-
1
-
-
20144363192
-
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
-
Baxter EJ, Scott LM, Campbell PJ, East C, Fourouclas N, Swanton S. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 2005, 365(9464):1054-1061.
-
(2005)
Lancet
, vol.365
, Issue.9464
, pp. 1054-1061
-
-
Baxter, E.J.1
Scott, L.M.2
Campbell, P.J.3
East, C.4
Fourouclas, N.5
Swanton, S.6
-
2
-
-
17844383458
-
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
-
10.1038/nature03546, 15793561
-
James C, Ugo V, Le Couedic JP, Staerk J, Delhommeau F, Lacout C, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 2005, 434(7037):1144-1148. 10.1038/nature03546, 15793561.
-
(2005)
Nature
, vol.434
, Issue.7037
, pp. 1144-1148
-
-
James, C.1
Ugo, V.2
Le Couedic, J.P.3
Staerk, J.4
Delhommeau, F.5
Lacout, C.6
-
3
-
-
17644424955
-
A gain-of-function mutation of JAK2 in myeloproliferative disorders
-
10.1056/NEJMoa051113, 15858187
-
Kralovics R, Passamonti F, Buser AS, Teo SS, Tiedt R, Passweg JR, et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med 2005, 352(17):1779-1790. 10.1056/NEJMoa051113, 15858187.
-
(2005)
N Engl J Med
, vol.352
, Issue.17
, pp. 1779-1790
-
-
Kralovics, R.1
Passamonti, F.2
Buser, A.S.3
Teo, S.S.4
Tiedt, R.5
Passweg, J.R.6
-
4
-
-
20244369569
-
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
-
10.1016/j.ccr.2005.03.023, 15837627
-
Levine RL, Wadleigh M, Cools J, Ebert BL, Wernig G, Huntly BJ, et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 2005, 7(4):387-397. 10.1016/j.ccr.2005.03.023, 15837627.
-
(2005)
Cancer Cell
, vol.7
, Issue.4
, pp. 387-397
-
-
Levine, R.L.1
Wadleigh, M.2
Cools, J.3
Ebert, B.L.4
Wernig, G.5
Huntly, B.J.6
-
5
-
-
25844432737
-
Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2
-
10.1182/blood-2005-05-1889, 16081684
-
Kralovics R, Teo SS, Buser AS, Brutsche M, Tiedt R, Tichelli A, et al. Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2. Blood 2005, 106(10):3374-3376. 10.1182/blood-2005-05-1889, 16081684.
-
(2005)
Blood
, vol.106
, Issue.10
, pp. 3374-3376
-
-
Kralovics, R.1
Teo, S.S.2
Buser, A.S.3
Brutsche, M.4
Tiedt, R.5
Tichelli, A.6
-
6
-
-
35448929374
-
JAK2V617F-negative ET patients do not display constitutively active JAK/STAT signaling
-
10.1016/j.exphem.2007.07.004, 2270411, 17764814
-
Schwemmers S, Will B, Waller CF, Abdulkarim K, Johansson P, Andreasson B, et al. JAK2V617F-negative ET patients do not display constitutively active JAK/STAT signaling. Exp Hematol 2007, 35(11):1695-1703. 10.1016/j.exphem.2007.07.004, 2270411, 17764814.
-
(2007)
Exp Hematol
, vol.35
, Issue.11
, pp. 1695-1703
-
-
Schwemmers, S.1
Will, B.2
Waller, C.F.3
Abdulkarim, K.4
Johansson, P.5
Andreasson, B.6
-
7
-
-
47549097907
-
Gene expression profiling distinguishes JAK2V617F-negative from JAK2V617F-positive patients in essential thrombocythemia
-
10.1038/leu.2008.112, 18480837
-
Puigdecanet E, Espinet B, Lozano JJ, Sumoy L, Bellosillo B, Arenillas L, et al. Gene expression profiling distinguishes JAK2V617F-negative from JAK2V617F-positive patients in essential thrombocythemia. Leukemia 2008, 22(7):1368-1376. 10.1038/leu.2008.112, 18480837.
-
(2008)
Leukemia
, vol.22
, Issue.7
, pp. 1368-1376
-
-
Puigdecanet, E.1
Espinet, B.2
Lozano, J.J.3
Sumoy, L.4
Bellosillo, B.5
Arenillas, L.6
-
8
-
-
65649088338
-
Advances in understanding and management of myeloproliferative neoplasms
-
10.3322/caac.20009, 19369682
-
Vannucchi AM, Guglielmelli P, Tefferi A. Advances in understanding and management of myeloproliferative neoplasms. CA Cancer J Clin 2009, 59(3):171-191. 10.3322/caac.20009, 19369682.
-
(2009)
CA Cancer J Clin
, vol.59
, Issue.3
, pp. 171-191
-
-
Vannucchi, A.M.1
Guglielmelli, P.2
Tefferi, A.3
-
9
-
-
44349140532
-
Essential thrombocythemia, polycythemia vera, and myelofibrosis: current management and the prospect of targeted therapy
-
10.1002/ajh.21183, 18429051
-
Tefferi A. Essential thrombocythemia, polycythemia vera, and myelofibrosis: current management and the prospect of targeted therapy. Am J Hematol 2008, 83(6):491-497. 10.1002/ajh.21183, 18429051.
-
(2008)
Am J Hematol
, vol.83
, Issue.6
, pp. 491-497
-
-
Tefferi, A.1
-
10
-
-
84863393110
-
A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis
-
10.1056/NEJMoa1110557, 22375971
-
Verstovsek S, Mesa RA, Gotlib J, Levy RS, Gupta V, DiPersio JF, et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med 2012, 366(9):799-807. 10.1056/NEJMoa1110557, 22375971.
-
(2012)
N Engl J Med
, vol.366
, Issue.9
, pp. 799-807
-
-
Verstovsek, S.1
Mesa, R.A.2
Gotlib, J.3
Levy, R.S.4
Gupta, V.5
DiPersio, J.F.6
-
11
-
-
84876082159
-
Effect of ruxolitinib therapy on myelofibrosis-related symptoms and other patient-reported outcomes in COMFORT-I: a randomized, double-blind, placebo-controlled trial
-
10.1200/JCO.2012.44.4489, 23423753
-
Mesa RA, Gotlib J, Gupta V, Catalano JV, Deininger MW, Shields AL, et al. Effect of ruxolitinib therapy on myelofibrosis-related symptoms and other patient-reported outcomes in COMFORT-I: a randomized, double-blind, placebo-controlled trial. J Clin Oncol 2013, 31(10):1285-1292. 10.1200/JCO.2012.44.4489, 23423753.
-
(2013)
J Clin Oncol
, vol.31
, Issue.10
, pp. 1285-1292
-
-
Mesa, R.A.1
Gotlib, J.2
Gupta, V.3
Catalano, J.V.4
Deininger, M.W.5
Shields, A.L.6
-
12
-
-
43249122885
-
Two-dimensional polyacrylamide gel electrophoresis (2D-PAGE): advances and perspectives
-
700
-
Issaq H, Veenstra T. Two-dimensional polyacrylamide gel electrophoresis (2D-PAGE): advances and perspectives. Biotechniques 2008, 44(5):697-698. 700.
-
(2008)
Biotechniques
, vol.44
, Issue.5
, pp. 697-698
-
-
Issaq, H.1
Veenstra, T.2
-
13
-
-
77957854088
-
HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans
-
10.1172/JCI42442, 2947224, 20852385
-
Marubayashi S, Koppikar P, Taldone T, Abdel-Wahab O, West N, Bhagwat N, et al. HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans. J Clin Invest 2010, 120(10):3578-3593. 10.1172/JCI42442, 2947224, 20852385.
-
(2010)
J Clin Invest
, vol.120
, Issue.10
, pp. 3578-3593
-
-
Marubayashi, S.1
Koppikar, P.2
Taldone, T.3
Abdel-Wahab, O.4
West, N.5
Bhagwat, N.6
-
14
-
-
10744227948
-
Chemosensitization by a non-apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant
-
Schmitt E, Parcellier A, Gurbuxani S, Cande C, Hammann A, Morales MC, et al. Chemosensitization by a non-apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant. Cancer Res 2003, 63(23):8233-8240.
-
(2003)
Cancer Res
, vol.63
, Issue.23
, pp. 8233-8240
-
-
Schmitt, E.1
Parcellier, A.2
Gurbuxani, S.3
Cande, C.4
Hammann, A.5
Morales, M.C.6
-
15
-
-
0029991234
-
Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility
-
10.1073/pnas.93.8.3264, 39594, 8622925
-
Dix DJ, Allen JW, Collins BW, Mori C, Nakamura N, Poorman-Allen P, et al. Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility. Proc Natl Acad Sci U S A 1996, 93(8):3264-3268. 10.1073/pnas.93.8.3264, 39594, 8622925.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, Issue.8
, pp. 3264-3268
-
-
Dix, D.J.1
Allen, J.W.2
Collins, B.W.3
Mori, C.4
Nakamura, N.5
Poorman-Allen, P.6
-
16
-
-
0035862331
-
Caspase activation is required for terminal erythroid differentiation
-
10.1084/jem.193.2.247, 2193347, 11208865
-
Zermati Y, Garrido C, Amsellem S, Fishelson S, Bouscary D, Valensi F, et al. Caspase activation is required for terminal erythroid differentiation. J Exp Med 2001, 193(2):247-254. 10.1084/jem.193.2.247, 2193347, 11208865.
-
(2001)
J Exp Med
, vol.193
, Issue.2
, pp. 247-254
-
-
Zermati, Y.1
Garrido, C.2
Amsellem, S.3
Fishelson, S.4
Bouscary, D.5
Valensi, F.6
-
17
-
-
33845913216
-
Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy
-
Schmitt E, Gehrmann M, Brunet M, Multhoff G, Garrido C. Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy. J Leukoc Biol 2007, 81(1):15-27.
-
(2007)
J Leukoc Biol
, vol.81
, Issue.1
, pp. 15-27
-
-
Schmitt, E.1
Gehrmann, M.2
Brunet, M.3
Multhoff, G.4
Garrido, C.5
-
18
-
-
0034745354
-
Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth
-
10.1038/35060068, 11231577
-
Song J, Takeda M, Morimoto RI. Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth. Nat Cell Biol 2001, 3(3):276-282. 10.1038/35060068, 11231577.
-
(2001)
Nat Cell Biol
, vol.3
, Issue.3
, pp. 276-282
-
-
Song, J.1
Takeda, M.2
Morimoto, R.I.3
-
19
-
-
13144292426
-
BAG-1 haplo-insufficiency impairs lung tumorigenesis
-
10.1186/1471-2407-4-85, 539250, 15560850
-
Gotz R, Kramer BW, Camarero G, Rapp UR. BAG-1 haplo-insufficiency impairs lung tumorigenesis. BMC Cancer 2004, 4:85. 10.1186/1471-2407-4-85, 539250, 15560850.
-
(2004)
BMC Cancer
, vol.4
, pp. 85
-
-
Gotz, R.1
Kramer, B.W.2
Camarero, G.3
Rapp, U.R.4
-
20
-
-
84877832281
-
Inhibition of related JAK/STAT pathways with molecular targeted drugs shows strong synergy with ruxolitinib in chronic myeloproliferative neoplasm
-
10.1111/bjh.12308, 23560534
-
Barrio S, Gallardo M, Arenas A, Ayala R, Rapado I, Rueda D, et al. Inhibition of related JAK/STAT pathways with molecular targeted drugs shows strong synergy with ruxolitinib in chronic myeloproliferative neoplasm. Br J Haematol 2013, 161(5):667-676. 10.1111/bjh.12308, 23560534.
-
(2013)
Br J Haematol
, vol.161
, Issue.5
, pp. 667-676
-
-
Barrio, S.1
Gallardo, M.2
Arenas, A.3
Ayala, R.4
Rapado, I.5
Rueda, D.6
-
21
-
-
0034253533
-
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome
-
10.1038/35019501, 10934466
-
Beere HM, Wolf BB, Cain K, Mosser DD, Mahboubi A, Kuwana T, et al. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol 2000, 2(8):469-475. 10.1038/35019501, 10934466.
-
(2000)
Nat Cell Biol
, vol.2
, Issue.8
, pp. 469-475
-
-
Beere, H.M.1
Wolf, B.B.2
Cain, K.3
Mosser, D.D.4
Mahboubi, A.5
Kuwana, T.6
-
22
-
-
81055145456
-
Heterogeneity and dynamics in the assembly of the heat shock protein 90 chaperone complexes
-
10.1073/pnas.1106261108, 3207645, 22011577
-
Ebong IO, Morgner N, Zhou M, Saraiva MA, Daturpalli S, Jackson SE, et al. Heterogeneity and dynamics in the assembly of the heat shock protein 90 chaperone complexes. Proc Natl Acad Sci U S A 2011, 108(44):17939-17944. 10.1073/pnas.1106261108, 3207645, 22011577.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.44
, pp. 17939-17944
-
-
Ebong, I.O.1
Morgner, N.2
Zhou, M.3
Saraiva, M.A.4
Daturpalli, S.5
Jackson, S.E.6
-
23
-
-
79954994442
-
Extracellular heat shock protein (Hsp)70 and Hsp90alpha assist in matrix metalloproteinase-2 activation and breast cancer cell migration and invasion
-
10.1371/journal.pone.0018848, 3077417, 21533148
-
Sims JD, McCready J, Jay DG. Extracellular heat shock protein (Hsp)70 and Hsp90alpha assist in matrix metalloproteinase-2 activation and breast cancer cell migration and invasion. PLoS One 2011, 6(4):e18848. 10.1371/journal.pone.0018848, 3077417, 21533148.
-
(2011)
PLoS One
, vol.6
, Issue.4
-
-
Sims, J.D.1
McCready, J.2
Jay, D.G.3
-
24
-
-
0030603202
-
Human cytogenetic consequences of the Chernobyl accident
-
10.1016/S0165-1161(96)90226-5, 8816940
-
Schevchenko VA, Akayeva EA, Yeliseyeva IM, Yelisova TV, Yofa EL, Nilova IN, et al. Human cytogenetic consequences of the Chernobyl accident. Mutat Res 1996, 361(1):29-34. 10.1016/S0165-1161(96)90226-5, 8816940.
-
(1996)
Mutat Res
, vol.361
, Issue.1
, pp. 29-34
-
-
Schevchenko, V.A.1
Akayeva, E.A.2
Yeliseyeva, I.M.3
Yelisova, T.V.4
Yofa, E.L.5
Nilova, I.N.6
-
25
-
-
77950684805
-
Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms
-
10.1182/blood-2009-04-214957, 20130243
-
Quintas-Cardama A, Vaddi K, Liu P, Manshouri T, Li J, Scherle PA, et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood 2010, 115(15):3109-17. 10.1182/blood-2009-04-214957, 20130243.
-
(2010)
Blood
, vol.115
, Issue.15
, pp. 3109-3117
-
-
Quintas-Cardama, A.1
Vaddi, K.2
Liu, P.3
Manshouri, T.4
Li, J.5
Scherle, P.A.6
-
26
-
-
70449497349
-
In essential thrombocythemia, multiple JAK2-V617F clones are present in most mutant-positive patients: a new disease paradigm
-
10.1182/blood-2009-03-209916, 19541820
-
Lambert JR, Everington T, Linch DC, Gale RE. In essential thrombocythemia, multiple JAK2-V617F clones are present in most mutant-positive patients: a new disease paradigm. Blood 2009, 114(14):3018-3023. 10.1182/blood-2009-03-209916, 19541820.
-
(2009)
Blood
, vol.114
, Issue.14
, pp. 3018-3023
-
-
Lambert, J.R.1
Everington, T.2
Linch, D.C.3
Gale, R.E.4
-
27
-
-
33747199312
-
Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders
-
10.1182/blood-2005-11-009605, 16675710
-
Kralovics R, Teo SS, Li S, Theocharides A, Buser AS, Tichelli A, et al. Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders. Blood 2006, 108(4):1377-1380. 10.1182/blood-2005-11-009605, 16675710.
-
(2006)
Blood
, vol.108
, Issue.4
, pp. 1377-1380
-
-
Kralovics, R.1
Teo, S.S.2
Li, S.3
Theocharides, A.4
Buser, A.S.5
Tichelli, A.6
-
28
-
-
33645400695
-
X-inactivation-based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoiesis
-
Epub 2006, 10.1182/blood-2005-09-3900, 1895292, 16434490
-
Levine RL, Belisle C, Wadleigh M, Zahrieh D, Lee S, Chagnon P, et al. X-inactivation-based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoiesis. Blood 2006, 107(10):4139-41. Epub 2006, 10.1182/blood-2005-09-3900, 1895292, 16434490.
-
(2006)
Blood
, vol.107
, Issue.10
, pp. 4139-4141
-
-
Levine, R.L.1
Belisle, C.2
Wadleigh, M.3
Zahrieh, D.4
Lee, S.5
Chagnon, P.6
-
29
-
-
33845755386
-
Polycythemia vera is not initiated by JAK2V617F mutation
-
Nussenzveig RH, Swierczek SI, Jelinek J, Gaikwad A, Liu E, Verstovsek S, et al. Polycythemia vera is not initiated by JAK2V617F mutation. Exp Hematol 2007, 35(1):32-38.
-
(2007)
Exp Hematol
, vol.35
, Issue.1
, pp. 32-38
-
-
Nussenzveig, R.H.1
Swierczek, S.I.2
Jelinek, J.3
Gaikwad, A.4
Liu, E.5
Verstovsek, S.6
-
30
-
-
60649096136
-
Clonal diversity in the myeloproliferative neoplasms: independent origins of genetically distinct clones
-
10.1111/j.1365-2141.2008.07560.x, 19170680
-
Beer PA, Jones AV, Bench AJ, Goday-Fernandez A, Boyd EM, Vaghela KJ, et al. Clonal diversity in the myeloproliferative neoplasms: independent origins of genetically distinct clones. Br J Haematol 2009, 144(6):904-908. 10.1111/j.1365-2141.2008.07560.x, 19170680.
-
(2009)
Br J Haematol
, vol.144
, Issue.6
, pp. 904-908
-
-
Beer, P.A.1
Jones, A.V.2
Bench, A.J.3
Goday-Fernandez, A.4
Boyd, E.M.5
Vaghela, K.J.6
-
31
-
-
43549105688
-
Clonal heterogeneity in polycythemia vera patients with JAK2 exon12 and JAK2-V617F mutations
-
10.1182/blood-2007-09-111971, 18195094
-
Li S, Kralovics R, De Libero G, Theocharides A, Gisslinger H, Skoda RC. Clonal heterogeneity in polycythemia vera patients with JAK2 exon12 and JAK2-V617F mutations. Blood 2008, 111(7):3863-3866. 10.1182/blood-2007-09-111971, 18195094.
-
(2008)
Blood
, vol.111
, Issue.7
, pp. 3863-3866
-
-
Li, S.1
Kralovics, R.2
De Libero, G.3
Theocharides, A.4
Gisslinger, H.5
Skoda, R.C.6
-
32
-
-
66249137734
-
Mutation in TET2 in myeloid cancers
-
10.1056/NEJMoa0810069, 19474426
-
Delhommeau F, Dupont S, Della Valle V, James C, Trannoy S, Masse A, et al. Mutation in TET2 in myeloid cancers. N Engl J Med 2009, 360(22):2289-2301. 10.1056/NEJMoa0810069, 19474426.
-
(2009)
N Engl J Med
, vol.360
, Issue.22
, pp. 2289-2301
-
-
Delhommeau, F.1
Dupont, S.2
Della Valle, V.3
James, C.4
Trannoy, S.5
Masse, A.6
-
33
-
-
84878964181
-
The HSP70 family and cancer
-
10.1093/carcin/bgt111, 23563090
-
Murphy ME. The HSP70 family and cancer. Carcinogenesis 2013, 34(6):1181-8. 10.1093/carcin/bgt111, 23563090.
-
(2013)
Carcinogenesis
, vol.34
, Issue.6
, pp. 1181-1188
-
-
Murphy, M.E.1
-
34
-
-
0032076542
-
Jak2 is essential for signaling through a variety of cytokine receptors
-
10.1016/S0092-8674(00)81167-8, 9590173
-
Parganas E, Wang D, Stravopodis D, Topham DJ, Marine JC, Teglund S, et al. Jak2 is essential for signaling through a variety of cytokine receptors. Cell 1998, 93(3):385-395. 10.1016/S0092-8674(00)81167-8, 9590173.
-
(1998)
Cell
, vol.93
, Issue.3
, pp. 385-395
-
-
Parganas, E.1
Wang, D.2
Stravopodis, D.3
Topham, D.J.4
Marine, J.C.5
Teglund, S.6
-
35
-
-
80054028202
-
Long-term outcome of treatment with ruxolitinib in myelofibrosis
-
10.1056/NEJMc1109555, 21995409
-
Tefferi A, Litzow MR, Pardanani A. Long-term outcome of treatment with ruxolitinib in myelofibrosis. N Engl J Med 2011, 365(15):1455-7. 10.1056/NEJMc1109555, 21995409.
-
(2011)
N Engl J Med
, vol.365
, Issue.15
, pp. 1455-1457
-
-
Tefferi, A.1
Litzow, M.R.2
Pardanani, A.3
|