-
1
-
-
84874433733
-
Regulation of small GTPases by GEFs, GAPs, and GDIs
-
Cherfils, J., and Zeghouf, M. (2013) Regulation of small GTPases by GEFs, GAPs, and GDIs. Physiol. Rev. 93, 269-309
-
(2013)
Physiol. Rev
, vol.93
, pp. 269-309
-
-
Cherfils, J.1
Zeghouf, M.2
-
2
-
-
78751656754
-
Role of Rab GTPases in membrane traffic and cell physiology
-
Hutagalung, A. H., and Novick, P. J. (2011) Role of Rab GTPases in membrane traffic and cell physiology. Physiol. Rev. 91, 119-149
-
(2011)
Physiol. Rev
, vol.91
, pp. 119-149
-
-
Hutagalung, A.H.1
Novick, P.J.2
-
3
-
-
84874366009
-
RabGEFs are a major determinant for specific Rab membrane targeting
-
Blümer, J., Rey, J., Dehmelt, L., Mazel, T., Wu, Y. W., Bastiaens, P., Goody, R. S., and Itzen, A. (2013) RabGEFs are a major determinant for specific Rab membrane targeting. J. Cell Biol. 200, 287-300
-
(2013)
J. Cell Biol
, vol.200
, pp. 287-300
-
-
Blümer, J.1
Rey, J.2
Dehmelt, L.3
Mazel, T.4
Wu, Y.W.5
Bastiaens, P.6
Goody, R.S.7
Itzen, A.8
-
4
-
-
0029819793
-
Rab8 promotes polarized membrane transport through reorganization of actin and microtubules in fibroblasts
-
Peränen, J., Auvinen, P., Virta, H., Wepf, R., and Simons, K. (1996) Rab8 promotes polarized membrane transport through reorganization of actin and microtubules in fibroblasts. J. Cell Biol. 135, 153-167
-
(1996)
J. Cell Biol
, vol.135
, pp. 153-167
-
-
Peränen, J.1
Auvinen, P.2
Virta, H.3
Wepf, R.4
Simons, K.5
-
5
-
-
0036732902
-
A Rab8- specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport
-
Hattula, K., Furuhjelm, J., Arffman, A., and Peränen, J. (2002) A Rab8- specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport. Mol. Biol. Cell 13, 3268-3280
-
(2002)
Mol. Biol. Cell
, vol.13
, pp. 3268-3280
-
-
Hattula, K.1
Furuhjelm, J.2
Arffman, A.3
Peränen, J.4
-
6
-
-
33845903831
-
Characterization of the Rab8-specific membrane traffic route linked to protrusion formation
-
Hattula, K., Furuhjelm, J., Tikkanen, J., Tanhuanpää, K., Laakkonen, P., and Peränen, J. (2006) Characterization of the Rab8-specific membrane traffic route linked to protrusion formation. J. Cell Sci. 119, 4866-4877
-
(2006)
J. Cell Sci
, vol.119
, pp. 4866-4877
-
-
Hattula, K.1
Furuhjelm, J.2
Tikkanen, J.3
Tanhuanpää, K.4
Laakkonen, P.5
Peränen, J.6
-
7
-
-
34250012834
-
A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis
-
Nachury, M. V., Loktev, A. V., Zhang, Q., Westlake, C. J., Peränen, J., Merdes, A., Slusarski, D. C., Scheller, R. H., Bazan, J. F., Sheffield, V. C., and Jackson, P. K. (2007) A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell 129, 1201-1213
-
(2007)
Cell
, vol.129
, pp. 1201-1213
-
-
Nachury, M.V.1
Loktev, A.V.2
Zhang, Q.3
Westlake, C.J.4
Peränen, J.5
Merdes, A.6
Slusarski, D.C.7
Scheller, R.H.8
Bazan, J.F.9
Sheffield, V.C.10
Jackson, P.K.11
-
8
-
-
34547590810
-
Functional dissection of Rab GTPases involved in primary cilium formation
-
Yoshimura, S., Egerer, J., Fuchs, E., Haas, A. K., and Barr, F. A. (2007) Functional dissection of Rab GTPases involved in primary cilium formation. J. Cell Biol. 178, 363-369
-
(2007)
J. Cell Biol
, vol.178
, pp. 363-369
-
-
Yoshimura, S.1
Egerer, J.2
Fuchs, E.3
Haas, A.K.4
Barr, F.A.5
-
9
-
-
80054759802
-
Rab8 GTPase as a regulator of cell shape
-
Peränen, J. (2011) Rab8 GTPase as a regulator of cell shape. Cytoskeleton 68, 527-539
-
(2011)
Cytoskeleton
, vol.68
, pp. 527-539
-
-
Peränen, J.1
-
10
-
-
77950877404
-
Coordination of Rab8 and Rab11 in primary ciliogenesis
-
Knödler, A., Feng, S., Zhang, J., Zhang, X., Das, A., Peränen, J., and Guo, W. (2010) Coordination of Rab8 and Rab11 in primary ciliogenesis. Proc. Natl. Acad. Sci. U.S.A. 107, 6346-6351
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 6346-6351
-
-
Knödler, A.1
Feng, S.2
Zhang, J.3
Zhang, X.4
Das, A.5
Peränen, J.6
Guo, W.7
-
11
-
-
79952597165
-
Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome
-
Westlake, C. J., Baye, L. M., Nachury, M. V., Wright, K. J., Ervin, K. E., Phu, L., Chalouni, C., Beck, J. S., Kirkpatrick, D. S., Slusarski, D. C., Sheffield, V. C., Scheller, R. H., and Jackson, P. K. (2011) Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome. Proc. Natl. Acad. Sci. U.S.A. 108, 2759-2764
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 2759-2764
-
-
Westlake, C.J.1
Baye, L.M.2
Nachury, M.V.3
Wright, K.J.4
Ervin, K.E.5
Phu, L.6
Chalouni, C.7
Beck, J.S.8
Kirkpatrick, D.S.9
Slusarski, D.C.10
Sheffield, V.C.11
Scheller, R.H.12
Jackson, P.K.13
-
12
-
-
17944372902
-
GRAB: A physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase
-
Luo, H. R., Saiardi, A., Nagata, E., Ye, K., Yu, H., Jung, T. S., Luo, X., Jain, S., Sawa, A., and Snyder, S. H. (2001) GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase. Neuron 31, 439-451
-
(2001)
Neuron
, vol.31
, pp. 439-451
-
-
Luo, H.R.1
Saiardi, A.2
Nagata, E.3
Ye, K.4
Yu, H.5
Jung, T.S.6
Luo, X.7
Jain, S.8
Sawa, A.9
Snyder, S.H.10
-
13
-
-
77958471298
-
Family-wide characterization of theDENNdomain Rab GDPGTP exchange factors
-
Yoshimura, S., Gerondopoulos, A., Linford, A., Rigden, D. J., and Barr, F. A. (2010) Family-wide characterization of theDENNdomain Rab GDPGTP exchange factors. J. Cell Biol. 191, 367-381
-
(2010)
J. Cell Biol
, vol.191
, pp. 367-381
-
-
Yoshimura, S.1
Gerondopoulos, A.2
Linford, A.3
Rigden, D.J.4
Barr, F.A.5
-
14
-
-
0036656168
-
Exchange factors, effectors, GAPs and motor proteins: Common thermodynamic and kinetic principles for different functions
-
Goody, R. S., and Hofmann-Goody, W. (2002) Exchange factors, effectors, GAPs and motor proteins: common thermodynamic and kinetic principles for different functions. Eur. Biophys. J. 31, 268-274
-
(2002)
Eur. Biophys. J
, vol.31
, pp. 268-274
-
-
Goody, R.S.1
Hofmann-Goody, W.2
-
15
-
-
61749097741
-
Chaperoneassisted production of active human Rab8A GTPase in Escherichia coli
-
Bleimling, N., Alexandrov, K., Goody, R., and Itzen, A. (2009) Chaperoneassisted production of active human Rab8A GTPase in Escherichia coli. Protein Expr. Purif. 65, 190-195
-
(2009)
Protein Expr. Purif
, vol.65
, pp. 190-195
-
-
Bleimling, N.1
Alexandrov, K.2
Goody, R.3
Itzen, A.4
-
16
-
-
84873414031
-
Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB
-
Mihai Gazdag, E., Streller, A., Haneburger, I., Hilbi, H., Vetter, I. R., Goody, R. S., and Itzen, A. (2013) Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB. EMBO Rep. 14, 199-205
-
(2013)
EMBO Rep
, vol.14
, pp. 199-205
-
-
Mihai Gazdag, E.1
Streller, A.2
Haneburger, I.3
Hilbi, H.4
Vetter, I.R.5
Goody, R.S.6
Itzen, A.7
-
17
-
-
34247846396
-
A versatile ligationindependent cloning method suitable for high-throughput expression screening applications
-
Berrow, N. S., Alderton, D., Sainsbury, S., Nettleship, J., Assenberg, R., Rahman, N., Stuart, D. I., and Owens, R. J. (2007) A versatile ligationindependent cloning method suitable for high-throughput expression screening applications. Nucleic Acids Res. 35, e45
-
(2007)
Nucleic Acids Res
, vol.35
-
-
Berrow, N.S.1
Alderton, D.2
Sainsbury, S.3
Nettleship, J.4
Assenberg, R.5
Rahman, N.6
Stuart, D.I.7
Owens, R.J.8
-
18
-
-
79955000748
-
A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1
-
Hou, X., Hagemann, N., Schoebel, S., Blankenfeldt, W., Goody, R. S., Erdmann, K. S., and Itzen, A. (2011) A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1. EMBO J. 30, 1659-1670
-
(2011)
EMBO J
, vol.30
, pp. 1659-1670
-
-
Hou, X.1
Hagemann, N.2
Schoebel, S.3
Blankenfeldt, W.4
Goody, R.S.5
Erdmann, K.S.6
Itzen, A.7
-
19
-
-
77955872117
-
The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b
-
Müller, M. P., Peters, H., Blümer, J., Blankenfeldt, W., Goody, R. S., and Itzen, A. (2010) The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b. Science 329, 946-949
-
(2010)
Science
, vol.329
, pp. 946-949
-
-
Müller, M.P.1
Peters, H.2
Blümer, J.3
Blankenfeldt, W.4
Goody, R.S.5
Itzen, A.6
-
20
-
-
0027879008
-
Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants
-
Kabsch, W. (1993) Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants. J. Appl. Crystallogr. 26, 795-800
-
(1993)
J. Appl. Crystallogr
, vol.26
, pp. 795-800
-
-
Kabsch, W.1
-
21
-
-
23844546311
-
Likelihood-enhanced fast translation functions
-
McCoy, A. J., Grosse-Kunstleve, R. W., Storoni, L. C., and Read, R. J. (2005) Likelihood-enhanced fast translation functions. Acta Crystallogr. D Biol. Crystallogr. 61, 458-464
-
(2005)
Acta Crystallogr. D Biol. Crystallogr
, vol.61
, pp. 458-464
-
-
McCoy, A.J.1
Grosse-Kunstleve, R.W.2
Storoni, L.C.3
Read, R.J.4
-
22
-
-
0032897075
-
Efficient anisotropic refinement of macromolecular structures using FFT
-
Murshudov, G. N., Vagin, A. A., Lebedev, A., Wilson, K. S., and Dodson, E. J. (1999) Efficient anisotropic refinement of macromolecular structures using FFT. Acta Crystallogr. D Biol. Crystallogr. 55, 247-255
-
(1999)
Acta Crystallogr. D Biol. Crystallogr
, vol.55
, pp. 247-255
-
-
Murshudov, G.N.1
Vagin, A.A.2
Lebedev, A.3
Wilson, K.S.4
Dodson, E.J.5
-
23
-
-
77949535720
-
Features and development of Coot
-
Emsley, P., Lohkamp, B., Scott, W. G., and Cowtan, K. (2010) Features and development of Coot. Acta Crystallogr. D Biol. Crystallogr. 66, 486-501
-
(2010)
Acta Crystallogr. D Biol. Crystallogr
, vol.66
, pp. 486-501
-
-
Emsley, P.1
Lohkamp, B.2
Scott, W.G.3
Cowtan, K.4
-
24
-
-
33846028702
-
Sec2 is a highly efficient exchange factor for the Rab protein Sec4
-
Itzen, A., Rak, A., and Goody, R. S. (2007) Sec2 is a highly efficient exchange factor for the Rab protein Sec4. J. Mol. Biol. 365, 1359-1367
-
(2007)
J. Mol. Biol
, vol.365
, pp. 1359-1367
-
-
Itzen, A.1
Rak, A.2
Goody, R.S.3
-
25
-
-
33645742291
-
Nucleotide exchange via local protein unfolding-structure of Rab8 in complex with MSS4
-
Itzen, A., Pylypenko, O., Goody, R. S., Alexandrov, K., and Rak, A. (2006) Nucleotide exchange via local protein unfolding-structure of Rab8 in complex with MSS4. EMBO J. 25, 1445-1455
-
(2006)
EMBO J
, vol.25
, pp. 1445-1455
-
-
Itzen, A.1
Pylypenko, O.2
Goody, R.S.3
Alexandrov, K.4
Rak, A.5
-
26
-
-
0032546533
-
Kinetic analysis by fluorescence of the interaction between Ras and the catalytic domain of the guanine nucleotide exchange factor Cdc25Mm
-
Lenzen, C., Cool, R. H., Prinz, H., Kuhlmann, J., and Wittinghofer, A. (1998) Kinetic analysis by fluorescence of the interaction between Ras and the catalytic domain of the guanine nucleotide exchange factor Cdc25Mm. Biochemistry 37, 7420-7430
-
(1998)
Biochemistry
, vol.37
, pp. 7420-7430
-
-
Lenzen, C.1
Cool, R.H.2
Prinz, H.3
Kuhlmann, J.4
Wittinghofer, A.5
-
27
-
-
72449132474
-
RabGDI displacement by DrrA from Legionella is a consequence of its guanine nucleotide exchange activity
-
Schoebel, S., Oesterlin, L. K., Blankenfeldt, W., Goody, R. S., and Itzen, A. (2009) RabGDI displacement by DrrA from Legionella is a consequence of its guanine nucleotide exchange activity. Mol. Cell 36, 1060-1072
-
(2009)
Mol. Cell
, vol.36
, pp. 1060-1072
-
-
Schoebel, S.1
Oesterlin, L.K.2
Blankenfeldt, W.3
Goody, R.S.4
Itzen, A.5
-
28
-
-
34347250847
-
Crystal structure of the Sec4p·Sec2p complex in the nucleotide exchanging intermediate state
-
Sato, Y., Fukai, S., Ishitani, R., and Nureki, O. (2007) Crystal structure of the Sec4p·Sec2p complex in the nucleotide exchanging intermediate state. Proc. Natl. Acad. Sci. U.S.A. 104, 8305-8310
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 8305-8310
-
-
Sato, Y.1
Fukai, S.2
Ishitani, R.3
Nureki, O.4
-
29
-
-
0036646473
-
Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE
-
Buchwald, G., Friebel, A., Galán, J. E., Hardt, W. D., Wittinghofer, A., and Scheffzek, K. (2002) Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE. EMBO J. 21, 3286-3295
-
(2002)
EMBO J
, vol.21
, pp. 3286-3295
-
-
Buchwald, G.1
Friebel, A.2
Galán, J.E.3
Hardt, W.D.4
Wittinghofer, A.5
Scheffzek, K.6
-
30
-
-
0141732282
-
A structural state of the myosin v motor without bound nucleotide
-
Coureux, P. D., Wells, A. L., Ménétrey, J., Yengo, C. M., Morris, C. A., Sweeney, H. L., and Houdusse, A. (2003) A structural state of the myosin V motor without bound nucleotide. Nature 425, 419-423
-
(2003)
Nature
, vol.425
, pp. 419-423
-
-
Coureux, P.D.1
Wells, A.L.2
Ménétrey, J.3
Yengo, C.M.4
Morris, C.A.5
Sweeney, H.L.6
Houdusse, A.7
-
31
-
-
0026002058
-
P21 with a phenylalanine 28 3 leucine mutation reacts normally with the GTPase activating protein GAP but nevertheless has transforming properties
-
Reinstein, J., Schlichting, I., Frech, M., Goody, R. S., and Wittinghofer, A. (1991) p21 with a phenylalanine 28 3 leucine mutation reacts normally with the GTPase activating protein GAP but nevertheless has transforming properties. J. Biol. Chem. 266, 17700-17706
-
(1991)
J. Biol. Chem
, vol.266
, pp. 17700-17706
-
-
Reinstein, J.1
Schlichting, I.2
Frech, M.3
Goody, R.S.4
Wittinghofer, A.5
-
32
-
-
0032560850
-
The structural basis of the activation of Ras by Sos
-
Boriack-Sjodin, P. A., Margarit, S. M., Bar-Sagi, D., and Kuriyan, J. (1998) The structural basis of the activation of Ras by Sos. Nature 394, 337-343
-
(1998)
Nature
, vol.394
, pp. 337-343
-
-
Boriack-Sjodin, P.A.1
Margarit, S.M.2
Bar-Sagi, D.3
Kuriyan, J.4
-
33
-
-
0034619877
-
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
-
Worthylake, D. K., Rossman, K. L., and Sondek, J. (2000) Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1. Nature 408, 682-688
-
(2000)
Nature
, vol.408
, pp. 682-688
-
-
Worthylake, D.K.1
Rossman, K.L.2
Sondek, J.3
-
34
-
-
0039818755
-
A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the β-phosphate to destabilize GDP on ARF1
-
Béraud-Dufour, S., Robineau, S., Chardin, P., Paris, S., Chabre, M., Cherfils, J., and Antonny, B. (1998) A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the β-phosphate to destabilize GDP on ARF1. EMBO J. 17, 3651-3659
-
(1998)
EMBO J
, vol.17
, pp. 3651-3659
-
-
Béraud-Dufour, S.1
Robineau, S.2
Chardin, P.3
Paris, S.4
Chabre, M.5
Cherfils, J.6
Antonny, B.7
-
35
-
-
78449261563
-
GDP-bound and nucleotide-free intermediates of the guanine nucleotide exchange in the Rab5·Vps9 system
-
Uejima, T., Ihara, K., Goh, T., Ito, E., Sunada, M., Ueda, T., Nakano, A., and Wakatsuki, S. (2010) GDP-bound and nucleotide-free intermediates of the guanine nucleotide exchange in the Rab5·Vps9 system. J. Biol. Chem. 285, 36689-36697
-
(2010)
J. Biol. Chem
, vol.285
, pp. 36689-36697
-
-
Uejima, T.1
Ihara, K.2
Goh, T.3
Ito, E.4
Sunada, M.5
Ueda, T.6
Nakano, A.7
Wakatsuki, S.8
-
36
-
-
0029831063
-
Kinetics of interaction of Rab5 and Rab7 with nucleotides and magnesium ions
-
Simon, I., Zerial, M., and Goody, R. S. (1996) Kinetics of interaction of Rab5 and Rab7 with nucleotides and magnesium ions. J. Biol. Chem. 271, 20470-20478
-
(1996)
J. Biol. Chem
, vol.271
, pp. 20470-20478
-
-
Simon, I.1
Zerial, M.2
Goody, R.S.3
-
37
-
-
0028801195
-
The kinetic mechanism of Ran-nucleotide exchange catalyzed by RCC1
-
Klebe, C., Prinz, H., Wittinghofer, A., and Goody, R. S. (1995) The kinetic mechanism of Ran-nucleotide exchange catalyzed by RCC1. Biochemistry 34, 12543-12552
-
(1995)
Biochemistry
, vol.34
, pp. 12543-12552
-
-
Klebe, C.1
Prinz, H.2
Wittinghofer, A.3
Goody, R.S.4
-
38
-
-
42749086991
-
The role of the conserved switch II glutamate in guanine nucleotide exchange factor-mediated nucleotide exchange of GTP-binding proteins
-
Gasper, R., Thomas, C., Ahmadian, M. R., and Wittinghofer, A. (2008) The role of the conserved switch II glutamate in guanine nucleotide exchange factor-mediated nucleotide exchange of GTP-binding proteins. J. Mol. Biol. 379, 51-63
-
(2008)
J. Mol. Biol
, vol.379
, pp. 51-63
-
-
Gasper, R.1
Thomas, C.2
Ahmadian, M.R.3
Wittinghofer, A.4
-
39
-
-
79953294214
-
Identification and characterisation of novel Mss4-binding Rab GTPases
-
Wixler, V., Wixler, L., Altenfeld, A., Ludwig, S., Goody, R. S., and Itzen, A. (2011) Identification and characterisation of novel Mss4-binding Rab GTPases. Biol. Chem. 392, 239-248
-
(2011)
Biol. Chem
, vol.392
, pp. 239-248
-
-
Wixler, V.1
Wixler, L.2
Altenfeld, A.3
Ludwig, S.4
Goody, R.S.5
Itzen, A.6
-
40
-
-
0028149342
-
Specific interactions of Mss4 with members of the Rab GTPase subfamily
-
Burton, J. L., Burns, M. E., Gatti, E., Augustine, G. J., and De Camilli, P. (1994) Specific interactions of Mss4 with members of the Rab GTPase subfamily. EMBO J. 13, 5547-5558
-
(1994)
EMBO J
, vol.13
, pp. 5547-5558
-
-
Burton, J.L.1
Burns, M.E.2
Gatti, E.3
Augustine, G.J.4
De Camilli, P.5
-
41
-
-
33846665911
-
A catalytic coiled coil: Structural insights into the activation of the Rab GTPase Sec4p by Sec2p
-
Dong, G., Medkova, M., Novick, P., and Reinisch, K. M. (2007) A catalytic coiled coil: structural insights into the activation of the Rab GTPase Sec4p by Sec2p. Mol. Cell 25, 455-462
-
(2007)
Mol. Cell
, vol.25
, pp. 455-462
-
-
Dong, G.1
Medkova, M.2
Novick, P.3
Reinisch, K.M.4
-
42
-
-
70249105718
-
Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor
-
Yang, J., Zhang, Z., Roe, S. M., Marshall, C. J., and Barford, D. (2009) Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor. Science 325, 1398-1402
-
(2009)
Science
, vol.325
, pp. 1398-1402
-
-
Yang, J.1
Zhang, Z.2
Roe, S.M.3
Marshall, C.J.4
Barford, D.5
|