HtrA, RseP, and Tsp proteins do not elicit a pathology-related serum IgG response during sexually transmitted infection with Chlamydia trachomatis

Journal of Reproductive Immunology

Volumn 85, Issue 2, 2010, Pages 168-171

  Huston, Wilhelmina M ^a,c   Armitage, Charles W ^a,c   Lawrence, Amba ^a,c   Gloeckl, Sarina ^a,c   Bell, Steven J ^a,c   Debattista, Joseph ^b,c   Allan, John A ^c,d   Timms, Peter ^a,c  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^b QUEENSLAND HEALTH   (Australia)

^c Queensland Clinical Chlamydia Research Network   (Australia)

^d WESLEY HOSPITAL   (Australia)

Author keywords

Chlamydia; HtrA; Infertility; Serum IgG; Tsp

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL PROTEIN; HEAT SHOCK PROTEIN 10; HEAT SHOCK PROTEIN 60; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4; PROTEIN HTRA; PROTEIN RSEP; PROTEIN TSP; UNCLASSIFIED DRUG;

ARTICLE; CHLAMYDIA TRACHOMATIS; CONTROLLED STUDY; GENITAL SYSTEM DISEASE; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; NONHUMAN; PRIORITY JOURNAL; SEROPREVALENCE; SEXUALLY TRANSMITTED DISEASE;

BACTERIAL PROTEINS; BIOLOGICAL MARKERS; CHAPERONIN 60; CHLAMYDIA INFECTIONS; CHLAMYDIA TRACHOMATIS; ENDOPEPTIDASES; FEMALE; HEAT-SHOCK PROTEINS; HUMANS; IMMUNITY, HUMORAL; IMMUNOGLOBULIN G; SEXUALLY TRANSMITTED DISEASES, BACTERIAL;

EID: 77953616382     PISSN: 01650378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jri.2010.02.007     Document Type: Article

References (8)

1. Debattista J., Timms P., Allan J., Allan J. Reduced levels of gamma-interferon secretion in response to chlamydial 60kDa heat shock protein amongst women with pelvic inflammatory disease and a history of repeated Chlamydia trachomatis infections. Immunol. Lett. 2002, 81:205-210.
2. den Hartog J.E., Morre S.A., Land J.A. Chlamydia trachomatis-associated tubal factor subfertility: immunogenetic aspects and serological screening. Hum. Reprod. Update 2006, 12:719-730.
3. Huston W.M., Swedberg J.E., Harris J.M., Walsh T.P., Mathews S.A., TIMMS P. The temperature activated HtrA protease from pathogen Chlamydia trachomatis acts as both a chaperone and protease at 37°C. FEBS Lett. 2007, 581:3382-3386.
4. Huston W.M., Theodoropoulos C., Mathews S.A., Timms P. Chlamydia trachomatis responds to heat shock, penicillin induced persistence, and IFN-gamma persistence by altering levels of the extracytoplasmic stress response protease HtrA. BMC Microbiol. 2008, 8.
5. Lad S.P., Li J., Correia J.D.S., Pan Q., Gadwal S., Ulevitch R.J., Li E. Cleavage of p65/Re1A of the NF-kappa B pathway by Chlamydia. PNAS 2007, 104:2933-2938.
6. Persson K., Osser S., Birkelund S., Christiansen G., Brade H. Antibodies to Chlamydia trachomatis heat shock proteins in women with tubal factor infertility are associated with prior infection by C. trachomatis but not by C. pneumoniae. Hum. Reprod. 1999, 14:1969-1973.
7. Sharma J., Zhong Y., Fong F., Piper J.M., Wang G., Zhong G. Profiling of human antibody responses to Chlamydia trachomatis urogenitcal tract infection using micropaltes arrayed with 156 chlamdydial fusion proteins. Infect. Immun. 2006, 74:1490-1499.
8. Spandorfer S.D., Neuer A., Laverda D., Byrne G., Liu H.C., Rosenwaks Z., Witkin S.S. Previously undetected Chlamydia trachomatis infection, immunity to heat shock proteins and tubal occlusion in women undergoing in-vitro fertilisation. Hum. Reprod. 1999, 14:60-64.