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Volumn 48, Issue 3, 2005, Pages 658-660

Structure of human cytidine deaminase bound to a potent inhibitor

Author keywords

[No Author keywords available]

Indexed keywords

CYTIDINE DEAMINASE; DIAZEPINE DERIVATIVE; DIAZEPINONE RIBOSIDE; ENZYME INHIBITOR; PHENYLALANINE; UNCLASSIFIED DRUG;

EID: 13444265938     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0496279     Document Type: Article
Times cited : (66)

References (23)
  • 1
  • 2
    • 0017833068 scopus 로고
    • Cytidine deaminases (from Escherichia coli and human liver)
    • Wentworth, D. F.; Wolfenden, R. Cytidine deaminases (from Escherichia coli and human liver). Methods Enzymol. 1978, 51, 401-407.
    • (1978) Methods Enzymol. , vol.51 , pp. 401-407
    • Wentworth, D.F.1    Wolfenden, R.2
  • 3
    • 13444263910 scopus 로고
    • Cytidine aminohydrolase from sheep liver
    • Wisdom, G. B.; Orsi, B. A. Cytidine aminohydrolase from sheep liver. Biochem. J. 1967, 104, 7P.
    • (1967) Biochem. J. , vol.104
    • Wisdom, G.B.1    Orsi, B.A.2
  • 4
    • 0031658826 scopus 로고    scopus 로고
    • Drug resistance to 5-aza-2′-deoxycytidine, 2′, 2′-difluorodeoxycytidine, and cytosine arabinoside conferred by retroviral-mediated transfer of human cytidine deaminase cDNA into murine cells
    • Eliopoulos, N.; Cournoyer, D.; Momparler, R. L. Drug resistance to 5-aza-2′-deoxycytidine, 2′, 2′-difluorodeoxycytidine, and cytosine arabinoside conferred by retroviral-mediated transfer of human cytidine deaminase cDNA into murine cells. Cancer Chemother. Pharmacol. 1998, 42, 373-378.
    • (1998) Cancer Chemother. Pharmacol. , vol.42 , pp. 373-378
    • Eliopoulos, N.1    Cournoyer, D.2    Momparler, R.L.3
  • 5
    • 0024999580 scopus 로고
    • Induction of cytidine deaminase in HL-60 myeloid leukemic cells by 5-aza-2′-deoxycytidine
    • Momparler, R. L.; Laliberte, J. Induction of cytidine deaminase in HL-60 myeloid leukemic cells by 5-aza-2′-deoxycytidine. Leukemia Res. 1990, 14, 751-754.
    • (1990) Leukemia Res. , vol.14 , pp. 751-754
    • Momparler, R.L.1    Laliberte, J.2
  • 6
    • 0024382419 scopus 로고
    • Development of resistance to 1-β-D-arabinofuranosylcytosine after high-dose treatment in childhood lymphoblastic leukemia: Analysis of resistance mechanism in established cell lines
    • Kees, U. R.; Ford, J.; Dawson, V. M.; Piall, E.; Aherne, G. W. Development of resistance to 1-β-D-arabinofuranosylcytosine after high-dose treatment in childhood lymphoblastic leukemia: analysis of resistance mechanism in established cell lines. Cancer Res. 1989, 49, 3015-3019.
    • (1989) Cancer Res. , vol.49 , pp. 3015-3019
    • Kees, U.R.1    Ford, J.2    Dawson, V.M.3    Piall, E.4    Aherne, G.W.5
  • 7
    • 0347632481 scopus 로고
    • Anti-herpes virus activity of 5-methoxymethyl-2′-deoxycytidine in combination with deaminase inhibitors
    • Aduma, P. J.; Gupta, S. V.; Stuart, A. L.; Tourigny, G. Anti-herpes virus activity of 5-methoxymethyl-2′-deoxycytidine in combination with deaminase inhibitors. Antiviral Chem. Chemother. 1990, 1, 255-262.
    • (1990) Antiviral Chem. Chemother. , vol.1 , pp. 255-262
    • Aduma, P.J.1    Gupta, S.V.2    Stuart, A.L.3    Tourigny, G.4
  • 8
    • 0015242222 scopus 로고
    • Effects of murine viral leukemia on spleen nucleoside deaminase. Purification and properties of the enzyme from leukemic spleen
    • Malathi, V. G.; Silber, R. Effects of murine viral leukemia on spleen nucleoside deaminase. Purification and properties of the enzyme from leukemic spleen. Biochim. Biophys. Acta 1971, 238, 377-387.
    • (1971) Biochim. Biophys. Acta , vol.238 , pp. 377-387
    • Malathi, V.G.1    Silber, R.2
  • 9
    • 0026574097 scopus 로고
    • Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2′-deoxycytidine by human cytidine deaminase
    • Laliberte, J.; Marquez, V. E.; Momparler, R. L. Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2′-deoxycytidine by human cytidine deaminase. Cancer Chemother. Pharmacol. 1992, 30, 7-11.
    • (1992) Cancer Chemother. Pharmacol. , vol.30 , pp. 7-11
    • Laliberte, J.1    Marquez, V.E.2    Momparler, R.L.3
  • 10
    • 0026323307 scopus 로고
    • Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues
    • Driscoll, J. S.; Marquez, V. E.; Plowman, J.; Liu, P. S.; Kelley, J. A.; Barchi, J. J., Jr. Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues. J. Med. Chem. 1991, 34, 3280-3284.
    • (1991) J. Med. Chem. , vol.34 , pp. 3280-3284
    • Driscoll, J.S.1    Marquez, V.E.2    Plowman, J.3    Liu, P.S.4    Kelley, J.A.5    Barchi Jr., J.J.6
  • 11
    • 0024332902 scopus 로고
    • Binding of pyrimidin-2-one ribonucleoside by cytidine deaminase as the transition-state analogue 3,4-dihydrouridine and contribution of the 4-hydroxyl group to its binding affinity
    • Frick, L.; Yang, C.; Marquez, V. E.; Wolfenden, R. V. Binding of pyrimidin-2-one ribonucleoside by cytidine deaminase as the transition-state analogue 3,4-dihydrouridine and contribution of the 4-hydroxyl group to its binding affinity. Biochemistry 1989, 28, 9423-9430.
    • (1989) Biochemistry , vol.28 , pp. 9423-9430
    • Frick, L.1    Yang, C.2    Marquez, V.E.3    Wolfenden, R.V.4
  • 13
    • 0014681301 scopus 로고
    • Transition state analogues for enzyme catalysis
    • Wolfenden, R. V. Transition state analogues for enzyme catalysis. Nature 1969, 223, 704-705.
    • (1969) Nature , vol.223 , pp. 704-705
    • Wolfenden, R.V.1
  • 14
    • 0020261555 scopus 로고
    • A phosphorus-containing pyrimidine analog as a potent inhibitor of cytidine deaminase
    • Ashley, G. W.; Bartlett, P. A. A phosphorus-containing pyrimidine analog as a potent inhibitor of cytidine deaminase. Biochem. Biophys. Res. Commun. 1982, 108, 1467-1474.
    • (1982) Biochem. Biophys. Res. Commun. , vol.108 , pp. 1467-1474
    • Ashley, G.W.1    Bartlett, P.A.2
  • 15
    • 0028057520 scopus 로고
    • Cytidine deaminase. The 2.3 Å crystal structure of an enzyme: Transition-state analog complex
    • Betts, L.; Xiang, S.; Short, S. A.; Wolfenden, R.; Carter, C. W., Jr. Cytidine deaminase. The 2.3 Å crystal structure of an enzyme: transition-state analog complex. J. Mol. Biol. 1994, 235, 635-656.
    • (1994) J. Mol. Biol. , vol.235 , pp. 635-656
    • Betts, L.1    Xiang, S.2    Short, S.A.3    Wolfenden, R.4    Carter Jr., C.W.5
  • 16
    • 0028921384 scopus 로고
    • The nucleoside deaminases for cytidine and adenosine: Structure, transition state stabilization, mechanism, and evolution
    • Carter, C. W., Jr. The nucleoside deaminases for cytidine and adenosine: structure, transition state stabilization, mechanism, and evolution. Biochimie 1995, 77, 92-98.
    • (1995) Biochimie , vol.77 , pp. 92-98
    • Carter Jr., C.W.1
  • 17
    • 0028958685 scopus 로고
    • Transition-state selectivity for a single hydroxyl group during catalysis by cytidine deaminase
    • Xiang, S.; Short, S. A.; Wolfenden, R.; Carter, C. W., Jr. Transition-state selectivity for a single hydroxyl group during catalysis by cytidine deaminase. Biochemistry 1995, 34, 4516-4523.
    • (1995) Biochemistry , vol.34 , pp. 4516-4523
    • Xiang, S.1    Short, S.A.2    Wolfenden, R.3    Carter Jr., C.W.4
  • 18
    • 0037176913 scopus 로고    scopus 로고
    • Crystal Structure of the Tetrameric Cytidine Deaminase from Bacillus subtilis at 2.0 Å resolution
    • Johansson, E.; Mejlhede, N.; Neuhard, J.; Larsen, S. Crystal Structure of the Tetrameric Cytidine Deaminase from Bacillus subtilis at 2.0 Å resolution. Biochemistry 2002, 41, 2563-2570.
    • (2002) Biochemistry , vol.41 , pp. 2563-2570
    • Johansson, E.1    Mejlhede, N.2    Neuhard, J.3    Larsen, S.4
  • 19
    • 0022519219 scopus 로고
    • Synthesis of pyrimidin-2-one nucleosides as acid-stable inhibitors of cytidine deaminase
    • Kim, C. H.; Marquez, V. E.; Mao, D. T.; Haines, D. R.; McCormack, J. J. Synthesis of pyrimidin-2-one nucleosides as acid-stable inhibitors of cytidine deaminase. J. Med. Chem. 1986, 29, 1374-1380.
    • (1986) J. Med. Chem. , vol.29 , pp. 1374-1380
    • Kim, C.H.1    Marquez, V.E.2    Mao, D.T.3    Haines, D.R.4    McCormack, J.J.5
  • 20
    • 0018878649 scopus 로고
    • Synthesis of 1,3-diazepin-2-one nucleosides as transition-state inhibitors of cytidine deaminase
    • Marquez, V. E.; Liu, P. S.; Kelley, J. A.; Driscoll, J. S.; MeCormack, J. J. Synthesis of 1,3-diazepin-2-one nucleosides as transition-state inhibitors of cytidine deaminase. J. Med. Chem. 1980, 23, 713-715.
    • (1980) J. Med. Chem. , vol.23 , pp. 713-715
    • Marquez, V.E.1    Liu, P.S.2    Kelley, J.A.3    Driscoll, J.S.4    Mecormack, J.J.5
  • 21
    • 0242598000 scopus 로고
    • Cyclic urea nucleosides. Cytidine deaminase activity as a function of aglycon ring size
    • Liu, P. S.; Marquez, V. E.; Kelley, J. A.; Driscoll, J. S. Cyclic urea nucleosides. Cytidine deaminase activity as a function of aglycon ring size. J. Org. Chem. 1980, 45, 5225-5227.
    • (1980) J. Org. Chem. , vol.45 , pp. 5225-5227
    • Liu, P.S.1    Marquez, V.E.2    Kelley, J.A.3    Driscoll, J.S.4
  • 22
    • 0019413967 scopus 로고
    • Synthesis of 1,3-diazepin-2-one nucleosides as transition-state inhibitors of cytidine deaminase
    • Liu, P. S.; Marquez, V. E.; Driscoll, J. S.; Fuller, R. W.; McCormack, J. J. Synthesis of 1,3-diazepin-2-one nucleosides as transition-state inhibitors of cytidine deaminase. J. Med. Chem. 1981, 24, 662-666.
    • (1981) J. Med. Chem. , vol.24 , pp. 662-666
    • Liu, P.S.1    Marquez, V.E.2    Driscoll, J.S.3    Fuller, R.W.4    McCormack, J.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.