Lactoferrin inhibits dexamethasone-induced chondrocyte impairment from osteoarthritic cartilage through up-regulation of extracellular signal-regulated kinase 1/2 and suppression of FASL, FAS, and Caspase 3

Biochemical and Biophysical Research Communications

Volumn 441, Issue 1, 2013, Pages 249-255

  Tu, Yihui ^a   Xue, Huaming ^a,b   Francis, Wendy ^b   Davies, Andrew P ^c   Pallister, Ian ^b   Kanamarlapudi, Venkateswarlu ^b   Xia, Zhidao ^b  

^a TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SWANSEA UNIVERSITY   (United Kingdom)

^c MORRISTON HOSPITAL   (United Kingdom)

Author keywords

Apoptosis; Chondrocyte; Dexamethasone; Lactoferrin; Osteoarthritis

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANABOLIC AGENT; CASPASE 3; DEXAMETHASONE; FAS ANTIGEN; FAS LIGAND; LACTOFERRIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RECOMBINANT PROTEIN; FAS PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE;

ADULT; APOPTOSIS; ARTICLE; ASSAY; CARTILAGE CELL; CELL PROLIFERATION; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR MECHANICS; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; UPREGULATION; ARTICULAR CARTILAGE; CELL SURVIVAL; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY;

ANTIGENS, CD95; APOPTOSIS; CARTILAGE, ARTICULAR; CASPASE 3; CELL PROLIFERATION; CELL SURVIVAL; CHONDROCYTES; DEXAMETHASONE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FAS LIGAND PROTEIN; GENE EXPRESSION REGULATION; HUMANS; LACTOFERRIN; MIDDLE AGED; OSTEOARTHRITIS; RNA, MESSENGER; UP-REGULATION;

EID: 84887477844     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.10.047     Document Type: Article

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