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Volumn 2, Issue 1, 2013, Pages 58-72

Role of phenothiazines and structurally similar compounds of plant origin in the fight against infections by drug resistant bacteria

Author keywords

Antimicrobial activities; Efflux pumps; Phenothiazines; Quorum sensing; Reversal of antibiotic resistance

Indexed keywords

ALIMEMAZINE; CHLORPROMAZINE; FLUPENTIXOL; FLUPHENAZINE; METHDILAZINE; PHENOTHIAZINE DERIVATIVE; PROCHLORPERAZINE; PROMAZINE; PROMETHAZINE; THIORIDAZINE; TRIFLUOPERAZINE; TRIFLUPROMAZINE;

EID: 84887610539     PISSN: None     EISSN: 20796382     Source Type: Journal    
DOI: 10.3390/antibiotics2010058     Document Type: Review
Times cited : (42)

References (81)
  • 1
    • 34248160010 scopus 로고    scopus 로고
    • Pandrug-resistant Gram-negative bacteria: The dawn of the post-antibiotic era
    • Falagas, M. E.; Bliziotis, I. A. Pandrug-resistant Gram-negative bacteria: The dawn of the post-antibiotic era. Int. J. Antimicrob. Agents 2007, 29, 630-636.
    • (2007) Int. J. Antimicrob. Agents , vol.29 , pp. 630-636
    • Falagas, M.E.1    Bliziotis, I.A.2
  • 2
    • 84969301493 scopus 로고    scopus 로고
    • A cheap and effective anti-Mdr/Xdr/Tdr Tb drug is already available
    • doi: 10. 4172/2167-0501. 1000e137
    • Amaral, L.; Udwadia, Z. F.; van Soolingen, D. A cheap and effective anti-Mdr/Xdr/Tdr Tb drug is already available. Biochem. Pharmacol. J. 2012, doi: 10. 4172/2167-0501. 1000e137.
    • (2012) Biochem. Pharmacol. J.
    • Amaral, L.1    Udwadia, Z.F.2    van Soolingen, D.3
  • 3
    • 84866532211 scopus 로고    scopus 로고
    • Why and how the old neuroleptic thioridazine cures the XDR-TB patient
    • Amaral, L.; Molnar, J. Why and how the old neuroleptic thioridazine cures the XDR-TB patient. Pharmaceuticals 2012, 5, 1021-1031.
    • (2012) Pharmaceuticals , vol.5 , pp. 1021-1031
    • Amaral, L.1    Molnar, J.2
  • 6
    • 0027073297 scopus 로고
    • The antimicrobial activity of non-antibiotics. Report from a congress on the antimicrobial effect of drugs other than antibiotics on bacteria, viruses, protozoa, and other organisms
    • Kristiansen, J. E. The antimicrobial activity of non-antibiotics. Report from a congress on the antimicrobial effect of drugs other than antibiotics on bacteria, viruses, protozoa, and other organisms. APMIS. Suppl. 1992, 30, 7-14.
    • (1992) APMIS. Suppl. , vol.30 , pp. 7-14
    • Kristiansen, J.E.1
  • 8
    • 0030801767 scopus 로고    scopus 로고
    • The potential management of resistant infections with non-antibiotics
    • Kristiansen, J. E.; Amaral, L. The potential management of resistant infections with non-antibiotics. J. Antimicrob. Chemother. 1997, 40, 319-327.
    • (1997) J. Antimicrob. Chemother. , vol.40 , pp. 319-327
    • Kristiansen, J.E.1    Amaral, L.2
  • 12
    • 0041784908 scopus 로고    scopus 로고
    • Antimicrobial potentiality of a new non-antibiotic: The cardiovascular drug oxyfedrine hydrochloride
    • Mazumdar, K.; Ganguly, K.; Kumar, K. A.; Dutta, N. K.; Chakrabarty, A. N.; Dastidar, S. G. Antimicrobial potentiality of a new non-antibiotic: The cardiovascular drug oxyfedrine hydrochloride. Microbiol. Res. 2003, 158, 259-264.
    • (2003) Microbiol. Res. , vol.158 , pp. 259-264
    • Mazumdar, K.1    Ganguly, K.2    Kumar, K.A.3    Dutta, N.K.4    Chakrabarty, A.N.5    Dastidar, S.G.6
  • 13
    • 79953210160 scopus 로고    scopus 로고
    • Antibacterial Activity of Artificial Phenothiazines and Isoflavones from Plants
    • In, VI; Springer: Berlin/Heidelberg, Germany
    • Dasgupta, A.; Dastidar, S. G.; Shiratki, Y.; Motohashi, N. Antibacterial Activity of Artificial Phenothiazines and Isoflavones from Plants. In Bioactive Heterocycles VI; Springer: Berlin/Heidelberg, Germany, 2008; Volume 15, pp. 67-132.
    • (2008) Bioactive Heterocycles , vol.15 , pp. 67-132
    • Dasgupta, A.1    Dastidar, S.G.2    Shiratki, Y.3    Motohashi, N.4
  • 14
    • 0018718216 scopus 로고
    • Experiments to illustrate the effect of chlorpromazine on the permeability of the bacterial cell wall
    • Kristiansen, J. E. Experiments to illustrate the effect of chlorpromazine on the permeability of the bacterial cell wall. Acta Pathol. Microbiol. Scand. B 1979, 87, 317-319.
    • (1979) Acta Pathol. Microbiol. Scand. B , vol.87 , pp. 317-319
    • Kristiansen, J.E.1
  • 15
    • 0022997767 scopus 로고
    • Chlorpromazine as permeabilizer and reagent for detection of microbial peroxidase and peroxidaselike activities
    • Galeazzi, L.; Turchetti, G.; Grilli, G.; Groppa, G.; Giunta, S. Chlorpromazine as permeabilizer and reagent for detection of microbial peroxidase and peroxidaselike activities. Appl. Environ. Microbiol. 1986, 52, 1433-1435.
    • (1986) Appl. Environ. Microbiol. , vol.52 , pp. 1433-1435
    • Galeazzi, L.1    Turchetti, G.2    Grilli, G.3    Groppa, G.4    Giunta, S.5
  • 16
    • 0025850483 scopus 로고
    • Effects of chlorpromazine on the cell envelope proteins of Echerichia coli
    • Amaral, L.; Lorian, V. Effects of chlorpromazine on the cell envelope proteins of Echerichia coli. Antimicrob. Agents Chemother. 1991, 35, 1923-1924.
    • (1991) Antimicrob. Agents Chemother. , vol.35 , pp. 1923-1924
    • Amaral, L.1    Lorian, V.2
  • 17
    • 0034115335 scopus 로고    scopus 로고
    • The effect of chlorpromazine on the outer cell wall constituents of Salmonella typhimurium ensuring resistance to the drug
    • Amaral, L.; Kristiansen, J. E.; Thomsen, V. F.; Markowich, B. The effect of chlorpromazine on the outer cell wall constituents of Salmonella typhimurium ensuring resistance to the drug. Int. J. Antimicrob. Agents 2000, 14, 225-229.
    • (2000) Int. J. Antimicrob. Agents , vol.14 , pp. 225-229
    • Amaral, L.1    Kristiansen, J.E.2    Thomsen, V.F.3    Markowich, B.4
  • 18
    • 0033033874 scopus 로고    scopus 로고
    • Potentiality of tricyclic compound thioridazine as an effective antibacterial and antiplasmid agent
    • Radhakrishnan, V.; Ganguly, K.; Ganguly, M.; Dastidar, S. G.; Chakrabarty, A. N. Potentiality of tricyclic compound thioridazine as an effective antibacterial and antiplasmid agent. Indian J. Exp. Biol. 1999, 37, 671-675.
    • (1999) Indian J. Exp. Biol. , vol.37 , pp. 671-675
    • Radhakrishnan, V.1    Ganguly, K.2    Ganguly, M.3    Dastidar, S.G.4    Chakrabarty, A.N.5
  • 19
    • 0028790130 scopus 로고
    • Effects of phenothiazine neuroleptic drugs on the microtubular-membrane complex in bloodstream forms of Trypanosoma brucei
    • Page, A. M.; Lagnado, J. R. Effects of phenothiazine neuroleptic drugs on the microtubular-membrane complex in bloodstream forms of Trypanosoma brucei. Parasitology 1995, 111, 493-504.
    • (1995) Parasitology , vol.111 , pp. 493-504
    • Page, A.M.1    Lagnado, J.R.2
  • 20
    • 0027017181 scopus 로고
    • In vitro antimicrobial activity of 18 phenothiazine derivatives: Structure-activity relationship
    • Bourlioux, P.; Moreaux, J. M.; Su, W. J.; Boureau, H. In vitro antimicrobial activity of 18 phenothiazine derivatives: Structure-activity relationship. APMIS Suppl. 1992, 30, 40-43.
    • (1992) APMIS , vol.30 , Issue.SUPPL. , pp. 40-43
    • Bourlioux, P.1    Moreaux, J.M.2    Su, W.J.3    Boureau, H.4
  • 22
    • 0035996896 scopus 로고    scopus 로고
    • Intracellular activity of clinical concentrations of phenothiazines including thioridazine against phagocytosed Staphylococcus aureus
    • Ordway, D.; Viveiros, M.; Leandro, C.; Arroz, M. J.; Amaral, L. Intracellular activity of clinical concentrations of phenothiazines including thioridazine against phagocytosed Staphylococcus aureus. Int. J. Antimicrob. Agents 2001, 20, 34-43.
    • (2001) Int. J. Antimicrob. Agents , vol.20 , pp. 34-43
    • Ordway, D.1    Viveiros, M.2    Leandro, C.3    Arroz, M.J.4    Amaral, L.5
  • 23
    • 39149121434 scopus 로고    scopus 로고
    • Potential role of non-antibiotics (helper compounds) in the treatment of multi-drug resistant Gram negative infections: Mechanisms for their direct and indirect activities
    • Martins, M.; Dastidar, S. G.; Fanning, S.; Kristiansen, J. E.; Molnar, J.; Pagès, J. M.; Schelz, Z.; Spengler, G.; Viveiros, M.; Amaral, L. Potential role of non-antibiotics (helper compounds) in the treatment of multi-drug resistant Gram negative infections: Mechanisms for their direct and indirect activities. Int. J. Antimicrob. Agents 2008, 31, 198-208.
    • (2008) Int. J. Antimicrob. Agents , vol.31 , pp. 198-208
    • Martins, M.1    Dastidar, S.G.2    Fanning, S.3    Kristiansen, J.E.4    Molnar, J.5    Pagès, J.M.6    Schelz, Z.7    Spengler, G.8    Viveiros, M.9    Amaral, L.10
  • 24
    • 79959961390 scopus 로고    scopus 로고
    • New Patentable use of an old neuroleptic compound thioridazine to combat against tuberculosis: Gene regulation perspective
    • Dutta, N. K.; Mazumdar, K.; Dastidar, S. G.; Amaral, L. New Patentable use of an old neuroleptic compound thioridazine to combat against tuberculosis: Gene regulation perspective. Recent Pat. Anti-Infect. Drug Discov. 2011, 6, 128-138.
    • (2011) Recent Pat. Anti-Infect. Drug Discov. , vol.6 , pp. 128-138
    • Dutta, N.K.1    Mazumdar, K.2    Dastidar, S.G.3    Amaral, L.4
  • 29
    • 78650262885 scopus 로고    scopus 로고
    • Inhibition of efflux pumps of methicillin-resistant Staphylococcus aureus and Enterococcus faecalis resistant strains by triterpenoids from Momordica balsamina
    • Ramalhete, C.; Spengler, G.; Mulhovo, S.; Costa, S.; Couto, I.; Viveiros, M.; Ferreira, M. J. U.; Amaral, L. Inhibition of efflux pumps of methicillin-resistant Staphylococcus aureus and Enterococcus faecalis resistant strains by triterpenoids from Momordica balsamina. Int. J. Antimicrob. Agents 2011, 77, 70-74.
    • (2011) Int. J. Antimicrob. Agents , vol.77 , pp. 70-74
    • Ramalhete, C.1    Spengler, G.2    Mulhovo, S.3    Costa, S.4    Couto, I.5    Viveiros, M.6    Ferreira, M.J.U.7    Amaral, L.8
  • 32
    • 34447558018 scopus 로고    scopus 로고
    • Antibacterial activity of ergosterol peroxide against Mycobacterium tuberculosis: Dependence upon system and medium employed
    • Duarte, N.; Ferreira, M. J.; Martins, M.; Viveiros, M.; Amaral, L. Antibacterial activity of ergosterol peroxide against Mycobacterium tuberculosis: Dependence upon system and medium employed. Phytother. Res. 2007, 21, 601-604.
    • (2007) Phytother. Res. , vol.21 , pp. 601-604
    • Duarte, N.1    Ferreira, M.J.2    Martins, M.3    Viveiros, M.4    Amaral, L.5
  • 33
    • 66149148982 scopus 로고    scopus 로고
    • Helichrysum italicum essential oil contains compounds that restore chloramphenicol activity on multi-drug resistant isolates from Gram-negative species
    • Lorenzi, V.; Muselli, A.; Bernardini, A. F.; Berti, L.; Pagès, J. M.; Amaral, L.; Bolla, J. M. Helichrysum italicum essential oil contains compounds that restore chloramphenicol activity on multi-drug resistant isolates from Gram-negative species. Antimicrob. Agents Chemother. 2008, 53, 2209-2211.
    • (2008) Antimicrob. Agents Chemother. , vol.53 , pp. 2209-2211
    • Lorenzi, V.1    Muselli, A.2    Bernardini, A.F.3    Berti, L.4    Pagès, J.M.5    Amaral, L.6    Bolla, J.M.7
  • 35
    • 79958257266 scopus 로고    scopus 로고
    • Recent progress in biological activities of synthesized phenothiazines
    • Pluta, K.; Morak-Młodawska, B.; Jeleń, M. Recent progress in biological activities of synthesized phenothiazines. Eur. J. Med. Chem. 2011, 46, 3179-3189.
    • (2011) Eur. J. Med. Chem. , vol.46 , pp. 3179-3189
    • Pluta, K.1    Morak-Młodawska, B.2    Jeleń, M.3
  • 37
    • 22944439377 scopus 로고    scopus 로고
    • Phenothiazinium based photosensitisers-photodynamic agents with a multiplicity of cellular targets and clinical applications
    • Harris, F.; Chatfield, L. K.; Phoenix, D. A. Phenothiazinium based photosensitisers-photodynamic agents with a multiplicity of cellular targets and clinical applications. Curr. Drug Targets 2005, 6, 615-627.
    • (2005) Curr. Drug Targets , vol.6 , pp. 615-627
    • Harris, F.1    Chatfield, L.K.2    Phoenix, D.A.3
  • 38
    • 0036294844 scopus 로고    scopus 로고
    • Fluorescent and photoactivable probes in depth-dependent analysis of membranes
    • Lala, A. K. Fluorescent and photoactivable probes in depth-dependent analysis of membranes. Chem. Phys. Lipids 2002, 116, 177-188.
    • (2002) Chem. Phys. Lipids , vol.116 , pp. 177-188
    • Lala, A.K.1
  • 39
    • 33748479692 scopus 로고    scopus 로고
    • Interactions of phenothiazines with lipid bilayer and their role in multidrug resistance reversal
    • Michalak, K.; Wesolowska, O.; Motohashi, N.; Molnar, J.; Hendrich, A. B. Interactions of phenothiazines with lipid bilayer and their role in multidrug resistance reversal. Curr. Drug Targets 2006, 7, 1095-1105.
    • (2006) Curr. Drug Targets , vol.7 , pp. 1095-1105
    • Michalak, K.1    Wesolowska, O.2    Motohashi, N.3    Molnar, J.4    Hendrich, A.B.5
  • 40
    • 0019470522 scopus 로고
    • Interaction of chlorpromazine with tea and coffee
    • Cheeseman, H. J.; Neal, M. J. Interaction of chlorpromazine with tea and coffee. Br. J. Clin. Pharmacol. 1981, 12, 165-169.
    • (1981) Br. J. Clin. Pharmacol. , vol.12 , pp. 165-169
    • Cheeseman, H.J.1    Neal, M.J.2
  • 42
    • 0021995178 scopus 로고
    • Antispasticity drugs: Mechanisms of action
    • Davidoff, R. A. Antispasticity drugs: Mechanisms of action. Ann. Neurol. 1985, 17, 107-116.
    • (1985) Ann. Neurol. , vol.17 , pp. 107-116
    • Davidoff, R.A.1
  • 44
    • 52449130017 scopus 로고    scopus 로고
    • Clinical impact of the over-expression of efflux pump in nonfermentative Gram-negative bacilli, development of efflux pump inhibitors
    • Vila, J.; Martínez, J. L. Clinical impact of the over-expression of efflux pump in nonfermentative Gram-negative bacilli, development of efflux pump inhibitors. Curr. Drug Targets 2008, 9, 797-807.
    • (2008) Curr. Drug Targets , vol.9 , pp. 797-807
    • Vila, J.1    Martínez, J.L.2
  • 45
    • 64649103209 scopus 로고    scopus 로고
    • Mechanisms of drug efflux and strategies to combat them: Challenging the efflux pump of Gram-negative bacteria
    • Pagès, J. M.; Amaral, L. Mechanisms of drug efflux and strategies to combat them: challenging the efflux pump of Gram-negative bacteria. Biochim. Biophys. Acta 2009, 1794, 826-833.
    • (2009) Biochim. Biophys. Acta , vol.1794 , pp. 826-833
    • Pagès, J.M.1    Amaral, L.2
  • 46
    • 79957550202 scopus 로고    scopus 로고
    • Efflux pumps of gram-negative bacteria: Genetic responses to stress and the modulation of their activity by pH, inhibitors, and phenothiazines
    • Amaral, L.; Fanning, S.; Pagès, J. M. Efflux pumps of gram-negative bacteria: Genetic responses to stress and the modulation of their activity by pH, inhibitors, and phenothiazines. Adv. Enzymol. Relat. Areas Mol. Biol. 2011, 77, 61-108.
    • (2011) Adv. Enzymol. Relat. Areas Mol. Biol. , vol.77 , pp. 61-108
    • Amaral, L.1    Fanning, S.2    Pagès, J.M.3
  • 47
    • 84855160972 scopus 로고    scopus 로고
    • Thioridazine induces apoptosis of multidrug-resistant mouse lymphoma cells transfected with the human ABCB1 andinhibits the expression of P-glycoprotein
    • Spengler, G.; Molnar, J.; Viveiros, M.; Amaral, L. Thioridazine induces apoptosis of multidrug-resistant mouse lymphoma cells transfected with the human ABCB1 andinhibits the expression of P-glycoprotein. Anticancer Res. 2011, 31, 4201-4205.
    • (2011) Anticancer Res. , vol.31 , pp. 4201-4205
    • Spengler, G.1    Molnar, J.2    Viveiros, M.3    Amaral, L.4
  • 48
    • 80054745363 scopus 로고    scopus 로고
    • Modulation of multidrug efflux pump activity by new hydantoin derivatives on colon adenocarcinoma cells without inducing apoptosis
    • Spengler, G.; Handzlik, J.; Ocsovszki, I.; Viveiros, M.; Kiec-Kononowicz, K.; Molnar, J.; Amaral, L. Modulation of multidrug efflux pump activity by new hydantoin derivatives on colon adenocarcinoma cells without inducing apoptosis. Anticancer Res. 2011, 31, 3285-3288.
    • (2011) Anticancer Res. , vol.31 , pp. 3285-3288
    • Spengler, G.1    Handzlik, J.2    Ocsovszki, I.3    Viveiros, M.4    Kiec-Kononowicz, K.5    Molnar, J.6    Amaral, L.7
  • 50
    • 23044454231 scopus 로고    scopus 로고
    • Inducement and reversal of tetracycline resistance in Escherichia coli K-12 and the expression of proton gradient dependent multidrug efflux pump genes
    • Viveiros, M.; Jesus, A.; Brito, M.; Leandro, C.; Martins, M.; Ordway, D.; Molnar, A. M.; Molnar, J.; Amaral, L. Inducement and reversal of tetracycline resistance in Escherichia coli K-12 and the expression of proton gradient dependent multidrug efflux pump genes. Antimicrob. Agents Chemother. 2005, 49, 3578-3582.
    • (2005) Antimicrob. Agents Chemother. , vol.49 , pp. 3578-3582
    • Viveiros, M.1    Jesus, A.2    Brito, M.3    Leandro, C.4    Martins, M.5    Ordway, D.6    Molnar, A.M.7    Molnar, J.8    Amaral, L.9
  • 52
    • 84962044479 scopus 로고    scopus 로고
    • Sequential responses of bacteria to noxious agents (antibiotics) leading to accumulation of mutations and permanent resistance
    • doi: 10. 4172/2167-0501. 1000104
    • Martins, A.; Spengler, G.; Molnar, J.; Amaral, L. Sequential responses of bacteria to noxious agents (antibiotics) leading to accumulation of mutations and permanent resistance. Biochem. Pharmacol. 2012, 1, doi: 10. 4172/2167-0501. 1000104.
    • (2012) Biochem. Pharmacol. , vol.1
    • Martins, A.1    Spengler, G.2    Molnar, J.3    Amaral, L.4
  • 53
    • 0037699291 scopus 로고    scopus 로고
    • The role of mutators in the emergence of antibiotic-resistant bacteria
    • Chopra, I.; O'Neill, A. J.; Miller, K. The role of mutators in the emergence of antibiotic-resistant bacteria. Drug Resist. Updat. 2003, 6, 137-145.
    • (2003) Drug Resist. Updat. , vol.6 , pp. 137-145
    • Chopra, I.1    O'Neill, A.J.2    Miller, K.3
  • 54
    • 80054939368 scopus 로고    scopus 로고
    • Exploring the contribution of efflux on the resistance to fluoroquinolones in clinical isolates of Staphylococcus aureus
    • doi: 10. 1186/1471-2180-11-241
    • Costa, S. S.; Falcão, C.; Viveiros, M.; Machado, D.; Martins, M.; Melo-Cristino, J.; Amaral, L.; Couto, I. Exploring the contribution of efflux on the resistance to fluoroquinolones in clinical isolates of Staphylococcus aureus. BMC Microbiol. 2011, 11, doi: 10. 1186/1471-2180-11-241.
    • (2011) BMC Microbiol. , vol.11
    • Costa, S.S.1    Falcão, C.2    Viveiros, M.3    Machado, D.4    Martins, M.5    Melo-Cristino, J.6    Amaral, L.7    Couto, I.8
  • 55
    • 78249239176 scopus 로고    scopus 로고
    • Identification of the plasmid-encoded qacA efflux pump gene in meticillin-resistant Staphylococcus aureus (MRSA) strain HPV107, a representative of the MRSA Iberian clone
    • Costa, S. S.; Ntokou, E.; Martins, A.; Viveiros, M.; Pournaras, S.; Couto, I.; Amaral, L. Identification of the plasmid-encoded qacA efflux pump gene in meticillin-resistant Staphylococcus aureus (MRSA) strain HPV107, a representative of the MRSA Iberian clone. Int. J. Antimicrob. Agents 2010, 36, 557-561.
    • (2010) Int. J. Antimicrob. Agents , vol.36 , pp. 557-561
    • Costa, S.S.1    Ntokou, E.2    Martins, A.3    Viveiros, M.4    Pournaras, S.5    Couto, I.6    Amaral, L.7
  • 59
    • 84859421891 scopus 로고    scopus 로고
    • Contribution of efflux activity to isoniazid resistance in the Mycobacterium tuberculosis complex
    • Rodrigues, L.; Machado, D.; Couto, I.; Amaral, L.; Viveiros, M. Contribution of efflux activity to isoniazid resistance in the Mycobacterium tuberculosis complex. Infect. Genet. Evol. 2012, 12, 695-700.
    • (2012) Infect. Genet. Evol. , vol.12 , pp. 695-700
    • Rodrigues, L.1    Machado, D.2    Couto, I.3    Amaral, L.4    Viveiros, M.5
  • 61
    • 17144387894 scopus 로고    scopus 로고
    • Proton transfer dynamics at membrane/water interface and mechanism of biological energy conversion
    • Mulkidjanian, A. Y.; Cherepanov, D. A.; Heberle, J.; Junge, W. Proton transfer dynamics at membrane/water interface and mechanism of biological energy conversion. Biochemistry (Moscow) 2005, 70, 251-256.
    • (2005) Biochemistry (Moscow) , vol.70 , pp. 251-256
    • Mulkidjanian, A.Y.1    Cherepanov, D.A.2    Heberle, J.3    Junge, W.4
  • 62
    • 33749128697 scopus 로고    scopus 로고
    • Protons @ interfaces: Implications for biological energy conversion
    • Mulkidjanian, A. Y.; Heberle, J.; Cherepanov, D. A. Protons @ interfaces: Implications for biological energy conversion. Biochim. Biophys. Acta 2006, 1757, 913-930.
    • (2006) Biochim. Biophys. Acta , vol.1757 , pp. 913-930
    • Mulkidjanian, A.Y.1    Heberle, J.2    Cherepanov, D.A.3
  • 64
    • 0027793370 scopus 로고
    • Mechanisms of antimotility action of tricyclic compounds in Proteus vulgaris
    • Ren, J. K.; Petöfi, S.; Molnár, J. Mechanisms of antimotility action of tricyclic compounds in Proteus vulgaris. Acta Microbiol. Hung. 1993, 40, 369-377.
    • (1993) Acta Microbiol. Hung. , vol.40 , pp. 369-377
    • Ren, J.K.1    Petöfi, S.2    Molnár, J.3
  • 65
    • 0027052626 scopus 로고
    • Chlorpromazine: A drug potentially useful for treating mycobacteria infections
    • Crowle, A. J.; Douvas, G. S.; May, M. H. Chlorpromazine: A drug potentially useful for treating mycobacteria infections. Chemotherapy 1992, 38, 410-419.
    • (1992) Chemotherapy , vol.38 , pp. 410-419
    • Crowle, A.J.1    Douvas, G.S.2    May, M.H.3
  • 66
    • 0030462751 scopus 로고    scopus 로고
    • Inhibition of the respiration of multi-drug resistant clinical isolates of Mycobacterium tuberculosis by Thioridazine: Potential use for the initial therapy of freshly diagnosed tuberculosis
    • Amaral, L.; Kristiansen, J. E.; Abebe, L. S.; Millet, W. Inhibition of the respiration of multi-drug resistant clinical isolates of Mycobacterium tuberculosis by Thioridazine: Potential use for the initial therapy of freshly diagnosed tuberculosis. J. Antimicrob. Chemother. 1996, 38, 1049-1053.
    • (1996) J. Antimicrob. Chemother. , vol.38 , pp. 1049-1053
    • Amaral, L.1    Kristiansen, J.E.2    Abebe, L.S.3    Millet, W.4
  • 67
    • 0037416986 scopus 로고    scopus 로고
    • Clinical concentrations of Thioridazine kill intracellular Multi-drug resistant Mycobacterium tuberculosis
    • Ordway, D.; Viveiros, M.; Leandro, C.; Amaral, L. Clinical concentrations of Thioridazine kill intracellular Multi-drug resistant Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 2003, 47, 917-922.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 917-922
    • Ordway, D.1    Viveiros, M.2    Leandro, C.3    Amaral, L.4
  • 68
    • 62949134547 scopus 로고    scopus 로고
    • Sila Compound 421, an Inhibitor of efflux pumps of cancer cells, enhances the killing of intracellular XDRTB
    • Martins, M.; Viveiros, M.; Amaral, L. Sila Compound 421, an Inhibitor of efflux pumps of cancer cells, enhances the killing of intracellular XDRTB. Int. J. Antimicrob. Agents 2008, 33, 479-482.
    • (2008) Int. J. Antimicrob. Agents , vol.33 , pp. 479-482
    • Martins, M.1    Viveiros, M.2    Amaral, L.3
  • 69
    • 35648948351 scopus 로고    scopus 로고
    • The curative activity of thioridazine on mice infected with Mycobacterium tuberculosis
    • Martins, M.; Viveiros, M.; Amaral, L. The curative activity of thioridazine on mice infected with Mycobacterium tuberculosis. In Vivo 2007, 21, 771-776.
    • (2007) In Vivo , vol.21 , pp. 771-776
    • Martins, M.1    Viveiros, M.2    Amaral, L.3
  • 72
    • 84865699664 scopus 로고    scopus 로고
    • Totally Drug Resistant Tuberculosis can be Treated with Thioridazine in Combination with Antibiotics to which the Patient was Initially Resistant
    • doi: 10. 4172/bcpc. 1000e102
    • Amaral, L. Totally Drug Resistant Tuberculosis can be Treated with Thioridazine in Combination with Antibiotics to which the Patient was Initially Resistant. Biochem. Pharmacol. 2012, doi: 10. 4172/bcpc. 1000e102.
    • (2012) Biochem. Pharmacol.
    • Amaral, L.1
  • 73
    • 84859428822 scopus 로고    scopus 로고
    • Why thioridazine in combination with antibiotics cures extensively drug-resistant Mycobacterium tuberculosis infections
    • Amaral, L.; Viveiros, M. Why thioridazine in combination with antibiotics cures extensively drug-resistant Mycobacterium tuberculosis infections. Int. J. Antimicrob. Agents 2012, 39, 376-380.
    • (2012) Int. J. Antimicrob. Agents , vol.39 , pp. 376-380
    • Amaral, L.1    Viveiros, M.2
  • 74
    • 84857879092 scopus 로고    scopus 로고
    • Potential therapy of multidrug-resistant and extremely drug-resistant tuberculosis with thioridazine
    • Amaral, L.; Molnar, J. Potential therapy of multidrug-resistant and extremely drug-resistant tuberculosis with thioridazine. In Vivo 2012, 26, 231-236.
    • (2012) In Vivo , vol.26 , pp. 231-236
    • Amaral, L.1    Molnar, J.2
  • 75
    • 79959935423 scopus 로고    scopus 로고
    • Safety and efficacy of thioridazine as salvagetherapy in Indian patients with XDR-TB
    • Udwadia, Z. F.; Sen, T.; Pinto, L. M. Safety and efficacy of thioridazine as salvagetherapy in Indian patients with XDR-TB. Recent Pat. Antiinfect. Drug Discov. 2011, 6, 88-91.
    • (2011) Recent Pat. Antiinfect. Drug Discov. , vol.6 , pp. 88-91
    • Udwadia, Z.F.1    Sen, T.2    Pinto, L.M.3
  • 77
    • 33646849578 scopus 로고    scopus 로고
    • Synergistic interaction between proton pump inhibitors and resistance modifiers: Promoting effects of antibiotics and plasmid curing
    • Wolfart, K.; Spengler, G.; Kawase, M.; Motohashi, N.; Molnár, J.; Viveiros, M.; Amaral, L. Synergistic interaction between proton pump inhibitors and resistance modifiers: Promoting effects of antibiotics and plasmid curing. In Vivo 2006, 20, 367-372.
    • (2006) In Vivo , vol.20 , pp. 367-372
    • Wolfart, K.1    Spengler, G.2    Kawase, M.3    Motohashi, N.4    Molnár, J.5    Viveiros, M.6    Amaral, L.7
  • 78
    • 0042334479 scopus 로고    scopus 로고
    • Enhancement of plasmid curing by 9-aminoacridine and two phenothiazines in the presence of proton pump inhibitor 1-(2-benzoxazolyl)-3, 3, 3-trifluoro-2-propanone
    • Spengler, G.; Miczák, A.; Hajdú, E.; Kawase, M.; Amaral, L.; Molnár, J. Enhancement of plasmid curing by 9-aminoacridine and two phenothiazines in the presence of proton pump inhibitor 1-(2-benzoxazolyl)-3, 3, 3-trifluoro-2-propanone. Int. J. Antimicrob. Agents 2003, 22, 223-227.
    • (2003) Int. J. Antimicrob. Agents , vol.22 , pp. 223-227
    • Spengler, G.1    Miczák, A.2    Hajdú, E.3    Kawase, M.4    Amaral, L.5    Molnár, J.6
  • 79
    • 0033033874 scopus 로고    scopus 로고
    • Potentiality of tricyclic compound thioridazine as an effective antibacterial and antiplasmid agent
    • Radhakrishnan, V.; Ganguly, K.; Ganguly, M.; Dastidar, S. G.; Chakrabarty, A. N. Potentiality of tricyclic compound thioridazine as an effective antibacterial and antiplasmid agent. Indian J. Exp. Biol. 1999, 37, 671-675.
    • (1999) Indian J. Exp. Biol. , vol.37 , pp. 671-675
    • Radhakrishnan, V.1    Ganguly, K.2    Ganguly, M.3    Dastidar, S.G.4    Chakrabarty, A.N.5
  • 80
    • 0030624055 scopus 로고    scopus 로고
    • Effect of promethazine hydrochloride (pipolphen) on the stability of R plasmid resistance in Escherichia coli (in Russian)
    • Evdokimova, O. V.; Smirnov, I. V.; Artem'eva, N. A.; Rozhkova, E. A. Effect of promethazine hydrochloride (pipolphen) on the stability of R plasmid resistance in Escherichia coli (in Russian). Antibiot Khimioter 1997, 42, 8-11.
    • (1997) Antibiot Khimioter , vol.42 , pp. 8-11
    • Evdokimova, O.V.1    Smirnov, I.V.2    Artem'eva, N.A.3    Rozhkova, E.A.4
  • 81
    • 0021321945 scopus 로고
    • Inhibition of bacterial plasmid replication by stereoselective binding by tricyclic psychopharmacons
    • Molnár, J.; Gálfi, M.; Lózsa, A.; Nakamura, M. J. Inhibition of bacterial plasmid replication by stereoselective binding by tricyclic psychopharmacons. Res. Commun. Chem. Pathol. Pharmacol. 1984, 43, 235-249.
    • (1984) Res. Commun. Chem. Pathol. Pharmacol. , vol.43 , pp. 235-249
    • Molnár, J.1    Gálfi, M.2    Lózsa, A.3    Nakamura, M.J.4


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