Ethidium bromide efflux by Salmonella: Modulation by metabolic energy, pH, ions and phenothiazines

International Journal of Antimicrobial Agents

Volumn 38, Issue 2, 2011, Pages 140-145

  Amaral, Leonard ^a,b   Cerca, Pedro ^a   Spengler, Gabriella ^a   MacHado, Lisa ^a   Martins, Ana ^a   Couto, Isabel ^a,c   Viveiros, Miguel ^a,b   Fanning, Séamus ^b,d   Pags, Jean Marie ^b,e  

^a INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

^b European Commission/European Science Foundation ^*  (Portugal)

^c UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^d UNIVERSITY COLLEGE DUBLIN   (Ireland)

^e Aix Marseille University   (France)

Author keywords

CCCP; Efflux pump; Hydronium ions; Ions; Metabolic energy; pH; Proton motive force; Salmonella Enteritidis; Thioridazine

Indexed keywords

CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; CARRIER PROTEIN; DEIONIZED WATER; ETHIDIUM BROMIDE; GLUCOSE; ORTHOVANADIC ACID; PHENOTHIAZINE DERIVATIVE; SODIUM; THIORIDAZINE; UNCLASSIFIED DRUG; WATER;

ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME INHIBITION; METABOLIC CAPACITY; NONHUMAN; PH; PRIORITY JOURNAL; SALMONELLA ENTERITIDIS;

BIOLOGICAL TRANSPORT, ACTIVE; CULTURE MEDIA; ENERGY METABOLISM; ETHIDIUM; HUMANS; HYDROGEN-ION CONCENTRATION; IONOPHORES; PHENOTHIAZINES; SALMONELLA ENTERICA;

EID: 79959759805     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2011.03.014     Document Type: Article

References (30)

1. M. Karczmarczyk, M. Martins, M. McCusker, S. Mattar, L. Amaral, and N. Leonard Characterization of antimicrobial resistance in Salmonella enterica food and animal isolates from Colombia: identification of a qnrB19-mediated quinolone resistance marker in two novel serovars FEMS Microbiol Lett 313 2010 10 19
2. A. Martins, C. Iversen, L. Rodrigues, G. Spengler, J. Ramos, and W.V. Kern An AcrAB-mediated multidrug-resistant phenotype is maintained following restoration of wild-type activities by efflux pump genes and their regulators Int J Antimicrob Agents 34 2009 602 604
3. M. Viveiros, M. Dupont, L. Rodrigues, I. Couto, A. Davin-Regli, and M. Martins Antibiotic stress, genetic response and altered permeability of E. coli PLoS One 2 2007 e365
4. M. Viveiros, A. Jesus, M. Brito, C. Leandro, M. Martins, and D. Ordway Inducement and reversal of tetracycline resistance in Escherichia coli K-12 and expression of proton gradient-dependent multidrug efflux pump genes Antimicrob Agents Chemother 49 2005 3578 3582 (Pubitemid 41060625)
5. T. Quinn, R. O'Mahony, A.W. Baird, D. Drudy, P. Whyte, and S. Fanning Multi-drug resistance in Salmonella enterica: efflux mechanisms and their relationships with the development of chromosomal resistance gene clusters Curr Drug Targets 7 2006 849 860
6. J.-M. Pags, and L. Amaral Mechanisms of drug efflux and strategies to combat them: challenging the efflux pump of Gram-negative bacteria Biochim Biophys Acta 1794 2009 826 833
7. J.M. Pages Biosynthesis and transport of envelope proteins of Escherichia coli Biochimie 65 1983 531 541 [in French]
8. T. Eicher, L. Brandstätter, and K.M. Pos Structural and functional aspects of the multidrug efflux pump AcrB Biol Chem 390 2009 693 699
9. K.M. Pos Drug transport mechanism of the AcrB efflux pump Biochim Biophys Acta 1794 2009 782 793
10. M.A. Seeger, K. Diederichs, T. Eicher, L. Brandstätter, A. Schiefner, and F. Verrey The AcrB efflux pump: conformational cycling and peristalsis lead to multidrug resistance Curr Drug Targets 9 2008 729 749
11. H. Nikaido, and Y. Takatsuka Mechanisms of RND multidrug efflux pumps Biochim Biophys Acta 1794 2009 769 781
12. C.C. Su, H. Nikaido, and E.W. Yu Ligand-transporter interaction in the AcrB multidrug efflux pump determined by fluorescence polarization assay FEBS Lett 581 2007 4972 4976 (Pubitemid 47531772)
13. M. Martins, I. Couto, M. Viveiros, and L. Amaral Identification of efflux-mediated multi-drug resistance in bacterial clinical isolates by two simple methods Methods Mol Biol 642 2010 143 157
14. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; seventeenth informational supplement. Document M100-S17. Wayne, PA: CLSI; 2007.
15. M. Viveiros, L. Rodrigues, M. Martins, I. Couto, G. Spengler, and A. Martins Evaluation of efflux activity of bacteria by a semi-automated fluorometric system Methods Mol Biol 642 2010 159 172
16. A. Martins, G. Spengler, L. Rodrigues, M. Viveiros, J. Ramos, and M. Martins pH modulation of efflux pump activity of multi-drug resistant Escherichia coli: protection during its passage and eventual colonization of the colon PLoS One 4 2009 e6656
17. L. Amaral, S. Fanning, and J.M. Pages Efflux pumps of Gram-negative bacteria: genetic responses to stress and the modulation of their activity by pH, inhibitors, and phenothiazines E.J. Toone, Advances in enzymology and related areas of molecular biology 2011 John Wiley & Sons, Inc. 61 108
18. J.M.A. Blair, and L.J.V. Piddock Structure, function and inhibition of RND efflux pumps in Gram-negative bacteria: an update Curr Opin Microbiol 12 2009 512 519
19. A. Martins, L. Machado, S. Costa, P. Cerca, G. Spengler, and M. Viveiros maral L. Role of calcium in efflux system of E coli. International Journal Antimicrobial Agents. 37 2011 410 414
20. L. Amaral, S. Fanning, M McCusker, G. Spengler, L. Rodrigues, and C. Iversen Genetic regulation, physiology, assessment and inhibition of efflux pumps responsible for multi-drug resistant phenotypes of bacterial pathogens A.R. Bonilla, K.P. Muniz, Antibiotic resistance: causes and risk factors, mechanisms and alternatives 2009 Nova Science New York, NY 313 332
21. I.D. Kerr, P.M. Jones, and A.M. George Multidrug efflux pumps: the structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues FEBS J 277 2010 550 563
22. +-transporting ATP synthases: insights into how their electrochemically driven motor might serve as a drug target Yakugaku Zasshi 130 2010 191 197 [in Japanese]
23. C. von Ballmoos, A. Wiedenmann, and P. Dimroth Essentials for ATP synthesis by F1F0 ATP synthases Annu Rev Biochem 78 2009 649 672
24. P. Turina, A. Rebecchi, M. D'Alessandro, S. Anefors, and B.A. Melandri Modulation of proton pumping efficiency in bacterial ATP synthases Biochim Biophys Acta 1757 2009 320 325 (Pubitemid 43993864)
25. A.Y. Mulkidjanian Proton in the well and through the desolvation barrier Biochim Biophys Acta 1757 2009 415 427 (Pubitemid 43993866)
26. A.Y. Mulkidjanian, J. Heberle, and D.A. Cherepanov Protons @ interfaces: implications for biological energy conversion Biochim Biophys Acta 1757 2006 913 930 (Pubitemid 44467835)
27. A.Y. Mulkidjanian, D.A. Cherepanov, J. Heberle, and W. Junge Proton transfer dynamics at membrane/water interface and mechanism of biological energy conversion Biochemistry (Mosc) 70 2005 251 256 (Pubitemid 40512335)
28. M.A. Seeger, C. von Ballmoos, F. Verrey, and K.M. Pos Crucial role of Asp408 in the proton translocation pathway of multidrug transporter AcrB: evidence from site-directed mutagenesis and carbodiimide labeling Biochemistry 48 2009 5801 5812
29. L. Cuthbertson, V. Kos, and C. Whitfield ABC transporters involved in export of cell surface glycoconjugates Microbiol Mol Biol Rev 74 2010 341 362
30. G. Benga Water channel proteins (later called aquaporins) and relatives: past, present, and future IUBMB Life 61 2009 112 133