Human cytidine deaminase: A biochemical characterization of its naturally occurring variants

International Journal of Biological Macromolecules

Volumn 63, Issue , 2014, Pages 64-74

  Micozzi, Daniela ^a   Carpi, Francesco Martino ^a   Pucciarelli, Stefania ^a   Polzonetti, Valeria ^a   Polidori, Paolo ^a   Vilar, Santiago ^b   Williams, Brian ^c   Costanzi, Stefano ^c   Vincenzetti, Silvia ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c AMERICAN UNIVERSITY   (United States)

Author keywords

Cytidine deaminase; Genetic polymorphism; Kinetic analysis; Molecular modeling; Site directed mutagenesis

Indexed keywords

ADENINE; ALANINE; CYTARABINE; CYTIDINE DEAMINASE; CYTIDINE DERIVATIVE; CYTOSINE; FAZARABINE; GLUTAMIC ACID; GLUTAMINE; GUANINE; LYSINE; PRODRUG; TETRAHYDRODEOXYURIDINE; TETRAHYDROURIDINE; THREONINE; THYMINE; ZEBULARINE;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; ENZYME ACTIVITY; EXPOSURE; GENE FUNCTION; GENETIC CONSERVATION; HUMAN; MOLECULAR INTERACTION; MOLECULAR MODEL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN STABILITY; PROTEIN STRUCTURE; SINGLE NUCLEOTIDE POLYMORPHISM; SITE DIRECTED MUTAGENESIS;

ARA;

1-Β-D-ARABINO FURANOSYLCYTOSINE OR CYTARABINE; 1-Β-D-ARABINOFURANOSYL-5-AZACYTOSINE; 2′,2′-DIFLUORODEOXYCYTIDINE OR GEMCITABINE; 2′,3′-CDR; 2′,3′-DIDEOXYCYTIDINE; 2′-DEOXYCYTIDINE; 5′-AZADEOXYCYTIDINE; 6-AZA-CR; 6-AZACYTIDINE; ARA-C; AZA-CDR; CDA; CDR; CR; CYTIDINE; CYTIDINE DEAMINASE; DFDC; DITHIOTHREITOL DITHIOTHREITOL; DTT; EDTA; ETHYLENEDIAMINETETRAACETIC ACID; FAZARABINE; GENETIC POLYMORPHISM; IPTG; ISOPROPYL-THIO-Β-D-GALACTOPYRANOSIDE; KINETIC ANALYSIS; MOLECULAR MODELING; SINGLE NUCLEOTIDE POLYMORPHISMS; SITE-DIRECTED MUTAGENESIS; SNP; TETRAHYDROURIDINE; THU;

ANTINEOPLASTIC AGENTS; CATALYSIS; CYTARABINE; CYTIDINE DEAMINASE; HUMANS; KINETICS; LEUKEMIA; MUTAGENESIS, SITE-DIRECTED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84887576932     PISSN: 01418130     EISSN: 18790003     Source Type: Journal    
DOI: 10.1016/j.ijbiomac.2013.10.029     Document Type: Article

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