Micronutrients supplementation and nutritional status in cognitively impaired elderly persons: A two-month open label pilot study

Nutrition Journal

Volumn 12, Issue 1, 2013, Pages

  Von Arnim, Christine A F ^a   Dismar, Stephanie ^b   Ott Renzer, Cornelia S ^b   Noeth, Nathalie ^a   Ludolph, Albert C ^a   Biesalski, Hans K ^b  

^a UNIVERSITY OF ULM   (Germany)

^b UNIVERSITY OF HOHENHEIM   (Germany)

Author keywords

B vitamins; Intracellular antioxidative status; Micronutrient supplement; Mini nutritional assessment

Indexed keywords

ALPHA CAROTENE; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; BIOLOGICAL MARKER; CAROTENOID; COCARBOXYLASE; CYANOCOBALAMIN; FOLIC ACID; HOLOTRANSCOBALAMIN; HOMOCYSTEINE; LYCOPENE; THIAMINE; TRACE ELEMENT; TRANSCOBALAMIN; UNCLASSIFIED DRUG; VITAMIN B GROUP; ZINC;

ADULT; ARTICLE; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; DIET SUPPLEMENTATION; FEMALE; FOLIC ACID DEFICIENCY; HEALTH STATUS; HUMAN; INTERVENTION STUDY; MALE; MUCOSA CELL; NUTRIENT SUPPLY; NUTRITIONAL ASSESSMENT; NUTRITIONAL STATUS; PILOT STUDY; PROTEIN BLOOD LEVEL; QUALITY OF LIFE; SELF CONCEPT; THIAMINE DEFICIENCY;

AGED; AGED, 80 AND OVER; ALPHA-TOCOPHEROL; ANTIOXIDANTS; BETA CAROTENE; CAROTENOIDS; COGNITION DISORDERS; DIETARY SUPPLEMENTS; FEMALE; FOLIC ACID; HUMANS; LUTEIN; MALE; MICRONUTRIENTS; MIDDLE AGED; MOUTH MUCOSA; NUTRITION ASSESSMENT; NUTRITIONAL STATUS; PILOT PROJECTS; VITAMIN B COMPLEX;

EID: 84887553261     PISSN: None     EISSN: 14752891     Source Type: Journal    
DOI: 10.1186/1475-2891-12-148     Document Type: Article

References (46)

1. Age as a determinant of nutritional status: a cross sectional study. Forster S, Gariballa S, Nutr J 2005 4 28 10.1186/1475-2891-4-28 16253135 (Pubitemid 41741785)
2. Body composition, changing physiological functions and nutrient requirements of the elderly. Elmadfa I, Meyer AL, Ann Nutr Metab 2008 52 1 2 5 10.1159/000115339 18382069 (Pubitemid 351496696)
3. Nutritional situation of the elderly in the european union: data of the european nutrition and health report (2004). Fabian E, Elmadfa I, Ann Nutr Metab 2008 52 1 57 61 10.1159/000115352 18382082 (Pubitemid 351496709)
4. Vitamin b-12 deficiency in the elderly: current dilemmas. Stabler SP, Lindenbaum J, Allen RH, Am J Clin Nutr 1997 66 741 749 9322547 (Pubitemid 27415556)
5. Characteristics of alzheimer's disease patients with a rapid weight loss during a six-year follow-up. Guerin O, Andrieu S, Schneider SM, Cortes F, Cantet C, Gillette-Guyonnet S, Vellas B, Clin Nutr 2009 28 141 146 10.1016/j.clnu.2009.01.014 19232792
6. Plasma homocysteine and risk of mild cognitive impairment. Reitz C, Tang MX, Miller J, Green R, Luchsinger JA, Dement Geriatr Cogn Disord 2009 27 11 17 10.1159/000182421 19088473
7. B vitamins, homocysteine, and neurocognitive function in the elderly. Selhub J, Bagley LC, Miller J, Rosenberg IH, Am J Clin Nutr 2000 71 614S 620S 10681269 (Pubitemid 30061246)
8. Midlife homocysteine and late-life dementia in women. A prospective population study. Zylberstein DE, Lissner L, Björkelund C, Mehlig K, Thelle DS, Gustafson D, Ostling S, Waern M, Guo X, Skoog I, Neurobiol Aging 2011 32 3 380 386 Mar 10.1016/j.neurobiolaging.2009.02.024 19342123
9. Dietary intake of antioxidants and risk of alzheimer disease. Engelhart MJ, Geerlings MI, Ruitenberg A, van Swieten JC, Hofman A, Witteman JC, Breteler MM, JAMA 2002 287 3223 3229 10.1001/jama.287.24.3223 12076218 (Pubitemid 34686103)
10. Antioxidants in central nervous system diseases: preclinical promise and translational challenges. Kamat CD, Gadal S, Mhatre M, Williamson KS, Pye QN, Hensley K, J Alzheimers Dis 2008 15 473 493 18997301
11. High-dose b vitamin supplementation and cognitive decline in alzheimer disease: a randomized controlled trial. Aisen PS, Schneider LS, Sano M, Diaz-Arrastia R, van Dyck CH, Weiner MF, Bottiglieri T, Jin S, Stokes KT, Thomas RG, et al. JAMA 2008 300 1774 1783 10.1001/jama.300.15.1774 18854539
12. Dietary supplementation with antioxidants improves functions and decreases oxidative stress of leukocytes from prematurely aging mice. Alvarado C, Alvarez P, Puerto M, Gausseres N, Jimenez L, De la Fuente M, Nutrition 2006 22 767 777 10.1016/j.nut.2006.05.007 16815491 (Pubitemid 43947509)
13. Effect of 3-year folic acid supplementation on cognitive function in older adults in the facit trial: a randomised, double blind, controlled trial. Durga J, van Boxtel MP, Schouten EG, Kok FJ, Jolles J, Katan MB, Verhoef P, Lancet 2007 369 208 216 10.1016/S0140-6736(07)60109-3 17240287 (Pubitemid 46107683)
14. Effect of multivitamin and multimineral supplementation on cognitive function in men and women aged 65 years and over: a randomised controlled trial. McNeill G, Avenell A, Campbell MK, Cook JA, Hannaford PC, Kilonzo MM, Milne AC, Ramsay CR, Seymour DG, Stephen AI, et al. Nutr J 2007 6 10 10.1186/1475-2891-6- 10 17474991 (Pubitemid 46789398)
15. Efficacy of a medical food in mild alzheimer's disease: a randomized, controlled trial. Scheltens P, Kamphuis PJ, Verhey FR, Olde Rikkert MG, Wurtman RJ, Wilkinson D, Twisk JW, Kurz A, Alzheimers Dement 2010 6 1 10 e11 10.1016/j.jalz.2009.10.003 20129316
16. Efficacy of souvenaid in mild alzheimer's disease: results from a randomized, controlled trial. Scheltens P, Twisk JW, Blesa R, Scarpini E, von Arnim CA, Bongers A, Harrison J, Swinkels SH, Stam CJ, de Waal H, et al. J Alzheimers Dis 2012 31 225 236 22766770
17. The effect of a nutrient dense drink on mental and physical function in institutionalized elderly people. Manders M, De Groot LC, Hoefnagels WH, Dhonukshe-Rutten RA, Wouters-Wesseling W, Mulders AJ, Van Staveren WA, J Nutr Health Aging 2009 13 760 767 10.1007/s12603-009-0211-x 19812865
18. Effectiveness of nutritional supplements on cognitive functioning in elderly persons: a systematic review. Manders M, de Groot LC, van Staveren WA, Wouters-Wesseling W, Mulders AJ, Schols JM, Hoefnagels WH, J Gerontol A Biol Sci Med Sci 2004 59 1041 1049 10.1093/gerona/59.10.M1041 15528776 (Pubitemid 39441794)
19. Changes in plasma antioxidant status during eccentric exercise and the effect of vitamin supplementation. Maxwell SR, Jakeman P, Thomason H, Leguen C, Thorpe GH, Free Radic Res Commun 1993 19 191 202 10.3109/10715769309111602 8244088
20. Laboratory diagnosis of vitamin b12 and folate deficiency: a guide for the primary care physician. Snow CF, Arch Intern Med 1999 159 1289 1298 10.1001/archinte.159.12.1289 10386505 (Pubitemid 29293591)
21. Influence of feeding different vegetables on plasma levels of carotenoids, folate and vitamin c. Effect of disruption of the veg matrix. van het Hof KH, Tijburg LB, Pietrzik K, Weststrate JA, Br J Nutr 1999 82 203 212 10655967 (Pubitemid 29438389)
22. Role of antioxidants in buccal mucosa cells and plasma on the incidence and severity of oral mucositis after allogeneic haematopoietic cell transplantation. Urbain P, Raynor A, Bertz H, Lambert C, Biesalski HK, Support Care Cancer 2012 20 8 1831 1838 Aug 10.1007/s00520-011-1284-8 21964619
23. Biological variation of holo-transcobalamin in elderly individuals. McCaddon A, Hudson P, McCracken C, Ellis R, Clin Chem 2003 49 1542 1544 10.1373/49.9.1542 12928243 (Pubitemid 37011750)
24. Cobalamin status (holo-transcobalamin, methylmalonic acid) and folate as determinants of homocysteine concentration. Obeid R, Jouma M, Herrmann W, Clin Chem 2002 48 2064 2065 12407000 (Pubitemid 35222772)
25. Properties and functions of the thiamin diphosphate dependent enzyme transketolase. Schenk G, Duggleby RG, Nixon PF, Int J Biochem Cell Biol 1998 30 1297 1318 10.1016/S1357-2725(98)00095-8 9924800 (Pubitemid 29002974)
26. The evaluation of erythrocyte thiamin diphosphate as an indicator of thiamin status in man, and its comparison with erythrocyte transketolase activity measurements. Baines M, Davies G, Ann Clin Biochem 1988 25 Pt 6 698 705 3254112
27. The determination of thiamin pyrophosphate in blood and other tissues, and its correlation with erythrocyte transketolase activity. Warnock LG, Prudhomme CR, Wagner C, J Nutr 1978 108 421 427 627916 (Pubitemid 9204335)
28. Carotenoid reversed-phase high-performance liquid chromatography methods: reference compendium. Craft NE, Methods Enzymol 1992 213 185 205 1435302 (Pubitemid 23012216)
29. The present status of antioxidant vitamins and beta-carotene. Sies H, Krinsky NI, Am J Clin Nutr 1995 62 1299S 1300S
30. Assessing the nutritional status of the elderly: the mini nutritional assessment as part of the geriatric evaluation. Guigoz Y, Vellas B, Garry PJ, Nutr Rev 1996 54 59 S65
31. Serum zinc in the progression of alzheimer's disease. Dong J, Robertson JD, Markesbery WR, Lovell MA, J Alzheimers Dis 2008 15 443 450 18997297
32. Mineral requirements of elderly people. Wood RJ, Suter PM, Russell RM, Am J Clin Nutr 1995 62 493 505 7661110
33. Serum zinc and pneumonia in nursing home elderly. Meydani SN, Barnett JB, Dallal GE, Fine BC, Jacques PF, Leka LS, Hamer DH, Am J Clin Nutr 2007 86 1167 1173 17921398 (Pubitemid 47538323)
34. Concentrations and plasma-tissue-diet relationships of carotenoids, retinoids, and tocopherols in humans. Peng YM, Peng YS, Lin Y, Moon T, Roe DJ, Ritenbaugh C, Nutr Cancer 1995 23 233 246 10.1080/01635589509514378 7603884
35. Carotenoids in human buccal mucosa cells after 4 wk of supplementation with tomato juice or lycopene supplements. Paetau I, Rao D, Wiley ER, Brown ED, Clevidence BA, Am J Clin Nutr 1999 70 490 494 10500017 (Pubitemid 29463442)
36. Homocysteine, folate, and vitamin b-12 in mild cognitive impairment, alzheimer disease, and vascular dementia. Quadri P, Fragiacomo C, Pezzati R, Zanda E, Forloni G, Tettamanti M, Lucca U, Am J Clin Nutr 2004 80 114 122 15213037 (Pubitemid 41115564)
37. Metabolic evidence that deficiencies of vitamin b-12 (cobalamin), folate, and vitamin b-6 occur commonly in elderly people. Joosten E, van den Berg A, Riezler R, Naurath HJ, Lindenbaum J, Stabler SP, Allen RH, Am J Clin Nutr 1993 58 468 476 8037789 (Pubitemid 23307402)
38. Thiamine status of healthy and institutionalized elderly subjects: analysis of dietary intake and biochemical indices. O'Rourke NP, Bunker VW, Thomas AJ, Finglas PM, Bailey AL, Clayton BE, Age Ageing 1990 19 325 329 10.1093/ageing/19.5.325 2251966 (Pubitemid 20328666)
39. Effect of an enriched drink on cognitive function in frail elderly persons. Wouters-Wesseling W, Wagenaar LW, Rozendaal M, Deijen JB, de Groot LC, Bindels JG, van Staveren WA, J Gerontol A Biol Sci Med Sci 2005 60 265 270 10.1093/gerona/60.2.265 15814873 (Pubitemid 40524870)
40. Population-specific mini nutritional assessment effectively predicts the nutritional state and follow-up mortality of institutionalized elderly taiwanese regardless of cognitive status. Tsai AC, Ku PY, Br J Nutr 2008 100 152 158 18053309
41. The mini nutritional assessment (mna) review of the literature-what does it tell us? Guigoz Y, J Nutr Health Aging 2006 10 466 485 discussion 485-467 17183419 (Pubitemid 46127189)
42. Characteristics of the mini-nutritional assessment in elderly home-care patients. Soini H, Routasalo P, Lagstrom H, Eur J Clin Nutr 2004 58 64 70 10.1038/sj.ejcn.1601748 14679369 (Pubitemid 38159315)
43. Risk of malnutrition in retirement homes elderly persons measured by the "mini-nutritional assessment" Griep MI, Mets TF, Collys K, Ponjaert-Kristoffersen I, Massart DL, J Gerontol A Biol Sci Med Sci 2000 55 57 M63 10737686
44. Evaluation of nutritional assessment techniques in elderly people newly admitted to municipal care. Christensson L, Unosson M, Ek AC, Eur J Clin Nutr 2002 56 810 818 10.1038/sj.ejcn.1601394 12209369
45. Effect of a multivitamin and mineral supplement on infection and quality of life. A randomized, double-blind, placebo-controlled trial. Barringer TA, Kirk JK, Santaniello AC, Foley KL, Michielutte R, Ann Intern Med 2003 138 365 371 10.7326/0003-4819-138-5-200303040-00005 12614088 (Pubitemid 36262646)
46. Effect of multivitamin and mineral supplementation on episodes of infection in nursing home residents: a randomized, placebo-controlled study. Liu BA, McGeer A, McArthur MA, Simor AE, Aghdassi E, Davis L, Allard JP, J Am Geriatr Soc 2007 55 35 42 10.1111/j.1532-5415.2006.01033.x 17233683 (Pubitemid 46046226)