Clinical strategies to enhance thymic recovery after allogeneic hematopoietic stem cell transplantation

Immunology Letters

Volumn 155, Issue 1-2, 2013, Pages 31-35

  Velardi, Enrico ^a,b   Dudakov, Jarrod A ^a,c   Van den Brink, Marcel R M ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF PERUGIA   (Italy)

^c MONASH UNIVERSITY   (Australia)

Author keywords

Allogeneic hematopoietic stem cell transplantation; Immune regeneration; Thymus

Indexed keywords

CYT 107; CYT 99007; GHRELIN; GOSERELIN; GROWTH HORMONE; INTERLEUKIN 22; INTERLEUKIN 7; KERATINOCYTE GROWTH FACTOR; LEUPRORELIN; SEX HORMONE; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; CALORIC RESTRICTION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; DENDRITIC CELL; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; ENDOTHELIUM CELL; EPITHELIUM CELL; FIBROBLAST; HUMAN; MUCOSA INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; THYMOCYTE; THYMUS; TISSUE REGENERATION;

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNE REGENERATION; THYMUS;

ANIMALS; CLINICAL TRIALS AS TOPIC; GONADAL STEROID HORMONES; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOMODULATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKINS; PRECURSOR CELLS, T-LYMPHOID; REGENERATION; THYMUS GLAND; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 84887817115     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2013.09.016     Document Type: Review

References (42)

1. Bosch M., Khan F.M., Storek J. Immune reconstitution after hematopoietic cell transplantation. Current Opinion in Hematology 2012, 19:324-335.
2. Small T.N., Avigan D., Dupont B., Smith K., Black P., Heller G., et al. Immune reconstitution following T-cell depleted bone marrow transplantation: effect of age and posttransplant graft rejection prophylaxis. Biology of Blood and Marrow Transplantation 1997, 3:65-75.
3. Storek J., Witherspoon R.P., Storb R. T cell reconstitution after bone marrow transplantation into adult patients does not resemble T cell development in early life. Bone Marrow Transplantation 1995, 16:413-425.
4. Hakim F.T., Memon S.A., Cepeda R., Jones E.C., Chow C.K., Kasten-Sportes C., et al. Age-dependent incidence, time course, and consequences of thymic renewal in adults. Journal of Clinical Investigation 2005, 115:930-939.
5. Pasquini M.C., Wang Z. Current use and outcome of hematopoietic stem cell transplantation: CIBMTR Summary Slides 2012, Available at:. http://www.cibmtr.org/.
6. Takahama Y. Journey through the thymus: stromal guides for T-cell development and selection. Nature Reviews Immunology 2006, 6:127-135.
7. Wils E.J., van der Holt B., Broers A.E., Posthumus-van Sluijs S.J., Gratama J.W., Braakman E., et al. Insufficient recovery of thymopoiesis predicts for opportunistic infections in allogeneic hematopoietic stem cell transplant recipients. Haematologica 2011, 96:1846-1854.
8. Finch P.W., Rubin J.S. Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair. Advances in Cancer Research 2004, 91:69-136.
9. Alpdogan O., Hubbard V.M., Smith O.M., Patel N., Lu S., Goldberg G.L., et al. Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration. Blood 2006, 107:2453-2460.
10. Min D., Taylor P.A., Panoskaltsis-Mortari A., Chung B., Danilenko D.M., Farrell C., et al. Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation. Blood 2002, 99:4592-4600.
11. Wang Y., Chen G., Qiao S., Ma X., Tang X., Sun A., et al. Keratinocyte growth factor enhanced immune reconstitution in murine allogeneic umbilical cord blood cell transplant. Leukemia & Lymphoma 2011, 52:1556-1566.
12. Rossi S.W., Jeker L.T., Ueno T., Kuse S., Keller M.P., Zuklys S., et al. Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells. Blood 2007, 109:3803-3811.
13. Seggewiss R., Lore K., Guenaga F.J., Pittaluga S., Mattapallil J., Chow C.K., et al. Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques. Blood 2007, 110:441-449.
14. Goldberg J.D., Zheng J., Castro-Malaspina H., Jakubowski A.A., Heller G., van den Brink M.R., et al. Palifermin is efficacious in recipients of TBI-based but not chemotherapy-based allogeneic hematopoietic stem cell transplants. Bone Marrow Transplantation 2013, 48:99-104.
15. Alpdogan O., van den Brink M.R. IL-7 and IL-15: therapeutic cytokines for immunodeficiency. Trends in Immunology 2005, 26:56-64.
16. Alpdogan O., Schmaltz C., Muriglan S.J., Kappel B.J., Perales M.A., Rotolo J.A., et al. Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease. Blood 2001, 98:2256-2265.
17. Maki K., Sunaga S., Komagata Y., Kodaira Y., Mabuchi A., Karasuyama H., et al. Interleukin 7 receptor-deficient mice lack gammadelta T cells. Proceedings of the National Academy of Sciences of the United States of America 1996, 93:7172-7177.
18. Tasher D., Dalal I. The genetic basis of severe combined immunodeficiency and its variants. Application of Clinical Genetics 2012, 5:67-80.
19. Sportes C., Babb R.R., Krumlauf M.C., Hakim F.T., Steinberg S.M., Chow C.K., et al. Phase I study of recombinant human interleukin-7 administration in subjects with refractory malignancy. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 2010, 16:727-735.
20. Perales M.A., Goldberg J.D., Yuan J., Koehne G., Lechner L., Papadopoulos E.B., et al. Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation. Blood 2012, 120:4882-4891.
21. Hince M., Sakkal S., Vlahos K., Dudakov J., Boyd R., Chidgey A. The role of sex steroids and gonadectomy in the control of thymic involution. Cellular Immunology 2008, 252:122-138.
22. Dudakov J.A., Goldberg G.L., Reiseger J.J., Chidgey A.P., Boyd R.L. Withdrawal of sex steroids reverses age- and chemotherapy-related defects in bone marrow lymphopoiesis. Journal of Immunology 2009, 182:6247-6260.
23. Goldberg G.L., King C.G., Nejat R.A., Suh D.Y., Smith O.M., Bretz J.C., et al. Luteinizing hormone-releasing hormone enhances T cell recovery following allogeneic bone marrow transplantation. Journal of Immunology 2009, 182:5846-5854.
24. Sutherland J.S., Spyroglou L., Muirhead J.L., Heng T.S., Prieto-Hinojosa A., Prince H.M., et al. Enhanced immune system regeneration in humans following allogeneic or autologous hemopoietic stem cell transplantation by temporary sex steroid blockade. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 2008, 14:1138-1149.
25. Taub D.D., Murphy W.J., Longo D.L. Rejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathways. Current Opinion in Pharmacology 2010, 10:408-424.
26. Chen B.J., Cui X., Sempowski G.D., Chao N.J. Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice. Experimental Hematology 2003, 31:953-958.
27. Napolitano L.A., Schmidt D., Gotway M.B., Ameli N., Filbert E.L., Ng M.M., et al. Growth hormone enhances thymic function in HIV-1-infected adults. Journal of Clinical Investigation 2008, 118:1085-1098.
28. + progenitor cells mature to T cells on OP9-DL1 stromal cell line without thymus microenvironment. Blood Cells, Molecules & Diseases 2004, 33:227-232.
29. La Motte-Mohs R.N., Herer E., Zuniga-Pflucker J.C. Induction of T-cell development from human cord blood hematopoietic stem cells by Delta-like 1 in vitro. Blood 2005, 105:1431-1439.
30. Zakrzewski J.L., Kochman A.A., Lu S.X., Terwey T.H., Kim T.D., Hubbard V.M., et al. Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation. Nature Medicine 2006, 12:1039-1047.
31. Holland A.M., Zakrzewski J.L., Goldberg G.L., Ghosh A., van den Brink M.R. Adoptive precursor cell therapy to enhance immune reconstitution after hematopoietic stem cell transplantation in mouse and man. Seminars in Immunopathology 2008, 30:479-487.
32. Zakrzewski J.L., Suh D., Markley J.C., Smith O.M., King C., Goldberg G.L., et al. Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors. Nature Biotechnology 2008, 26:453-461.
33. Pae M., Meydani S.N., Wu D. The role of nutrition in enhancing immunity in aging. Aging and Disease 2012, 3:91-129.
34. Dixit V.D. Thymic fatness and approaches to enhance thymopoietic fitness in aging. Current Opinion in Immunology 2010, 22:521-528.
35. Yang H., Youm Y.H., Vandanmagsar B., Rood J., Kumar K.G., Butler A.A., et al. Obesity accelerates thymic aging. Blood 2009, 114:3803-3812.
36. Chen J., Astle C.M., Harrison D.E. Hematopoietic senescence is postponed and hematopoietic stem cell function is enhanced by dietary restriction. Experimental Hematology 2003, 31:1097-1103.
37. Cohen H.Y., Miller C., Bitterman K.J., Wall N.R., Hekking B., Kessler B., et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 2004, 305:390-392.
38. Rutz S., Eidenschenk C., Ouyang W. IL-22, not simply a Th17 cytokine. Immunological Reviews 2013, 252:116-132.
39. Sonnenberg G.F., Fouser L.A., Artis D. Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22. Nature Immunology 2011, 12:383-390.
40. Dudakov J.A., Hanash A.M., Jenq R.R., Young L.F., Ghosh A., Singer N.V., et al. Interleukin-22 drives endogenous thymic regeneration in mice. Science 2012, 336:91-95.
41. Kelly R.M., Highfill S.L., Panoskaltsis-Mortari A., Taylor P.A., Boyd R.L., Hollander G.A., et al. Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation. Blood 2008, 111:5734-5744.
42. Kelly R.M., Goren E.M., Taylor P.A., Mueller S.N., Stefanski H.E., Osborn M.J., et al. Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation. Blood 2010, 115:1088-1097.