-
1
-
-
85039645779
-
-
EMA/ CHMP/604998/2012. 2012. [Consultado 26/02/2013]. Disponible en
-
CHMP summary of positive opinion for Constella. EMA/ CHMP/604998/2012. 2012. [Consultado 26/02/2013]. Disponible en: http://www.ema.europa.eu/docs/en_GB/document_library/Summary_ of_opinion_-_Initial_authorisation/human/002490/WC500132840.pdf
-
CHMP summary of positive opinion for Constella
-
-
-
2
-
-
84865430465
-
Diagnostic criteria in IBS: Useful or not?
-
Mearin F, Lacy BE. Diagnostic criteria in IBS: Useful or not? Neurogastroenterol Motil 2012;24:791-801.
-
(2012)
Neurogastroenterol Motil
, vol.24
, pp. 791-801
-
-
Mearin, F.1
Lacy, B.E.2
-
3
-
-
84873921198
-
Irritable bowel syndrome with constipation: A European-focused systematic literature review of disease burden
-
Fortea J, Prior M. Irritable bowel syndrome with constipation: A European-focused systematic literature review of disease burden. J Med Econ 2013;16:329-41.
-
(2013)
J Med Econ
, vol.16
, pp. 329-341
-
-
Fortea, J.1
Prior, M.2
-
4
-
-
33646201684
-
Functional bowel disorders
-
Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional bowel disorders. Gastroenterology 2006;130:1480-91.
-
(2006)
Gastroenterology
, vol.130
, pp. 1480-1491
-
-
Longstreth, G.F.1
Thompson, W.G.2
Chey, W.D.3
Houghton, L.A.4
Mearin, F.5
Spiller, R.C.6
-
5
-
-
84862651150
-
Global prevalence of and risk factors for irritable bowel syndrome: A meta-analysis
-
712-21e4
-
Lovell RM, Ford AC. Global prevalence of and risk factors for irritable bowel syndrome: A meta-analysis. Clin Gastroenterol Hepatol 2012;10:712-21 e4.
-
(2012)
Clin Gastroenterol Hepatol
, vol.10
-
-
Lovell, R.M.1
Ford, A.C.2
-
6
-
-
0033035168
-
Irritable bowel syndrome in patients with dyspepsia: A community-based study in southern Europe
-
Caballero-Plasencia AM, Sofos-Kontoyannis S, Valenzuela-Barranco M, Martin-Ruiz JL, Casado-Caballero FJ, Lopez-Manas JG. Irritable bowel syndrome in patients with dyspepsia: A community-based study in southern Europe. Eur J Gastroenterol Hepatol 1999;11:517-22.
-
(1999)
Eur J Gastroenterol Hepatol
, vol.11
, pp. 517-522
-
-
Caballero-Plasencia, A.M.1
Sofos-Kontoyannis, S.2
Valenzuela-Barranco, M.3
Martin-Ruiz, J.L.4
Casado-Caballero, F.J.5
Lopez-Manas, J.G.6
-
7
-
-
17944363484
-
Irritable bowel syndrome prevalence varies enormously depending on the employed diagnostic criteria: Comparison of Rome II versus previous criteria in a general population
-
Mearin F, Badia X, Balboa A, Baro E, Caldwell E, Cucala M, et al. Irritable bowel syndrome prevalence varies enormously depending on the employed diagnostic criteria: Comparison of Rome II versus previous criteria in a general population. Scand J Gastroenterol 2001;36:1155-61.
-
(2001)
Scand J Gastroenterol
, vol.36
, pp. 1155-1161
-
-
Mearin, F.1
Badia, X.2
Balboa, A.3
Baro, E.4
Caldwell, E.5
Cucala, M.6
-
8
-
-
85039637711
-
Prevalencia de trastornos funcionales intestinales en la poblacion espanola y su asociacion con sintomas digestivos altos
-
Rey E, Mearin F. Prevalencia de trastornos funcionales intestinales en la poblacion espanola y su asociacion con sintomas digestivos altos. Rev Esp Enferm Dig 2012;104 (Supl. 1):89-90.
-
(2012)
Rev Esp Enferm Dig
, vol.104
, Issue.SUPLL. 1
, pp. 89-90
-
-
Rey, E.1
Mearin, F.2
-
9
-
-
79958838396
-
Without doubt, functional digestive disorders constitute one of the main reasons for consultation in both gastroenterology and primary health care
-
Mearin F. Without doubt, functional digestive disorders constitute one of the main reasons for consultation in both gastroenterology and primary health care. Foreword. J Clin Gastroenterol 2011;45 (Supl.):S81.
-
(2011)
Foreword. J Clin Gastroenterol
, vol.45
, Issue.SUPLL.
-
-
Mearin, F.1
-
10
-
-
84861174122
-
Canadian Digestive Health Foundation Public Impact Series 3: Irritable bowel syndrome in Canada. Incidence, prevalence, and direct and indirect economic impact
-
Fedorak RN, Vanner SJ, Paterson WG, Bridges RJ. Canadian Digestive Health Foundation Public Impact Series 3: Irritable bowel syndrome in Canada. Incidence, prevalence, and direct and indirect economic impact. Can J Gastroenterol 2012;26:252-6.
-
(2012)
Can J Gastroenterol
, vol.26
, pp. 252-256
-
-
Fedorak, R.N.1
Vanner, S.J.2
Paterson, W.G.3
Bridges, R.J.4
-
11
-
-
79958735935
-
All-cause health care charges among managed care patients with constipation and comorbid irritable bowel syndrome
-
Mitra D, Davis KL, Baran RW. All-cause health care charges among managed care patients with constipation and comorbid irritable bowel syndrome. Postgrad Med 2011;123:122-32.
-
(2011)
Postgrad Med
, vol.123
, pp. 122-132
-
-
Mitra, D.1
Davis, K.L.2
Baran, R.W.3
-
12
-
-
79951569700
-
The effect of irritable bowel syndrome on health-related quality of life and health care expenditures
-
Agarwal N, Spiegel BM. The effect of irritable bowel syndrome on health-related quality of life and health care expenditures. Gastroenterol Clin North Am 2011;40:11-9.
-
(2011)
Gastroenterol Clin North Am
, vol.40
, pp. 11-19
-
-
Agarwal, N.1
Spiegel, B.M.2
-
13
-
-
58149125374
-
Determinants of quality of life in irritable bowel syndrome
-
Rey E, Garcia-Alonso MO, Moreno-Ortega M, Alvarez-Sanchez A, Diaz-Rubio M. Determinants of quality of life in irritable bowel syndrome. J Clin Gastroenterol 2008;42:1003-9.
-
(2008)
J Clin Gastroenterol
, vol.42
, pp. 1003-1009
-
-
Rey, E.1
Garcia-Alonso, M.O.2
Moreno-Ortega, M.3
Alvarez-Sanchez, A.4
Diaz-Rubio, M.5
-
14
-
-
33746942245
-
Sindrome del intestino irritable: Una enfermedad con una elevada carga socioeconomica y sanitaria
-
Pique JM, Lanas A. Sindrome del intestino irritable: una enfermedad con una elevada carga socioeconomica y sanitaria. Aten Primaria 2006;38:69-71.
-
(2006)
Aten Primaria
, vol.38
, pp. 69-71
-
-
Pique, J.M.1
Lanas, A.2
-
15
-
-
84869017221
-
Burden of constipation-predominant irritable bowel syndrome (IBS-C) in France, Italy, and the United Kingdom
-
Dibonaventura MD, Prior M, Prieto P, Fortea J. Burden of constipation-predominant irritable bowel syndrome (IBS-C) in France, Italy, and the United Kingdom. Clin Exp Gastroenterol 2012;5:203-12.
-
(2012)
Clin Exp Gastroenterol
, vol.5
, pp. 203-212
-
-
Dibonaventura, M.D.1
Prior, M.2
Prieto, P.3
Fortea, J.4
-
16
-
-
0035117098
-
Meta-analysis of smooth muscle relaxants in the treatment of irritable bowel syndrome
-
Poynard T, Regimbeau C, Benhamou Y. Meta-analysis of smooth muscle relaxants in the treatment of irritable bowel syndrome. Aliment Pharmacol Ther 2001;15:355-61.
-
(2001)
Aliment Pharmacol Ther
, vol.15
, pp. 355-361
-
-
Poynard, T.1
Regimbeau, C.2
Benhamou, Y.3
-
17
-
-
79960563170
-
Randomised clinical trial: Otilonium bromide improves frequency of abdominal pain, severity of distention and time to relapse in patients with irritable bowel syndrome
-
Clave P, Acalovschi M, Triantafillidis JK, Uspensky YP, Kalayci C, Shee V, et al. Randomised clinical trial: Otilonium bromide improves frequency of abdominal pain, severity of distention and time to relapse in patients with irritable bowel syndrome. Aliment Pharmacol Ther 2011;34:432-42.
-
(2011)
Aliment Pharmacol Ther
, vol.34
, pp. 432-442
-
-
Clave, P.1
Acalovschi, M.2
Triantafillidis, J.K.3
Uspensky, Y.P.4
Kalayci, C.5
Shee, V.6
-
18
-
-
61649089108
-
Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: Systematic review and meta-analysis
-
Ford AC, Talley NJ, Schoenfeld PS, Quigley EM, Moayyedi P. Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: Systematic review and meta-analysis. Gut 2009;58:367-78.
-
(2009)
Gut
, vol.58
, pp. 367-378
-
-
Ford, A.C.1
Talley, N.J.2
Schoenfeld, P.S.3
Quigley, E.M.4
Moayyedi, P.5
-
19
-
-
0021348189
-
Role of loperamide and placebo in management of irritable bowel syndrome (IBS)
-
Cann PA, Read NW, Holdsworth CD, Barends D. Role of loperamide and placebo in management of irritable bowel syndrome (IBS). Dig Dis Sci 1984;29:239-47.
-
(1984)
Dig Dis Sci
, vol.29
, pp. 239-247
-
-
Cann, P.A.1
Read, N.W.2
Holdsworth, C.D.3
Barends, D.4
-
20
-
-
0023083675
-
Loperamide treatment of the irritable bowel syndrome
-
Hovdenak N. Loperamide treatment of the irritable bowel syndrome. Scand J Gastroenterol Suppl 1987;130:81-4.
-
(1987)
Scand J Gastroenterol Suppl
, vol.130
, pp. 81-84
-
-
Hovdenak, N.1
-
21
-
-
0029946003
-
A double-blind placebo-controlled trial with loperamide in irritable bowel syndrome
-
Efskind PS, Bernklev T, Vatn MH. A double-blind placebo-controlled trial with loperamide in irritable bowel syndrome. Scand J Gastroenterol 1996;31:463-8.
-
(1996)
Scand J Gastroenterol
, vol.31
, pp. 463-468
-
-
Efskind, P.S.1
Bernklev, T.2
Vatn, M.H.3
-
22
-
-
33745659814
-
Systematic review: The efficacy of treatments for irritable bowel syndrome-a European perspective
-
Tack J, Fried M, Houghton LA, Spicak J, Fisher G. Systematic review: The efficacy of treatments for irritable bowel syndrome-a European perspective. Aliment Pharmacol Ther 2006;24:183-205.
-
(2006)
Aliment Pharmacol Ther
, vol.24
, pp. 183-205
-
-
Tack, J.1
Fried, M.2
Houghton, L.A.3
Spicak, J.4
Fisher, G.5
-
23
-
-
42749097353
-
Effects of 5-hydroxytryptamine (serotonin) type 3 antagonists on symptom relief and constipation in nonconstipated irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials
-
Andresen V, Montori VM, Keller J, West CP, Layer P, Camilleri M. Effects of 5-hydroxytryptamine (serotonin) type 3 antagonists on symptom relief and constipation in nonconstipated irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials. Clin Gastroenterol Hepatol 2008;6:545-55.
-
(2008)
Clin Gastroenterol Hepatol
, vol.6
, pp. 545-555
-
-
Andresen, V.1
Montori, V.M.2
Keller, J.3
West, C.P.4
Layer, P.5
Camilleri, M.6
-
24
-
-
40949131857
-
Clinical trial: Phase 2 study of lubiprostone for irritable bowel syndrome with constipation
-
Johanson JF, Drossman DA, Panas R, Wahle A, Ueno R. Clinical trial: Phase 2 study of lubiprostone for irritable bowel syndrome with constipation. Aliment Pharmacol Ther 2008;27:685-96.
-
(2008)
Aliment Pharmacol Ther
, vol.27
, pp. 685-696
-
-
Johanson, J.F.1
Drossman, D.A.2
Panas, R.3
Wahle, A.4
Ueno, R.5
-
25
-
-
58149103805
-
Clinical trial: Lubiprostone in patients with constipation-associated irritable bowel syndrome-results of two randomized, placebo-controlled studies
-
Drossman DA, Chey WD, Johanson JF, Fass R, Scott C, Panas R, et al. Clinical trial: Lubiprostone in patients with constipation-associated irritable bowel syndrome-results of two randomized, placebo-controlled studies. Aliment Pharmacol Ther 2009;29:329-41.
-
(2009)
Aliment Pharmacol Ther
, vol.29
, pp. 329-341
-
-
Drossman, D.A.1
Chey, W.D.2
Johanson, J.F.3
Fass, R.4
Scott, C.5
Panas, R.6
-
26
-
-
84856707088
-
Safety and patient outcomes with lubiprostone for up to 52 weeks in patients with irritable bowel syndrome with constipation
-
Chey WD, Drossman DA, Johanson JF, Scott C, Panas RM, Ueno R. Safety and patient outcomes with lubiprostone for up to 52 weeks in patients with irritable bowel syndrome with constipation. Aliment Pharmacol Ther 2012;35:587-99.
-
(2012)
Aliment Pharmacol Ther
, vol.35
, pp. 587-599
-
-
Chey, W.D.1
Drossman, D.A.2
Johanson, J.F.3
Scott, C.4
Panas, R.M.5
Ueno, R.6
-
27
-
-
79951852079
-
Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases
-
Potter LR. Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases. Pharmacol Ther 2011;130:71-82.
-
(2011)
Pharmacol Ther
, vol.130
, pp. 71-82
-
-
Potter, L.R.1
-
28
-
-
85006184506
-
Linaclotide: A new drug for the treatment of chronic constipation and irritable bowel syndrome with constipation
-
Corsetti M, Tack J. Linaclotide: A new drug for the treatment of chronic constipation and irritable bowel syndrome with constipation. United European Gastroenterology Journal 2013;1:7-20.
-
(2013)
United European Gastroenterology Journal
, vol.1
, pp. 7-20
-
-
Corsetti, M.1
Tack, J.2
-
29
-
-
78049283798
-
Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit
-
Busby RW, Bryant AP, Bartolini WP, Cordero EA, Hannig G, Kessler MM, et al. Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit. Eur J Pharmacol 2010;649:328-35.
-
(2010)
Eur J Pharmacol
, vol.649
, pp. 328-335
-
-
Busby, R.W.1
Bryant, A.P.2
Bartolini, W.P.3
Cordero, E.A.4
Hannig, G.5
Kessler, M.M.6
-
30
-
-
76349088961
-
Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain
-
312-e84
-
Eutamene H, Bradesi S, Larauche M, Theodorou V, Beaufrand C, Ohning G, et al. Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain. Neurogastroenterol Motil 2010;22:312-e84.
-
(2010)
Neurogastroenterol Motil
, vol.22
-
-
Eutamene, H.1
Bradesi, S.2
Larauche, M.3
Theodorou, V.4
Beaufrand, C.5
Ohning, G.6
-
31
-
-
84870565183
-
Guanylate cyclase-C receptor activation: Unexpected biology
-
Brierley SM. Guanylate cyclase-C receptor activation: Unexpected biology. Curr Opin Pharmacol 2012;12:632-40.
-
(2012)
Curr Opin Pharmacol
, vol.12
, pp. 632-640
-
-
Brierley, S.M.1
-
32
-
-
79958248056
-
Linaclotide, a synthetic guanylate cyclase C agonist, for the treatment of functional gastrointestinal disorders associated with constipation
-
Vazquez Roque M, Camilleri M. Linaclotide, a synthetic guanylate cyclase C agonist, for the treatment of functional gastrointestinal disorders associated with constipation. Expert Rev Gastroenterol Hepatol 2011;5:301-10.
-
(2011)
Expert Rev Gastroenterol Hepatol
, vol.5
, pp. 301-310
-
-
Vazquez Roque, M.1
Camilleri, M.2
-
33
-
-
84871682733
-
Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation
-
Busby RW, Kessler MM, Bartolini WP, Bryant AP, Hannig G, Higgins CS, et al. Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation. J Pharmacol Exp Ther 2013;344:196-206.
-
(2013)
J Pharmacol Exp Ther
, vol.344
, pp. 196-206
-
-
Busby, R.W.1
Kessler, M.M.2
Bartolini, W.P.3
Bryant, A.P.4
Hannig, G.5
Higgins, C.S.6
-
34
-
-
60749099506
-
Pilot study on the effect of linaclotide in patients with chronic constipation
-
Johnston JM, Kurtz CB, Drossman DA, Lembo AJ, Jeglinski BI, Mac-Dougall JE, et al. Pilot study on the effect of linaclotide in patients with chronic constipation. Am J Gastroenterol 2009;104:125-32.
-
(2009)
Am J Gastroenterol
, vol.104
, pp. 125-132
-
-
Johnston, J.M.1
Kurtz, C.B.2
Drossman, D.A.3
Lembo, A.J.4
Jeglinski, B.I.5
Mac-Dougall, J.E.6
-
35
-
-
77249122338
-
Efficacy of linaclotide for patients with chronic constipation
-
886-95e1
-
Lembo AJ, Kurtz CB, Macdougall JE, Lavins BJ, Currie MG, Fitch DA, et al. Efficacy of linaclotide for patients with chronic constipation. Gastroenterology 2010;138:886-95 e1.
-
(2010)
Gastroenterology
, vol.138
-
-
Lembo, A.J.1
Kurtz, C.B.2
McDougall, J.E.3
Lavins, B.J.4
Currie, M.G.5
Fitch, D.A.6
-
36
-
-
34548500315
-
Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome
-
Andresen V, Camilleri M, Busciglio IA, Grudell A, Burton D, McKinzie S, et al. Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome. Gastroenterology 2007;133:761-8.
-
(2007)
Gastroenterology
, vol.133
, pp. 761-768
-
-
Andresen, V.1
Camilleri, M.2
Busciglio, I.A.3
Grudell, A.4
Burton, D.5
McKinzie, S.6
-
37
-
-
78649690668
-
Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation
-
1877-86e2
-
Johnston JM, Kurtz CB, Macdougall JE, Lavins BJ, Currie MG, Fitch DA, et al. Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation. Gastroenterology 2010;139:1877-86 e2.
-
(2010)
Gastroenterology
, vol.139
-
-
Johnston, J.M.1
Kurtz, C.B.2
McDougall, J.E.3
Lavins, B.J.4
Currie, M.G.5
Fitch, D.A.6
-
38
-
-
83455235015
-
Clarification of trial end points presented in a recent review of linaclotide
-
Johnston JM, Schneier HA. Clarification of trial end points presented in a recent review of linaclotide. Expert Rev Gastroenterol Hepatol 2012;6:13-4.
-
(2012)
Expert Rev Gastroenterol Hepatol
, vol.6
, pp. 13-14
-
-
Johnston, J.M.1
Schneier, H.A.2
-
39
-
-
80051640525
-
Two randomized trials of linaclotide for chronic constipation
-
Lembo AJ, Schneier HA, Shiff SJ, Kurtz CB, MacDougall JE, Jia XD, et al. Two randomized trials of linaclotide for chronic constipation. N Engl J Med 2011;365:527-36.
-
(2011)
N Engl J Med
, vol.365
, pp. 527-536
-
-
Lembo, A.J.1
Schneier, H.A.2
Shiff, S.J.3
Kurtz, C.B.4
McDougall, J.E.5
Jia, X.D.6
-
40
-
-
84869493876
-
A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation
-
Rao S, Lembo AJ, Shiff SJ, Lavins BJ, Currie MG, Jia XD, et al. A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation. Am J Gastroenterol 2012;107:1714-24.
-
(2012)
Am J Gastroenterol
, vol.107
, pp. 1714-1724
-
-
Rao, S.1
Lembo, A.J.2
Shiff, S.J.3
Lavins, B.J.4
Currie, M.G.5
Jia, X.D.6
-
41
-
-
84869491248
-
Linaclotide for irritable bowel syndrome with constipation: A 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety
-
Chey WD, Lembo AJ, Lavins BJ, Shiff SJ, Kurtz CB, Currie MG, et al. Linaclotide for irritable bowel syndrome with constipation: A 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety. Am J Gastroenterol 2012;107:1702-12.
-
(2012)
Am J Gastroenterol
, vol.107
, pp. 1702-1712
-
-
Chey, W.D.1
Lembo, A.J.2
Lavins, B.J.3
Shiff, S.J.4
Kurtz, C.B.5
Currie, M.G.6
-
44
-
-
84870601331
-
Randomised clinical trials: Linaclotide phase 3 studies in IBS-C-A prespecified further analysis based on European Medicines Agencyspecified endpoints
-
Quigley EM, Tack J, Chey WD, Rao SS, Fortea J, Falques M, et al. Randomised clinical trials: Linaclotide phase 3 studies in IBS-C-A prespecified further analysis based on European Medicines Agencyspecified endpoints. Aliment Pharmacol Ther 2013;37:49-61.
-
(2013)
Aliment Pharmacol Ther
, vol.37
, pp. 49-61
-
-
Quigley, E.M.1
Tack, J.2
Chey, W.D.3
Rao, S.S.4
Fortea, J.5
Falques, M.6
|