메뉴 건너뛰기




Volumn 105, Issue 6, 2013, Pages 345-354

Linaclotide in the treatment of patients with irritable bowel syndrome and constipation - Analysis of an opportunity;Linaclotida en el tratamiento de pacientes con síndrome del intestino irritable con estreñimiento: Análisis de una oportunidad

Author keywords

Constipation; Irritable bowel syndrome; Visceral pain

Indexed keywords

LINACLOTIDE; PLACEBO; PEPTIDE;

EID: 84887512496     PISSN: 11300108     EISSN: None     Source Type: Journal    
DOI: 10.4321/S1130-01082013000600006     Document Type: Article
Times cited : (2)

References (44)
  • 1
    • 85039645779 scopus 로고    scopus 로고
    • EMA/ CHMP/604998/2012. 2012. [Consultado 26/02/2013]. Disponible en
    • CHMP summary of positive opinion for Constella. EMA/ CHMP/604998/2012. 2012. [Consultado 26/02/2013]. Disponible en: http://www.ema.europa.eu/docs/en_GB/document_library/Summary_ of_opinion_-_Initial_authorisation/human/002490/WC500132840.pdf
    • CHMP summary of positive opinion for Constella
  • 2
    • 84865430465 scopus 로고    scopus 로고
    • Diagnostic criteria in IBS: Useful or not?
    • Mearin F, Lacy BE. Diagnostic criteria in IBS: Useful or not? Neurogastroenterol Motil 2012;24:791-801.
    • (2012) Neurogastroenterol Motil , vol.24 , pp. 791-801
    • Mearin, F.1    Lacy, B.E.2
  • 3
    • 84873921198 scopus 로고    scopus 로고
    • Irritable bowel syndrome with constipation: A European-focused systematic literature review of disease burden
    • Fortea J, Prior M. Irritable bowel syndrome with constipation: A European-focused systematic literature review of disease burden. J Med Econ 2013;16:329-41.
    • (2013) J Med Econ , vol.16 , pp. 329-341
    • Fortea, J.1    Prior, M.2
  • 5
    • 84862651150 scopus 로고    scopus 로고
    • Global prevalence of and risk factors for irritable bowel syndrome: A meta-analysis
    • 712-21e4
    • Lovell RM, Ford AC. Global prevalence of and risk factors for irritable bowel syndrome: A meta-analysis. Clin Gastroenterol Hepatol 2012;10:712-21 e4.
    • (2012) Clin Gastroenterol Hepatol , vol.10
    • Lovell, R.M.1    Ford, A.C.2
  • 7
    • 17944363484 scopus 로고    scopus 로고
    • Irritable bowel syndrome prevalence varies enormously depending on the employed diagnostic criteria: Comparison of Rome II versus previous criteria in a general population
    • Mearin F, Badia X, Balboa A, Baro E, Caldwell E, Cucala M, et al. Irritable bowel syndrome prevalence varies enormously depending on the employed diagnostic criteria: Comparison of Rome II versus previous criteria in a general population. Scand J Gastroenterol 2001;36:1155-61.
    • (2001) Scand J Gastroenterol , vol.36 , pp. 1155-1161
    • Mearin, F.1    Badia, X.2    Balboa, A.3    Baro, E.4    Caldwell, E.5    Cucala, M.6
  • 8
    • 85039637711 scopus 로고    scopus 로고
    • Prevalencia de trastornos funcionales intestinales en la poblacion espanola y su asociacion con sintomas digestivos altos
    • Rey E, Mearin F. Prevalencia de trastornos funcionales intestinales en la poblacion espanola y su asociacion con sintomas digestivos altos. Rev Esp Enferm Dig 2012;104 (Supl. 1):89-90.
    • (2012) Rev Esp Enferm Dig , vol.104 , Issue.SUPLL. 1 , pp. 89-90
    • Rey, E.1    Mearin, F.2
  • 9
    • 79958838396 scopus 로고    scopus 로고
    • Without doubt, functional digestive disorders constitute one of the main reasons for consultation in both gastroenterology and primary health care
    • Mearin F. Without doubt, functional digestive disorders constitute one of the main reasons for consultation in both gastroenterology and primary health care. Foreword. J Clin Gastroenterol 2011;45 (Supl.):S81.
    • (2011) Foreword. J Clin Gastroenterol , vol.45 , Issue.SUPLL.
    • Mearin, F.1
  • 10
    • 84861174122 scopus 로고    scopus 로고
    • Canadian Digestive Health Foundation Public Impact Series 3: Irritable bowel syndrome in Canada. Incidence, prevalence, and direct and indirect economic impact
    • Fedorak RN, Vanner SJ, Paterson WG, Bridges RJ. Canadian Digestive Health Foundation Public Impact Series 3: Irritable bowel syndrome in Canada. Incidence, prevalence, and direct and indirect economic impact. Can J Gastroenterol 2012;26:252-6.
    • (2012) Can J Gastroenterol , vol.26 , pp. 252-256
    • Fedorak, R.N.1    Vanner, S.J.2    Paterson, W.G.3    Bridges, R.J.4
  • 11
    • 79958735935 scopus 로고    scopus 로고
    • All-cause health care charges among managed care patients with constipation and comorbid irritable bowel syndrome
    • Mitra D, Davis KL, Baran RW. All-cause health care charges among managed care patients with constipation and comorbid irritable bowel syndrome. Postgrad Med 2011;123:122-32.
    • (2011) Postgrad Med , vol.123 , pp. 122-132
    • Mitra, D.1    Davis, K.L.2    Baran, R.W.3
  • 12
    • 79951569700 scopus 로고    scopus 로고
    • The effect of irritable bowel syndrome on health-related quality of life and health care expenditures
    • Agarwal N, Spiegel BM. The effect of irritable bowel syndrome on health-related quality of life and health care expenditures. Gastroenterol Clin North Am 2011;40:11-9.
    • (2011) Gastroenterol Clin North Am , vol.40 , pp. 11-19
    • Agarwal, N.1    Spiegel, B.M.2
  • 14
    • 33746942245 scopus 로고    scopus 로고
    • Sindrome del intestino irritable: Una enfermedad con una elevada carga socioeconomica y sanitaria
    • Pique JM, Lanas A. Sindrome del intestino irritable: una enfermedad con una elevada carga socioeconomica y sanitaria. Aten Primaria 2006;38:69-71.
    • (2006) Aten Primaria , vol.38 , pp. 69-71
    • Pique, J.M.1    Lanas, A.2
  • 15
    • 84869017221 scopus 로고    scopus 로고
    • Burden of constipation-predominant irritable bowel syndrome (IBS-C) in France, Italy, and the United Kingdom
    • Dibonaventura MD, Prior M, Prieto P, Fortea J. Burden of constipation-predominant irritable bowel syndrome (IBS-C) in France, Italy, and the United Kingdom. Clin Exp Gastroenterol 2012;5:203-12.
    • (2012) Clin Exp Gastroenterol , vol.5 , pp. 203-212
    • Dibonaventura, M.D.1    Prior, M.2    Prieto, P.3    Fortea, J.4
  • 16
    • 0035117098 scopus 로고    scopus 로고
    • Meta-analysis of smooth muscle relaxants in the treatment of irritable bowel syndrome
    • Poynard T, Regimbeau C, Benhamou Y. Meta-analysis of smooth muscle relaxants in the treatment of irritable bowel syndrome. Aliment Pharmacol Ther 2001;15:355-61.
    • (2001) Aliment Pharmacol Ther , vol.15 , pp. 355-361
    • Poynard, T.1    Regimbeau, C.2    Benhamou, Y.3
  • 17
    • 79960563170 scopus 로고    scopus 로고
    • Randomised clinical trial: Otilonium bromide improves frequency of abdominal pain, severity of distention and time to relapse in patients with irritable bowel syndrome
    • Clave P, Acalovschi M, Triantafillidis JK, Uspensky YP, Kalayci C, Shee V, et al. Randomised clinical trial: Otilonium bromide improves frequency of abdominal pain, severity of distention and time to relapse in patients with irritable bowel syndrome. Aliment Pharmacol Ther 2011;34:432-42.
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 432-442
    • Clave, P.1    Acalovschi, M.2    Triantafillidis, J.K.3    Uspensky, Y.P.4    Kalayci, C.5    Shee, V.6
  • 18
    • 61649089108 scopus 로고    scopus 로고
    • Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: Systematic review and meta-analysis
    • Ford AC, Talley NJ, Schoenfeld PS, Quigley EM, Moayyedi P. Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: Systematic review and meta-analysis. Gut 2009;58:367-78.
    • (2009) Gut , vol.58 , pp. 367-378
    • Ford, A.C.1    Talley, N.J.2    Schoenfeld, P.S.3    Quigley, E.M.4    Moayyedi, P.5
  • 19
    • 0021348189 scopus 로고
    • Role of loperamide and placebo in management of irritable bowel syndrome (IBS)
    • Cann PA, Read NW, Holdsworth CD, Barends D. Role of loperamide and placebo in management of irritable bowel syndrome (IBS). Dig Dis Sci 1984;29:239-47.
    • (1984) Dig Dis Sci , vol.29 , pp. 239-247
    • Cann, P.A.1    Read, N.W.2    Holdsworth, C.D.3    Barends, D.4
  • 20
    • 0023083675 scopus 로고
    • Loperamide treatment of the irritable bowel syndrome
    • Hovdenak N. Loperamide treatment of the irritable bowel syndrome. Scand J Gastroenterol Suppl 1987;130:81-4.
    • (1987) Scand J Gastroenterol Suppl , vol.130 , pp. 81-84
    • Hovdenak, N.1
  • 21
    • 0029946003 scopus 로고    scopus 로고
    • A double-blind placebo-controlled trial with loperamide in irritable bowel syndrome
    • Efskind PS, Bernklev T, Vatn MH. A double-blind placebo-controlled trial with loperamide in irritable bowel syndrome. Scand J Gastroenterol 1996;31:463-8.
    • (1996) Scand J Gastroenterol , vol.31 , pp. 463-468
    • Efskind, P.S.1    Bernklev, T.2    Vatn, M.H.3
  • 22
    • 33745659814 scopus 로고    scopus 로고
    • Systematic review: The efficacy of treatments for irritable bowel syndrome-a European perspective
    • Tack J, Fried M, Houghton LA, Spicak J, Fisher G. Systematic review: The efficacy of treatments for irritable bowel syndrome-a European perspective. Aliment Pharmacol Ther 2006;24:183-205.
    • (2006) Aliment Pharmacol Ther , vol.24 , pp. 183-205
    • Tack, J.1    Fried, M.2    Houghton, L.A.3    Spicak, J.4    Fisher, G.5
  • 23
    • 42749097353 scopus 로고    scopus 로고
    • Effects of 5-hydroxytryptamine (serotonin) type 3 antagonists on symptom relief and constipation in nonconstipated irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials
    • Andresen V, Montori VM, Keller J, West CP, Layer P, Camilleri M. Effects of 5-hydroxytryptamine (serotonin) type 3 antagonists on symptom relief and constipation in nonconstipated irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials. Clin Gastroenterol Hepatol 2008;6:545-55.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 545-555
    • Andresen, V.1    Montori, V.M.2    Keller, J.3    West, C.P.4    Layer, P.5    Camilleri, M.6
  • 24
    • 40949131857 scopus 로고    scopus 로고
    • Clinical trial: Phase 2 study of lubiprostone for irritable bowel syndrome with constipation
    • Johanson JF, Drossman DA, Panas R, Wahle A, Ueno R. Clinical trial: Phase 2 study of lubiprostone for irritable bowel syndrome with constipation. Aliment Pharmacol Ther 2008;27:685-96.
    • (2008) Aliment Pharmacol Ther , vol.27 , pp. 685-696
    • Johanson, J.F.1    Drossman, D.A.2    Panas, R.3    Wahle, A.4    Ueno, R.5
  • 25
    • 58149103805 scopus 로고    scopus 로고
    • Clinical trial: Lubiprostone in patients with constipation-associated irritable bowel syndrome-results of two randomized, placebo-controlled studies
    • Drossman DA, Chey WD, Johanson JF, Fass R, Scott C, Panas R, et al. Clinical trial: Lubiprostone in patients with constipation-associated irritable bowel syndrome-results of two randomized, placebo-controlled studies. Aliment Pharmacol Ther 2009;29:329-41.
    • (2009) Aliment Pharmacol Ther , vol.29 , pp. 329-341
    • Drossman, D.A.1    Chey, W.D.2    Johanson, J.F.3    Fass, R.4    Scott, C.5    Panas, R.6
  • 26
    • 84856707088 scopus 로고    scopus 로고
    • Safety and patient outcomes with lubiprostone for up to 52 weeks in patients with irritable bowel syndrome with constipation
    • Chey WD, Drossman DA, Johanson JF, Scott C, Panas RM, Ueno R. Safety and patient outcomes with lubiprostone for up to 52 weeks in patients with irritable bowel syndrome with constipation. Aliment Pharmacol Ther 2012;35:587-99.
    • (2012) Aliment Pharmacol Ther , vol.35 , pp. 587-599
    • Chey, W.D.1    Drossman, D.A.2    Johanson, J.F.3    Scott, C.4    Panas, R.M.5    Ueno, R.6
  • 27
    • 79951852079 scopus 로고    scopus 로고
    • Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases
    • Potter LR. Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases. Pharmacol Ther 2011;130:71-82.
    • (2011) Pharmacol Ther , vol.130 , pp. 71-82
    • Potter, L.R.1
  • 28
    • 85006184506 scopus 로고    scopus 로고
    • Linaclotide: A new drug for the treatment of chronic constipation and irritable bowel syndrome with constipation
    • Corsetti M, Tack J. Linaclotide: A new drug for the treatment of chronic constipation and irritable bowel syndrome with constipation. United European Gastroenterology Journal 2013;1:7-20.
    • (2013) United European Gastroenterology Journal , vol.1 , pp. 7-20
    • Corsetti, M.1    Tack, J.2
  • 29
    • 78049283798 scopus 로고    scopus 로고
    • Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit
    • Busby RW, Bryant AP, Bartolini WP, Cordero EA, Hannig G, Kessler MM, et al. Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit. Eur J Pharmacol 2010;649:328-35.
    • (2010) Eur J Pharmacol , vol.649 , pp. 328-335
    • Busby, R.W.1    Bryant, A.P.2    Bartolini, W.P.3    Cordero, E.A.4    Hannig, G.5    Kessler, M.M.6
  • 31
    • 84870565183 scopus 로고    scopus 로고
    • Guanylate cyclase-C receptor activation: Unexpected biology
    • Brierley SM. Guanylate cyclase-C receptor activation: Unexpected biology. Curr Opin Pharmacol 2012;12:632-40.
    • (2012) Curr Opin Pharmacol , vol.12 , pp. 632-640
    • Brierley, S.M.1
  • 32
    • 79958248056 scopus 로고    scopus 로고
    • Linaclotide, a synthetic guanylate cyclase C agonist, for the treatment of functional gastrointestinal disorders associated with constipation
    • Vazquez Roque M, Camilleri M. Linaclotide, a synthetic guanylate cyclase C agonist, for the treatment of functional gastrointestinal disorders associated with constipation. Expert Rev Gastroenterol Hepatol 2011;5:301-10.
    • (2011) Expert Rev Gastroenterol Hepatol , vol.5 , pp. 301-310
    • Vazquez Roque, M.1    Camilleri, M.2
  • 33
    • 84871682733 scopus 로고    scopus 로고
    • Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation
    • Busby RW, Kessler MM, Bartolini WP, Bryant AP, Hannig G, Higgins CS, et al. Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation. J Pharmacol Exp Ther 2013;344:196-206.
    • (2013) J Pharmacol Exp Ther , vol.344 , pp. 196-206
    • Busby, R.W.1    Kessler, M.M.2    Bartolini, W.P.3    Bryant, A.P.4    Hannig, G.5    Higgins, C.S.6
  • 36
    • 34548500315 scopus 로고    scopus 로고
    • Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome
    • Andresen V, Camilleri M, Busciglio IA, Grudell A, Burton D, McKinzie S, et al. Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome. Gastroenterology 2007;133:761-8.
    • (2007) Gastroenterology , vol.133 , pp. 761-768
    • Andresen, V.1    Camilleri, M.2    Busciglio, I.A.3    Grudell, A.4    Burton, D.5    McKinzie, S.6
  • 37
    • 78649690668 scopus 로고    scopus 로고
    • Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation
    • 1877-86e2
    • Johnston JM, Kurtz CB, Macdougall JE, Lavins BJ, Currie MG, Fitch DA, et al. Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation. Gastroenterology 2010;139:1877-86 e2.
    • (2010) Gastroenterology , vol.139
    • Johnston, J.M.1    Kurtz, C.B.2    McDougall, J.E.3    Lavins, B.J.4    Currie, M.G.5    Fitch, D.A.6
  • 38
    • 83455235015 scopus 로고    scopus 로고
    • Clarification of trial end points presented in a recent review of linaclotide
    • Johnston JM, Schneier HA. Clarification of trial end points presented in a recent review of linaclotide. Expert Rev Gastroenterol Hepatol 2012;6:13-4.
    • (2012) Expert Rev Gastroenterol Hepatol , vol.6 , pp. 13-14
    • Johnston, J.M.1    Schneier, H.A.2
  • 40
    • 84869493876 scopus 로고    scopus 로고
    • A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation
    • Rao S, Lembo AJ, Shiff SJ, Lavins BJ, Currie MG, Jia XD, et al. A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation. Am J Gastroenterol 2012;107:1714-24.
    • (2012) Am J Gastroenterol , vol.107 , pp. 1714-1724
    • Rao, S.1    Lembo, A.J.2    Shiff, S.J.3    Lavins, B.J.4    Currie, M.G.5    Jia, X.D.6
  • 41
    • 84869491248 scopus 로고    scopus 로고
    • Linaclotide for irritable bowel syndrome with constipation: A 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety
    • Chey WD, Lembo AJ, Lavins BJ, Shiff SJ, Kurtz CB, Currie MG, et al. Linaclotide for irritable bowel syndrome with constipation: A 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety. Am J Gastroenterol 2012;107:1702-12.
    • (2012) Am J Gastroenterol , vol.107 , pp. 1702-1712
    • Chey, W.D.1    Lembo, A.J.2    Lavins, B.J.3    Shiff, S.J.4    Kurtz, C.B.5    Currie, M.G.6
  • 44
    • 84870601331 scopus 로고    scopus 로고
    • Randomised clinical trials: Linaclotide phase 3 studies in IBS-C-A prespecified further analysis based on European Medicines Agencyspecified endpoints
    • Quigley EM, Tack J, Chey WD, Rao SS, Fortea J, Falques M, et al. Randomised clinical trials: Linaclotide phase 3 studies in IBS-C-A prespecified further analysis based on European Medicines Agencyspecified endpoints. Aliment Pharmacol Ther 2013;37:49-61.
    • (2013) Aliment Pharmacol Ther , vol.37 , pp. 49-61
    • Quigley, E.M.1    Tack, J.2    Chey, W.D.3    Rao, S.S.4    Fortea, J.5    Falques, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.