C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 46, 2013, Pages

  Lobsiger, Christian S ^a,b,c,d   Boillée, Severine ^a,b,c,d   Pozniake, Christine ^e   Khan, Amir M ^a,f   McAlonis Downes, Melissa ^a   Lewcock, Joseph W ^e   Cleveland, Don W ^a  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (United States)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c CNRS   (France)

^d SORBONNE UNIVERSITÉ   (France)

^e GENENTECH INC   (United States)

^f ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

Author keywords

Amyotrophic lateral sclerosis; Gender differences; Motoneuron; Neuroinflammation; Synaptic density

Indexed keywords

COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C2; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; VESICULAR ACETYLCHOLINE TRANSPORTER;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT SYSTEM; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE DELETION; INNATE IMMUNITY; INTERNEURON; MALE; MOTONEURON; MOUSE; NERVE DEGENERATION; NERVE ENDING; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN INDUCTION; SPINAL CORD; SPINAL CORD VENTRAL HORN;

AMYOTROPHIC LATERAL SCLEROSIS; GENDER DIFFERENCES; MOTONEURON; NEUROINFLAMMATION; SYNAPTIC DENSITY;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; COMPLEMENT C1Q; COMPLEMENT PATHWAY, CLASSICAL; GENE DELETION; IMMUNOHISTOCHEMISTRY; MICE; MICE, KNOCKOUT; MICROGLIA; MOTOR NEURONS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPINAL CORD; SUPEROXIDE DISMUTASE; SURVIVAL ANALYSIS;

EID: 84887488703     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1318309110     Document Type: Article

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