Recruiting cytotoxic T cells to folate-receptor-positive cancer cells

Angewandte Chemie - International Edition

Volumn 52, Issue 46, 2013, Pages 12101-12104

  Kularatne, Sumith A ^a   Deshmukh, Vishal ^a   Gymnopoulos, Marco ^b   Biroc, Sandra L ^b   Xia, Jinming ^b   Srinagesh, Shailaja ^b   Sun, Ying ^b   Zou, Ning ^b   Shimazu, Mark ^b   Pinkstaff, Jason ^b   Ensari, Semsi ^b   Knudsen, Nick ^b   Manibusan, Anthony ^b   Axup, Jun Y ^a   Kim, Chan Hyuk ^a   Smider, Vaughn V ^a   Javahishvili, Tsotne ^b   Schultz, Peter G ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b AMBRX INC   (United States)

Author keywords

bispecific antibody; cancer; folate receptor; immunotherapy; T cells

Indexed keywords

ANTIBODY BINDING SITES; CANCER; CANCER CELLS; FOLATE RECEPTOR; IMMUNOTHERAPY; PRECISE CONTROL; RELATIVE GEOMETRY; UNNATURAL AMINO ACIDS;

AMINO ACIDS; BINDING SITES; T-CELLS; TUMORS;

ANTIBODIES;

CD3 ANTIGEN; FOLATE RECEPTOR; FOLIC ACID; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FACB FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G;

ANIMAL; CHEMISTRY; COCULTURE; CYTOLOGY; CYTOTOXIC T LYMPHOCYTE; HUMAN; IMMUNOLOGY; IMMUNOTHERAPY; MALE; METABOLISM; MONONUCLEAR CELL; MOUSE; NEOPLASMS; NONOBESE DIABETIC MOUSE; PATHOLOGY; RAT; SCID MOUSE; SPRAGUE DAWLEY RAT; TUMOR CELL LINE;

ANIMALS; ANTIGENS, CD3; CELL LINE, TUMOR; COCULTURE TECHNIQUES; FOLATE RECEPTORS, GPI-ANCHORED; FOLIC ACID; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; IMMUNOTHERAPY; LEUKOCYTES, MONONUCLEAR; MALE; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASMS; RATS; RATS, SPRAGUE-DAWLEY; T-LYMPHOCYTES, CYTOTOXIC;

EID: 84887495716     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201306866     Document Type: Article

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