A core hSSB1-INTS complex participates in the DNA damage response

Journal of Cell Science

Volumn 126, Issue 21, 2013, Pages 4850-4855

  Zhang, Feng ^a   Ma, Teng ^a   Yu, Xiaochun ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

DNA damage response; Homologous recombination; hSSB1 INTS complex

Indexed keywords

BRCA1 PROTEIN; HUMAN SINGLE STRANDED DNA BINDING PROTEIN 1; INTEGRATOR COMPLEX SUBUNIT 3; INTEGRATOR COMPLEX SUBUNIT 6; MULTIPROTEIN COMPLEX; RAD51 PROTEIN; SINGLE STRANDED DNA BINDING PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DNA DAMAGE; DNA PROTEIN COMPLEX; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN SUBUNIT;

DNA DAMAGE RESPONSE; HOMOLOGOUS RECOMBINATION; HSSB1-INTS COMPLEX;

CELL LINE, TUMOR; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; HUMANS; MITOCHONDRIAL PROTEINS; PROTEIN BINDING; RIBOSOMAL PROTEINS; TUMOR SUPPRESSOR PROTEINS;

EID: 84887590010     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.132514     Document Type: Article

References (28)

1. Aguilera, A. and Gómez-González, B. (2008). Genome instability: a mechanistic view of its causes and consequences. Nat. Rev. Genet., 9, 204-217.
2. Baillat, D., Hakimi, M. A., Näär, A. M., Shilatifard, A., Cooch, N. and Shiekhattar, R. (2005). Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Cell, 123, 265-276.
3. Bartek, J., Lukas, C. and Lukas, J. (2004). Checking on DNA damage in S phase. Nat. Rev. Mol. Cell Biol., 5, 792-804.
4. Cejka, P., Cannavo, E., Polaczek, P., Masuda-Sasa, T., Pokharel, S., Campbell, J. L. and Kowalczykowski, S. C. (2010). DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2. Nature, 467, 112-116.
5. Ciccia, A. and Elledge, S. J. (2010). The DNA damage response: making it safe to play with knives. Mol. Cell, 40, 179-204.
6. Cotta-Ramusino, C., McDonald, E. R., III, Hurov, K., Sowa, M. E., Harper, J. W. and Elledge, S. J. (2011). A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. Science, 332, 1313-1317.
7. Deans, A. J. and West, S. C. (2011). DNA interstrand crosslink repair and cancer. Nat. Rev. Cancer, 11, 467-480.
8. Gravel, S., Chapman, J. R., Magill, C. and Jackson, S. P. (2008). DNA helicases Sgs1 and BLM promote DNA double-strand break resection. Genes Dev., 22, 2767-2772.
9. Harper, J. W. and Elledge, S. J. (2007). The DNA damage response: ten years after. Mol. Cell, 28, 739-745.
10. Hopkins, B. B. and Paull, T. T. (2008). The P. furiosus mre11/rad50 complex promotes 59 strand resection at a DNA double-strand break. Cell, 135, 250-260.
11. Huang, J., Gong, Z., Ghosal, G. and Chen, J. (2009). SOSS complexes participate in the maintenance of genomic stability. Mol. Cell, 35, 384-393.
12. Huertas, P. (2010). DNA resection in eukaryotes: deciding how to fix the break. Nat. Struct. Mol. Biol., 17, 11-16.
13. Li, Y., Bolderson, E., Kumar, R., Muniandy, P. A., Xue, Y., Richard, D. J., Seidman, M., Pandita, T. K., Khanna, K. K. and Wang, W. (2009). HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. J. Biol. Chem., 284, 23525-23531.
14. Lukas, J. and Bartek, J. (2004). Watching the DNA repair ensemble dance. Cell, 118, 666-668.
15. Mimitou, E. P. and Symington, L. S. (2008). Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature, 455, 770-774.
16. Nicolette, M. L., Lee, K., Guo, Z., Rani, M., Chow, J. M., Lee, S. E. and Paull, T. T. (2010). Mre11-Rad50-Xrs2 and Sae2 promote 59 strand resection of DNA doublestrand breaks. Nat. Struct. Mol. Biol., 17, 1478-1485.
17. Niu, H., Chung, W. H., Zhu, Z., Kwon, Y., Zhao, W., Chi, P., Prakash, R., Seong, C., Liu, D., Lu, L. et al. (2010). Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae. Nature, 467, 108-111.
18. Richard, D. J., Bolderson, E., Cubeddu, L., Wadsworth, R. I., Savage, K., Sharma, G. G., Nicolette, M. L., Tsvetanov, S., McIlwraith, M. J., Pandita, R. K. et al. (2008). Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature, 453, 677-681.
19. Rouse, J. and Jackson, S. P. (2002). Interfaces between the detection, signaling, and repair of DNA damage. Science, 297, 547-551.
20. Sancar, A., Lindsey-Boltz, L. A., Unsal-Kaçmaz, K. and Linn, S. (2004). Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu. Rev. Biochem., 73, 39-85.
21. Skaar, J. R., Richard, D. J., Saraf, A., Toschi, A., Bolderson, E., Florens, L., Washburn, M. P., Khanna, K. K. and Pagano, M. (2009). INTS3 controls the hSSB1-mediated DNA damage response. J. Cell Biol., 187, 25-32.
22. Takeda, S., Nakamura, K., Taniguchi, Y. and Paull, T. T. (2007). Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination. Mol. Cell, 28, 351-352.
23. Wang, W. (2007). Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins. Nat. Rev. Genet., 8, 735-748.
24. Weinstock, D. M., Nakanishi, K., Helgadottir, H. R. and Jasin, M. (2006). Assaying double-strand break repair pathway choice in mammalian cells using a targeted endonuclease or the RAG recombinase. Methods Enzymol., 409, 524-540.
25. West, S. C. (2003). Molecular views of recombination proteins and their control. Nat. Rev. Mol. Cell Biol., 4, 435-445.
26. Williams, R. S., Moncalian, G., Williams, J. S., Yamada, Y., Limbo, O., Shin, D. S., Groocock, L. M., Cahill, D., Hitomi, C., Guenther, G. et al. (2008). Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair. Cell, 135, 97-109.
27. Zhang, F., Ma, J., Wu, J., Ye, L., Cai, H., Xia, B. and Yu, X. (2009a). PALB2 links BRCA1 and BRCA2 in the DNA-damage response. Curr. Biol., 19, 524-529.
28. Zhang, F., Wu, J. and Yu, X. (2009b). Integrator3, a partner of single-stranded DNAbinding protein 1, participates in the DNA damage response. J. Biol. Chem., 284, 30408-30415.