Inhibition of related JAK/STAT pathways with molecular targeted drugs shows strong synergy with ruxolitinib in chronic myeloproliferative neoplasm

British Journal of Haematology

Volumn 161, Issue 5, 2013, Pages 667-676

  Barrio, Santiago ^a   Gallardo, Miguel ^a,b   Arenas, Alicia ^a   Ayala, Rosa ^a   Rapado, Inmaculada ^a   Rueda, Daniel ^a   Jimenez, Ana ^a   Albizua, Enriqueta ^a,c   Burgaleta, Carmen ^d   Gilsanz, Florinda ^a   Martinez Lopez, Joaquin ^a  

^a HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c HOSPITAL VIRGEN DE LA SALUD   (Spain)

^d HOSPITAL UNIVERSITARIO PRÍNCIPE DE ASTURIAS   (Spain)

Author keywords

Drug synergisms; KNK437; Myeloproliferative disease; Ruxolitinib; Stem cells

Indexed keywords

ANTINEOPLASTIC AGENT; DASATINIB; JANUS KINASE; JANUS KINASE 2; KNK 437; MITOGEN ACTIVATED PROTEIN KINASE P38; PERIFOSINE; RUXOLITINIB; SORAFENIB; STAT5 PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; HUMAN; IN VITRO STUDY; MALE; MITOSIS INHIBITION; MOLECULARLY TARGETED THERAPY; MYELOPROLIFERATIVE NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; BENZHYDRYL COMPOUNDS; CELL PROLIFERATION; CELLS, CULTURED; CHRONIC DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; DRUG SYNERGISM; FEMALE; HUMANS; JANUS KINASE 2; JANUS KINASES; MALE; MIDDLE AGED; MYELOPROLIFERATIVE DISORDERS; NIACINAMIDE; PHENYLUREA COMPOUNDS; PHOSPHORYLCHOLINE; POLYCYTHEMIA VERA; PROTEIN KINASE INHIBITORS; PYRAZOLES; PYRIMIDINES; PYRROLIDINONES; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; THIAZOLES; THROMBOCYTHEMIA, ESSENTIAL; TUMOR CELLS, CULTURED;

EID: 84877832281     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12308     Document Type: Article

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