메뉴 건너뛰기




Volumn 14, Issue 1, 2013, Pages

The IL-6 response to Chlamydia from primary reproductive epithelial cells is highly variable and may be involved in differential susceptibility to the immunopathological consequences of chlamydial infection

Author keywords

Chlamydia; IL 6; Immunopathology; Infertility

Indexed keywords

INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 4; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEINASE;

EID: 84887534564     PISSN: None     EISSN: 14712172     Source Type: Journal    
DOI: 10.1186/1471-2172-14-50     Document Type: Article
Times cited : (24)

References (33)
  • 1
    • 0010985882 scopus 로고    scopus 로고
    • World Health Organisation
    • World Health Organisation. http://www.who.int/reproductivehealth/publications/rtis/stisestimates/en/index.html.
  • 3
    • 0842326271 scopus 로고    scopus 로고
    • Heat shock protein 60 is the major antigen which stimulates delayed-type hypersensitivity reaction in the macaque model of Chlamydia trachomatis salpingitis
    • 10.1128/IAI.72.2.1159-1161.2004, 321634, 14742566
    • Lichtenwalner AB, Patton DL, Van Voorhis WC, Sweeney YT, Kuo CC. Heat shock protein 60 is the major antigen which stimulates delayed-type hypersensitivity reaction in the macaque model of Chlamydia trachomatis salpingitis. Infect Immun 2004, 72:1159-1161. 10.1128/IAI.72.2.1159-1161.2004, 321634, 14742566.
    • (2004) Infect Immun , vol.72 , pp. 1159-1161
    • Lichtenwalner, A.B.1    Patton, D.L.2    Van Voorhis, W.C.3    Sweeney, Y.T.4    Kuo, C.C.5
  • 4
    • 23444460846 scopus 로고
    • Demonstration of delayed hypersensitivity in Chlamydia trachomatis salpingitis in monkeys: a pathogenic mechanism of tubal damage
    • 10.1093/infdis/169.3.680, 8158051
    • Patton DL, Sweeney YT, Kuo CC. Demonstration of delayed hypersensitivity in Chlamydia trachomatis salpingitis in monkeys: a pathogenic mechanism of tubal damage. J Infect Dis 1994, 169:680-683. 10.1093/infdis/169.3.680, 8158051.
    • (1994) J Infect Dis , vol.169 , pp. 680-683
    • Patton, D.L.1    Sweeney, Y.T.2    Kuo, C.C.3
  • 5
    • 33748997929 scopus 로고    scopus 로고
    • Chlamydia trachomatis and chlamydial heat shock protein 60-specific antibody and cell-mediated responses predict tubal factor infertility
    • 10.1093/humrep/del014, 16478761
    • Tiitinen A, Surcel HM, Halttunen M, Birkelund S, Bloigu A, Christiansen G, Koskela P, Morrison SG, Morrison RP, Paavonen J. Chlamydia trachomatis and chlamydial heat shock protein 60-specific antibody and cell-mediated responses predict tubal factor infertility. Hum Reprod 2006, 21:1533-1538. 10.1093/humrep/del014, 16478761.
    • (2006) Hum Reprod , vol.21 , pp. 1533-1538
    • Tiitinen, A.1    Surcel, H.M.2    Halttunen, M.3    Birkelund, S.4    Bloigu, A.5    Christiansen, G.6    Koskela, P.7    Morrison, S.G.8    Morrison, R.P.9    Paavonen, J.10
  • 6
    • 0031864310 scopus 로고    scopus 로고
    • Circulating antibodies to a conserved epitope of the Chlamydia trachomatis 60 kDa heat shock protein (hsp60) in infertile couples and its relationship to antibodies to C. trachomatis surface antigens and the Escherichia coli and human HSP60
    • 10.1093/humrep/13.5.1175, 9647542
    • Witkin SS, Askienazy-Elbhar M, Henry-Suchet J, Belaisch-Allart J, Tort-Grumbach J, Sarjdine K. Circulating antibodies to a conserved epitope of the Chlamydia trachomatis 60 kDa heat shock protein (hsp60) in infertile couples and its relationship to antibodies to C. trachomatis surface antigens and the Escherichia coli and human HSP60. Hum Reprod 1998, 13:1175-1179. 10.1093/humrep/13.5.1175, 9647542.
    • (1998) Hum Reprod , vol.13 , pp. 1175-1179
    • Witkin, S.S.1    Askienazy-Elbhar, M.2    Henry-Suchet, J.3    Belaisch-Allart, J.4    Tort-Grumbach, J.5    Sarjdine, K.6
  • 7
    • 77952883861 scopus 로고    scopus 로고
    • Comparison of five commercial serological tests for the detection of anti-Chlamydia trachomatis antibodies
    • 10.1007/s10096-010-0912-4, 20349260
    • Baud D, Regan L, Greub G. Comparison of five commercial serological tests for the detection of anti-Chlamydia trachomatis antibodies. Eur J Clin Microbiol Infect Dis 2010, 29:669-675. 10.1007/s10096-010-0912-4, 20349260.
    • (2010) Eur J Clin Microbiol Infect Dis , vol.29 , pp. 669-675
    • Baud, D.1    Regan, L.2    Greub, G.3
  • 8
    • 79960493609 scopus 로고    scopus 로고
    • Tubal factor infertility is associated with antibodies against Chlamydia trachomatis heat shock protein 60 but not human HSP60
    • 10.1093/humrep/der167, 21642639
    • Hjelholt A, Christiansen G, Johannesson TG, Ingerslev HJ, Birkelund S. Tubal factor infertility is associated with antibodies against Chlamydia trachomatis heat shock protein 60 but not human HSP60. Hum Reprod 2011, 26:2069-2076. 10.1093/humrep/der167, 21642639.
    • (2011) Hum Reprod , vol.26 , pp. 2069-2076
    • Hjelholt, A.1    Christiansen, G.2    Johannesson, T.G.3    Ingerslev, H.J.4    Birkelund, S.5
  • 9
    • 0037233027 scopus 로고    scopus 로고
    • The cellular paradigm of chlamydial pathogenesis
    • 10.1016/S0966-842X(02)00011-2, 12526854
    • Stephens RS. The cellular paradigm of chlamydial pathogenesis. Trends Microbiol 2003, 11:44-51. 10.1016/S0966-842X(02)00011-2, 12526854.
    • (2003) Trends Microbiol , vol.11 , pp. 44-51
    • Stephens, R.S.1
  • 10
    • 35948943102 scopus 로고    scopus 로고
    • Interleukin-1 is the initiator of fallopian tube destruction during Chlamydia trachomatis infection
    • 10.1111/j.1462-5822.2007.00996.x, 17614966
    • Hvid M, Baczynska A, Deleuran B, Fedder J, Knudsen HJ, Chrisiansen G, Birkelund S. Interleukin-1 is the initiator of fallopian tube destruction during Chlamydia trachomatis infection. Cell Microbiol 2007, 9:2795-2803. 10.1111/j.1462-5822.2007.00996.x, 17614966.
    • (2007) Cell Microbiol , vol.9 , pp. 2795-2803
    • Hvid, M.1    Baczynska, A.2    Deleuran, B.3    Fedder, J.4    Knudsen, H.J.5    Chrisiansen, G.6    Birkelund, S.7
  • 11
    • 77953616382 scopus 로고    scopus 로고
    • HtrA, RseP, and Tsp proteins do not elicit a pathology-related serum IgG response during sexually transmitted infection with Chlamydia trachomatis
    • 10.1016/j.jri.2010.02.007, 20444505
    • Huston WM, Armitage CW, Lawrence A, Gloeckl S, Bell SJ, Debattista J, Allan JA, Timms P. HtrA, RseP, and Tsp proteins do not elicit a pathology-related serum IgG response during sexually transmitted infection with Chlamydia trachomatis. J Reprod Immunol 2010, 85:168-171. 10.1016/j.jri.2010.02.007, 20444505.
    • (2010) J Reprod Immunol , vol.85 , pp. 168-171
    • Huston, W.M.1    Armitage, C.W.2    Lawrence, A.3    Gloeckl, S.4    Bell, S.J.5    Debattista, J.6    Allan, J.A.7    Timms, P.8
  • 12
    • 56549129619 scopus 로고    scopus 로고
    • Chlamydia trachomatis responds to heat shock, penicillin induced persistence, and IFN-gamma persistence by altering levels of the extracytoplasmic stress response protease HtrA
    • 10.1186/1471-2180-8-190, 2585093, 18986550
    • Huston WM, Theodoropoulos C, Mathews SA, Timms P. Chlamydia trachomatis responds to heat shock, penicillin induced persistence, and IFN-gamma persistence by altering levels of the extracytoplasmic stress response protease HtrA. BMC Microbiol 2008, 8:190. 10.1186/1471-2180-8-190, 2585093, 18986550.
    • (2008) BMC Microbiol , vol.8 , pp. 190
    • Huston, W.M.1    Theodoropoulos, C.2    Mathews, S.A.3    Timms, P.4
  • 13
    • 33847286488 scopus 로고    scopus 로고
    • Cleavage of p65/Re1A of the NF-kappa B pathway by Chlamydia
    • 10.1073/pnas.0608393104, 1815284, 17301240
    • Lad SP, Li J, Correia JS, Pan Q, Gadwal S, Ulevitch RJ, Li E. Cleavage of p65/Re1A of the NF-kappa B pathway by Chlamydia. Proc Natl Acad Sci USA 2007, 104:2933-2938. 10.1073/pnas.0608393104, 1815284, 17301240.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 2933-2938
    • Lad, S.P.1    Li, J.2    Correia, J.S.3    Pan, Q.4    Gadwal, S.5    Ulevitch, R.J.6    Li, E.7
  • 14
    • 79955133850 scopus 로고    scopus 로고
    • The chlamydial periplasmic stress response serine protease cHtrA is secreted into host cell cytosol
    • 10.1186/1471-2180-11-87, 3107777, 21527029
    • Wu X, Lei L, Gong S, Chen D, Flores R, Zhong G. The chlamydial periplasmic stress response serine protease cHtrA is secreted into host cell cytosol. BMC Microbiol 2011, 11:87. 10.1186/1471-2180-11-87, 3107777, 21527029.
    • (2011) BMC Microbiol , vol.11 , pp. 87
    • Wu, X.1    Lei, L.2    Gong, S.3    Chen, D.4    Flores, R.5    Zhong, G.6
  • 15
    • 0031036103 scopus 로고    scopus 로고
    • Characterization of integrin expression in a well differentiated endometrial adenocarcinoma cell line (Ishikawa)
    • 10.1210/jc.82.1.136, 8989247
    • Castelbaum AJ, Ying L, Somkuti SG, Sun J, Ilesanmi AO, Lessey BA. Characterization of integrin expression in a well differentiated endometrial adenocarcinoma cell line (Ishikawa). J Clin Endocrinol Metab 1997, 82:136-142. 10.1210/jc.82.1.136, 8989247.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 136-142
    • Castelbaum, A.J.1    Ying, L.2    Somkuti, S.G.3    Sun, J.4    Ilesanmi, A.O.5    Lessey, B.A.6
  • 16
    • 33747585340 scopus 로고    scopus 로고
    • ECC-1 cells: a well-differentiated steroid-responsive endometrial cell line with characteristics of luminal epithelium
    • 10.1095/biolreprod.106.051870, 16707768
    • Mo B, Vendrov AE, Palomino WA, DuPont BR, Apparao KB, Lessey BA. ECC-1 cells: a well-differentiated steroid-responsive endometrial cell line with characteristics of luminal epithelium. Biol Reprod 2006, 75:387-394. 10.1095/biolreprod.106.051870, 16707768.
    • (2006) Biol Reprod , vol.75 , pp. 387-394
    • Mo, B.1    Vendrov, A.E.2    Palomino, W.A.3    DuPont, B.R.4    Apparao, K.B.5    Lessey, B.A.6
  • 17
    • 0034059453 scopus 로고    scopus 로고
    • Detection of Chlamydia pneumoniae DNA and antigen in the circulating mononuclear cell fractions of humans and koalas
    • 10.1128/IAI.68.5.2744-2747.2000, 97483, 10768968
    • Bodetti TJ, Timms P. Detection of Chlamydia pneumoniae DNA and antigen in the circulating mononuclear cell fractions of humans and koalas. Infect Immun 2000, 68:2744-2747. 10.1128/IAI.68.5.2744-2747.2000, 97483, 10768968.
    • (2000) Infect Immun , vol.68 , pp. 2744-2747
    • Bodetti, T.J.1    Timms, P.2
  • 18
    • 79953707342 scopus 로고    scopus 로고
    • Apoptosis is induced in Chlamydia trachomatis-infected HEp-2 cells by the addition of a combination innate immune activation compounds and the inhibitor wedelolactone
    • 10.1111/j.1600-0897.2010.00936.x, 21463376
    • Huston WM, Gloeckl S, de Boer L, Beagley KW, Timms P. Apoptosis is induced in Chlamydia trachomatis-infected HEp-2 cells by the addition of a combination innate immune activation compounds and the inhibitor wedelolactone. Am J Reprod Immunol 2011, 65:460-465. 10.1111/j.1600-0897.2010.00936.x, 21463376.
    • (2011) Am J Reprod Immunol , vol.65 , pp. 460-465
    • Huston, W.M.1    Gloeckl, S.2    de Boer, L.3    Beagley, K.W.4    Timms, P.5
  • 19
    • 0036263223 scopus 로고    scopus 로고
    • Differences in the innate immune responses (in vitro) to HeLa cells infected with nondisseminating serovar E and disseminating serovar L2 of Chlamydia trachomatis
    • 10.1128/IAI.70.6.3234-3248.2002, 128021, 12011019
    • Dessus-Babus S, Darville T, Cuozzo FP, Ferguson K, Wyrick PB. Differences in the innate immune responses (in vitro) to HeLa cells infected with nondisseminating serovar E and disseminating serovar L2 of Chlamydia trachomatis. Infect Immun 2002, 70:3234-3248. 10.1128/IAI.70.6.3234-3248.2002, 128021, 12011019.
    • (2002) Infect Immun , vol.70 , pp. 3234-3248
    • Dessus-Babus, S.1    Darville, T.2    Cuozzo, F.P.3    Ferguson, K.4    Wyrick, P.B.5
  • 20
    • 33644819043 scopus 로고    scopus 로고
    • Sustained interleukin-6 and interleukin-8 expression following infection with Chlamydia trachomatis serovar L2 in a HeLa/THP-1 cell co-culture model
    • 10.1111/j.1365-3083.2006.01734.x, 16499573
    • Mpiga P, Mansour S, Morisset R, Beaulieu R, Ravaoarinoro M. Sustained interleukin-6 and interleukin-8 expression following infection with Chlamydia trachomatis serovar L2 in a HeLa/THP-1 cell co-culture model. Scand J Immunol 2006, 63:199-207. 10.1111/j.1365-3083.2006.01734.x, 16499573.
    • (2006) Scand J Immunol , vol.63 , pp. 199-207
    • Mpiga, P.1    Mansour, S.2    Morisset, R.3    Beaulieu, R.4    Ravaoarinoro, M.5
  • 21
    • 0031020373 scopus 로고    scopus 로고
    • Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggest a central role for eptihelial cells in chlamydial pathogenesis
    • 10.1172/JCI119136, 507770, 9011579
    • Rasmussen SJ, Eckmann L, Quayle AJ, Shen L, Zhang Y-X, Anderson DJ, Fierer J, Stephens RS, Kagnoff MF. Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggest a central role for eptihelial cells in chlamydial pathogenesis. J Clin Invest 1997, 99:77-87. 10.1172/JCI119136, 507770, 9011579.
    • (1997) J Clin Invest , vol.99 , pp. 77-87
    • Rasmussen, S.J.1    Eckmann, L.2    Quayle, A.J.3    Shen, L.4    Zhang, Y.-X.5    Anderson, D.J.6    Fierer, J.7    Stephens, R.S.8    Kagnoff, M.F.9
  • 22
    • 0036568789 scopus 로고    scopus 로고
    • Reduced levels of gamma-interferon secretion in response to chlamydial 60 kDa heat shock protein amongst women with pelvic inflammatory disease and a history of repeated Chlamydia trachomatis infections
    • 10.1016/S0165-2478(02)00036-6, 11947926
    • Debattista J, Timms P, Allan J. Reduced levels of gamma-interferon secretion in response to chlamydial 60 kDa heat shock protein amongst women with pelvic inflammatory disease and a history of repeated Chlamydia trachomatis infections. Immunol Lett 2002, 81:205-210. 10.1016/S0165-2478(02)00036-6, 11947926.
    • (2002) Immunol Lett , vol.81 , pp. 205-210
    • Debattista, J.1    Timms, P.2    Allan, J.3
  • 23
    • 44949205416 scopus 로고    scopus 로고
    • In infertile women, cells from Chlamydia trachomatis infected site release higher levels of interferon-gamma, interluekin-10 and tumor necrosis factor-alpha upon heat shock protein stimulation than fertile women
    • Srivastava P, Rajneesh J, Bas S, Salhan S, Mittal A. In infertile women, cells from Chlamydia trachomatis infected site release higher levels of interferon-gamma, interluekin-10 and tumor necrosis factor-alpha upon heat shock protein stimulation than fertile women. Reprod Biol Endo 2008, 6:20-25.
    • (2008) Reprod Biol Endo , vol.6 , pp. 20-25
    • Srivastava, P.1    Rajneesh, J.2    Bas, S.3    Salhan, S.4    Mittal, A.5
  • 24
    • 84878209301 scopus 로고    scopus 로고
    • Proof of concept: a bioinformatic and serological screening method for identifying new peptide antigens for chlamydia trachomatis related sequelae in women
    • in press
    • Stansfield SH, Patel P, Debattista J, Armitage CW, Cunningham K, Timms P, Allan J, Mittal A, Huston WM. Proof of concept: a bioinformatic and serological screening method for identifying new peptide antigens for chlamydia trachomatis related sequelae in women. Res Immunol 2013, in press.
    • (2013) Res Immunol
    • Stansfield, S.H.1    Patel, P.2    Debattista, J.3    Armitage, C.W.4    Cunningham, K.5    Timms, P.6    Allan, J.7    Mittal, A.8    Huston, W.M.9
  • 25
    • 0037314046 scopus 로고    scopus 로고
    • Chlamydia trachomatis heat shock protein -60 induced infterferon-gamma and interleukin-10 production in infertile women
    • 10.1046/j.1365-2249.2003.02048.x, 1808640, 12562392
    • Kinnunen AH, Surcel HM, Halttunen M, Tiitinen A, Morrison RP, Morrison SG, Koskela P, Lehtinen M, Paavonen J. Chlamydia trachomatis heat shock protein -60 induced infterferon-gamma and interleukin-10 production in infertile women. Clin Exp Immunol 2003, 131:299-303. 10.1046/j.1365-2249.2003.02048.x, 1808640, 12562392.
    • (2003) Clin Exp Immunol , vol.131 , pp. 299-303
    • Kinnunen, A.H.1    Surcel, H.M.2    Halttunen, M.3    Tiitinen, A.4    Morrison, R.P.5    Morrison, S.G.6    Koskela, P.7    Lehtinen, M.8    Paavonen, J.9
  • 26
    • 33751222572 scopus 로고    scopus 로고
    • Interleukin-6 trans-signaling in inflammatory bowel disease
    • 10.1016/j.cytogfr.2006.09.003, 17045835
    • Mitsuyama K, Sata M, Rose-John S. Interleukin-6 trans-signaling in inflammatory bowel disease. Cytokine Growth Factor Rev 2006, 17:451-461. 10.1016/j.cytogfr.2006.09.003, 17045835.
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 451-461
    • Mitsuyama, K.1    Sata, M.2    Rose-John, S.3
  • 27
    • 54449088686 scopus 로고    scopus 로고
    • Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1
    • 10.1074/jbc.M707692200, 2533786, 18515365
    • Cahill CM, Rogers JT. Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1. J Biol Chem 2008, 283:25900-25912. 10.1074/jbc.M707692200, 2533786, 18515365.
    • (2008) J Biol Chem , vol.283 , pp. 25900-25912
    • Cahill, C.M.1    Rogers, J.T.2
  • 28
    • 77249118801 scopus 로고    scopus 로고
    • The inflammasomes: mechanisms of activation and function
    • 10.1016/j.coi.2009.12.004, 2844336, 20060699
    • Latz E. The inflammasomes: mechanisms of activation and function. Curr Opin Immunol 2010, 22:28-33. 10.1016/j.coi.2009.12.004, 2844336, 20060699.
    • (2010) Curr Opin Immunol , vol.22 , pp. 28-33
    • Latz, E.1
  • 29
    • 41149179018 scopus 로고    scopus 로고
    • The involvement of the interleukin-1 receptor-associated kinases (IRAKs) in cellualr signaling networsk controlling inflammation
    • 10.1016/j.cyto.2007.12.012, 2377356, 18249132
    • Ringwood L, Li L. The involvement of the interleukin-1 receptor-associated kinases (IRAKs) in cellualr signaling networsk controlling inflammation. Cytokine 2008, 42:1-7. 10.1016/j.cyto.2007.12.012, 2377356, 18249132.
    • (2008) Cytokine , vol.42 , pp. 1-7
    • Ringwood, L.1    Li, L.2
  • 30
    • 0031935085 scopus 로고    scopus 로고
    • Neither interleukin-6 nor inducible nitric oxide syntahse is required for clearance of Chlamydia trachomatis from the murine genital tract epithelium
    • 108045, 9488425
    • Perry LL, Feilzer K, Caldwell HD. Neither interleukin-6 nor inducible nitric oxide syntahse is required for clearance of Chlamydia trachomatis from the murine genital tract epithelium. Infect Immun 1998, 66:1265-1269. 108045, 9488425.
    • (1998) Infect Immun , vol.66 , pp. 1265-1269
    • Perry, L.L.1    Feilzer, K.2    Caldwell, H.D.3
  • 31
    • 0034997925 scopus 로고    scopus 로고
    • Early local cytokine profiles in strains of mice with different outcomes from chlamydial genital tract infection
    • 10.1128/IAI.69.6.3556-3561.2001, 98334, 11349013
    • Darville T, Andrews CW, Sikes J, Fraley PL, Rank RG. Early local cytokine profiles in strains of mice with different outcomes from chlamydial genital tract infection. Infect Immun 2001, 69:3556-3561. 10.1128/IAI.69.6.3556-3561.2001, 98334, 11349013.
    • (2001) Infect Immun , vol.69 , pp. 3556-3561
    • Darville, T.1    Andrews, C.W.2    Sikes, J.3    Fraley, P.L.4    Rank, R.G.5
  • 32
    • 84863286745 scopus 로고    scopus 로고
    • The anti-inflammatory cytokine, interleukin-10, inhibits inflammatory mediators in human epithelial cells and mouse macrophages exposed to live and UV-inactivated Chlamydia trachomatis
    • 3317056, 22529524
    • Yilma AN, Singh SR, Fairley SJ, Taha MA, Dennis VA. The anti-inflammatory cytokine, interleukin-10, inhibits inflammatory mediators in human epithelial cells and mouse macrophages exposed to live and UV-inactivated Chlamydia trachomatis. Mediators Inflamm 2012, 2012:520174. 3317056, 22529524.
    • (2012) Mediators Inflamm , vol.2012 , pp. 520174
    • Yilma, A.N.1    Singh, S.R.2    Fairley, S.J.3    Taha, M.A.4    Dennis, V.A.5
  • 33
    • 67650065440 scopus 로고    scopus 로고
    • Host immune responses to chlamydial inclusion membrane proteins B and C in Chlamydia trachomatis infected women with or without fertility disorders
    • 10.1186/1477-7827-7-38, 2695819, 19397832
    • Gupta R, Srivastava P, Vardhan H, Salhan S, Mittal A. Host immune responses to chlamydial inclusion membrane proteins B and C in Chlamydia trachomatis infected women with or without fertility disorders. Reprod Biol Endocrinol 2009, 7:38-43. 10.1186/1477-7827-7-38, 2695819, 19397832.
    • (2009) Reprod Biol Endocrinol , vol.7 , pp. 38-43
    • Gupta, R.1    Srivastava, P.2    Vardhan, H.3    Salhan, S.4    Mittal, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.