Biol Psychiatry , vol.20 , pp. 185-205
    • Griebel, G.1    Blanchard, D.C.2    Blanchard, R.J.3
  • 30
    • 34447523544 scopus 로고    scopus 로고
    • Innate defensive behavior and panic-like reactions evoked by rodents during aggressive encounters with Brazilian constrictor snakes in a complex labyrinth: Behavioural validation of a new model to study affective and agonistic reactions in a prey versus predator paradigm
    • Guimarães-Costa R, Guimarães-Costa MB, Pippa-Gadioli L, et al. Innate defensive behavior and panic-like reactions evoked by rodents during aggressive encounters with Brazilian constrictor snakes in a complex labyrinth: Behavioural validation of a new model to study affective and agonistic reactions in a prey versus predator paradigm. J Neurosci Meth. 2007 ; 165: 25-37
    • (2007) J Neurosci Meth , vol.165 , pp. 25-37
    • Guimarães-Costa, R.1    Guimarães-Costa, M.B.2    Pippa-Gadioli, L.3
  • 31
    • 1642565250 scopus 로고    scopus 로고
    • Development of defensive behavior and conditioning to cat odor in the rat
    • Hubbard DT, Blanchard DC, Yang M, et al. Development of defensive behavior and conditioning to cat odor in the rat. Physiol Behav. 2004 ; 80: 525-530
    • (2004) Physiol Behav , vol.80 , pp. 525-530
    • Hubbard, D.T.1    Blanchard, D.C.2    Yang, M.3
  • 32
    • 0002844255 scopus 로고
    • LeDoux JE Hirst W, ed. New York: Cambridge University Press;
    • LeDoux JE Mind and Brain. LeDoux JE Hirst W, ed. New York: Cambridge University Press ; 1986: 301-354.
    • (1986) Mind and Brain , pp. 301-354
    • Ledoux, J.E.1
  • 33
    • 50549104610 scopus 로고    scopus 로고
    • Cellular prion protein modulates defensive attention and innate fear-induced behaviour evoked in transgenic mice submitted to an agonistic encounter with the tropical coral snake
    • Lobão-Soares B, Walz R, Prediger RDS, et al. Cellular prion protein modulates defensive attention and innate fear-induced behaviour evoked in transgenic mice submitted to an agonistic encounter with the tropical coral snake. Oxyrhopus guibei. Behav Brain Res. 2008 ; 194: 129-137
    • (2008) Oxyrhopus Guibei. Behav Brain Res , vol.194 , pp. 129-137
    • Lobão-Soares, B.1    Walz, R.2    Rds, P.3
  • 34
    • 84864467149 scopus 로고    scopus 로고
    • Periaqueductal gray matter modulates the hypercapnic ventilatory response
    • Lopes LT, Patrone LG, Bícego KC, et al. Periaqueductal gray matter modulates the hypercapnic ventilatory response. Pflügers Arch-Eur J Physiol. 2012 ; 464: 155-166
    • (2012) Pflügers Arch-Eur J Physiol , vol.464 , pp. 155-166
    • Lopes, L.T.1    Patrone, L.G.2    Bícego, K.C.3
  • 35
    • 60149109047 scopus 로고    scopus 로고
    • Activation of CB1 cannabinoid receptors impairs memory consolidation and hippocampal polysialylated neural cell adhesion molecule expression in contextual fear conditioning
    • Mackowiak M, Chocyk A, Dudys D, et al. Activation of CB1 cannabinoid receptors impairs memory consolidation and hippocampal polysialylated neural cell adhesion molecule expression in contextual fear conditioning. Neuroscience. 2009 ; 158: 1708-1716
    • (2009) Neuroscience , vol.158 , pp. 1708-1716
    • MacKowiak, M.1    Chocyk, A.2    Dudys, D.3
  • 36
    • 0034662868 scopus 로고    scopus 로고
    • The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
    • Malfait AM, Gallily R, Sumariwalla PF, et al. The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc Natl Acad Sci USA. 2000 ; 97: 9561-9566
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 9561-9566
    • Malfait, A.M.1    Gallily, R.2    Sumariwalla, P.F.3
  • 37
    • 61849162748 scopus 로고    scopus 로고
    • Functional role of the endocannabinoid system in emotional homeostasis
    • Marco EM, Viveros MP. Functional role of the endocannabinoid system in emotional homeostasis. Rev Neurol. 2009 ; 48: 20-26
    • (2009) Rev Neurol , vol.48 , pp. 20-26
    • Marco, E.M.1    Viveros, M.P.2
  • 38
    • 3042590043 scopus 로고    scopus 로고
    • A two-dimensional neuropsychology of defense: Fear/anxiety and defensive distance
    • McNaughton N, Corr PJ. A two-dimensional neuropsychology of defense: Fear/anxiety and defensive distance. Neurosci Biobehav Rev. 2004 ; 28: 285-305
    • (2004) Neurosci Biobehav Rev , vol.28 , pp. 285-305
    • McNaughton, N.1    Corr, P.J.2
  • 39
    • 0037207079 scopus 로고    scopus 로고
    • Cannabidiol: An overview of some pharmacological aspects
    • Mechoulam R, Parker LA, Gallily R. Cannabidiol: An overview of some pharmacological aspects. Chem Phys Lipids. 2002 ; 121: 35-43
    • (2002) Chem Phys Lipids , vol.121 , pp. 35-43
    • Mechoulam, R.1    Parker, L.A.2    Gallily, R.3
  • 40
    • 18244396915 scopus 로고    scopus 로고
    • Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism
    • Mishima K, Hayakawa K, Abe K, et al. Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism. Stroke. 2005 ; 36: 1077-1082
    • (2005) Stroke , vol.36 , pp. 1077-1082
    • Mishima, K.1    Hayakawa, K.2    Abe, K.3
  • 41
    • 34548293775 scopus 로고    scopus 로고
    • When fear is near: Threat imminence elicits prefrontal-periaqueductal gray shifts in humans
    • Mobbs D, Petrovic P, Marchant JL, et al. When fear is near: Threat imminence elicits prefrontal-periaqueductal gray shifts in humans. Science. 2007 ; 314: 1079-1083
    • (2007) Science , vol.314 , pp. 1079-1083
    • Mobbs, D.1    Petrovic, P.2    Marchant, J.L.3
  • 42
    • 61649089261 scopus 로고    scopus 로고
    • Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: Focus on anxiety and depression
    • Moreira FA, Grieb M, Lutz B. Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: Focus on anxiety and depression. Best Pract Res Clin Endocrinol Metab. 2009 ; 23: 133-144
    • (2009) Best Pract Res Clin Endocrinol Metab , vol.23 , pp. 133-144
    • Moreira, F.A.1    Grieb, M.2    Lutz, B.3
  • 43
    • 63849121078 scopus 로고    scopus 로고
    • Dissecting the brain's fear system reveals the hypothalamus is critical for responding in subordinate conspecific intruders
    • Motta SC, Goto M, Gouveia FV, et al. Dissecting the brain's fear system reveals the hypothalamus is critical for responding in subordinate conspecific intruders. Proc Natl Acad Sci USA. 2009 ; 106: 4870-4875
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 4870-4875
    • Motta, S.C.1    Goto, M.2    Gouveia, F.V.3
  • 44
    • 0029164519 scopus 로고
    • Role of 5-HT receptor subtypes in the modulation of dorsal periaqueductal gray generated aversion
    • Nogueira RL, Graeff FG. Role of 5-HT receptor subtypes in the modulation of dorsal periaqueductal gray generated aversion. Pharmacol Biochem Behav. 1995 ; 52: 1-6
    • (1995) Pharmacol Biochem Behav , vol.52 , pp. 1-6
    • Nogueira, R.L.1    Graeff, F.G.2
  • 45
    • 65549106424 scopus 로고    scopus 로고
    • 5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats
    • Resstel LB, Tavares RF, Lisboa SF, et al. 5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats. Br J Pharmacol. 2009 ; 156: 181-188
    • (2009) Br J Pharmacol , vol.156 , pp. 181-188
    • Resstel, L.B.1    Tavares, R.F.2    Lisboa, S.F.3
  • 46
    • 77950834228 scopus 로고    scopus 로고
    • Potential antipsychotic properties of central cannabinoid (CB(1)) receptor antagonists
    • Roser P, Vollenweider FX, Kawohl W. Potential antipsychotic properties of central cannabinoid (CB(1)) receptor antagonists. World J Biol Psychiatry. 2008 ; 11: 208-219
    • (2008) World J Biol Psychiatry , vol.11 , pp. 208-219
    • Roser, P.1    Vollenweider, F.X.2    Kawohl, W.3
  • 47
    • 27644440716 scopus 로고    scopus 로고
    • Agonistic properties of cannabidiol at 5-HT1A receptors
    • Russo EB, Burnett A, Hall B, et al. Agonistic properties of cannabidiol at 5-HT1A receptors. Neurochem Res. 2005 ; 30: 1037-1043
    • (2005) Neurochem Res , vol.30 , pp. 1037-1043
    • Russo, E.B.1    Burnett, A.2    Hall, B.3
  • 48
    • 0033976134 scopus 로고    scopus 로고
    • Acute and chronic effects of gepirone and fluoxetine in rats tested in the elevated plus-maze: An ethological analysis
    • Silva RC, Brandão ML. Acute and chronic effects of gepirone and fluoxetine in rats tested in the elevated plus-maze: An ethological analysis. Pharmacol Biochem Behav. 2000 ; 65: 209-216
    • (2000) Pharmacol Biochem Behav , vol.65 , pp. 209-216
    • Silva, R.C.1    Brandão, M.L.2
  • 49
    • 77953917373 scopus 로고    scopus 로고
    • Intra-dorsal periaqueductal gray administration of cannabidiol blocks panic-like response by activating 5-HT1A receptors
    • Soares VP, Campos AC, Bortoli VC, et al. Intra-dorsal periaqueductal gray administration of cannabidiol blocks panic-like response by activating 5-HT1A receptors. Behav Brain Res. 2010 ; 213: 225-229
    • (2010) Behav Brain Res , vol.213 , pp. 225-229
    • Soares, V.P.1    Campos, A.C.2    Bortoli, V.C.3
  • 50
    • 84869885389 scopus 로고    scopus 로고
    • Differential involvement of dorsal raphe subnuclei in the regulation of anxiety- and panic-related defensive behaviors
    • Spiacci A, Coimbra NC, Zangrossi A. Differential involvement of dorsal raphe subnuclei in the regulation of anxiety- and panic-related defensive behaviors. Neuroscience. 2012 ; 227: 350-360
    • (2012) Neuroscience , vol.227 , pp. 350-360
    • Spiacci, A.1    Coimbra, N.C.2    Zangrossi, A.3
  • 51
    • 62649083097 scopus 로고    scopus 로고
    • Modulation of anxiety by acute blockade and genetic deletion of the CB1 cannabinoid receptor in mice together with biogenic amine changes in the forebrain
    • Thiemann G, Watt CA, Ledent C, et al. Modulation of anxiety by acute blockade and genetic deletion of the CB1 cannabinoid receptor in mice together with biogenic amine changes in the forebrain. Behav Brain Res. 2009 ; 200: 60-67
    • (2009) Behav Brain Res , vol.200 , pp. 60-67
    • Thiemann, G.1    Watt, C.A.2    Ledent, C.3
  • 52
    • 33847653702 scopus 로고    scopus 로고
    • Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
    • Thomas A, Baillie GL, Phillips AM, et al. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. Br J Pharmacol. 2007 ; 150: 613-623
    • (2007) Br J Pharmacol , vol.150 , pp. 613-623
    • Thomas, A.1    Baillie, G.L.2    Phillips, A.M.3
  • 53
    • 0031981037 scopus 로고    scopus 로고
    • Comparative receptor binding analyses of cannabinoid agonists and antagonists
    • Thomas BF, Gilliam AF, Burch DF, et al. Comparative receptor binding analyses of cannabinoid agonists and antagonists. J Pharmacol Exp Ther. 1998 ; 285: 285-292
    • (1998) J Pharmacol Exp Ther , vol.285 , pp. 285-292
    • Thomas, B.F.1    Gilliam, A.F.2    Burch, D.F.3
  • 54
    • 84856053335 scopus 로고    scopus 로고
    • Anti-aversive effects of cannabidiol on innate fear-induced behaviors evoked by an ethological model of panic attacks based on a prey vs the wild snake Epicrates cenchria crassus confrontation paradigm
    • Uribe-Mariño A, Francisco A, Castiblanco-Urbina MA, et al. Anti-aversive effects of cannabidiol on innate fear-induced behaviors evoked by an ethological model of panic attacks based on a prey vs the wild snake Epicrates cenchria crassus confrontation paradigm. Neuropsychopharmacology. 2012 ; 37: 412-421
    • (2012) Neuropsychopharmacology , vol.37 , pp. 412-421
    • Uribe-Mariño, A.1    Francisco, A.2    Castiblanco-Urbina, M.A.3
  • 55
    • 34447540942 scopus 로고    scopus 로고
    • Neuromorphologic evidence for c-Fos-immunoreactive neurons in forebrain, diencephalon and brainstem structures involved in the elaboration of panic and fear in golden hamster after aggressive encounter with South American coral snake
    • Weltson A, Pippa-Gadioli L, Koji-Narazaki F, et al. Neuromorphologic evidence for c-Fos-immunoreactive neurons in forebrain, diencephalon and brainstem structures involved in the elaboration of panic and fear in golden hamster after aggressive encounter with South American coral snake. Int J Psychophysiol. 2002 ; 45: 156-157
    • (2002) Int J Psychophysiol , vol.45 , pp. 156-157
    • Weltson, A.1    Pippa-Gadioli, L.2    Koji-Narazaki, F.3
  • 56
    • 0025876938 scopus 로고
    • Effects of cannabidiol in animal models predictive of antipsychotic activity
    • Zuardi AW, Antunes Rodrigues J, Cunha JM. Effects of cannabidiol in animal models predictive of antipsychotic activity. Psychopharmacology. 1991 ; 104: 260-264
    • (1991) Psychopharmacology , vol.104 , pp. 260-264
    • Zuardi, A.W.1    Antunes Rodrigues, J.2    Cunha, J.M.3


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