Neuroprotection by μ-calpain and matrix metalloproteinases inhibition by Piroxicam in cerebral ischemia: An in silico study

Medicinal Chemistry Research

Volumn 22, Issue 11, 2013, Pages 5112-5119

  Bhattacharya, Pallab ^a   Pandey, Anand Kumar ^a   Shukla, Swet Chand ^a   Paul, Sudip ^a   Patnaik, Ranjana ^a  

^a BANARAS HINDU UNIVERSITY   (India)

Author keywords

Calpain; Cerebral ischemia; Matrix metalloproteinase; Neuroprotection; Piroxicam

Indexed keywords

CALPAIN 1; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE; PIROXICAM;

ARTICLE; BRAIN ISCHEMIA; COMPUTER MODEL; HYDROGEN BOND; MOLECULAR DOCKING; NEUROPROTECTION; PROTEIN INTERACTION; PROTEIN TARGETING;

EID: 84887446398     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-013-0514-7     Document Type: Article

References (45)

1. Asahi M, Asahi K, Wang X et al (2000) Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats. J Cereb Blood Flow Metab 20:452-457
2. Bartus RT (1997) The calpain hypothesis of neurodegeneration: evidence for a common cytotoxic pathway. Neuroscientist 3:314-327
3. Bhattacharya P, Pandey AK, Paul S, Patnaik R (2012a) Neuroprotective potential of Piroxicam in cerebral ischemia: an in silico evaluation of the hypothesis to explore its therapeutic efficacy by inhibition of aquaporin-4 and acid sensing ion channel 1a. Med Hypotheses 79(1):352-357
4. Bhattacharya P, Pandey AK, Paul S, Patnaik R (2012b) Cognitive effects of NSAIDs in cerebral ischemia: a hypothesis exploring mechanical action mediated pharmacotherapy. Med Hypotheses 79(1):393-395
5. Bhattacharya P, Pandey AK, Paul S, Patnaik R (2012c) Combination therapy of Ifenprodil with Piroxicam may be an effective therapeutic intervention in cerebral stroke: a hypothesis. Med Hypotheses 79(1):516-518
6. Conti AC, Raghupathi R, Trojanowski JQ et al (1998) Experimental brain injury induces regionally distinct apoptosis during the acute and delayed post-traumatic period. J Neurosci 18:5663-5672
7. Courtman DW, Franco CD, Meng Q et al (2004) Inward remodeling of the rabbit aorta is blocked by the matrix metalloproteinase inhibitor doxycycline. J Vasc Res 41:157-165
8. Donkor IO, Han J, Zheng X (2004) Design, synthesis, molecular modeling studies, and calpain inhibitory activity of novel α-ketoamides incorporating polar residues at the P1′-position. J Med Chem 47:72-79
9. Doyle GA, Pierce RA, Parks WC (1997) Transcriptional induction of collagenase-1 in differentiated monocyte like (U937) cells is regulated by AP-1 and an upstream C/EBP-β site. J Biol Chem 272:11840-11849
10. Gidday JM (2006) Cerebral preconditioning and ischemic tolerance. Nat Rev Neurosci 7:437-448
11. Goll DE, Thompson VF, Li H et al (2003) The calpain system. Physiol Rev 83:731-801
12. Hamann GF, Liebetrau M, Martens HK (2002) Microvascular basal lamina injury following experimental focal cerebral ischemia and reperfusion. J Cereb Blood Flow Metab 22:526-533
13. Hanemaaijer R, Visser H, Koolwijk P et al (1998) Inhibition of MMP synthesis by doxycycline and chemically modified tetracyclines (CMTs) in human endothelial cells. Adv Dent Res 12:114-118
14. Huang Y, Wang KKW (2001) The calpain family in human disease. Trends Mol Med 7:355-362
15. Jordan J, Galindo MF, Miller RJ (1997) Role of calpain- and interleukin-I (3 converting enzyme-like proteases in the (3-amyloid-induced death of rat hippocampal neurons in culture. J Neurochem 68:1612-1621
16. Kampfl A, Posmantur R, Nixon R et al (1996) mu-Calpain activation and calpain mediated cytoskeletal proteolysis following traumatic brain injury. J Neurochem 67:1575-1583
17. Kampfl A, Posmantur RM, Zhao X et al (1997) Mechanisms of cal pain proteolysis following traumatic brain injury: implications for pathology and therapy: a review and update. J Neurotrauma 14:121-134
18. Khorchid A, Ikura M (2002) How calpain is activated by calcium. Nat Struct Biol 9:239-241
19. Kirino T (2002) Ischemic tolerance. J Cereb Blood Flow Metab 22:1283-1296
20. Kiyama R, Tamura Y, Watanabe F et al (1999) Homology modeling of gelatinase catalytic domains and docking simulations of novel sulfonamide inhibitors. J Med Chem 42:1723-1738
21. Lebart MC, Benyamin Y (2006) Calpain involvement in the remodeling of cytoskeletal anchorage complexes. FEBS J 273:3415-3426
22. Magnoni S, Baker A, George SJ et al (2004) Differential alterations in the expression and activity of matrix metalloproteinases 2 and 9 after transient cerebral ischemia in mice. Neurobiol Dis 17:188-197
23. Matresian LM (1992) The matrix-degrading metalloproteinases. BioEssays 14:455-463
24. Mishra V, Verma R, Raghubir R (2010) Neuroprotective effect of flurbiprofen in focal cerebral ischemia: the possible role of ASIC1a. Neuropharmacology 59:582-588
25. Nagaoka I, Hirota S (2000) Increased expression of matrix metalloproteinase-9 in neutrophils in glycogeninduced peritoneal inflammation of guinea pigs. Inflamm Res 49:55-62
26. Newcomb JK, Kampf A, Posmantur RM et al (1997) Immunohistochemical study of calpain-mediated breakdown products to a-spectrin following controlled cortical impact injury in the rat. J Neurotrauma 14:369-383
27. Nguyen M, Arkell J, Jackson CJ (2001) Human endothelial gelatinases and angiogenesis. Int J Biochem Cell Biol 33:960-970
28. Ozben T, Balkan E, Balkan S (2005) Effects of MK-801 on nitrite and cGMP levels during focal cerebral ischemia in rats. Nitric Oxide 13:210-215
29. Pandey AK, Verma S, Bhattacharya P et al (2012) An in silico strategy to explore neuroprotection by quercetin in cerebral ischemia: a novel hypothesis based on inhibition of matrix metalloproteinase (MMPs) and acid sensing ion channel 1a (ASIC1a). Med Hypotheses 79(1):76-81
30. Ram M, Sherer Y, Shoenfeld Y (2006) Matrix metalloproteinase-9 and autoimmune diseases. J Clin Immunol 26(4):299-307
31. Raynaud F, Carnac G, Marcilhac A et al (2004) m-Calpain implication in cell cycle during muscle precursor cell activation. Exp Cell Res 298:48-57
32. Romanic AM, Raymond FW, Anthony JA (1998) Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size. Stroke 29:1020-1030
33. RosenbergB GA, Estrada EY, Dencoff JE (1998) Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain. Stroke 29:2189-2195
34. Saatman KE, Bozyczko-Coyne D, Marcy V et al (1996) Prolonged calpain-mediated spectrin breakdown occurs regionally following experimental brain injury in the rat. J Neuropathol Exp Neurol 55:850-860
35. Saido TC, Sorimachi H, Suzuki K (1994) Calpain: new perspectives in molecular diversity and physiological-pathological involvement. FASEB J 8:814-822
36. Shoeman RL, Traub P (1990) Calpains and the cytoskeleton. In: Mellgren RL, Murachi T (eds) Intracellular calcium-dependent proteolysis. CRC Press, Boca Raton, pp 191-209
37. Sorimachi H, Ishiura S, Suzuki K (1997) Structure and physiological function of calpains. Biochem J 328:721-732
38. Stenzel-Poore MP, Stevens SL, King JS et al (2007) Preconditioning reprograms the response to ischemic injury and primes the emergence of unique endogenous neuroprotective phenotypes: a speculative synthesis. Stroke 38:680-685
39. Suzuki K, Hata S, Kawabata Y et al (2004) Structure, activation, and biology of calpain. Diabetes 53:S12-S18
40. Vartiainen N, Huang CY, Salminen A et al (2001) Piroxicam and NS-398 rescue neurones from hypoxia/reoxygenation damage by a mechanism independent of cyclo-oxygenase inhibition. J Neurochem 76(2):480-489
41. Wang KKW (2000) Calpain and caspase: can you tell the difference? Trends Neurosci 23:20-26
42. Wang KKW, Yuen PW (1995) Calpain inhibition: an overview of its therapeutic potential. Trends Pharmacol Sci 15:412-419
43. Wilczynski GM, Konopacki FA, Wilczek E et al (2008) Important role of matrix metalloproteinase-9 in epileptogenesis. J Cell Biol 180:1021-1035
44. 2+-dependent proteases in ischemic neuronal death: a conserved "calpain-cathepsin cascade" from nematodes to primates. Cell Calcium 36:285-293
45. Yurchenko PD, Schittney JC (1990) Molecular architecture of the basement membrane. FASEB J 4:1577-1590