CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release

Journal of Biological Chemistry

Volumn 288, Issue 45, 2013, Pages 32685-32699

  Malenczyk, Katarzyna ^a,b   Jazurek, Magdalena ^a   Keimpema, Erik ^b   Silvestri, Cristoforo ^c   Janikiewicz, Justyna ^a   Mackie, Ken ^d   Di Marzo, Vincenzo ^c   Redowicz, Maria J ^a   Harkany, Tibor ^b,e   Dobrzyn, Agnieszka ^a  

^a NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

^b KAROLINSKA INSTITUTE   (Sweden)

^c CNR Consiglio Nazionale delle Ricerche   (Italy)

^d INDIANA UNIVERSITY   (United States)

^e UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID RECEPTORS; EXTRACELLULAR SIGNAL-REGULATED KINASE; FOCAL ADHESION KINASE; FOCAL ADHESION PLAQUES; MECHANISTIC LINK; MOLECULAR CASCADES; MOLECULAR PHARMACOLOGY; SECRETORY VESICLES;

ADHESION; BIOCHEMISTRY; CELL SIGNALING; DRUG PRODUCTS; ENZYMES; MACHINERY; MOLECULAR BIOLOGY;

INSULIN;

2 ARACHIDONOYLGLYCEROL; ANANDAMIDE; CANNABINOID 1 RECEPTOR; FOCAL ADHESION KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; 2-ARACHIDONYLGLYCEROL; ACYLGLYCEROL; AMIDE; ARACHIDONIC ACID DERIVATIVE; CANNABINOID RECEPTOR AGONIST; ENDOCANNABINOID; FOCAL ADHESION KINASE 1; INSULIN; PTK2 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; BIOAVAILABILITY; CELL STRAIN; CELL STRAIN INS 1E; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FOCAL ADHESION; HORMONAL REGULATION; IN VIVO STUDY; INSULIN RELEASE; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; RECEPTOR BINDING; SIGNAL TRANSDUCTION; AGONISTS; ANIMAL; CELL LINE; DRUG EFFECTS; EXOCYTOSIS; GENETICS; HUMAN; HYPERINSULINISM; KNOCKOUT MOUSE; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOLOGY; SECRETION (PROCESS); SECRETORY VESICLE; CANNABINOID RECEPTORS; DRUG EFFECT; DRUG POTENTIATION;

ANIMALS; ARACHIDONIC ACIDS; CANNABINOID RECEPTOR AGONISTS; CELL LINE; DIABETES MELLITUS, TYPE 2; ENDOCANNABINOIDS; ENZYME ACTIVATION; EXOCYTOSIS; FOCAL ADHESION KINASE 1; GLYCERIDES; HUMANS; HYPERINSULINISM; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, KNOCKOUT; POLYUNSATURATED ALKAMIDES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, CANNABINOID, CB1; SECRETORY VESICLES;

CANNABINOID RECEPTORS; CYTOSKELETON; ENDOCANNABINOIDS; EXOCYTOSIS; FOCAL ADHESION KINASE; INSULIN RELEASE;

EID: 84887455171     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.478354     Document Type: Article

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