The use of cationic microbubbles to improve ultrasound-targeted gene delivery to the ischemic myocardium

Biomaterials

Volumn 34, Issue 8, 2013, Pages 2107-2116

  Sun, Lu ^a,b,c   Huang, Chia Wen ^d   Wu, Jun ^b,c   Chen, Ko Jie ^d   Li, Shu Hong ^b,c   Weisel, Richard D ^b,c   Rakowski, Harry ^e   Sung, Hsing Wen ^d   Li, Ren Ke ^b,c  

^a THE SECOND AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^e UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

AKT; Gene therapy; Heart function; Ischemic myocardium; Microbubble; Ultrasound targeted microbubble destruction

Indexed keywords

AKT; HEART FUNCTION; ISCHEMIC MYOCARDIUM; MICRO-BUBBLE; ULTRASOUND-TARGETED MICROBUBBLE DESTRUCTION;

CELL DEATH; EFFICIENCY; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; ULTRASONICS;

HEART;

GENE THERAPY AGENT; PLASMID DNA; PROTEIN KINASE B;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DENSITY; GENE EXPRESSION; GENE TARGETING; HEART FUNCTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART PERFUSION; IN VIVO STUDY; MICROBUBBLE; NONHUMAN; PRIORITY JOURNAL; RAT; REPORTER GENE; ULTRASOUND TARGETED MICROBUBBLE;

ANIMALS; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; BLOOD VESSELS; CATIONS; DNA; GENE TRANSFER TECHNIQUES; HEART FUNCTION TESTS; LUCIFERASES; MICROBUBBLES; MICROTUBULE-ASSOCIATED PROTEINS; MYOCARDIAL ISCHEMIA; MYOCARDIUM; PERFUSION; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; ULTRASONICS;

RATTUS; RODENTIA;

EID: 84871495806     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.11.041     Document Type: Article

References (23)

1. St.John Sutton M.G., Pfeffer M.A., Moye L., Plappert T., Rouleau J.L., Lamas G., et al. Cardiovascular death and left ventricular remodeling two years after myocardial infarction: baseline predictors and impact of long-term use of captopril: information from the Survival and Ventricular Enlargement (SAVE) trial. Circulation 1997, 96:3294-3299.
2. St.John Sutton M.G., Sharpe N. Left ventricular remodeling after myocardial infarction: pathophysiology and therapy. Circulation 2000, 101:2981-2988.
3. Bekeredjian R., Grayburn P.A., Shohet R.V. Use of ultrasound contrast agents for gene or drug delivery in cardiovascular medicine. J Am Coll Cardiol 2005, 45:329-335.
4. Yau T.M., Fung K., Weisel R.D., Fujii T., Mickle D.A., Li R.K. Enhanced myocardial angiogenesis by gene transfer with transplanted cells. Circulation 2001, 104:I218-I222.
5. Chen S., Shohet R.V., Bekeredjian R., Frenkel P., Grayburn P.A. Optimization of ultrasound parameters for cardiac gene delivery of adenoviral or plasmid deoxyribonucleic acid by ultrasound-targeted microbubble destruction. J Am Coll Cardiol 2003, 42:301-308.
6. Fujii H., Sun Z., Li S.H., Wu J., Fazel S., Weisel R.D., et al. Ultrasound-targeted gene delivery induces angiogenesis after a myocardial infarction in mice. JACC Cardiovasc Imaging 2009, 2:869-879.
7. Fujii H., Li S.H., Wu J., Miyagi Y., Yau T.M., Rakowski H., et al. Repeated and targeted transfer of angiogenic plasmids into the infarcted rat heart via ultrasound targeted microbubble destruction enhances cardiac repair. Eur Heart J 2011, 32:2075-2084.
8. Zhao Y.Z., Lu C.T., Li X.K., Tang Q.Q., Tian X.Q., Zhao Y.P., et al. Improving the cardio protective effect of aFGF in ischemic myocardium with ultrasound-mediated cavitation of heparin modified microbubbles: preliminary experiment. J Drug Target 2012, 20:623-631.
9. Song S., Shen Z., Chen L., Brayman A.A., Miao C.H. Explorations of high-intensity therapeutic ultrasound and microbubble-mediated gene delivery in mouse liver. Gene Ther 2011, 18:1006-1014.
10. Shiojima I., Walsh K. Role of Akt signaling in vascular homeostasis and angiogenesis. Circ Res 2002, 90:1243-1250.
11. Datta S.R., Dudek H., Tao X., Masters S., Fu H., Gotoh Y., et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997, 91:231-241.
12. Li F., Ambrosini G., Chu E.Y., Plescia J., Tognin S., Marchisio P.C., et al. Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 1998, 396:580-584.
13. Song G., Ouyang G., Bao S. The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med 2005, 9:59-71.
14. Mangi A.A., Noiseux N., Kong D., He H., Rezvani M., Ingwall J.S., et al. Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med 2003, 9:1195-1201.
15. Smith D.A., Porter T.M., Martinez J., Huang S., MacDonald R.C., McPherson D.D., et al. Destruction thresholds of echogenic liposomes with clinical diagnostic ultrasound. Ultrasound Med Biol 2007, 33:797-809.
16. Fedak P.W.M., Altamentova S.M., Weisel R.D., Nili N., Ohno N., Verma S., et al. Matrix remodeling in experimental and human heart failure: a possible regulatory role for TIMP-3. Am J Physiol Heart Circ Physiol 2003, 284:H626-H634.
17. Jessup M., Greenberg B., Mancini D., Cappola T., Pauly D.F., Jaski B., et al. Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure. Circulation 2011, 124:304-313.
18. Datta S.R., Brunet A., Greenberg M.E. Cellular survival: a play in three Akts. Genes Dev 1999, 13:2905-2927.
19. Houk B.E., Hochhaus G., Hughes J.A. Kinetic modeling of plasmid DNA degradation in rat plasma. AAPS PharmSci 1999, 1:15-20.
20. Lentacker I., De Geest B.G., Vandenbroucke R.E., Peeters L., Demeester J., De Smedt S.C., et al. Ultrasound-responsive polymer-coated microbubbles that bind and protect DNA. Langmuir 2006, 22:7273-7278.
21. Liu F., Shollenberger L.M., Conwell C.C., Yuan X., Huang L. Mechanism of naked DNA clearance after intravenous injection. J Gene Med 2007, 9:613-619.
22. Panje C.M., Wang D.S., Pysz M.A., Paulmurugan R., Ren Y., Tranquart F., et al. Ultrasound-mediated gene delivery with cationic versus neutral microbubbles: effect of DNA and microbubble dose on in vivo transfection efficiency. Theranostics 2012, 2:1078-1091.
23. Carson A.R., McTiernan C.F., Lavery L., Grata M., Leng X., Wang J., et al. Ultrasound-targeted microbubble destruction to deliver siRNA cancer therapy. Cancer Res 2012, 72:6191-6199.