Serum zinc and pneumonia in nursing home elderly

American Journal of Clinical Nutrition

Volumn 86, Issue 4, 2007, Pages 1167-1173

  Meydani, Simin N ^a,b   Barnett, Junaidah B ^a,b,c   Dallal, Gerard E ^a,b   Fine, Basil C ^d   Jacques, Paul F ^a,b   Leka, Lynette S ^a   Hamer, Davidson H ^a,b,e,f  

^a TUFTS UNIVERSITY   (United States)

^b TUFTS UNIVERSITY   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Travel and Tropical Medicine Practice   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Antibiotic use; Mortality; Nursing home elderly; Pneumonia; Serum zinc

Indexed keywords

ALPHA TOCOPHEROL; ANTIBIOTIC AGENT; ASCORBIC ACID; CYANOCOBALAMIN; FOLIC ACID; MINERAL; NICOTINIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; RETINOL; RIBOFLAVIN; THIAMINE; VITAMIN D; ZINC;

AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; DISEASE DURATION; ELDERLY CARE; FEMALE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MORTALITY; NURSING HOME; NUTRITIONAL ASSESSMENT; OBSERVATIONAL STUDY; PNEUMONIA; PRESCRIPTION; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; TREATMENT OUTCOME; VITAMIN SUPPLEMENTATION;

EID: 35148880625     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/86.4.1167     Document Type: Article

References (50)

1. LaCroix AZ, Lipson S, Miles TP, White L. Prospective study of pneumonia hospitalizations and mortality of U.S. older people: the role of chronic conditions, health behaviors, and nutritional status. Public Health Rep 1989;104:350-60.
2. Miller RA. The cell biology of aging: immunological models. J Gerontol 1989;44:B4-8.
3. Mocchegiani E, Giacconi R, Muzzioli M, et al. Zinc, infections and immunosenescence Mech Ageing Dev 2000;121:21-35. (Published erratum appears in Mech Ageing Dev 2001;122:353.)
4. Riquelme R, Torres A, el-Ebiary M, et al. Community-acquired pneumonia in the elderly. Clinical and nutritional aspects. Am J Respir Crit Care Med 1997;156:1908-14.
5. Fraker PJ, King LE, Laakko T, et al. The dynamic link between the integrity of the immune system and zinc status. J Nutr 2000;130(suppl):1399S- 406S.
6. Allen JI, Perri RT, McClain CJ, Kay NE. Alterations in human natural killer cell activity and monocyte cytotoxicity induced by zinc deficiency. J Lab Clin Med 1983;102:577-89.
7. Oleske JM, Westphal ML, Shore S, et al. Zinc therapy of depressed cellular immunity in acrodermatitis enteropathica. Its correction. Am J Dis Child 1979;133:915-8.
8. Beck FW, Prasad AS, Kaplan J, Fitzgerald JT, Brewer GJ. Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans. Am J Physiol 1997;272:E1002-7.
9. Prasad AS, Fitzgerald JT, Hess JW, Kaplan J, Pelen F, Dardenne M. Zinc deficiency in elderly patients. Nutrition 1993;9:218-24.
10. Sandstead HH, Henriksen LK, Greger JL, et al. Zinc nutriture in the elderly in relation to taste acuity, immune response, and wound healing. Am J Clin Nutr 1982;36:1046-59.
11. Lindeman RD, Clark ML, Colmore JP, Lindeman RD, Clark ML, Colmore JP. Influence of age and sex on plasma and red-cell zinc concentrations. J Gerontol 1971;26:358-63.
12. Wagner PA, Jernigan JA, Bailey LB, Nickens C, Brazzi GA. Zinc nutriture and cell-mediated immunity in the aged. Int J Vitamin Nutr Res 1983;53:94-101.
13. Bogden JD, Oleske JM, Lavenhar MA, et al. Effects of one year of supplementation with zinc and other micronutrients on cellular immunity in the elderly. J Am Coll Nutr 1990;9:214-25.
14. Kajanachumpol S, Srisurapanon S, Supanit I, et al. Effect of zinc supplementation on zinc status, copper status and cellular immunity in elderly patients with diabetes mellitus. J Med Assoc Thailand 1995;78:344-9.
15. Duchateau J, Delepesse G, Vrijens R, Collet H. Beneficial effects of oral zinc supplementation on the immune response of old people. Am J Med 1981;70:1001-4.
16. Bahl R, Bhandari N, Hambidge KM, Bhan MK. Plasma zinc as a predictor of diarrheal and respiratory morbidity in children in an urban slum setting. Am J Clin Nutr 1998;68(suppl):414S-7S.
17. Brooks WA, Santosham M, Naheed A, et al. Effect of weekly zinc supplements on incidence of pneumonia and diarrhoea in children younger than 2 years in an urban, low-income population in Bangladesh: randomised controlled trial. Lancet 2005;366:999-1004.
18. Brooks WA, Yunus M, Santosham M, et al. Zinc for severe pneumonia in very young children: double-blind placebo-controlled trial. Lancet 2004;363:1683-8.
19. Meydani SN, Leka LS, Fine BC, et al. Vitamin E and respiratory tract infections in elderly nursing home residents: a randomized controlled trial. JAMA 2004;292:828-36. (Published erratum appears in JAMA 2004;292:1305.)
20. Drinka PJ, Goodwin JS, Drinka PJ, Goodwin JS. Prevalence and consequences of vitamin deficiency in the nursing home: a critical review. J Am Geriatr Soc 1991;39:1008-17.
21. National Research Council (US), Subcommittee on the Tenth Edition of the RDAs, National Institutes of Health (US), National Research Council (US), Committee on Dietary Allowances. Recommended dietary allowances. 10th ed. Washington, DC: National Academy Press, 1989.
22. Fiatarone M, Fiatarone M. Nutrition in the geriatric patient. Hospital Practice (Office Edition) 1990;25:38-40.
23. Institute of Medicine (US), Panel on Micronutrients. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc: a report of the Panel on Micronutrients. Washington, DC: National Academy Press, 2002.
24. Hotz C, Peerson JM, Brown KH, Hotz C, Peerson JM, Brown KH. Suggested lower cutoffs of serum zinc concentrations for assessing zinc status: reanalysis of the second National Health and Nutrition Examination Survey data (1976-1980). Am J Clin Nutr 2003;78:756-64.
25. Prasad AS Beck FW, Bao B, Fitzgerald JT, Snell DC, Steinberg JD, Cardozo LJ. Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress. Am J Clin Nutr 2007;85(3):837-44.
26. Smith JC Jr, Butrimovitz GP, Purdy WC. Direct measurement of zinc in plasma by atomic absorption spectroscopy. Clin Chem 1979;25:1487-91.
27. McGeer A, Campbell B, Emori TG, et al. Definitions of infection for surveillance in long-term care facilities. Am J Infect Control 1991;19:1-7.
28. Ramsey FL, Schafer DW. The statistical sleuth: a course in methods of data analysis. 2nd ed. Pacific Grove, CA: Duxbury/Thomson Learning, 2002.
29. Mandell LA, Bartlett JG, Dowell SF, et al. Update of practice guidelines for the management of community-acquired pneumonia in immunocompetent adults. Clin Infect Dis 2003;37:1405-33.
30. Koivula I, Sten M, Makela PH. Risk factors for pneumonia in the elderly. Am J Med 1994;96:313-20.
31. Mocchegiani E, Muzzioli M, Gaetti R, et al. Contribution of zinc to reduce CD4+ risk factor for 'severe' infection relapse in aging: parallelism with HIV. Int J Immunopharmacol 1999;21:271-81.
32. Janssens J-P, Krause K-H. Pneumonia in the very old. Lancet Infect Dis 2004;4:112-24.
33. Clemons TE, Kurinij N, Sperduto RD, Group AR. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study. Arch Ophthalmol 2004;122:716 -26. (AREDS report no. 13.)
34. Baqui AH, Black RE, El Arifeen S, et al. Effect of zinc supplementation started during diarrhoea on morbidity and mortality in Bangladeshi children: community randomised trial. BMJ 2002;325:1059.
35. Sazawal S, Black RE, Menon VP, et al. Zinc supplementation in infants born small for gestational age reduces mortality: a prospective, randomized, controlled trial. Pediatrics 2001;108:1280-6.
36. Sazawal S, Black RE, Ramsan M, et al. Effect of zinc supplementation on mortality in children aged 1-48 months: a community-based randomised placebo-controlled trial. Lancet 2007;369:927-34.
37. Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr 1998;68(suppl):447S-63S.
38. Rink L, Kirchner H, Rink L, Kirchner H. Zinc-altered immune function and cytokine production. J Nutr 2000;130(suppl):1407S-11S.
39. Ibs KH, Rink L, Ibs K-H, Rink L. Zinc-altered immune function. J Nutr 2003;133(suppl):1452S-6S.
40. Briefel RR, Bialostosky K, Kennedy-Stephenson J, et al. Zinc intake of the U.S. population: findings from the third National Health and Nutrition Examination Survey, 1988-1994. J Nutr 2000;130(suppl):1367S-73S.
41. Schmuck A, Roussel AM, Arnaud J, et al. Analyzed dietary intakes, plasma concentrations of zinc, copper, and selenium, and related antioxidant enzyme activities in hospitalized elderly women. J Am Coll Nutr 1996;15:462-8.
42. Bogden JD, Oleske JM, Munves EM, et al. Zinc and immunocompetence in the elderly: baseline data on zinc nutriture and immunity in unsupplemented subjects. Am J Clin Nutr 1987;46:101-9.
43. Brown KH. Effect of infections on plasma zinc concentration and implications for zinc status assessment in low-income countries. Am J Clin Nutr 1998;68(suppl):425S-9S.
44. Duggan C, MacLeod WB, Krebs NF, et al. Plasma zinc concentrations are depressed during the acute phase response in children with falciparum malaria. J Nutr 2005;135:802-7.
45. Kushner I, Kushner I. The phenomenon of the acute phase response. Ann NY Acad Sci 1982;389:39-48.
46. Halm EA, Fine MJ, Marrie TJ, et al. Time to clinical stability in patients hospitalized with community-acquired pneumonia: implications for practice guidelines. JAMA 1998;279:1452-7.
47. Fortes C, Forastiere F, Agabiti N, et al. The effect of zinc and vitamin A supplementation on immune response in an older population. J Am Geriatr Soc 1998;46:19-26.
48. Cakman I, Kirchner H, Rink L. Zinc supplementation reconstitutes the production of interferon-alpha by leukocytes from elderly persons. J Interferon Cytokine Res 1997;17:469-72.
49. Girodon F, Lombard M, Galan P, et al. Effect of micronutrient supplementation on infection in institutionalized elderly subjects: a controlled trial. Ann Nutr Metab 1997;41:98-107.
50. Girodon F, Galan P, Monget AL, et al. Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients: a randomized controlled trial. MIN. VIT. AOX. geriatric network Arch Intern Med 1999;159:748-54.